Rapid suppression of 7-dehydrocholesterol reductase activity in keratinocytes by vitamin D

Journal of Steroid Biochemistry and Molecular Biology

Volumn 148, Issue , 2015, Pages 64-71

  Zou, Ling ^a   Porter, Todd D ^a  

^a University of Kentucky   (United States)

Author keywords

7 Dehydrocholesterol reductase; Cholesterol regulation; Differentiation; Hedgehog; Keratinocytes; Vitamin D

Indexed keywords

7 DEHYDROCHOLESTEROL; 7 DEHYDROCHOLESTEROL REDUCTASE; CALCIFEDIOL; CALCITRIOL; COLECALCIFEROL; CYCLOPAMINE; LANOSTEROL; OXIDOREDUCTASE; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D RECEPTOR; 7-DEHYDROCHOLESTEROL REDUCTASE; SONIC HEDGEHOG PROTEIN; VITAMIN;

ADULT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; EPIDERMIS CELL; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMORTALIZED CELL LINE; KERATINOCYTE; NONHUMAN; PRIMARY CELL LINE; RAT; SIGNAL TRANSDUCTION; SKIN CELL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; HEK293 CELL LINE; HEPG2 CELL LINE; IMMUNOBLOTTING; METABOLISM; PHOSPHORYLATION; RADIATION RESPONSE; ULTRAVIOLET RADIATION;

ADULT; CELLS, CULTURED; HEDGEHOG PROTEINS; HEK293 CELLS; HEP G2 CELLS; HUMANS; IMMUNOBLOTTING; KERATINOCYTES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; ULTRAVIOLET RAYS; VITAMIN D; VITAMINS;

EID: 84925499865     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.12.001     Document Type: Article

References (15)

1. J.D. Horton, J.L. Goldstein, and S. Brown M.S.S.R.E.B.Ps activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Invest. 109 2002 1125 1131
2. Shefer, G. Salen, A. Honda, A.K. Batta, L.B. Nguyen, and G.S. Tint Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation J. Lipid Res. 39 1998 2471 2476
3. K. Takada, A. Takashima, T. Kobayashi, and Y. Shimoi Application of high-performance liquid chromatography to the study of esterified 7-dehydrocholesterol in rat skin Biochim. Biophys. Acta. 666 1981 307 312
4. K. Takada Effect of u.v. rays on 7-dehydrocholesterol content in rat skin J. Steroid Biochem. 18 1983 507 509
5. S. Takase, K. Oizumi, S. Moriuchi, and N. Hosoya Binding of 7-dehydrocholesterol to sterol carrier protein and vitamin D3 effect J. Nutr. Sci. Vitaminol. 21 1975 387 394
6. L. Zou, L. Li, and T.D. Porter 7-Dehydrocholesterol reductase activity is independent of cytochrome P450 reductase J. Steroid Biochem. Mol. Biol. 127 2011 435 438
7. M.F. Bijlsma, C.A. Spek, D. Zivkovic, S. van de Water, F. Rezaee, and M.P. Peppelenbosch Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion PLoS Biol. 4 2006 e232
8. J.Y. Tang, T.Z. Xiao, Y. Oda, K.S. Chang, E. Shpall, and A. Wu Vitamin D3 inhibits hedgehog signaling and proliferation in murine basal cell carcinomas Cancer Prev. Res. (Phila.) 4 2011 744 751
9. P. Heretsch, L. Tzagkaroulaki, and A. Giannis Modulators of the hedgehog signaling pathway Bioorg. Med. Chem. 18 2010 6613 6624
10. F.M. Watt Involucrin and other markers of keratinocyte terminal differentiation J. Invest. Dermatol. 81 1983 100s 103s
11. D.D. Bikle, Y. Oda, and Z. Xie Calcium and 1,25(OH) 2D: interacting drivers of epidermal differentiation J. Steroid Biochem. Mol. Biol. 89-90 2004 355 360
12. M.F. Holick, J.A. MacLaughlin, M.B. Clark, S.A. Holick, J.T. Potts Jr.; and R.R. Anderson Photosynthesis of previtamin D3 in human skin and the physiologic consequences Science 210 1980 203 205
13. A.K. Gupta, R.C. Sexton, and H. Rudney Effect of vitamin D3 derivatives on cholesterol synthesis and HMG-CoA reductase activity in cultured cells J. Lipid Res. 30 1989 379 386
14. M. Honda, G.S. Tint, A. Honda, L.B. Nguyen, T.S. Chen, and S. Shefer 7-Dehydrocholesterol down-regulates cholesterol biosynthesis in cultured Smith-Lemli-Opitz syndrome skin fibroblasts J Lipid Res. 39 1998 647 657
15. D.D. Bikle, H. Elalieh, J. Welsh, D. Oh, J. Cleaver, and A. Teichert Protective role of vitamin D signaling in skin cancer formation J. Steroid Biochem. Mol. Biol. 136 2013 271 279