메뉴 건너뛰기




Volumn 54, Issue , 2016, Pages 1-29

Aldose reductase, ocular diabetic complications and the development of topical Kinostat®

Author keywords

Aldose reductase inhibitor; Diabetic cataract; Diabetic keratopathy; Diabetic retinopathy; Kinostat

Indexed keywords

2 METHYLSORBINIL; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; GALACTOSE; SORBINIL; ZENARESTAT; ENZYME INHIBITOR; EYE DROPS; IMIDAZOLIDINE DERIVATIVE;

EID: 84965076002     PISSN: 13509462     EISSN: 18731635     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2016.04.006     Document Type: Review
Times cited : (67)

References (257)
  • 1
    • 79954515223 scopus 로고    scopus 로고
    • New therapeutic approaches in the treatment of diabetic keratopathy: a review
    • Abdelkader, H., Patel, D.V., McGhee, C., Alany, R.G., New therapeutic approaches in the treatment of diabetic keratopathy: a review. Clin. Exp. Ophthalmol. 39 (2011), 259–270.
    • (2011) Clin. Exp. Ophthalmol. , vol.39 , pp. 259-270
    • Abdelkader, H.1    Patel, D.V.2    McGhee, C.3    Alany, R.G.4
  • 3
    • 0023084653 scopus 로고
    • Immunohistochemical localization for aldose reductase in diabetic lenses
    • Akagi, Y., Kador, P.F., Kinoshita, J.H., Immunohistochemical localization for aldose reductase in diabetic lenses. Invest. Ophthalmol. Vis. Sci. 28 (1987), 163–167.
    • (1987) Invest. Ophthalmol. Vis. Sci. , vol.28 , pp. 163-167
    • Akagi, Y.1    Kador, P.F.2    Kinoshita, J.H.3
  • 5
    • 84864297936 scopus 로고
    • Aldose Reductase Localization in Rat Sugar Cataracts
    • Exerpta Medica Amsterdam
    • Akagi, Y., Tasaka, H., Terubayashi, H., Kador, P.F., Kinoshita, J.H., Aldose Reductase Localization in Rat Sugar Cataracts. 1986, Exerpta Medica, Amsterdam.
    • (1986)
    • Akagi, Y.1    Tasaka, H.2    Terubayashi, H.3    Kador, P.F.4    Kinoshita, J.H.5
  • 6
    • 84990309013 scopus 로고
    • Repair of Corneal Endothelium in Galactosemic Rats
    • Exerpta Medica Amsterdam
    • Akagi, Y., Terubayashi, H., Ikebe, H., Kador, P.F., Kinoshita, J.H., Repair of Corneal Endothelium in Galactosemic Rats. 1986, Exerpta Medica, Amsterdam.
    • (1986)
    • Akagi, Y.1    Terubayashi, H.2    Ikebe, H.3    Kador, P.F.4    Kinoshita, J.H.5
  • 9
    • 0003796898 scopus 로고    scopus 로고
    • U.S. Pet Ownership and Demographics Sourcebook
    • American Veterinary Medical Association
    • American Veterinary Medical Association, U.S. Pet Ownership and Demographics Sourcebook. 2012, American Veterinary Medical Association.
    • (2012)
    • American Veterinary Medical Association1
  • 10
    • 0027185704 scopus 로고
    • Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique
    • Anderson, H.R., Stitt, A.W., Gardiner, T.A., Lloyd, S.J., Archer, D.B., Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique. Lab. Anim. 27 (1993), 281–285.
    • (1993) Lab. Anim. , vol.27 , pp. 281-285
    • Anderson, H.R.1    Stitt, A.W.2    Gardiner, T.A.3    Lloyd, S.J.4    Archer, D.B.5
  • 13
    • 43749084209 scopus 로고    scopus 로고
    • Hyperglycemia and the pathobiology of diabetic complications
    • Aronson, D., Hyperglycemia and the pathobiology of diabetic complications. Adv. Cardiol. 45 (2008), 1–16.
    • (2008) Adv. Cardiol. , vol.45 , pp. 1-16
    • Aronson, D.1
  • 14
    • 67649601287 scopus 로고    scopus 로고
    • Surgical outcomes of primary foldable intraocular lens implantation in children: understanding posterior opacification and the absence of glaucoma
    • Astle, W.F., Alewenah, O., Ingram, A.D., Paszuk, A., Surgical outcomes of primary foldable intraocular lens implantation in children: understanding posterior opacification and the absence of glaucoma. J. Cataract. Refract Surg. 35 (2009), 1216–1222.
    • (2009) J. Cataract. Refract Surg. , vol.35 , pp. 1216-1222
    • Astle, W.F.1    Alewenah, O.2    Ingram, A.D.3    Paszuk, A.4
  • 15
    • 33646247849 scopus 로고    scopus 로고
    • Acute irreversible diabetic cataract in adolescence: a case report
    • Awan, A., Saboor, T., Buchanan, L.M., Acute irreversible diabetic cataract in adolescence: a case report. Eye 20 (2005), 398–400.
    • (2005) Eye , vol.20 , pp. 398-400
    • Awan, A.1    Saboor, T.2    Buchanan, L.M.3
  • 16
    • 84990303078 scopus 로고
    • The Effect of Topical Aldose Reductase Inhibitor on Diabetic Keratopathy
    • Exerpta Medica Amsterdam
    • Awata, T., Matsuda, M., Ohashi, Y., Fukuda, M., The Effect of Topical Aldose Reductase Inhibitor on Diabetic Keratopathy. 1990, Exerpta Medica, Amsterdam.
    • (1990)
    • Awata, T.1    Matsuda, M.2    Ohashi, Y.3    Fukuda, M.4
  • 17
    • 0023767678 scopus 로고
    • Effect of an aldose reductase inhibitor, CT-112, on healing of the corneal epithelium in galactose-fed rats
    • Awata, T., Sogo, S., Yamagami, Y., Yamamoto, Y., Effect of an aldose reductase inhibitor, CT-112, on healing of the corneal epithelium in galactose-fed rats. J. Ocul. Pharmacol. 4 (1988), 195–201.
    • (1988) J. Ocul. Pharmacol. , vol.4 , pp. 195-201
    • Awata, T.1    Sogo, S.2    Yamagami, Y.3    Yamamoto, Y.4
  • 18
    • 0022502906 scopus 로고
    • Effects of aldose reductase inhibitor, CT-112, on sugar alcohol accumulation in corneal epithelium of galactose-fed rats
    • Awata, T., Sogo, S., Yamamoto, Y., Effects of aldose reductase inhibitor, CT-112, on sugar alcohol accumulation in corneal epithelium of galactose-fed rats. Jpn. J. Ophthalmol. 30 (1986), 245–250.
    • (1986) Jpn. J. Ophthalmol. , vol.30 , pp. 245-250
    • Awata, T.1    Sogo, S.2    Yamamoto, Y.3
  • 19
    • 0022450293 scopus 로고
    • The effect of oxidation on sorbitol pathway kinetics
    • Barnett, P.A., Gonzalez, R.G., Chylack, L.T. Jr., Cheng, H.M., The effect of oxidation on sorbitol pathway kinetics. Diabetes 35 (1986), 426–432.
    • (1986) Diabetes , vol.35 , pp. 426-432
    • Barnett, P.A.1    Gonzalez, R.G.2    Chylack, L.T.3    Cheng, H.M.4
  • 20
    • 0001428946 scopus 로고    scopus 로고
    • A retrospective-cohort study on the development of cataracts in dogs with diabetes mellitus: 200 cases
    • Beam, S., Correa, M.T., Davidson, M.G., A retrospective-cohort study on the development of cataracts in dogs with diabetes mellitus: 200 cases. Vet. Ophthalmol. 2 (1999), 169–172.
    • (1999) Vet. Ophthalmol. , vol.2 , pp. 169-172
    • Beam, S.1    Correa, M.T.2    Davidson, M.G.3
  • 21
    • 0032442968 scopus 로고    scopus 로고
    • Do changes in the hydration of the diabetic human lens precede cataract formation?
    • Bettelheim, F.A., Li, L., Zeng, F.F., Do changes in the hydration of the diabetic human lens precede cataract formation?. Res. Commun. Mol. Pathol. Pharmacol. 102 (1998), 3–14.
    • (1998) Res. Commun. Mol. Pathol. Pharmacol. , vol.102 , pp. 3-14
    • Bettelheim, F.A.1    Li, L.2    Zeng, F.F.3
  • 22
    • 0021968670 scopus 로고
    • Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor
    • Beyer-Mears, A., Cruz, E., Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. Diabetes 34 (1985), 15–21.
    • (1985) Diabetes , vol.34 , pp. 15-21
    • Beyer-Mears, A.1    Cruz, E.2
  • 23
    • 0021795715 scopus 로고
    • Reversal of stage-I sugar cataract by Sorbinil, an aldose reductase inhibitor
    • Beyer-Mears, A., Cruz, E., Varagiannis, E., Reversal of stage-I sugar cataract by Sorbinil, an aldose reductase inhibitor. Pharmacology 31 (1985), 88–96.
    • (1985) Pharmacology , vol.31 , pp. 88-96
    • Beyer-Mears, A.1    Cruz, E.2    Varagiannis, E.3
  • 24
    • 0030792829 scopus 로고    scopus 로고
    • Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract
    • Beyer-Mears, A., Diecke, F.P., Mistry, K., Ellison, C., Cruz, E., Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract. Pharmacology 55 (1997), 78–86.
    • (1997) Pharmacology , vol.55 , pp. 78-86
    • Beyer-Mears, A.1    Diecke, F.P.2    Mistry, K.3    Ellison, C.4    Cruz, E.5
  • 30
    • 0028286444 scopus 로고
    • Aldose reductase inhibition, nerve perfusion, oxygenation and function in streptozotocin-diabetic rats: dose-response considerations and independence from a myo-inositol mechanism
    • Cameron, N.E., Cotter, M.A., Dines, K.C., Maxfield, E.K., Carey, F., Mirrlees, D.J., Aldose reductase inhibition, nerve perfusion, oxygenation and function in streptozotocin-diabetic rats: dose-response considerations and independence from a myo-inositol mechanism. Diabetologia 37 (1994), 651–663.
    • (1994) Diabetologia , vol.37 , pp. 651-663
    • Cameron, N.E.1    Cotter, M.A.2    Dines, K.C.3    Maxfield, E.K.4    Carey, F.5    Mirrlees, D.J.6
  • 31
    • 85040153627 scopus 로고    scopus 로고
    • Canine Diabetes Mellitus
    • Society for Endocrinology BES 2007,. Endocrine Abstracts Birmingham, UK
    • Catchpole, B., Canine Diabetes Mellitus. 2007, Society for Endocrinology BES 2007,. Endocrine Abstracts, Birmingham, UK, S35.
    • (2007) , pp. S35
    • Catchpole, B.1
  • 32
    • 0022650672 scopus 로고
    • The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis
    • Cheng, H.M., Gonzalez, R.G., The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis. Metabolism 35 (1986), 10–14.
    • (1986) Metabolism , vol.35 , pp. 10-14
    • Cheng, H.M.1    Gonzalez, R.G.2
  • 34
    • 33644663628 scopus 로고    scopus 로고
    • Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice
    • Cheung, A.K., Fung, M.K., Lo, A.C., Lam, T.T., So, K.F., Chung, S.S., Chung, S.K., Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice. Diabetes 54 (2005), 3119–3125.
    • (2005) Diabetes , vol.54 , pp. 3119-3125
    • Cheung, A.K.1    Fung, M.K.2    Lo, A.C.3    Lam, T.T.4    So, K.F.5    Chung, S.S.6    Chung, S.K.7
  • 35
    • 0028355398 scopus 로고
    • Systemic delivery of polypeptide drugs through ocular route
    • Chiou, G.C., Systemic delivery of polypeptide drugs through ocular route. J. Ocul. Pharmacol. 10 (1994), 93–99.
    • (1994) J. Ocul. Pharmacol. , vol.10 , pp. 93-99
    • Chiou, G.C.1
  • 37
    • 0018572307 scopus 로고
    • Efficacy of Alrestatin, an aldose reductase inhibitor, in human diabetic and nondiabetic lenses
    • Chylack, L.T. Jr., Henriques, H.F. 3rd, Cheng, H.M., Tung, W.H., Efficacy of Alrestatin, an aldose reductase inhibitor, in human diabetic and nondiabetic lenses. Ophthalmology 86 (1979), 1579–1585.
