Age-dependent retinal capillary pericyte degeneration in galactose-fed dogs

Journal of Ocular Pharmacology and Therapeutics

Volumn 23, Issue 1, 2007, Pages 63-69

  Kador, Peter F ^a,b,c,e   Takahashi, Yukio ^d   Akagi, Yoshio ^d   Blessing, Karen ^a,b   Randazzo, James ^a   Wyman, Mjlton ^b  

^a NATIONAL EYE INSTITUTE   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF FUKUI   (Japan)

^e NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE; GALACTOSE; GLYCERALDEHYDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRYPSIN; XYLOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACTOGENESIS; CELL DEGENERATION; COMPARATIVE STUDY; COMPUTER ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETIC MICROANGIOPATHY; DIABETIC RETINOPATHY; DIETARY INTAKE; DISEASE SEVERITY; DOG; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME SUBSTRATE; IMAGE ANALYSIS; LENS; MALE; MICROANEURYSM; NONHUMAN; ONSET AGE; PERICYTE; RETINA CAPILLARY;

AGING; ANIMALS; CAPILLARIES; DIETARY CARBOHYDRATES; DOGS; GALACTOSE; GALACTOSEMIAS; LENS, CRYSTALLINE; MALE; NADH, NADPH OXIDOREDUCTASES; NADP; PERICYTES; RETINAL DEGENERATION; RETINAL VESSELS;

EID: 33947405654     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2006.0069     Document Type: Article

References (28)

1. Cogan, D.G., and Kuwabara, T. The mural cell in perspective. Arch. Ophthalmol. 78:133-139, 1967.
2. Hausler, H.R., Sibay, T.M., and Campbell, J. Retinopathy in a dog following diabetes induced by growth hormone. Diabetes 13:122-126, 1964.
3. Engerman, R.L., and Bloodworth, J.M.B., Jr. Experimental diabetic retinopathy in dogs. Arch. Ophthalmol. 73:205-210, 1965.
4. Engerman, R.L., and Kern, T.S. Experimental galactosemia produces diabetic-like retinopathy. Diabetes 33:97-100,1984.
5. Takahashi, Y., Wyman, M., Ferris, F., III, and Kador, F.F. Diabetes-like preproliferative retinal changes in galactose-fed dogs. Arch. Ophthalmol. 10:1295-1302, 1992.
6. Kador, F.F., Takahashi, Y., Wyman, M., et al. Diabetes-like proliferative retinal changes in galactose-fed dogs. Arch. Ophthalmol. 113:352-354, 1995.
7. Kador, F.F., Akagi, Y., Terubayashi, H., et al. Prevention of pericyte ghost formation in retinal capillaries of galactose-fed dogs by aldose reductase inhibitors. Arch. Ophthalmol. 106:1099-1102, 1988.
8. Akagi, Y., Kador, F.F., Kuwabara, T., et al. Aldose reductase localization in human retinal mural cells. Invest. Ophthalmol. Vis. Sci. 24:1516-1519, 1983.
9. Akagi, Y., Terubayashi, H., Millen, J., et al. Aldose reductase localization in dog retinal mural cells. Curr. Eye Res. 5:883-886, 1986.
10. Sato, S., Secchi, E.F., Fukase, S., et al. Polyol formation and NADPH-dependent reductases in cultured dog retinal capillary pericytes and endothelial cells. Invest, Ophthalmol. Vis. Sci. 40:697-704, 1999.
11. Sato, S., Murata, M., Ohta, N., et al. Galactose induces apoptosis of dog retinal capillary pericytes, but not of endothelial cells. Invest. Ophthalmol. Vis. Sci. 40:697-704, 1999.
12. Kador, F.F., Akagi, Y., Takahashi, Y., et al. Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors. Arch. Ophthalmol. 108:1301-1309, 1990.
13. Kador, P.P., Takahashi, Y., Sato, S., et al. Amelioration of diabetes-like retinal changes in galactose-fed dogs. Prev. Med. 23:717-721, 1994.
14. Takahashi, Y., Augustin, W., Wyman, M., et al. Quantitative analysis of retinal vessel changes in galactose-fed dogs. J. Ocul. Pharmacol. Ther. 9:257-269, 1993.
15. Neuenschwander, H., Takahashi, Y., and Kador, P.P. Dose-dependent reduction of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by the aldose reductase inhibitor M79175. J. Ocul. Pharmacol. Ther. 13:517-528, 1997.
16. Cusick, M., Chew, E.Y., Ferris, P., III, et al. The effects of aldose reductase inhibitors and galactose withdrawal on the fluorescein angiographic lesions in galactose-fed dogs. Arch. Ophthalmol. 21:1745-1751, 2003.
17. Kinoshita, J.H., Kador, P., and Datiles, M. Aldose reductase in diabetic cataracts. J. Am. Med. Assoc. 246: 257-261, 1981.
18. Lee, A.Y., Chung, S.K., and Chung, S.S. Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens. Proc. Nat. Acad. Sci. (USA) 92:2780-2784, 1995.
19. Lackner, P.A., Rodriguez, L., Sato, S., et al. Age-dependent changes in galactose-fed dogs. Exp. Eye Res. 64:431-436, 1997.
20. Lizak, M.J., Mori, K., Ceckler, T.L., et al. Quantitation of cataracts in dogs using magnetization transfer contrast enhanced magnetic resonance imaging. Invest. Ophtlhalmol. Vis. Sci. 37:2219-2227, 1996.
21. Terubayashi, H., Akagi, Y., Shiono, T., et al. Developmental changes of aldose reductase in the rat lens: Histological and biochemical studies. J. Eye (Atarashii Ganka) 4:707-710, 1987.
22. Richter, M., Guscetti, F., and Spiess, B. Aldose reductase activity and glucose-related opacities in incubated lenses from dogs and cats. Am. J. Vet. Res. 63:1591-1597, 2002.
23. Kador, F.F., Takahashi, Y., Akagi, Y., et al. Effect of galactose diet removal on the progression of retinal vessel changes in galactose-fed dogs. Invest. Ophthalmol. Vis. Sci. 43:1916-1921, 2002.
24. Sato, S., and Kador, F.F. NADPH-dependent reductases of the dog lens. Exp. Eye Res. 50:629-634, 1990.
25. Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254, 1976.
26. Schaffhauser, M.A., Sato, S., and Kador, F.F. NADPH-dependent reductases in dog thyroid: Comparison of a third enzyme glyceraldehyde reductase to dog thyroid aldehyde reductase. Int. J. Biochem. 28:275-284, 1996.
27. Van Heyningen, R. Metabolism of xylose by the lens of the eye. In International Symposium on Metabolism, Physiology, and Clinical Use of Pentoses and Pentitols. Berlin: Springer-Verlag, 109-123, 1969.
28. Chakravarthy, U., and Gardiner, T.A. Endothelium-derived agents in pericyte function/dysfunction. Prog. Ret. Eye Res. 8:511-527, 1999.