Epithelial cell density in cataractous lenses of patients with diabetes: Association with erythrocyte aldose reductase

Experimental Eye Research

Volumn 85, Issue 3, 2007, Pages 393-399

  Kumamoto, Yuko ^a   Takamura, Yoshihiro ^a   Kubo, Eri ^a   Tsuzuki, Syousai ^a   Akagi, Yoshio ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

aldose reductase; diabetes mellitus; diabetic cataract; lens epithelial cells

Indexed keywords

ALDEHYDE REDUCTASE; HEMOGLOBIN A1C; POLYOL;

ADULT; AGED; ARTICLE; CATARACT; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DIABETIC RETINOPATHY; DISEASE DURATION; ERYTHROCYTE; FEMALE; HUMAN; HUMAN TISSUE; LENS CAPSULE; LENS EPITHELIUM; MALE; MULTIPLE REGRESSION; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROSPECTIVE STUDY;

AGED; ALDEHYDE REDUCTASE; CATARACT; CELL COUNT; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; EPITHELIAL CELLS; ERYTHROCYTES; FEMALE; HUMANS; LENS CAPSULE, CRYSTALLINE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 34547877652     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2007.06.007     Document Type: Article

References (45)

1. Akagi Y., Kador P.F., and Kinoshita J.H. Immunohistochemical localization for aldose reductase in diabetic lenses. Invest. Ophthalmol. Vis. Sci. 28 (1987) 163-167
2. Argento C., and Zarate J. Study of the lens epithelial cell density in cataractous eyes operated on with extracapsular and intercapsular techniques. J. Cataract Refract. Surg 16 (1990) 207-210
3. Balaram M., Tung W.H., Kuszak J.R., Ayaki M., Shinohara T., and Chylack Jr. L.T. Noncontact specular microscopy of human lens epithelium. Invest. Ophthalmol. Vis. Sci. 41 (2000) 474-481
4. Bursch W., Paffe S., Putz B., Barthel G., and Schulte-Hermann R. Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats. Carcinogenesis 11 (1990) 847-853
5. Chylack Jr. L.T., Wolfe J.K., Singer D.M., Leske M.C., Bullimore M.A., Bailey I.L., Friend J., McCarthy D., and Wu S.Y. The lens opacities classification system III. Arch. Ophthalmol 111 (1993) 831-836
6. Datiles M., Fukui H., Kuwabara T., and Kinoshita J.H. Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study. Invest. Ophthalmol. Vis. Sci. 22 (1982) 174-179
7. Dvornik E., Simard-Duquesne N., Krami M., Sestanj K., Gabbay K.H., Kinoshita J.H., Varma S.D., and Merola L.O. Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor. Science 182 (1973) 1146-1148
8. Fagerholm P.P., and Philipson B.T. Human lens epithelium in normal and cataractous lenses. Invest. Ophthalmol. Vis. Sci. 21 (1981) 408-414
9. Gonzalez K., McVey S., Cunnick J., Udovichenko I.P., and Takemoto D.J. Acridine orange differential staining of total DNA and RNA in normal and galactosemic lens epithelial cells in culture using flow cytometry. Curr. Eye Res. 14 (1995) 269-273
10. Guggenmoos-Holzmann I., Engel B., Henke V., and Naumann G.O. Cell density of human lens epithelium in women higher than in men. Invest. Ophthalmol. Vis. Sci. 30 (1989) 330-332
11. Hamada Y., Kitoh R., and Raskin P. Association of erythrocyte aldose reductase activity with diabetic complications in type 1 diabetes mellitus. Diabet. Med 10 (1993) 33-38
12. Hamada Y., Nishimura C., Koh N., Sakakibara F., Nakamura J., Tanimoto T., and Hotta N. Influence of interindividual variability of aldose reductase protein content on polyol-pathway metabolites and redox state in erythrocytes in diabetic patients. Diabetes Care 21 (1998) 1014-1018
13. Harocopos G.J., Alvares K.M., Kolker A.E., and Beebe D.C. Human age-related cataract and lens epithelial cell death. Invest. Ophthalmol. Vis. Sci. 39 (1998) 2696-2706
14. Hayman S., and Kinoshita J.H. Isolation and properties of lens aldose reductase. J. Biol. Chem. 240 (1965) 877-882
15. Hennis A., Wu S.Y., Nemesure B., Leske M.C., and Barbados Eye Studies Group. Risk factors for incident cortical and posterior subcapsular lens opacities in the Barbados Eye Studies. Arch. Ophthalmol 122 (2004) 525-530
16. Ito T., Nishimura C., Takahashi Y., Saito T., and Omori Y. The level of erythrocyte aldose reductase: a risk factor for diabetic neuropathy?. Diabetes Res. Clin. Pract 36 (1997) 161-167
17. Kao Y.L., Donaghue K., Chan A., Knight J., and Silink M. A novel polymorphism in the aldose reductase gene promoter region is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes. Diabetes 48 (1999) 1338-1340
18. Karim A.K., Jacob T.J., and Thompson G.M. The human anterior lens capsule: cell density, morphology and mitotic index in normal and cataractous lenses. Exp. Eye Res. 45 (1987) 865-874
19. Ko B.C., Lam K.S., Wat N.M., and Chung S.S. An (A-C)n dinucleotide repeat polymorphic marker at the 5′ end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients. Diabetes 44 (1995) 727-732