    • (1979) Ophthalmology , vol.86 , pp. 1579-1585
    • Chylack, L.T.1    Henriques, H.F.2    Cheng, H.M.3    Tung, W.H.4
  • 38
    • 0014558793 scopus 로고
    • A biochemical evaluation of a cataract induced in a high-glucose medium
    • Chylack, L.T. Jr., Kinoshita, J.H., A biochemical evaluation of a cataract induced in a high-glucose medium. Invest. Ophthalmol. 8 (1969), 401–412.
    • (1969) Invest. Ophthalmol. , vol.8 , pp. 401-412
    • Chylack, L.T.1    Kinoshita, J.H.2
  • 39
    • 0023026663 scopus 로고
    • Sorbitol production in the lens: a means of counteracting glucose-derived osmotic stress
    • Chylack, L.T. Jr., Tung, W., Harding, R., Sorbitol production in the lens: a means of counteracting glucose-derived osmotic stress. Ophthalmic Res. 18 (1986), 313–320.
    • (1986) Ophthalmic Res. , vol.18 , pp. 313-320
    • Chylack, L.T.1    Tung, W.2    Harding, R.3
  • 40
    • 0035523824 scopus 로고    scopus 로고
    • Discoveries in research on diabetic keratopathy
    • Cisarik-Fredenburg, P., Discoveries in research on diabetic keratopathy. Optometry 72 (2001), 691–704.
    • (2001) Optometry , vol.72 , pp. 691-704
    • Cisarik-Fredenburg, P.1
  • 43
    • 0344305690 scopus 로고    scopus 로고
    • Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogs
    • Cusick, M., Chew, E.Y., Ferris, F. 3rd, Cox, T.A., Chan, C.C., Kador, P.F., Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogs. Archives Ophthalmol. 121 (2003), 1745–1751.
    • (2003) Archives Ophthalmol. , vol.121 , pp. 1745-1751
    • Cusick, M.1    Chew, E.Y.2    Ferris, F.3    Cox, T.A.4    Chan, C.C.5    Kador, P.F.6
  • 44
    • 66649108484 scopus 로고    scopus 로고
    • The accelerating epidemic of childhood diabetes
    • Dabelea, D., The accelerating epidemic of childhood diabetes. Lancet 373 (2009), 1999–2000.
    • (2009) Lancet , vol.373 , pp. 1999-2000
    • Dabelea, D.1
  • 46
    • 4344658774 scopus 로고    scopus 로고
    • Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy
    • Dagher, Z., Park, Y.S., Asnaghi, V., Hoehn, T., Gerhardinger, C., Lorenzi, M., Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy. Diabetes 53 (2004), 2404–2411.
    • (2004) Diabetes , vol.53 , pp. 2404-2411
    • Dagher, Z.1    Park, Y.S.2    Asnaghi, V.3    Hoehn, T.4    Gerhardinger, C.5    Lorenzi, M.6
  • 48
    • 0025225652 scopus 로고
    • The effects of sorbinil, an aldose reductase inhibitor, on the corneal endothelium in galactosemic dogs
    • Datiles, M.B., Kador, P.F., Kashima, K., Kinoshita, J.H., Sinha, A., The effects of sorbinil, an aldose reductase inhibitor, on the corneal endothelium in galactosemic dogs. Invest. Ophthalmol. Vis. Sci. 31 (1990), 2201–2204.
    • (1990) Invest. Ophthalmol. Vis. Sci. , vol.31 , pp. 2201-2204
    • Datiles, M.B.1    Kador, P.F.2    Kashima, K.3    Kinoshita, J.H.4    Sinha, A.5
  • 50
  • 51
    • 0033658367 scopus 로고    scopus 로고
    • Polymorphisms of the aldose reductase gene and susceptibility to retinopathy in type 1 diabetes mellitus
    • Demaine, A., Cross, D., Millward, A., Polymorphisms of the aldose reductase gene and susceptibility to retinopathy in type 1 diabetes mellitus. Invest. Ophthalmol. Vis. Sci. 41 (2000), 4064–4068.
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , pp. 4064-4068
    • Demaine, A.1    Cross, D.2    Millward, A.3
  • 52
    • 0041809017 scopus 로고    scopus 로고
    • Polymorphisms of the aldose reductase gene and susceptibility to diabetic microvascular complications
    • Demaine, A.G., Polymorphisms of the aldose reductase gene and susceptibility to diabetic microvascular complications. Curr. Med. Chem. 10 (2003), 1389–1398.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1389-1398
    • Demaine, A.G.1
  • 53
    • 0028915217 scopus 로고
    • Progression of retinopathy with intensive versus conventional treatment in the diabetes control and complications trial. Diabetes control and complications trial research group
    • Diabetes Complications Control Group. Progression of retinopathy with intensive versus conventional treatment in the diabetes control and complications trial. Diabetes control and complications trial research group. Ophthalmology 102 (1995), 647–661.
    • (1995) Ophthalmology , vol.102 , pp. 647-661
  • 54
    • 33745483315 scopus 로고    scopus 로고
    • The -106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes
    • dos Santos, K.G., Canani, L.H., Gross, J.L., Tschiedel, B., Souto, K.E., Roisenberg, I., The -106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes. Mol. Genet. Metab. 88 (2006), 280–284.
    • (2006) Mol. Genet. Metab. , vol.88 , pp. 280-284
    • dos Santos, K.G.1    Canani, L.H.2    Gross, J.L.3    Tschiedel, B.4    Souto, K.E.5    Roisenberg, I.6
  • 55
    • 0017739089 scopus 로고
    • Relationship of microvascular disease in diabetes to metabolic control
    • Engerman, R., Bloodworth, J.M. Jr., Nelson, S., Relationship of microvascular disease in diabetes to metabolic control. Diabetes 26 (1977), 760–769.
    • (1977) Diabetes , vol.26 , pp. 760-769
    • Engerman, R.1    Bloodworth, J.M.2    Nelson, S.3
  • 56
    • 0001652080 scopus 로고
    • Experimental diabetic retinopathy in dogs
    • Engerman, R.L., Bloodworth, J.M. Jr., Experimental diabetic retinopathy in dogs. Archives Ophthalmol. 73 (1965), 205–210.
    • (1965) Archives Ophthalmol. , vol.73 , pp. 205-210
    • Engerman, R.L.1    Bloodworth, J.M.2
  • 57
    • 0021368318 scopus 로고
    • Experimental galactosemia produces diabetic-like retinopathy
    • Engerman, R.L., Kern, T.S., Experimental galactosemia produces diabetic-like retinopathy. Diabetes 33 (1984), 97–100.
    • (1984) Diabetes , vol.33 , pp. 97-100
    • Engerman, R.L.1    Kern, T.S.2
  • 58
    • 0028954710 scopus 로고
    • Retinopathy in galactosemic dogs continues to progress after cessation of galactosemia
    • Engerman, R.L., Kern, T.S., Retinopathy in galactosemic dogs continues to progress after cessation of galactosemia. Arch. Ophthalmol. 113 (1995), 355–358.
    • (1995) Arch. Ophthalmol. , vol.113 , pp. 355-358
    • Engerman, R.L.1    Kern, T.S.2
  • 60
    • 0029904010 scopus 로고    scopus 로고
    • The Vanderbilt Classification System in the evaluation of diabetic retinopathy patients treated with Alredase
    • discussion 447–450
    • Feman, S.S., Leonard-Martin, T.C., Redman, J.R., The Vanderbilt Classification System in the evaluation of diabetic retinopathy patients treated with Alredase. Trans. Am. Ophthalmol. Soc. 94 (1996), 433–447 discussion 447–450.
    • (1996) Trans. Am. Ophthalmol. Soc. , vol.94 , pp. 433-447
    • Feman, S.S.1    Leonard-Martin, T.C.2    Redman, J.R.3
  • 61
    • 84990302801 scopus 로고    scopus 로고
    • Emerging therapies for diabetic retinopathy
    • Ferris, F.L. III, Emerging therapies for diabetic retinopathy. Johns Hopkins Adv. Stud. Ophthalmol., 2, 2005, 26030.
    • (2005) Johns Hopkins Adv. Stud. Ophthalmol. , vol.2 , pp. 26030
    • Ferris, F.L.1
  • 63
    • 3543050619 scopus 로고    scopus 로고
    • Prevalence of chronic diabetes complications depending on the method of insulin therapy in children and adolescents with type 1 diabetes
    • Florys, B., Oldytowska, A., Glowinska, B., Peczynska, J., Urban, M., Prevalence of chronic diabetes complications depending on the method of insulin therapy in children and adolescents with type 1 diabetes. Endokrynol. Diabetol. Chor. Przemiany Materii Wieku Rozw. 10 (2004), 31–39.
    • (2004) Endokrynol. Diabetol. Chor. Przemiany Materii Wieku Rozw. , vol.10 , pp. 31-39
    • Florys, B.1    Oldytowska, A.2    Glowinska, B.3    Peczynska, J.4    Urban, M.5
  • 64
    • 0018392742 scopus 로고
    • Factors related to corneal epithelial complications after closed vitrectomy in diabetics
    • Foulks, G.N., Thoft, R.A., Perry, H.D., Tolentino, F.I., Factors related to corneal epithelial complications after closed vitrectomy in diabetics. Arch. Ophthalmol. 97 (1979), 1076–1078.
    • (1979) Arch. Ophthalmol. , vol.97 , pp. 1076-1078
    • Foulks, G.N.1    Thoft, R.A.2    Perry, H.D.3    Tolentino, F.I.4
  • 65
    • 0021043111 scopus 로고
    • Galactose-induced retinal capillary basement membrane thickening: prevention by Sorbinil
    • Frank, R.N., Keirn, R.J., Kennedy, A., Frank, K.W., Galactose-induced retinal capillary basement membrane thickening: prevention by Sorbinil. Invest. Ophthalmol. Vis. Sci. 24 (1983), 1519–1524.
    • (1983) Invest. Ophthalmol. Vis. Sci. , vol.24 , pp. 1519-1524
    • Frank, R.N.1    Keirn, R.J.2    Kennedy, A.3    Frank, K.W.4
  • 66
    • 0012934487 scopus 로고
    • Contributions to histopathology of cataract
    • Friedenwald, J.S., Rytel, D., Contributions to histopathology of cataract. Arch. Ophthalmol. 53 (1955), 825–831.
    • (1955) Arch. Ophthalmol. , vol.53 , pp. 825-831
    • Friedenwald, J.S.1    Rytel, D.2
  • 67
    • 0033390623 scopus 로고    scopus 로고
    • Length rather than a specific allele of dinucleotide repeat in the 5’ upstream region of the aldose reductase gene is associated with diabetic retinopathy
    • Fujisawa, T., Ikegami, H., Kawaguchi, Y., Yamato, E., Nakagawa, Y., Shen, G.Q., Fukuda, M., Ogihara, T., Length rather than a specific allele of dinucleotide repeat in the 5’ upstream region of the aldose reductase gene is associated with diabetic retinopathy. Diabet. Med. 16 (1999), 1044–1047.
    • (1999) Diabet. Med. , vol.16 , pp. 1044-1047
    • Fujisawa, T.1    Ikegami, H.2    Kawaguchi, Y.3    Yamato, E.4    Nakagawa, Y.5    Shen, G.Q.6    Fukuda, M.7    Ogihara, T.8
  • 68
    • 0029951568 scopus 로고    scopus 로고
    • Improvement of corneal sensation and tear dynamics in diabetic patients by oral aldose reductase inhibitor, ONO-2235: a preliminary study
    • Fujishima, H., Shimazaki, J., Yagi, Y., Tsubota, K., Improvement of corneal sensation and tear dynamics in diabetic patients by oral aldose reductase inhibitor, ONO-2235: a preliminary study. Cornea 15 (1996), 368–375.
    • (1996) Cornea , vol.15 , pp. 368-375
    • Fujishima, H.1    Shimazaki, J.2    Yagi, Y.3    Tsubota, K.4
  • 69
    • 0036315857 scopus 로고    scopus 로고
    • Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235
    • Fujishima, H., Tsubota, K., Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235. Br. J. Ophthalmol. 86 (2002), 860–863.
    • (2002) Br. J. Ophthalmol. , vol.86 , pp. 860-863
    • Fujishima, H.1    Tsubota, K.2
  • 71
    • 0016500217 scopus 로고
    • Spontaneous cataract resorption and lens-induced uveitis in the dog
    • Gelatt, K.N., Spontaneous cataract resorption and lens-induced uveitis in the dog. Mod. Vet. Pract. 56 (1975), 331–335.
