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Volumn 106, Issue 5, 2010, Pages 842-853

The RAGE axis a fundamental mechanism signaling danger to the vulnerable vasculature

Author keywords

Cardiovascular complications; Diabetes; Inflammation; RAGE

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ADVANCED OXIDATION PROTEIN PRODUCT; AMYLOID BETA PROTEIN; CALGRANULIN; REACTIVE OXYGEN METABOLITE; ADVANCED GLYCOSYLATION END PRODUCT RECEPTOR; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; IMMUNOGLOBULIN RECEPTOR; LIGAND;

EID: 77950898257     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.212217     Document Type: Article
Times cited : (333)

References (98)
  • 1
    • 69249100372 scopus 로고    scopus 로고
    • RAGE: Therapeutic target and biomarker of the inflammatory response - The evidence mounts
    • Ramasamy R, Yan SF, Schmidt AM. RAGE: therapeutic target and biomarker of the inflammatory response - the evidence mounts. J Leukoc Biol. 2009;86:505-512.
    • (2009) J. Leukoc Biol. , vol.86 , pp. 505-512
    • Ramasamy, R.1    Yan, S.F.2    Schmidt, A.M.3
  • 3
    • 29144453326 scopus 로고    scopus 로고
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    • Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zinman B; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353:2643-2653.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2643-2653
    • Nathan, D.M.1    Cleary, P.A.2    Backlund, J.Y.3    Genuth, S.M.4    Lachin, J.M.5    Orchard, T.J.6    Raskin, P.7    Zinman, B.8
  • 4
    • 47649112674 scopus 로고    scopus 로고
    • Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: Cohort study
    • Dale AC, Vatten LJ, Nilsen TI, Midthjell K, Wiseth R. Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: cohort study. BMJ. 2008;337: a236.
    • (2008) BMJ , vol.337
    • Dale, A.C.1    Vatten, L.J.2    Nilsen, T.I.3    Midthjell, K.4    Wiseth, R.5
  • 5
    • 46349111711 scopus 로고    scopus 로고
    • Diabetes mellitus, hypothalamic hypoestrogenemia, and coronary artery disease in premenopausal women (from the National Heart, Lung, and Blood Institute sponsored WISE study)
    • WISE Study Group
    • Ahmed B, Bairey Merz CN, Johnson BD, Bittner V, Berga SL, Braunstein GD, Hodgson TK, Smith K, Shaw L, Kelsey SF, Sopko G; WISE Study Group. Diabetes mellitus, hypothalamic hypoestrogenemia, and coronary artery disease in premenopausal women (from the National Heart, Lung, and Blood Institute sponsored WISE study). Am J Cardiol. 2008;102:150-154.
    • (2008) Am. J. Cardiol. , vol.102 , pp. 150-154
    • Ahmed, B.1    Bairey Merz, C.N.2    Johnson, B.D.3    Bittner, V.4    Berga, S.L.5    Braunstein, G.D.6    Hodgson, T.K.7    Smith, K.8    Shaw, L.9    Kelsey, S.F.10    Sopko, G.11
  • 8
    • 0027176945 scopus 로고
    • Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products
    • Schmidt AM, Yan SD, Brett J, Mora R, Nowygrod R, Stern D. Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products. J Clin Invest. 1993;91:2155-2168.
    • (1993) J. Clin. Invest. , vol.91 , pp. 2155-2168
    • Schmidt, A.M.1    Yan, S.D.2    Brett, J.3    Mora, R.4    Nowygrod, R.5    Stern, D.6
  • 9
    • 65349167787 scopus 로고    scopus 로고
    • The receptor for advanced glycation endproducts and cardiovascular disease
    • Yan SF, Ramasamy R, Schmidt AM. The receptor for advanced glycation endproducts and cardiovascular disease. Expert Rev Mol Med. 2009;11: e9.
    • (2009) Expert Rev. Mol. Med. , vol.11
    • Yan, S.F.1    Ramasamy, R.2    Schmidt, A.M.3
  • 10
    • 0027479975 scopus 로고
    • Glycation and oxidation of human low density lipoproteins reduces heparin binding and modifies charge
    • Gugliucci Creriche A, Stahl AJ. Glycation and oxidation of human low density lipoproteins reduces heparin binding and modifies charge. Scand J Lab Clin Invest. 1993;53:125-132.
    • (1993) Scand. J. Lab. Clin. Invest. , vol.53 , pp. 125-132
    • Creriche, A.G.1    Stahl, A.J.2
  • 12
    • 0033615356 scopus 로고    scopus 로고
    • N (epsilon) - (carboxymethyl) lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression
    • Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, Hofmann M, Yan SF, Pischetsrieder M, Stern D, Schmidt AM. N (epsilon) - (carboxymethyl) lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J Biol Chem. 1999;274:31740-31749.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31740-31749
    • Kislinger, T.1    Fu, C.2    Huber, B.3    Qu, W.4    Taguchi, A.5    Du Yan, S.6    Hofmann, M.7    Yan, S.F.8    Pischetsrieder, M.9    Stern, D.10    Schmidt, A.M.11