20. Konofsky K., Naumann G.O., and Guggenmoos-Holzmann I. Cell density and sex chromatin in lens epithelium of human cataracts. Quantitative studies in flat preparation. Ophthalmology 94 (1987) 875-880
21. Kubo E., Urakami T., Fatma N., Akagi Y., and Singh D.P. Polyol pathway-dependent osmotic and oxidative stresses in aldose reductase-mediated apoptosis in human lens epithelial cells: role of AOP2. Biochem. Biophys. Res. Commun 314 (2004) 1050-1056
22. Lerner B.C., Varma S.D., and Richards R.D. Polyol pathway metabolites in human cataracts. Correlation of circulating glycosylated hemoglobin content and fasting blood glucose levels. Arch. Ophthalmol 102 (1984) 917-920
23. Li W.C., Kuszak J.R., Dunn K., Wang R.R., Ma W., Wang G.M., Spector A., Leib M., Cotliar A.M., and Weiss M. Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals. J. Cell Biol. 130 (1995) 169-181
24. Li W.C., and Spector A. Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract. Free Radic. Biol. Med 20 (1996) 301-311
25. Messam C.A., and Pittman R.N. Asynchrony and commitment to die during apoptosis. Exp. Cell Res. 238 (1998) 389-398
26. Michael R., Vrensen G.F., vanMarle J., Gan L., and Soderberg P.G. Apoptosis in the rat lens after in vivo threshold dose ultraviolet irradiation. Invest. Ophthalmol. Vis. Sci. 39 (1998) 2681-2687
27. Murata M., Ohta N., Sakurai S., Alam S., Tsai J., Kador P.F., and Sato S. The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis). Chem. Biol. Interact 130-132 (2001) 617-625
28. Nishimura C., Hamada Y., Tachikawa T., Ishikawa T., Gui T., Tsubouchi J., Hotta N., Tanimoto T., and Urakami T. Enzyme immunoassay for erythrocyte aldose reductase. Clin. Chem. 40 (1994) 889-894
29. Nishimura C., Saito T., Ito T., Omori Y., and Tanimoto T. High levels of erythrocyte aldose reductase and diabetic retinopathy in NIDDM patients. Diabetologia 37 (1994) 328-330
30. Ogata M., Iwasaki N., Kanamori M., Itoh T., Takahashi Y., Ohgawara H., and Omori Y. Polymorphism of the aldose reductase gene is associated with aldose reductase protein levels and diabetic microangiopathy. Diabetologia 40 (1997) A168
31. Oharazawa H., Ibaraki N., Matsui H., and Ohara K. Age-related changes of human lens epithelial cells in vivo. Ophthalmic Res. 33 (2001) 363-366
32. Ohnishi A., Tanimoto T., Nagaki J., Jinnouchi T., and Ishizu H. Relationship between erythrocyte aldose reductase level and diabetic complications among 98 NIDDM patients. J. Japan Diab. Soc. 39 (1996) 783-788
33. Oishi N., Kubo E., Takamura Y., Maekawa K., Tanimoto T., and Akagi Y. Correlation between erythrocyte aldose reductase level and human diabetic retinopathy. Br. J. Ophthalmol 86 (2002) 1363-1366
34. Oishi N., Morikubo S., Takamura Y., Kubo E., Tsuzuki S., Tanimoto T., and Akagi Y. Correlation between adult diabetic cataracts and red blood cell aldose reductase levels. Invest. Ophthalmol. Vis. Sci. 47 (2006) 2061-2064
35. Struck H.G., Heider C., and Lautenschlager C. Changes in the lens epithelium of diabetic and non-diabetic patients with various forms of opacities in senile cataract. Klin. Monatsbl. Augenheilkd 216 (2000) 204-209
36. Takamura Y., Kubo E., Tsuzuki S., and Akagi Y. Apoptotic cell death in the lens epithelium of rat sugar cataract. Exp. Eye Res. 77 (2003) 51-57
37. Tanimoto T., Maekawa K., Okada S., and Yabe-Nishimura C. Clinical analysis of aldose reductase for differential diagnosis of the pathogenesis of diabetic complication. Anal. Chim. Acta 365 (1998) 285-292
38. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med 329 (1993) 977-986
39. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20 (1997) 1183-1197
40. Tkachov S.I., Lautenschlager C., Ehrich D., and Struck H.G. Changes in the lens epithelium with respect to cataractogenesis: light microscopic and Scheimpflug densitometric analysis of the cataractous and the clear lens of diabetics and non-diabetics. Graefes Arch. Clin. Exp. Ophthalmol 244 (2006) 596-602
41. Tseng S.H., Yen J.S., and Chien H.L. Lens epithelium in senile cataract. J. Formos. Med. Assoc. 93 (1994) 93-98
42. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352 (1998) 837-853
43. Varma S.D., Hegde K., and Henein M. Oxidative damage to mouse lens in culture. Protective effect of pyruvate. Biochim. Biophys. Acta 1621 (2003) 246-252
44. Vasavada A.R., Cherian M., Yadav S., and Rawal U.M. Lens epithelial cell density and histomorphological study in cataractous lenses. J. Cataract Refract. Surg 17 (1991) 798-804
45. Wilkinson C.P., Ferris F.L., Klein R.E., Lee P.P., Agardh C.D., Davis M., Dills D., Kampik A., Pararajasegaram R., Verdaguer J.T., and the Global Diabetic Retinopathy Project Group. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110 (2003) 1677-1682