    • (1975) Mod. Vet. Pract. , vol.56 , pp. 331-335
    • Gelatt, K.N.1
  • 72
    • 84973529802 scopus 로고    scopus 로고
    • Incidence, progression, and associated risk factors of posterior vitreous detachment in type 2 diabetes mellitus: sankara nethralaya diabetic retinopathy epidemiology and molecular genetic study (SN-DREAMS II, report No. 7)
    • Gella, L., Raman, R., Pal, S.S., Ganesan, S., Sharma, T., Incidence, progression, and associated risk factors of posterior vitreous detachment in type 2 diabetes mellitus: sankara nethralaya diabetic retinopathy epidemiology and molecular genetic study (SN-DREAMS II, report No. 7). Semin. Ophthalmol., 1–7, 2015.
    • (2015) Semin. Ophthalmol. , vol.1-7
    • Gella, L.1    Raman, R.2    Pal, S.S.3    Ganesan, S.4    Sharma, T.5
  • 73
    • 0027635968 scopus 로고
    • The formation and reversal of acute cataracts in diabetes mellitus
    • Gelvin, J.B., Thonn, V.A., The formation and reversal of acute cataracts in diabetes mellitus. J. Am. Optom. Assoc. 64 (1993), 471–474.
    • (1993) J. Am. Optom. Assoc. , vol.64 , pp. 471-474
    • Gelvin, J.B.1    Thonn, V.A.2
  • 74
    • 77952468064 scopus 로고    scopus 로고
    • Activation of protein kinase C isoforms and its impact on diabetic complications
    • Geraldes, P., King, G.L., Activation of protein kinase C isoforms and its impact on diabetic complications. Circ. Res. 106 (2010), 1319–1331.
    • (2010) Circ. Res. , vol.106 , pp. 1319-1331
    • Geraldes, P.1    King, G.L.2
  • 76
    • 0020522383 scopus 로고
    • The effect of an aldose reductase inhibitor (Sorbinil) on the level of metabolites in lenses of diabetic rats
    • Gonzalez, A.M., Sochor, M., McLean, P., The effect of an aldose reductase inhibitor (Sorbinil) on the level of metabolites in lenses of diabetic rats. Diabetes 32 (1983), 482–485.
    • (1983) Diabetes , vol.32 , pp. 482-485
    • Gonzalez, A.M.1    Sochor, M.2    McLean, P.3
  • 77
    • 0033546655 scopus 로고    scopus 로고
    • Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group
    • Greene, D.A., Arezzo, J.C., Brown, M.B., Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group. Neurology 53 (1999), 580–591.
    • (1999) Neurology , vol.53 , pp. 580-591
    • Greene, D.A.1    Arezzo, J.C.2    Brown, M.B.3
  • 78
    • 78650222440 scopus 로고    scopus 로고
    • Animal models of choroidal and retinal neovascularization
    • Grossniklaus, H.E., Kang, S.J., Berglin, L., Animal models of choroidal and retinal neovascularization. Prog. Retin Eye Res. 29 (2010), 500–519.
    • (2010) Prog. Retin Eye Res. , vol.29 , pp. 500-519
    • Grossniklaus, H.E.1    Kang, S.J.2    Berglin, L.3
  • 79
    • 84891649533 scopus 로고    scopus 로고
    • Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus
    • Guo, C., Zhang, Z., Zhang, P., Makita, J., Kawada, H., Blessing, K., Kador, P.F., Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus. Exp. Eye Res. 119 (2014), 77–87.
    • (2014) Exp. Eye Res. , vol.119 , pp. 77-87
    • Guo, C.1    Zhang, Z.2    Zhang, P.3    Makita, J.4    Kawada, H.5    Blessing, K.6    Kador, P.F.7
  • 80
    • 0037984192 scopus 로고    scopus 로고
    • Time trends and risk factors for diabetes mellitus in dogs: analysis of veterinary medical data base records (1970-1999)
    • Guptill, L., Glickman, L., Glickman, N., Time trends and risk factors for diabetes mellitus in dogs: analysis of veterinary medical data base records (1970-1999). Vet. J. 165 (2003), 240–247.
    • (2003) Vet. J. , vol.165 , pp. 240-247
    • Guptill, L.1    Glickman, L.2    Glickman, N.3
  • 83
    • 0026887742 scopus 로고
    • Pharmacological treatment strategies in age-related cataracts
    • Harding, J.J., Pharmacological treatment strategies in age-related cataracts. Drugs Aging 2 (1992), 287–300.
    • (1992) Drugs Aging , vol.2 , pp. 287-300
    • Harding, J.J.1
  • 84
    • 0036723885 scopus 로고    scopus 로고
    • Plasma 3-deoxyglucosone elevation in chronic renal failure is associated with increased aldose reductase in erythrocytes
    • Hasuike, Y., Nakanishi, T., Otaki, Y., Nanami, M., Tanimoto, T., Taniguchi, N., T, Y., Plasma 3-deoxyglucosone elevation in chronic renal failure is associated with increased aldose reductase in erythrocytes. Am. J. Kidney Dis. 40 (2002), 464–471.
    • (2002) Am. J. Kidney Dis. , vol.40 , pp. 464-471
    • Hasuike, Y.1    Nakanishi, T.2    Otaki, Y.3    Nanami, M.4    Tanimoto, T.5    Taniguchi, N.6
  • 86
    • 0030903087 scopus 로고    scopus 로고
    • Polymorphism in the 5’-end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type I diabetes
    • Heesom, A.E., Hibberd, M.L., Millward, A., Demaine, A.G., Polymorphism in the 5’-end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type I diabetes. Diabetes 46 (1997), 287–291.
    • (1997) Diabetes , vol.46 , pp. 287-291
    • Heesom, A.E.1    Hibberd, M.L.2    Millward, A.3    Demaine, A.G.4
  • 87
    • 33747069158 scopus 로고    scopus 로고
    • Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage
    • Ho, E.C., Lam, K.S., Chen, Y.S., Yip, J.C., Arvindakshan, M., Yamagishi, S., Yagihashi, S., Oates, P.J., Ellery, C.A., Chung, S.S., Chung, S.K., Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage. Diabetes 55 (2006), 1946–1953.
    • (2006) Diabetes , vol.55 , pp. 1946-1953
    • Ho, E.C.1    Lam, K.S.2    Chen, Y.S.3    Yip, J.C.4    Arvindakshan, M.5    Yamagishi, S.6    Yagihashi, S.7    Oates, P.J.8    Ellery, C.A.9    Chung, S.S.10    Chung, S.K.11
  • 88
    • 0024557533 scopus 로고
    • Aldose reductase and polyol in cultured pericytes of human retinal capillaries
    • Hohman, T.C., Nishimura, C., Robison, W.G. Jr., Aldose reductase and polyol in cultured pericytes of human retinal capillaries. Exp. Eye Res. 48 (1989), 55–60.
    • (1989) Exp. Eye Res. , vol.48 , pp. 55-60
    • Hohman, T.C.1    Nishimura, C.2    Robison, W.G.3
  • 89
    • 0029823058 scopus 로고    scopus 로고
    • Effects of topical aldose reductase inhibitor CT-112 on corneal sensitivity of diabetic rats
    • Hosotani, H., Ohashi, Y., Kinoshita, S., Matsumoto, T., Awata, T., Effects of topical aldose reductase inhibitor CT-112 on corneal sensitivity of diabetic rats. Curr. Eye Res. 15 (1996), 1005–1007.
    • (1996) Curr. Eye Res. , vol.15 , pp. 1005-1007
    • Hosotani, H.1    Ohashi, Y.2    Kinoshita, S.3    Matsumoto, T.4    Awata, T.5
  • 90
    • 0028954662 scopus 로고
    • Reversal of abnormal corneal epithelial cell morphologic characteristics and reduced corneal sensitivity in diabetic patients by aldose reductase inhibitor, CT-112
    • Hosotani, H., Ohashi, Y., Yamada, M., Tsubota, K., Reversal of abnormal corneal epithelial cell morphologic characteristics and reduced corneal sensitivity in diabetic patients by aldose reductase inhibitor, CT-112. Am. J. Ophthalmol. 119 (1995), 288–294.
    • (1995) Am. J. Ophthalmol. , vol.119 , pp. 288-294
    • Hosotani, H.1    Ohashi, Y.2    Yamada, M.3    Tsubota, K.4
  • 91
    • 0022977635 scopus 로고
    • Treatment of diabetic keratopathy with a topical aldose reductase inhibitor
    • Hosotani, H., Tano, Y., Tamada, R., Treatment of diabetic keratopathy with a topical aldose reductase inhibitor. Olia Jpn. Ophthalmol. Clinica 37 (1986), 1359–1365.
    • (1986) Olia Jpn. Ophthalmol. Clinica , vol.37 , pp. 1359-1365
    • Hosotani, H.1    Tano, Y.2    Tamada, R.3
  • 93
    • 70549092145 scopus 로고    scopus 로고
    • Long-term visual function outcomes of congenital cataract surgery with intraocular lens implantation in children under 5 years of age
    • Hussin, H.M., Markham, R., Long-term visual function outcomes of congenital cataract surgery with intraocular lens implantation in children under 5 years of age. Eur. J. Ophthalmol. 19 (2009), 754–761.
    • (2009) Eur. J. Ophthalmol. , vol.19 , pp. 754-761
    • Hussin, H.M.1    Markham, R.2
  • 95
    • 0032886411 scopus 로고    scopus 로고
    • Association of an (A-C)n dinucleotide repeat polymorphic marker at the 5’-region of the aldose reductase gene with retinopathy but not with nephropathy or neuropathy in Japanese patients with Type 2 diabetes mellitus
    • Ichikawa, F., Yamada, K., Ishiyama-Shigemoto, S., Yuan, X., Nonaka, K., Association of an (A-C)n dinucleotide repeat polymorphic marker at the 5’-region of the aldose reductase gene with retinopathy but not with nephropathy or neuropathy in Japanese patients with Type 2 diabetes mellitus. Diabet. Med. 16 (1999), 744–748.
    • (1999) Diabet. Med. , vol.16 , pp. 744-748
    • Ichikawa, F.1    Yamada, K.2    Ishiyama-Shigemoto, S.3    Yuan, X.4    Nonaka, K.5
  • 96
    • 0033536561 scopus 로고    scopus 로고
    • Z-4 allele upstream of the aldose reductase gene is associated with proliferative retinopathy in Japanese patients with NIDDM, and elevated luciferase gene transcription in vitro
    • Ikegishi, Y., Tawata, M., Aida, K., Onaya, T., Z-4 allele upstream of the aldose reductase gene is associated with proliferative retinopathy in Japanese patients with NIDDM, and elevated luciferase gene transcription in vitro. Life Sci. 65 (1999), 2061–2070.
    • (1999) Life Sci. , vol.65 , pp. 2061-2070
    • Ikegishi, Y.1    Tawata, M.2    Aida, K.3    Onaya, T.4
  • 97
    • 0031980073 scopus 로고    scopus 로고
    • Diabetic-like corneal sensitivity loss in galactose-fed rats ameliorated with aldose reductase inhibitors
    • Jacot, J.L., Hosotani, H., Glover, J.P., Lois, N., Robison, W.G. Jr., Diabetic-like corneal sensitivity loss in galactose-fed rats ameliorated with aldose reductase inhibitors. J. Ocul. Pharmacol. Ther. 14 (1998), 169–180.
    • (1998) J. Ocul. Pharmacol. Ther. , vol.14 , pp. 169-180
    • Jacot, J.L.1    Hosotani, H.2    Glover, J.P.3    Lois, N.4    Robison, W.G.5
  • 100
    • 0003037042 scopus 로고
    • Prevention of ocular diabetic complications by aldose reductase inhibitors
    • Kador, P.F., Prevention of ocular diabetic complications by aldose reductase inhibitors. Swiss Pharma 12 (1990), 33–38.
    • (1990) Swiss Pharma , vol.12 , pp. 33-38
    • Kador, P.F.1
  • 101
    • 77950958590 scopus 로고    scopus 로고
    • Ocular pathology of diabetes mellitus
    • W. Tasman E. Jaeger Wolters Kluwer/Lippicott Williams and Wilkins Philadelphia
    • Kador, P.F., Ocular pathology of diabetes mellitus. Tasman, W., Jaeger, E., (eds.) Duane's Ophthalmology, 2007, Wolters Kluwer/Lippicott Williams and Wilkins, Philadelphia, 1–84.
    • (2007) Duane's Ophthalmology , pp. 1-84
    • Kador, P.F.1
  • 102
    • 84990301668 scopus 로고    scopus 로고
    • Diabetes-associated Cataracts
    • Saunders Elsevier
    • Kador, P.F., Diabetes-associated Cataracts. 2010, Saunders Elsevier.
    • (2010)
    • Kador, P.F.1
  • 103
    • 0022633518 scopus 로고
    • The effect of aldose reductase and its inhibition on sugar cataract formation
    • Kador, P.F., Akagi, Y., Kinoshita, J.H., The effect of aldose reductase and its inhibition on sugar cataract formation. Metabolism 35 (1986), 15–19.
    • (1986) Metabolism , vol.35 , pp. 15-19
    • Kador, P.F.1    Akagi, Y.2    Kinoshita, J.H.3
  • 104
    • 0025140713 scopus 로고
    • Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors
    • Kador, P.F., Akagi, Y., Takahashi, Y., Ikebe, H., Wyman, M., Kinoshita, J.H., Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors. Archives Ophthalmol. 108 (1990), 1301–1309.
    • (1990) Archives Ophthalmol. , vol.108 , pp. 1301-1309
    • Kador, P.F.1    Akagi, Y.2    Takahashi, Y.3    Ikebe, H.4    Wyman, M.5    Kinoshita, J.H.6
  • 105
    • 0023694725 scopus 로고
    • Prevention of pericyte ghost formation in retinal capillaries of galactose-fed dogs by aldose reductase inhibitors
    • Kador, P.F., Akagi, Y., Terubayashi, H., Wyman, M., Kinoshita, J.H., Prevention of pericyte ghost formation in retinal capillaries of galactose-fed dogs by aldose reductase inhibitors. Archives Ophthalmol. 106 (1988), 1099–1102.
    • (1988) Archives Ophthalmol. , vol.106 , pp. 1099-1102
    • Kador, P.F.1    Akagi, Y.2    Terubayashi, H.3    Wyman, M.4    Kinoshita, J.H.5
  • 106
    • 33750215446 scopus 로고    scopus 로고
    • Effects of topical administration of an aldose reductase inhibitor on cataract formation in dogs fed a diet high in galactose
    • Kador, P.F., Betts, D., Wyman, M., Blessing, K., Randazzo, J., Effects of topical administration of an aldose reductase inhibitor on cataract formation in dogs fed a diet high in galactose. Am. J. Vet. Res. 67 (2006), 1783–1787.
    • (2006) Am. J. Vet. Res. , vol.67 , pp. 1783-1787
    • Kador, P.F.1    Betts, D.2    Wyman, M.3    Blessing, K.4    Randazzo, J.5
  • 108
    • 0021665555 scopus 로고
    • Diabetic and galactosaemic cataracts
    • Kador, P.F., Kinoshita, J.H., Diabetic and galactosaemic cataracts. Ciba Found. Symp. 106 (1984), 110–131.
    • (1984) Ciba Found. Symp. , vol.106 , pp. 110-131
    • Kador, P.F.1    Kinoshita, J.H.2
  • 109
    • 0034092930 scopus 로고    scopus 로고
    • Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats
    • Kador, P.F., Lee, J.W., Fujisawa, S., Blessing, K., Lou, M.F., Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. J. Ocul. Pharmacol. Ther. 16 (2000), 149–160.
    • (2000) J. Ocul. Pharmacol. Ther. , vol.16 , pp. 149-160
    • Kador, P.F.1    Lee, J.W.2    Fujisawa, S.3    Blessing, K.4    Lou, M.F.5
  • 113
    • 0027945142 scopus 로고
    • Amelioration of diabetes-like retinal changes in galactose-fed dogs
    • Kador, P.F., Takahashi, Y., Sato, S., Wyman, M., Amelioration of diabetes-like retinal changes in galactose-fed dogs. Prev. Med. 23 (1994), 717–721.
    • (1994) Prev. Med. , vol.23 , pp. 717-721
    • Kador, P.F.1    Takahashi, Y.2    Sato, S.3    Wyman, M.4
  • 114
    • 0028927395 scopus 로고
    • Diabeteslike proliferative retinal changes in galactose-fed dogs
    • Kador, P.F., Takahashi, Y., Wyman, M., Ferris, F. 3rd, Diabeteslike proliferative retinal changes in galactose-fed dogs. Archives Ophthalmol. 113 (1995), 352–354.
    • (1995) Archives Ophthalmol. , vol.113 , pp. 352-354
    • Kador, P.F.1    Takahashi, Y.2    Wyman, M.3    Ferris, F.4
  • 115
    • 84990310480 scopus 로고
    • The role of aldose reductase in retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs
    • Department of Health and Human Services Bethesda, MD
    • Kador, P.F., Takahashi, Y., Wyman, M., K, J.H., The role of aldose reductase in retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs. National Eye Institute – Juvenile Diabetes Foundation Workshop on Aldose Reductase Inhibitors, 1990, Department of Health and Human Services, Bethesda, MD, 75–107.
    • (1990) National Eye Institute – Juvenile Diabetes Foundation Workshop on Aldose Reductase Inhibitors , pp. 75-107
    • Kador, P.F.1    Takahashi, Y.2    Wyman, M.3
  • 116
    • 78349266468 scopus 로고    scopus 로고
    • Topical KINOSTAT ameliorates the clinical development and progression of cataracts in dogs with diabetes mellitus
    • Kador, P.F., Webb, T.R., Bras, D., Ketring, K., Wyman, M., Topical KINOSTAT ameliorates the clinical development and progression of cataracts in dogs with diabetes mellitus. Vet. Ophthalmol. 13 (2010), 363–368.
    • (2010) Vet. Ophthalmol. , vol.13 , pp. 363-368
    • Kador, P.F.1    Webb, T.R.2    Bras, D.3    Ketring, K.4    Wyman, M.5
  • 118
    • 14744274580 scopus 로고    scopus 로고
    • Prevention of diabetic keratopathy
    • Kaji, Y., Prevention of diabetic keratopathy. Br. J. Ophthalmol. 89 (2005), 254–255.
    • (2005) Br. J. Ophthalmol. , vol.89 , pp. 254-255
    • Kaji, Y.1
  • 119
    • 84906058512 scopus 로고    scopus 로고
    • Emerging role of advanced glycation-end products (AGEs) in the pathobiology of eye diseases
    • Kandarakis, S.A., Piperi, C., Topouzis, F., Papavassiliou, A.G., Emerging role of advanced glycation-end products (AGEs) in the pathobiology of eye diseases. Prog. Retin Eye Res. 42 (2014), 85–102.
    • (2014) Prog. Retin Eye Res. , vol.42 , pp. 85-102
    • Kandarakis, S.A.1    Piperi, C.2    Topouzis, F.3    Papavassiliou, A.G.4
  • 120
    • 0032711922 scopus 로고    scopus 로고
    • An aldose reductase intragenic polymorphism associated with diabetic retinopathy
    • Kao, Y.L., Donaghue, K., Chan, A., Knight, J., Silink, M., An aldose reductase intragenic polymorphism associated with diabetic retinopathy. Diabetes Res. Clin. Pract. 46 (1999), 155–160.
    • (1999) Diabetes Res. Clin. Pract. , vol.46 , pp. 155-160
    • Kao, Y.L.1    Donaghue, K.2    Chan, A.3    Knight, J.4    Silink, M.5
  • 121
    • 77951769010 scopus 로고    scopus 로고
    • Comparison between normal values of 2- and 5-minute Schirmer test without anesthesia
    • Karampatakis, V., Karamitsos, A., Skriapa, A., Pastiadis, G., Comparison between normal values of 2- and 5-minute Schirmer test without anesthesia. Cornea 29 (2010), 497–501.
    • (2010) Cornea , vol.29 , pp. 497-501
    • Karampatakis, V.1    Karamitsos, A.2    Skriapa, A.3    Pastiadis, G.4
  • 122
    • 0020564549 scopus 로고
    • Aldose reductase activity in retinal and cerebral microvessels and cultured vascular cells
    • Kennedy, A., Frank, R.N., Varma, S.D., Aldose reductase activity in retinal and cerebral microvessels and cultured vascular cells. Invest. Ophthalmol. Vis. Sci. 24 (1983), 1250–1258.
    • (1983) Invest. Ophthalmol. Vis. Sci. , vol.24 , pp. 1250-1258
    • Kennedy, A.1    Frank, R.N.2    Varma, S.D.3
  • 124
    • 0026345211 scopus 로고
    • Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor
    • Kern, T.S., Engerman, R.L., Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor. Invest. Ophthalmol. Vis. Sci. 32 (1991), 3175–3177.
    • (1991) Invest. Ophthalmol. Vis. Sci. , vol.32 , pp. 3175-3177
    • Kern, T.S.1    Engerman, R.L.2
  • 125
    • 78149487597 scopus 로고    scopus 로고
    • Validation of structural and functional lesions of diabetic retinopathy in mice
    • Kern, T.S., Tang, J., Berkowitz, B.A., Validation of structural and functional lesions of diabetic retinopathy in mice. Mol. Vis. 16 (2010), 2121–2131.
    • (2010) Mol. Vis. , vol.16 , pp. 2121-2131
    • Kern, T.S.1    Tang, J.2    Berkowitz, B.A.3
  • 126
    • 76549199135 scopus 로고
    • Cataracts in galactosemia. The Jonas S. Friedenwald memorial lecture
    • Kinoshita, J.H., Cataracts in galactosemia. The Jonas S. Friedenwald memorial lecture. Invest. Ophthalmol. 4 (1965), 786–799.
    • (1965) Invest. Ophthalmol. , vol.4 , pp. 786-799
    • Kinoshita, J.H.1
  • 127
    • 0016243140 scopus 로고
    • Mechanisms initiating cataract formation. Proctor Lecture
    • Kinoshita, J.H., Mechanisms initiating cataract formation. Proctor Lecture. Invest. Ophthalmol. 13 (1974), 713–724.
    • (1974) Invest. Ophthalmol. , vol.13 , pp. 713-724
    • Kinoshita, J.H.1
  • 128
    • 0023024981 scopus 로고
    • Aldose reductase in the diabetic eye. XLIII Edward Jackson memorial lecture
    • Kinoshita, J.H., Aldose reductase in the diabetic eye. XLIII Edward Jackson memorial lecture. Am. J. Ophthalmol. 102 (1986), 685–692.
    • (1986) Am. J. Ophthalmol. , vol.102 , pp. 685-692
    • Kinoshita, J.H.1
  • 129
    • 0014642156 scopus 로고
    • Changes in the levels of free amino acids and myo-inositol in the galactose-exposed lens
    • Kinoshita, J.H., Barber, G.W., Merola, L.O., Tung, B., Changes in the levels of free amino acids and myo-inositol in the galactose-exposed lens. Invest. Ophthalmol. 8 (1969), 625–632.
    • (1969) Invest. Ophthalmol. , vol.8 , pp. 625-632
    • Kinoshita, J.H.1    Barber, G.W.2    Merola, L.O.3    Tung, B.4
  • 130
    • 0018748152 scopus 로고
    • Aldose reductase in diabetic complications of the eye
    • Kinoshita, J.H., Fukushi, S., Kador, P., Merola, L.O., Aldose reductase in diabetic complications of the eye. Metabolism 28 (1979), 462–469.
    • (1979) Metabolism , vol.28 , pp. 462-469
    • Kinoshita, J.H.1    Fukushi, S.2    Kador, P.3    Merola, L.O.4
  • 132
    • 0019502698 scopus 로고
    • Aldose reductase in diabetic cataracts
    • Kinoshita, J.H., Kador, P., Datiles, M., Aldose reductase in diabetic cataracts. Jama 246 (1981), 257–261.
    • (1981) Jama , vol.246 , pp. 257-261
    • Kinoshita, J.H.1    Kador, P.2    Datiles, M.3
  • 133
    • 0343610984 scopus 로고
    • Osmotic effects on the amino acid-concentrating mechanism in the rabbit lens
    • Kinoshita, J.H., Merola, L.O., Hayman, S., Osmotic effects on the amino acid-concentrating mechanism in the rabbit lens. J. Biol. Chem. 240 (1965), 310–315.
    • (1965) J. Biol. Chem. , vol.240 , pp. 310-315
    • Kinoshita, J.H.1    Merola, L.O.2    Hayman, S.3
  • 134
    • 0014233581 scopus 로고
    • Changes in cation permeability in the galactose–exposed rabbit lens
    • Kinoshita, J.H., Merola, L.O., Tung, B., Changes in cation permeability in the galactose–exposed rabbit lens. Exp. Eye Res. 7 (1968), 80–90.
    • (1968) Exp. Eye Res. , vol.7 , pp. 80-90
    • Kinoshita, J.H.1    Merola, L.O.2    Tung, B.3
  • 135
    • 79952175181 scopus 로고    scopus 로고
    • Postoperative complications and visual outcomes of phacoemulsification in 103 dogs (179 eyes): 2006-2008
    • Klein, H.E., Krohne, S.G., Moore, G.E., Stiles, J., Postoperative complications and visual outcomes of phacoemulsification in 103 dogs (179 eyes): 2006-2008. Vet. Ophthalmol. 14 (2011), 114–120.
    • (2011) Vet. Ophthalmol. , vol.14 , pp. 114-120
    • Klein, H.E.1    Krohne, S.G.2    Moore, G.E.3    Stiles, J.4
  • 136
    • 0029112492 scopus 로고
    • An (A-C)n dinucleotide repeat polymorphic marker at the 5’ end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients
    • Ko, B.C., Lam, K.S., Wat, N.M., Chung, S.S., An (A-C)n dinucleotide repeat polymorphic marker at the 5’ end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients. Diabetes 44 (1995), 727–732.
    • (1995) Diabetes , vol.44 , pp. 727-732
    • Ko, B.C.1    Lam, K.S.2    Wat, N.M.3    Chung, S.S.4
  • 137
    • 77951224619 scopus 로고    scopus 로고
    • Metabolic memory and diabetic retinopathy: role of inflammatory mediators in retinal pericytes
    • Kowluru, R.A., Zhong, Q., Kanwar, M., Metabolic memory and diabetic retinopathy: role of inflammatory mediators in retinal pericytes. Exp. Eye Res. 90 (2010), 617–623.
    • (2010) Exp. Eye Res. , vol.90 , pp. 617-623
    • Kowluru, R.A.1    Zhong, Q.2    Kanwar, M.3
  • 138
    • 0032863347 scopus 로고    scopus 로고
    • Inhibitory effect of orally administered aldose reductase inhibitor SNK-860 on corneal polyol accumulation in galactose-fed rats
    • Kubo, E., Nakamura, S., Tsuzuki, S., Takahashi, Y., Akagi, Y., Mizuno, K., Matsubara, A., Inhibitory effect of orally administered aldose reductase inhibitor SNK-860 on corneal polyol accumulation in galactose-fed rats. Graefes Arch. Clin. Exp. Ophthalmol. 237 (1999), 758–762.
    • (1999) Graefes Arch. Clin. Exp. Ophthalmol. , vol.237 , pp. 758-762
    • Kubo, E.1    Nakamura, S.2    Tsuzuki, S.3    Takahashi, Y.4    Akagi, Y.5    Mizuno, K.6    Matsubara, A.7
  • 139
    • 0742324141 scopus 로고    scopus 로고
    • Polyol pathway-dependent osmotic and oxidative stresses in aldose reductase-mediated apoptosis in human lens epithelial cells: role of AOP2
    • Kubo, E., Urakami, T., Fatma, N., Akagi, Y., Singh, D.P., Polyol pathway-dependent osmotic and oxidative stresses in aldose reductase-mediated apoptosis in human lens epithelial cells: role of AOP2. Biochem. Biophys. Res. Commun. 314 (2004), 1050–1056.
    • (2004) Biochem. Biophys. Res. Commun. , vol.314 , pp. 1050-1056
    • Kubo, E.1    Urakami, T.2    Fatma, N.3    Akagi, Y.4    Singh, D.P.5
  • 140
    • 34547877652 scopus 로고    scopus 로고
    • Epithelial cell density in cataractous lenses of patients with diabetes: association with erythrocyte aldose reductase
    • Kumamoto, Y., Takamura, Y., Kubo, E., Tsuzuki, S., Akagi, Y., Epithelial cell density in cataractous lenses of patients with diabetes: association with erythrocyte aldose reductase. Exp. Eye Res. 85 (2007), 393–399.
    • (2007) Exp. Eye Res. , vol.85 , pp. 393-399
    • Kumamoto, Y.1    Takamura, Y.2    Kubo, E.3    Tsuzuki, S.4    Akagi, Y.5
  • 142
    • 0014497293 scopus 로고
    • Electron microscopic study of galactose-induced cataract
    • Kuwabara, T., Kinoshita, J.H., Cogan, D.G., Electron microscopic study of galactose-induced cataract. Invest. Ophthalmol. 8 (1969), 133–149.
    • (1969) Invest. Ophthalmol. , vol.8 , pp. 133-149
    • Kuwabara, T.1    Kinoshita, J.H.2    Cogan, D.G.3
  • 145
    • 0028946316 scopus 로고
    • Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens
    • Lee, A.Y., Chung, S.K., Chung, S.S., Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens. Proc. Natl. Acad. Sci. U. S. A. 92 (1995), 2780–2784.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 2780-2784
    • Lee, A.Y.1    Chung, S.K.2    Chung, S.S.3
  • 146
    • 0032958288 scopus 로고    scopus 로고
    • Contributions of polyol pathway to oxidative stress in diabetic cataract
    • Lee, A.Y., Chung, S.S., Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J. 13 (1999), 23–30.
    • (1999) FASEB J. , vol.13 , pp. 23-30
    • Lee, A.Y.1    Chung, S.S.2
  • 147
    • 0034834739 scopus 로고    scopus 로고
    • Association of retinopathy with a microsatellite at 5’ end of the aldose reductase gene in Chinese patients with late-onset Type 2 diabetes
    • Lee, S.C., Wang, Y., Ko, G.T., Critchley, J.A., Ng, M.C., Tong, P.C., Cockram, C.S., Chan, J.C., Association of retinopathy with a microsatellite at 5’ end of the aldose reductase gene in Chinese patients with late-onset Type 2 diabetes. Ophthalmic Genet. 22 (2001), 63–67.
    • (2001) Ophthalmic Genet. , vol.22 , pp. 63-67
    • Lee, S.C.1    Wang, Y.2    Ko, G.T.3    Critchley, J.A.4    Ng, M.C.5    Tong, P.C.6    Cockram, C.S.7    Chan, J.C.8
  • 148
    • 0035002820 scopus 로고    scopus 로고
    • Risk factors for cataract in Chinese patients with type 2 diabetes: evidence for the influence of the aldose reductase gene
    • Lee, S.C., Wang, Y., Ko, G.T., Ma, R.C., Critchley, J.A., Cockram, C.S., Chan, J.C., Risk factors for cataract in Chinese patients with type 2 diabetes: evidence for the influence of the aldose reductase gene. Clin. Genet. 59 (2001), 356–359.
    • (2001) Clin. Genet. , vol.59 , pp. 356-359
    • Lee, S.C.1    Wang, Y.2    Ko, G.T.3    Ma, R.C.4    Critchley, J.A.5    Cockram, C.S.6    Chan, J.C.7
  • 149
    • 0024204090 scopus 로고
    • Sorbitol generation and its inhibition by Sorbinil in the aging normal human and rabbit lens and human diabetic cataracts
    • Lerman, S., Moran, M., Sorbitol generation and its inhibition by Sorbinil in the aging normal human and rabbit lens and human diabetic cataracts. Ophthalmic Res. 20 (1988), 348–352.
    • (1988) Ophthalmic Res. , vol.20 , pp. 348-352
    • Lerman, S.1    Moran, M.2
  • 150
    • 79954473601 scopus 로고    scopus 로고
    • Cataracts in 44 dogs (77 eyes): a comparison of outcomes for no treatment, topical medical management, or phacoemulsification with intraocular lens implantation
    • Lim, C.C., Bakker, S.C., Waldner, C.L., Sandmeyer, L.S., Grahn, B.H., Cataracts in 44 dogs (77 eyes): a comparison of outcomes for no treatment, topical medical management, or phacoemulsification with intraocular lens implantation. Can. Vet. J. 52 (2011), 283–288.
    • (2011) Can. Vet. J. , vol.52 , pp. 283-288
    • Lim, C.C.1    Bakker, S.C.2    Waldner, C.L.3    Sandmeyer, L.S.4    Grahn, B.H.5
  • 151
    • 0029795225 scopus 로고    scopus 로고
    • Quantitation of galactosemic cataracts in dogs using magnetization transfer contrast-enhanced magnetic resonance imaging
    • Lizak, M.J., Mori, K., Ceckler, T.L., Balaban, R.S., Kador, P.F., Quantitation of galactosemic cataracts in dogs using magnetization transfer contrast-enhanced magnetic resonance imaging. Invest. Ophthalmol. Vis. Sci. 37 (1996), 2219–2227.
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , pp. 2219-2227
    • Lizak, M.J.1    Mori, K.2    Ceckler, T.L.3    Balaban, R.S.4    Kador, P.F.5
  • 152
    • 0031792229 scopus 로고    scopus 로고
    • 3-FG as substrate for investigating flux through the polyol pathway in dog lens by 19F-NMR spectroscopy
    • Lizak, M.J., Secchi, E.F., Lee, J.W., Sato, S., Kubo, E., Akagi, Y., Kador, P.F., 3-FG as substrate for investigating flux through the polyol pathway in dog lens by 19F-NMR spectroscopy. Invest. Ophthalmol. Vis. Sci. 39 (1998), 2688–2695.
    • (1998) Invest. Ophthalmol. Vis. Sci. , vol.39 , pp. 2688-2695
    • Lizak, M.J.1    Secchi, E.F.2    Lee, J.W.3    Sato, S.4    Kubo, E.5    Akagi, Y.6    Kador, P.F.7
  • 153
    • 0001733320 scopus 로고    scopus 로고
    • The polyol pathway and diabetic retinopathy
    • D. E
    • Lorenzi, M., O, P.J., The polyol pathway and diabetic retinopathy. E, D., (eds.) Diabetic Retinopathy Totowa, NJ, 2008, 159–186.
    • (2008) Diabetic Retinopathy Totowa, NJ , pp. 159-186
    • Lorenzi, M.1
  • 154
    • 0021329503 scopus 로고
    • Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects
    • Malone, J.I., Leavengood, H., Peterson, M.J., O'Brien, M.M., Page, M.G., Aldinger, C.E., Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects. Diabetes 33 (1984), 45–49.
    • (1984) Diabetes , vol.33 , pp. 45-49
    • Malone, J.I.1    Leavengood, H.2    Peterson, M.J.3    O'Brien, M.M.4    Page, M.G.5    Aldinger, C.E.6
  • 155
    • 0023856594 scopus 로고
    • Purification and characterization of human liver sorbitol dehydrogenase
    • Maret, W., Auld, D.S., Purification and characterization of human liver sorbitol dehydrogenase. Biochemistry 27 (1988), 1622–1628.
    • (1988) Biochemistry , vol.27 , pp. 1622-1628
    • Maret, W.1    Auld, D.S.2
  • 157
    • 84990314077 scopus 로고    scopus 로고
    • Worldwide Prevalence of Diabetes
    • Mathew, B., Worldwide Prevalence of Diabetes. 2010 healthguideinfo.com.
    • (2010)
    • Mathew, B.1
  • 158
    • 0023149846 scopus 로고
    • The effects of aldose reductase inhibitor on the corneal endothelial morphology in diabetic rats
    • Matsuda, M., Awata, T., Ohashi, Y., Inaba, M., Fukuda, M., Manabe, R., The effects of aldose reductase inhibitor on the corneal endothelial morphology in diabetic rats. Curr. Eye Res. 6 (1987), 391–397.
    • (1987) Curr. Eye Res. , vol.6 , pp. 391-397
    • Matsuda, M.1    Awata, T.2    Ohashi, Y.3    Inaba, M.4    Fukuda, M.5    Manabe, R.6
  • 159
    • 0023894812 scopus 로고
    • Corneal endothelial morphology in the rat. Effects of aging, diabetes, and topical aldose reductase inhibitor treatment
    • Meyer, L.A., Ubels, J.L., Edelhauser, H.F., Corneal endothelial morphology in the rat. Effects of aging, diabetes, and topical aldose reductase inhibitor treatment. Invest. Ophthalmol. Vis. Sci. 29 (1988), 940–948.
    • (1988) Invest. Ophthalmol. Vis. Sci. , vol.29 , pp. 940-948
    • Meyer, L.A.1    Ubels, J.L.2    Edelhauser, H.F.3
  • 160
    • 34648843667 scopus 로고    scopus 로고
    • Placental growth factor-1 and epithelial haemato-retinal barrier breakdown: potential implication in the pathogenesis of diabetic retinopathy
    • Miyamoto, N., de Kozak, Y., Jeanny, J.C., Glotin, A., Mascarelli, F., Massin, P., BenEzra, D., Behar-Cohen, F., Placental growth factor-1 and epithelial haemato-retinal barrier breakdown: potential implication in the pathogenesis of diabetic retinopathy. Diabetologia 50 (2007), 461–470.
    • (2007) Diabetologia , vol.50 , pp. 461-470
    • Miyamoto, N.1    de Kozak, Y.2    Jeanny, J.C.3    Glotin, A.4    Mascarelli, F.5    Massin, P.6    BenEzra, D.7    Behar-Cohen, F.8
  • 161
    • 33845755363 scopus 로고    scopus 로고
    • Up-regulation of P-glycoprotein expression by osmotic stress in rat sugar cataract
    • Miyazawa, T., Kubo, E., Takamura, Y., Akagi, Y., Up-regulation of P-glycoprotein expression by osmotic stress in rat sugar cataract. Exp. Eye Res. 84 (2007), 246–253.
    • (2007) Exp. Eye Res. , vol.84 , pp. 246-253
    • Miyazawa, T.1    Kubo, E.2    Takamura, Y.3    Akagi, Y.4
  • 162
    • 0025346586 scopus 로고
    • Confirmation of lens hydration by Raman spectroscopy
    • Mizuno, A., Toshima, S., Mori, Y., Confirmation of lens hydration by Raman spectroscopy. Exp. Eye Res. 50 (1990), 647–649.
    • (1990) Exp. Eye Res. , vol.50 , pp. 647-649
    • Mizuno, A.1    Toshima, S.2    Mori, Y.3
  • 163
    • 0028857659 scopus 로고
    • Magnetic resonance imaging of the galactosemic dog eye using magnetization transfer contrast
    • Mori, K., Lizak, M.J., Ceckler, T.L., Balaban, R.S., Kador, P.F., Magnetic resonance imaging of the galactosemic dog eye using magnetization transfer contrast. Curr. Eye Res. 14 (1995), 1035–1040.
    • (1995) Curr. Eye Res. , vol.14 , pp. 1035-1040
    • Mori, K.1    Lizak, M.J.2    Ceckler, T.L.3    Balaban, R.S.4    Kador, P.F.5
  • 164
    • 84990308954 scopus 로고    scopus 로고
    • Effects of aldose reductase inhibitors on galactose-induced changes in corneal epithelium basal cells and basement membrane: a quantitative analysis on long-term galactose-fed rat corneas
    • P.N. Patil V.N. Puri Allied Publishers PVT Limited New Dehli
    • Mori, K., Takahashi, Y., Akagi, Y., Kador, P.F., Effects of aldose reductase inhibitors on galactose-induced changes in corneal epithelium basal cells and basement membrane: a quantitative analysis on long-term galactose-fed rat corneas. Patil, P.N., Puri, V.N., (eds.) Frontiers of Ocular Pharmacology and Therapeutic, 2002, Allied Publishers PVT Limited, New Dehli.
    • (2002) Frontiers of Ocular Pharmacology and Therapeutic
    • Mori, K.1    Takahashi, Y.2    Akagi, Y.3    Kador, P.F.4
  • 166
    • 34547881945 scopus 로고    scopus 로고
    • Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats
    • Mulhern, M.L., Madson, C.J., Kador, P.F., Randazzo, J., Shinohara, T., Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats. Mol. Vis. 13 (2007), 1397–1405.
    • (2007) Mol. Vis. , vol.13 , pp. 1397-1405
    • Mulhern, M.L.1    Madson, C.J.2    Kador, P.F.3    Randazzo, J.4    Shinohara, T.5
  • 167
    • 0036742753 scopus 로고    scopus 로고
    • Selective pericyte degeneration in the retinal capillaries of galactose-fed dogs results from apoptosis linked to aldose reductase-catalyzed galactitol accumulation
    • Murata, M., Ohta, N., Fujisawa, S., Tsai, J.Y., Sato, S., Akagi, Y., Takahashi, Y., Neuenschwander, H., Kador, P.F., Selective pericyte degeneration in the retinal capillaries of galactose-fed dogs results from apoptosis linked to aldose reductase-catalyzed galactitol accumulation. J. Diabetes Complicat. 16 (2002), 363–370.
    • (2002) J. Diabetes Complicat. , vol.16 , pp. 363-370
    • Murata, M.1    Ohta, N.2    Fujisawa, S.3    Tsai, J.Y.4    Sato, S.5    Akagi, Y.6    Takahashi, Y.7    Neuenschwander, H.8    Kador, P.F.9
  • 168
    • 0035969875 scopus 로고    scopus 로고
    • The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis)
    • Murata, M., Ohta, N., Sakurai, S., Alam, S., Tsai, J., Kador, P.F., Sato, S., The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis). Chem. Biol. Interact. 130–132 (2001), 617–625.
    • (2001) Chem. Biol. Interact. , vol.130-132 , pp. 617-625
    • Murata, M.1    Ohta, N.2    Sakurai, S.3    Alam, S.4    Tsai, J.5    Kador, P.F.6    Sato, S.7
  • 169
    • 14744281815 scopus 로고    scopus 로고
    • A randomised, placebo controlled clinical trial of the aldose reductase inhibitor CT-112 as management of corneal epithelial disorders in diabetic patients
    • Nakahara, M., Miyata, K., Otani, S., Miyai, T., Nejima, R., Yamagami, S., Amano, S., A randomised, placebo controlled clinical trial of the aldose reductase inhibitor CT-112 as management of corneal epithelial disorders in diabetic patients. Br. J. Ophthalmol. 89 (2005), 266–268.
    • (2005) Br. J. Ophthalmol. , vol.89 , pp. 266-268
    • Nakahara, M.1    Miyata, K.2    Otani, S.3    Miyai, T.4    Nejima, R.5    Yamagami, S.6    Amano, S.7
  • 171
    • 0031440825 scopus 로고    scopus 로고
    • Dose-dependent reduction of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by the aldose reductase inhibitor M79175
    • Neuenschwander, H., Takahashi, Y., Kador, P.F., Dose-dependent reduction of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by the aldose reductase inhibitor M79175. J. Ocul. Pharmacol. Ther. 13 (1997), 517–528.
    • (1997) J. Ocul. Pharmacol. Ther. , vol.13 , pp. 517-528
    • Neuenschwander, H.1    Takahashi, Y.2    Kador, P.F.3
  • 175
    • 0036369809 scopus 로고    scopus 로고
    • Polyol pathway and diabetic peripheral neuropathy
    • Oates, P.J., Polyol pathway and diabetic peripheral neuropathy. Int. Rev. Neurobiol. 50 (2002), 325–392.
    • (2002) Int. Rev. Neurobiol. , vol.50 , pp. 325-392
    • Oates, P.J.1
  • 176
    • 38849177363 scopus 로고    scopus 로고
    • Aldose reductase, still a compelling target for diabetic neuropathy
    • Oates, P.J., Aldose reductase, still a compelling target for diabetic neuropathy. Curr. Drug Targets 9 (2008), 14–36.
    • (2008) Curr. Drug Targets , vol.9 , pp. 14-36
    • Oates, P.J.1
  • 177
    • 0032693720 scopus 로고    scopus 로고
    • Aldose reductase inhibitors: therapeutic implications for diabetic complications
    • Oates, P.J., Mylari, B.L., Aldose reductase inhibitors: therapeutic implications for diabetic complications. Expert Opin. Investig. Drugs 8 (1999), 2095–2119.
    • (1999) Expert Opin. Investig. Drugs , vol.8 , pp. 2095-2119
    • Oates, P.J.1    Mylari, B.L.2
  • 179
    • 0031771998 scopus 로고    scopus 로고
    • Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-alpha-lipoic acid
    • Obrosova, I., Cao, X., Greene, D.A., Stevens, M.J., Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-alpha-lipoic acid. Diabetologia 41 (1998), 1442–1450.
    • (1998) Diabetologia , vol.41 , pp. 1442-1450
    • Obrosova, I.1    Cao, X.2    Greene, D.A.3    Stevens, M.J.4
  • 180
    • 0031045306 scopus 로고    scopus 로고
    • Glycolytic pathway, redox state of NAD(P)-couples and energy metabolism in lens in galactose-fed rats: effect of an aldose reductase inhibitor
    • Obrosova, I., Faller, A., Burgan, J., Ostrow, E., Williamson, J.R., Glycolytic pathway, redox state of NAD(P)-couples and energy metabolism in lens in galactose-fed rats: effect of an aldose reductase inhibitor. Curr. Eye Res. 16 (1997), 34–43.
    • (1997) Curr. Eye Res. , vol.16 , pp. 34-43
    • Obrosova, I.1    Faller, A.2    Burgan, J.3    Ostrow, E.4    Williamson, J.R.5
  • 181
    • 0036356513 scopus 로고    scopus 로고
    • How does glucose generate oxidative stress in peripheral nerve?
    • Obrosova, I.G., How does glucose generate oxidative stress in peripheral nerve?. Int. Rev. Neurobiol. 50 (2002), 3–35.
    • (2002) Int. Rev. Neurobiol. , vol.50 , pp. 3-35
    • Obrosova, I.G.1
  • 182
    • 33748516742 scopus 로고    scopus 로고
    • Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models
    • Obrosova, I.G., Drel, V.R., Kumagai, A.K., Szabo, C., Pacher, P., Stevens, M.J., Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models. Diabetologia 49 (2006), 2525–2533.
    • (2006) Diabetologia , vol.49 , pp. 2525-2533
    • Obrosova, I.G.1    Drel, V.R.2    Kumagai, A.K.3    Szabo, C.4    Pacher, P.5    Stevens, M.J.6
  • 183
    • 0033838210 scopus 로고    scopus 로고
    • Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study
    • Obrosova, I.G., Fathallah, L., Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study. Diabetologia 43 (2000), 1048–1055.
    • (2000) Diabetologia , vol.43 , pp. 1048-1055
    • Obrosova, I.G.1    Fathallah, L.2
  • 184
    • 79551676547 scopus 로고    scopus 로고
    • Aldose reductase/polyol inhibitors for diabetic retinopathy
    • Obrosova, I.G., Kador, P.F., Aldose reductase/polyol inhibitors for diabetic retinopathy. Curr. Pharm. Biotechnol. 12 (2011), 373–385.
    • (2011) Curr. Pharm. Biotechnol. , vol.12 , pp. 373-385
    • Obrosova, I.G.1    Kador, P.F.2
  • 185
    • 0344837811 scopus 로고    scopus 로고
    • Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    • Obrosova, I.G., Minchenko, A.G., Vasupuram, R., White, L., Abatan, O.I., Kumagai, A.K., Frank, R.N., Stevens, M.J., Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats. Diabetes 52 (2003), 864–871.
    • (2003) Diabetes , vol.52 , pp. 864-871
    • Obrosova, I.G.1    Minchenko, A.G.2    Vasupuram, R.3    White, L.4    Abatan, O.I.5    Kumagai, A.K.6    Frank, R.N.7    Stevens, M.J.8
  • 186
    • 77449131348 scopus 로고    scopus 로고
    • An infant with combination gene mutations for monogenic diabetes of youth (MODY) 2 and 4, presenting with diabetes mellitus requiring insulin (DMRI) at 8 months of age
    • Odem, J., Munzinger, E., Violand, S., Van Morlan, A., Rife, D., Bachrach, B., An infant with combination gene mutations for monogenic diabetes of youth (MODY) 2 and 4, presenting with diabetes mellitus requiring insulin (DMRI) at 8 months of age. Pediatr. Diabetes 10 (2009), 550–553.
    • (2009) Pediatr. Diabetes , vol.10 , pp. 550-553
    • Odem, J.1    Munzinger, E.2    Violand, S.3    Van Morlan, A.4    Rife, D.5    Bachrach, B.6
  • 187
    • 84916449457 scopus 로고
    • The effects of aldose reductase inhibitor (CT-112) on diabetic keratoepitheliopathy
    • N. Sakamoto J.H. Kinoshita P.F. kador N. Hotta Excerpta Medica Kaskikojima, Japan
    • Ohashi, Y., Mano, T., Umemoto, M., Hositani, H., Tamada, R., Tano, Y., Matsuda, M., Fukuda, M., Manabe, R., The effects of aldose reductase inhibitor (CT-112) on diabetic keratoepitheliopathy. Sakamoto, N., Kinoshita, J.H., kador, P.F., Hotta, N., (eds.) Polyol Pathway and its Role in Diabetic Complications, 1986, Excerpta Medica, Kaskikojima, Japan, 231–236.
    • (1986) Polyol Pathway and its Role in Diabetic Complications , pp. 231-236
    • Ohashi, Y.1    Mano, T.2    Umemoto, M.3    Hositani, H.4    Tamada, R.5    Tano, Y.6    Matsuda, M.7    Fukuda, M.8    Manabe, R.9
  • 189
    • 0029593572 scopus 로고
    • Topical aldose reductase inhibitor for correcting corneal endothelial changes in diabetic patients
    • Ohguro, N., Matsuda, M., Ohashi, Y., Fukuda, M., Topical aldose reductase inhibitor for correcting corneal endothelial changes in diabetic patients. Br. J. Ophthalmol. 79 (1995), 1074–1077.
    • (1995) Br. J. Ophthalmol. , vol.79 , pp. 1074-1077
    • Ohguro, N.1    Matsuda, M.2    Ohashi, Y.3    Fukuda, M.4
  • 190
    • 84865525580 scopus 로고    scopus 로고
    • Regulation of cell survival and death by pyridine nucleotides
    • Oka, S., Hsu, C.P., Sadoshima, J., Regulation of cell survival and death by pyridine nucleotides. Circ. Res. 111 (2012), 611–627.
    • (2012) Circ. Res. , vol.111 , pp. 611-627
    • Oka, S.1    Hsu, C.P.2    Sadoshima, J.3
  • 191
    • 77955165787 scopus 로고    scopus 로고
    • A comparison of anesthetic complications between diabetic and nondiabetic dogs undergoing phacoemulsification cataract surgery: a retrospective study
    • Oliver, J.A., Clark, L., Corletto, F., Gould, D.J., A comparison of anesthetic complications between diabetic and nondiabetic dogs undergoing phacoemulsification cataract surgery: a retrospective study. Vet. Ophthalmol. 13 (2010), 244–250.
    • (2010) Vet. Ophthalmol. , vol.13 , pp. 244-250
    • Oliver, J.A.1    Clark, L.2    Corletto, F.3    Gould, D.J.4
  • 194
    • 84990314074 scopus 로고    scopus 로고
    • U.S. Pet Ownership & Demographics Sourcebook
    • 2007 Edition AVMA
    • Organization, A.V.M., U.S. Pet Ownership & Demographics Sourcebook. 2007 Edition, 2007, AVMA.
    • (2007)
    • Organization, A.V.M.1
  • 195
    • 0642344420 scopus 로고    scopus 로고
    • Juvenile Diabetic cataract. A rare finding which lead us to the diagnosis of this illness
    • Orts Vila, P., Devesa Torregrosa, P., Belmonte Martinez, J., Juvenile Diabetic cataract. A rare finding which lead us to the diagnosis of this illness. Arch. Soc. Esp. Oftalmol. 78 (2003), 389–391.
    • (2003) Arch. Soc. Esp. Oftalmol. , vol.78 , pp. 389-391
    • Orts Vila, P.1    Devesa Torregrosa, P.2    Belmonte Martinez, J.3
  • 196
    • 28844462418 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme
    • Pacher, P., Szabo, C., Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme. Antioxid. Redox Signal 7 (2005), 1568–1580.
    • (2005) Antioxid. Redox Signal , vol.7 , pp. 1568-1580
    • Pacher, P.1    Szabo, C.2
  • 197
    • 0030987103 scopus 로고    scopus 로고
    • Growth factors and diabetic retinopathy
    • Paques, M., Massin, P., Gaudric, A., Growth factors and diabetic retinopathy. Diabetes Metab. 23 (1997), 125–130.
    • (1997) Diabetes Metab. , vol.23 , pp. 125-130
    • Paques, M.1    Massin, P.2    Gaudric, A.3
  • 198
  • 199
    • 84916416540 scopus 로고
    • Hyperglycemia and galactose cataract
    • Patterson, J.W., Hyperglycemia and galactose cataract. Am. J. Physiol. 165 (1954), 541–543.
    • (1954) Am. J. Physiol. , vol.165 , pp. 541-543
    • Patterson, J.W.1
  • 200
    • 0000059952 scopus 로고
    • Studies on diabetic retinopathy. I. Retinopathy in a dog with spontaneous diabetes mellitus
    • Patz, A., Maumenee, A.E., Studies on diabetic retinopathy. I. Retinopathy in a dog with spontaneous diabetes mellitus. Am. J. Ophthalmol. 54 (1962), 532–541.
    • (1962) Am. J. Ophthalmol. , vol.54 , pp. 532-541
    • Patz, A.1    Maumenee, A.E.2
  • 201
    • 0018003633 scopus 로고
    • Corneal complications after closed vitrectomy through the pars plana
    • Perry, H.D., Foulks, G.N., Thoft, R.A., Tolentino, F.I., Corneal complications after closed vitrectomy through the pars plana. Arch. Ophthalmol. 96 (1978), 1401–1403.
    • (1978) Arch. Ophthalmol. , vol.96 , pp. 1401-1403
    • Perry, H.D.1    Foulks, G.N.2    Thoft, R.A.3    Tolentino, F.I.4
  • 202
    • 0022649358 scopus 로고
    • Applicability of red blood cell sorbitol measurements to monitor the clinical activity of sorbinil
    • Peterson, M.J., Page, M.G., Just, L.J., Aldinger, C.E., Malone, J.I., Applicability of red blood cell sorbitol measurements to monitor the clinical activity of sorbinil. Metabolism 35 (1986), 93–95.
    • (1986) Metabolism , vol.35 , pp. 93-95
    • Peterson, M.J.1    Page, M.G.2    Just, L.J.3    Aldinger, C.E.4    Malone, J.I.5
  • 203
    • 84990314059 scopus 로고    scopus 로고
    • Diabetes in Dogs
    • PetMD, Diabetes in Dogs. 2011.
    • (2011)
    • PetMD1
  • 205
    • 14644407375 scopus 로고    scopus 로고
    • Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians
    • Petrovic, M.G., Peterlin, B., Hawlina, M., Petrovic, D., Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians. J. Diabetes Complicat. 19 (2005), 70–73.
    • (2005) J. Diabetes Complicat. , vol.19 , pp. 70-73
    • Petrovic, M.G.1    Peterlin, B.2    Hawlina, M.3    Petrovic, D.4
  • 206
    • 0030931810 scopus 로고    scopus 로고
    • Aldose reductase inhibitors: the end of an era or the need for different trial designs?
    • Pfeifer, M.A., Schumer, M.P., Gelber, D.A., Aldose reductase inhibitors: the end of an era or the need for different trial designs?. Diabetes 46:Suppl. 2 (1997), S82–S89.
    • (1997) Diabetes , vol.46 , pp. S82-S89
    • Pfeifer, M.A.1    Schumer, M.P.2    Gelber, D.A.3
  • 207
    • 0018185207 scopus 로고
    • Differential metabolism and leakage of protein in an inherited cataract and a normal lens cultured with ouabain
    • Piatigorsky, J., Fukui, H.N., Kinoshita, J.H., Differential metabolism and leakage of protein in an inherited cataract and a normal lens cultured with ouabain. Nature 274 (1978), 558–562.
    • (1978) Nature , vol.274 , pp. 558-562
    • Piatigorsky, J.1    Fukui, H.N.2    Kinoshita, J.H.3
  • 209
    • 33750486205 scopus 로고    scopus 로고
    • Diabetes and corneal cell densities in humans by in vivo confocal microscopy
    • Quadrado, M.J., Popper, M., Morgado, A.M., Murta, J.N., Van Best, J.A., Diabetes and corneal cell densities in humans by in vivo confocal microscopy. Cornea 25 (2006), 761–768.
    • (2006) Cornea , vol.25 , pp. 761-768
    • Quadrado, M.J.1    Popper, M.2    Morgado, A.M.3    Murta, J.N.4    Van Best, J.A.5
  • 210
    • 84862688640 scopus 로고    scopus 로고
    • Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome
    • Rabbani, N., Thornalley, P.J., Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome. Amino Acids 42 (2012), 1133–1142.
    • (2012) Amino Acids , vol.42 , pp. 1133-1142
    • Rabbani, N.1    Thornalley, P.J.2
  • 212
    • 79955584255 scopus 로고    scopus 로고
    • Orally active multi-functional antioxidants delay cataract formation in streptozotocin (type 1) diabetic and gamma-irradiated rats
    • Randazzo, J., Zhang, P., Makita, J., Blessing, K., Kador, P.F., Orally active multi-functional antioxidants delay cataract formation in streptozotocin (type 1) diabetic and gamma-irradiated rats. PLoS One, 6, 2011, e18980.
    • (2011) PLoS One , vol.6 , pp. e18980
    • Randazzo, J.1    Zhang, P.2    Makita, J.3    Blessing, K.4    Kador, P.F.5
  • 214
    • 0036847199 scopus 로고    scopus 로고
    • Aldose reductase activity and glucose-related opacities in incubated lenses from dogs and cats
    • Richter, M., Guscetti, F., Spiess, B., Aldose reductase activity and glucose-related opacities in incubated lenses from dogs and cats. Am. J. Vet. Res. 63 (2002), 1591–1597.
    • (2002) Am. J. Vet. Res. , vol.63 , pp. 1591-1597
    • Richter, M.1    Guscetti, F.2    Spiess, B.3
  • 215
    • 0025295353 scopus 로고
    • The role of lens epithelium in sugar cataract formation
    • Robison, W.G. Jr., Houlder, N., Kinoshita, J.H., The role of lens epithelium in sugar cataract formation. Exp. Eye Res. 50 (1990), 641–646.
    • (1990) Exp. Eye Res. , vol.50 , pp. 641-646
    • Robison, W.G.1    Houlder, N.2    Kinoshita, J.H.3
  • 216
    • 0020604667 scopus 로고
    • Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor
    • Robison, W.G. Jr., Kador, P.F., Kinoshita, J.H., Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor. Science 221 (1983), 1177–1179.
    • (1983) Science , vol.221 , pp. 1177-1179
    • Robison, W.G.1    Kador, P.F.2    Kinoshita, J.H.3
  • 217
    • 0025211833 scopus 로고
    • Diabetes-related histopathologies of the rat retina prevented with an aldose reductase inhibitor
    • Robison, W.G. Jr., Tillis, T.N., Laver, N., Kinoshita, J.H., Diabetes-related histopathologies of the rat retina prevented with an aldose reductase inhibitor. Exp. Eye Res. 50 (1990), 355–366.
    • (1990) Exp. Eye Res. , vol.50 , pp. 355-366
    • Robison, W.G.1    Tillis, T.N.2    Laver, N.3    Kinoshita, J.H.4
  • 218
    • 0027317913 scopus 로고
    • Aldose reductase in human retinal pigment epithelial cells
    • Sato, S., Lin, L.R., Reddy, V.N., Kador, P.F., Aldose reductase in human retinal pigment epithelial cells. Exp. Eye Res. 57 (1993), 235–241.
    • (1993) Exp. Eye Res. , vol.57 , pp. 235-241
    • Sato, S.1    Lin, L.R.2    Reddy, V.N.3    Kador, P.F.4
  • 219
    • 0031913050 scopus 로고    scopus 로고
    • Dose-dependent prevention of sugar cataracts in galactose-fed dogs by the aldose reductase inhibitor M79175
    • Sato, S., Mori, K., Wyman, M., Kador, P.F., Dose-dependent prevention of sugar cataracts in galactose-fed dogs by the aldose reductase inhibitor M79175. Exp. Eye Res. 66 (1998), 217–222.
    • (1998) Exp. Eye Res. , vol.66 , pp. 217-222
    • Sato, S.1    Mori, K.2    Wyman, M.3    Kador, P.F.4
  • 221
    • 0033852661 scopus 로고    scopus 로고
    • Role of the hexosamine biosynthetic pathway in diabetic nephropathy
    • Schleicher, E.D., Weigert, C., Role of the hexosamine biosynthetic pathway in diabetic nephropathy. Kidney Int. Suppl. 77 (2000), S13–S18.
    • (2000) Kidney Int. Suppl. , vol.77 , pp. S13-S18
    • Schleicher, E.D.1    Weigert, C.2
  • 223
    • 1242292942 scopus 로고    scopus 로고
    • Another aspect of the galactosemia enigma
    • author reply 255–257
    • Segal, S., Another aspect of the galactosemia enigma. Mol. Genet. Metab. 81 (2004), 253–254 author reply 255–257.
    • (2004) Mol. Genet. Metab. , vol.81 , pp. 253-254
    • Segal, S.1
  • 225
    • 0034999471 scopus 로고    scopus 로고
    • Acute transient bilateral diabetic posterior subcapsular cataracts(1)
    • Sharma, P., Vasavada, A.R., Acute transient bilateral diabetic posterior subcapsular cataracts(1). J. Cataract. Refract Surg. 27 (2001), 789–794.
    • (2001) J. Cataract. Refract Surg. , vol.27 , pp. 789-794
    • Sharma, P.1    Vasavada, A.R.2
  • 226
    • 0027996942 scopus 로고
    • Pathological definition and evaluation of diabetic neuropathy and clinical correlations
    • Sima, A.A., Pathological definition and evaluation of diabetic neuropathy and clinical correlations. Can. J. Neurol. Sci. 21 (1994), S13–S17.
    • (1994) Can. J. Neurol. Sci. , vol.21 , pp. S13-S17
    • Sima, A.A.1
  • 227
    • 84869210298 scopus 로고    scopus 로고
    • Laser in-situ keratomileusis in patients with diabetes mellitus: a review of the literature
    • Simpson, R.G., Moshirfar, M., Edmonds, J.N., Christiansen, S.M., Laser in-situ keratomileusis in patients with diabetes mellitus: a review of the literature. Clin. Ophthalmol. 6 (2012), 1665–1674.
    • (2012) Clin. Ophthalmol. , vol.6 , pp. 1665-1674
    • Simpson, R.G.1    Moshirfar, M.2    Edmonds, J.N.3    Christiansen, S.M.4
  • 228
  • 229
    • 0025073693 scopus 로고
    • A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy
    • Sorbinil Retinopathy Trial Research Group. A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy. Arch. Ophthalmol. 108 (1990), 1234–1244.
    • (1990) Arch. Ophthalmol. , vol.108 , pp. 1234-1244
  • 230
    • 0025907859 scopus 로고
    • In-vitro assessment of a hypersensitivity syndrome associated with sorbinil
    • Spielberg, S.P., Shear, N.H., Cannon, M., Hutson, N.J., Gunderson, K., In-vitro assessment of a hypersensitivity syndrome associated with sorbinil. Ann. Intern Med. 114 (1991), 720–724.
    • (1991) Ann. Intern Med. , vol.114 , pp. 720-724
    • Spielberg, S.P.1    Shear, N.H.2    Cannon, M.3    Hutson, N.J.4    Gunderson, K.5
  • 232
    • 0027378567 scopus 로고
    • Quantitative analysis of retinal vessel changes in galactose-fed dogs
    • Takahashi, Y., Augustin, W., Wyman, M., Kador, P.F., Quantitative analysis of retinal vessel changes in galactose-fed dogs. J. Ocul. Pharmacol. 9 (1993), 257–269.
    • (1993) J. Ocul. Pharmacol. , vol.9 , pp. 257-269
    • Takahashi, Y.1    Augustin, W.2    Wyman, M.3    Kador, P.F.4
  • 233
    • 0026705814 scopus 로고
    • Diabeteslike preproliferative retinal changes in galactose-fed dogs
    • Takahashi, Y., Wyman, M., Ferris, F. 3rd, Kador, P.F., Diabeteslike preproliferative retinal changes in galactose-fed dogs. Archives Ophthalmol. 110 (1992), 1295–1302.
    • (1992) Archives Ophthalmol. , vol.110 , pp. 1295-1302
    • Takahashi, Y.1    Wyman, M.2    Ferris, F.3    Kador, P.F.4
  • 234
    • 0038771958 scopus 로고    scopus 로고
    • Apoptotic cell death in the lens epithelium of rat sugar cataract
    • Takamura, Y., Kubo, E., Tsuzuki, S., Akagi, Y., Apoptotic cell death in the lens epithelium of rat sugar cataract. Exp. Eye Res. 77 (2003), 51–57.
    • (2003) Exp. Eye Res. , vol.77 , pp. 51-57
    • Takamura, Y.1    Kubo, E.2    Tsuzuki, S.3    Akagi, Y.4
  • 235
    • 0000493001 scopus 로고    scopus 로고
    • Immunohistochemical study of apoptosis of lens epithelial cells in human and diabetic rat cataracts
    • Takamura, Y., Sugimoto, Y., Kubo, E., Takahashi, Y., Akagi, Y., Immunohistochemical study of apoptosis of lens epithelial cells in human and diabetic rat cataracts. Jpn. J. Ophthalmol. 44 (2000), 569–570.
    • (2000) Jpn. J. Ophthalmol. , vol.44 , pp. 569-570
    • Takamura, Y.1    Sugimoto, Y.2    Kubo, E.3    Takahashi, Y.4    Akagi, Y.5
  • 236
    • 0027948999 scopus 로고
    • Effects of aldose reductase inhibition with tolrestat on diabetic retinopathy in a six months double blind trial
    • van Gerven, J.M., Boot, J.P., Lemkes, H.H., van Best, J.A., Effects of aldose reductase inhibition with tolrestat on diabetic retinopathy in a six months double blind trial. Doc. Ophthalmol. 87 (1994), 355–365.
    • (1994) Doc. Ophthalmol. , vol.87 , pp. 355-365
    • van Gerven, J.M.1    Boot, J.P.2    Lemkes, H.H.3    van Best, J.A.4
  • 237
    • 0000841548 scopus 로고
    • Formation of polyols in the lens of the rat with “sugar” cataract
    • Van Heyningen, R., Formation of polyols in the lens of the rat with “sugar” cataract. Nature 184 (1959), 194–195.
    • (1959) Nature , vol.184 , pp. 194-195
    • Van Heyningen, R.1
  • 238
    • 54449094194 scopus 로고    scopus 로고
    • Cataract update 2008: all you need to know about your pediatric cataract patients
    • Vanderveen, D.K., Cataract update 2008: all you need to know about your pediatric cataract patients. Binocul. Vis. Strabismus Q. 23 (2008), 145–158.
    • (2008) Binocul. Vis. Strabismus Q. , vol.23 , pp. 145-158
    • Vanderveen, D.K.1
  • 239
    • 0016354878 scopus 로고
    • The absence of cataracts in mice with congenital hyperglycemia
    • Varma, S.D., Kinoshita, J.H., The absence of cataracts in mice with congenital hyperglycemia. Exp. Eye Res. 19 (1974), 577–582.
    • (1974) Exp. Eye Res. , vol.19 , pp. 577-582
    • Varma, S.D.1    Kinoshita, J.H.2
  • 242
    • 0021241318 scopus 로고
    • Two cases of acutely developed cataract in diabetes mellitus
    • Vinding, T., Nielsen, N.V., Two cases of acutely developed cataract in diabetes mellitus. Acta Ophthalmol. (Copenh) 62 (1984), 373–377.
    • (1984) Acta Ophthalmol. (Copenh) , vol.62 , pp. 373-377
    • Vinding, T.1    Nielsen, N.V.2
  • 244
    • 84924144349 scopus 로고    scopus 로고
    • C-peptide: new findings and therapeutic possibilities
    • Wahren, J., Larsson, C., C-peptide: new findings and therapeutic possibilities. Diabetes Res. Clin. Pract. 107 (2015), 309–319.
    • (2015) Diabetes Res. Clin. Pract. , vol.107 , pp. 309-319
    • Wahren, J.1    Larsson, C.2
  • 245
    • 84896721908 scopus 로고    scopus 로고
    • Additive effect of aldose reductase Z-4 microsatellite polymorphism and glycaemic control on cataract development in type 2 diabetes
    • Wang, Y., Luk, A.O., Ng, M.C., Pang, C.C., Lam, V., Lee, S.C., Lam, D.S., Choy, K.W., Ma, R.C., So, W.Y., Chan, J.C., Additive effect of aldose reductase Z-4 microsatellite polymorphism and glycaemic control on cataract development in type 2 diabetes. J. Diabetes Complicat. 28 (2014), 147–151.
    • (2014) J. Diabetes Complicat. , vol.28 , pp. 147-151
    • Wang, Y.1    Luk, A.O.2    Ng, M.C.3    Pang, C.C.4    Lam, V.5    Lee, S.C.6    Lam, D.S.7    Choy, K.W.8    Ma, R.C.9    So, W.Y.10    Chan, J.C.11
  • 246
    • 0042023720 scopus 로고    scopus 로고
    • Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes
    • Wang, Y., Ng, M.C., Lee, S.C., So, W.Y., Tong, P.C., Cockram, C.S., Critchley, J.A., Chan, J.C., Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes. Diabetes Care 26 (2003), 2410–2415.
    • (2003) Diabetes Care , vol.26 , pp. 2410-2415
    • Wang, Y.1    Ng, M.C.2    Lee, S.C.3    So, W.Y.4    Tong, P.C.5    Cockram, C.S.6    Critchley, J.A.7    Chan, J.C.8
  • 248
    • 77950898257 scopus 로고    scopus 로고
    • The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature
    • Yan, S.F., Ramasamy, R., Schmidt, A.M., The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature. Circ. Res. 106 (2010), 842–853.
    • (2010) Circ. Res. , vol.106 , pp. 842-853
    • Yan, S.F.1    Ramasamy, R.2    Schmidt, A.M.3
  • 249
    • 0041965830 scopus 로고    scopus 로고
    • Functional differences between the susceptibility Z-2/C-106 and protective Z+2/T-106 promoter region polymorphisms of the aldose reductase gene may account for the association with diabetic microvascular complications
    • Yang, B., Millward, A., Demaine, A., Functional differences between the susceptibility Z-2/C-106 and protective Z+2/T-106 promoter region polymorphisms of the aldose reductase gene may account for the association with diabetic microvascular complications. Biochim. Biophys. Acta 1639 (2003), 1–7.
    • (2003) Biochim. Biophys. Acta , vol.1639 , pp. 1-7
    • Yang, B.1    Millward, A.2    Demaine, A.3
  • 250
    • 84896734586 scopus 로고    scopus 로고
    • Oxidative stress, a common molecular pathway for kidney disease: role of the redox enzyme p66Shc
    • Yang, S.K., Xiao, L., Li, J., Liu, F., Sun, L., Oxidative stress, a common molecular pathway for kidney disease: role of the redox enzyme p66Shc. Ren. Fail 36 (2014), 313–320.
    • (2014) Ren. Fail , vol.36 , pp. 313-320
    • Yang, S.K.1    Xiao, L.2    Li, J.3    Liu, F.4    Sun, L.5
  • 252
    • 0025324671 scopus 로고
    • The increase in lipid peroxidation in diabetic rat lens can be reversed by oral sorbinil
    • Yeh, L.A., Ashton, M.A., The increase in lipid peroxidation in diabetic rat lens can be reversed by oral sorbinil. Metabolism 39 (1990), 619–622.
    • (1990) Metabolism , vol.39 , pp. 619-622
    • Yeh, L.A.1    Ashton, M.A.2
  • 254
    • 0344211848 scopus 로고    scopus 로고
    • Diabetes can alter the signal transduction pathways in the lens of rats
    • Zatechka, D.S. Jr., Kador, P.F., Garcia-Castineiras, S., Lou, M.F., Diabetes can alter the signal transduction pathways in the lens of rats. Diabetes 52 (2003), 1014–1022.
    • (2003) Diabetes , vol.52 , pp. 1014-1022
    • Zatechka, D.S.1    Kador, P.F.2    Garcia-Castineiras, S.3    Lou, M.F.4
  • 255
    • 84864311656 scopus 로고    scopus 로고
    • Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation
    • Zhang, P., Xing, K., Randazzo, J., Blessing, K., Lou, M.F., Kador, P.F., Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation. Exp. Eye Res. 101 (2012), 36–43.
    • (2012) Exp. Eye Res. , vol.101 , pp. 36-43
    • Zhang, P.1    Xing, K.2    Randazzo, J.3    Blessing, K.4    Lou, M.F.5    Kador, P.F.6
  • 256
    • 84864311656 scopus 로고    scopus 로고
    • Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation
    • Zhang, Z., Xing, K., Randazzo, J., Blessing, K., Lou, M.F., Kador, P.F., Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation. Exp. Eye Res. 101 (2012), 36–43.
    • (2012) Exp. Eye Res. , vol.101 , pp. 36-43
    • Zhang, Z.1    Xing, K.2    Randazzo, J.3    Blessing, K.4    Lou, M.F.5    Kador, P.F.6
  • 257
    • 7044248709 scopus 로고    scopus 로고
    • Association of the Z-2 and 2 allele of aldose reductase gene with its erythrocyte activity and diabetic microangiopathy in Chinese with type 2 diabetes
    • Zou, X.-M., Zhao, H.-L., Song, H.-J., Lu, J.-M., C-Y, P., Association of the Z-2 and 2 allele of aldose reductase gene with its erythrocyte activity and diabetic microangiopathy in Chinese with type 2 diabetes. Diabetes Res. Clin. Pract. 57:Suppl. 1 (2002), S27–S28.
    • (2002) Diabetes Res. Clin. Pract. , vol.57 , pp. S27-S28
    • Zou, X.-M.1    Zhao, H.-L.2    Song, H.-J.3    Lu, J.-M.4    C-Y, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.