  • 14
    • 42549124546 scopus 로고    scopus 로고
    • Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products
    • Chang JS, Wendt T, Qu W, Kong L, Zou YS, Schmidt AM, Yan SF. Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ Res. 2008;102:905-913.
    • (2008) Circ. Res. , vol.102 , pp. 905-913
    • Chang, J.S.1    Wendt, T.2    Qu, W.3    Kong, L.4    Zou, Y.S.5    Schmidt, A.M.6    Yan, S.F.7
  • 15
    • 78650381612 scopus 로고    scopus 로고
    • Pharmacological blockage of the receptor for advanced glycation endproducts (RAGE) improves age-related endothelial dysfunction in rats
    • Abstract
    • Hallam K, Gomez T, Li Q, Ananthakrishnan R, Yan SF, Qu W, Schmidt AM, Ramasamy R. Pharmacological blockage of the receptor for advanced glycation endproducts (RAGE) improves age-related endothelial dysfunction in rats. Exp Biol. 2006; C292:463.8. Abstract.
    • (2006) Exp. Biol. , vol.C292 , pp. 4638
    • Hallam, K.1    Gomez, T.2    Li, Q.3    Ananthakrishnan, R.4    Yan, S.F.5    Qu, W.6    Schmidt, A.M.7    Ramasamy, R.8
  • 18
    • 0042915798 scopus 로고    scopus 로고
    • Production of N (epsilon) - (carboxymethyl) lysine is impaired in mice deficient in NADPH oxidase: A role for phagocyte-derived oxidants in the formation of advanced glycation end products during inflammation
    • Andersen MM, Heinecke JW. Production of N (epsilon) - (carboxymethyl) lysine is impaired in mice deficient in NADPH oxidase: a role for phagocyte-derived oxidants in the formation of advanced glycation end products during inflammation. Diabetes. 2003;52:2137-2143.
    • (2003) Diabetes , vol.52 , pp. 2137-2143
    • Andersen, M.M.1    Heinecke, J.W.2
  • 19
    • 0032694683 scopus 로고    scopus 로고
    • The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl) lysine on proteins: A mechanism for producing advanced glycation end products at sites of inflammation
    • Anderson MM, Requena JR, Crowley JR, Thorpe SR, Heinecke JW. The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl) lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation. J Clin Invest. 1999;104:103-113.
    • (1999) J. Clin. Invest. , vol.104 , pp. 103-113
    • Anderson, M.M.1    Requena, J.R.2    Crowley, J.R.3    Thorpe, S.R.4    Heinecke, J.W.5
  • 22
    • 33751330181 scopus 로고    scopus 로고
    • AGE-and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains
    • Kuhla B, Boeck K, Schmidt A, Ogunlade V, Arendt T, Munch G, Luth JH. AGE-and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains. Neurobiol Aging. 2007;28:29-41.
    • (2007) Neurobiol. Aging , vol.28 , pp. 29-41
    • Kuhla, B.1    Boeck, K.2    Schmidt, A.3    Ogunlade, V.4    Arendt, T.5    Munch, G.6    Luth, J.H.7
  • 23
    • 35348903240 scopus 로고    scopus 로고
    • Proteomic analysis defines altered cellular redox pathways and advanced glycation endproduct metabolism in glomeruli of db/db diabetic mice
    • Barati MT, Merchant ML, Kain AB, Jevans AW, McLeish KR, Klein JB. Proteomic analysis defines altered cellular redox pathways and advanced glycation endproduct metabolism in glomeruli of db/db diabetic mice. Am J Physiol Renal Physiol. 2007;293: F1157-F1165.
    • (2007) Am. J. Physiol. Renal Physiol. , vol.293
    • Barati, M.T.1    Merchant, M.L.2    Kain, A.B.3    Jevans, A.W.4    McLeish, K.R.5    Klein, J.B.6
  • 25
    • 33644668591 scopus 로고    scopus 로고
    • Common polymorphisms in the glyoxalase-1 gene and their association with pro-thrombotic events
    • Gale CP, Futers TS, Summers LK. Common polymorphisms in the glyoxalase-1 gene and their association with pro-thrombotic events. Diab Vasc Dis Res. 2004;1:34-39.
    • (2004) Diab Vasc. Dis. Res. , vol.1 , pp. 34-39
    • Gale, C.P.1    Futers, T.S.2    Summers, L.K.3
  • 29
    • 0017903484 scopus 로고
    • Nonhistone proteins HMG1 and HMG2 change the DNA helical structure
    • Javaherian K, Liu JF, Wang JC. Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. Science. 1978;199:1345-1346.
    • (1978) Science , vol.199 , pp. 1345-1346
    • Javaherian, K.1    Liu, J.F.2    Wang, J.C.3
  • 31
    • 48949087707 scopus 로고    scopus 로고
    • Early increases in serum S100B are associated with cerebral hemorrhage in a rat model of focal cerebral ischemia
    • Tanaka Y, Marumo T, Omura T, Yoshida S. Early increases in serum S100B are associated with cerebral hemorrhage in a rat model of focal cerebral ischemia. Brain Res. 2008;1227:248-254.
    • (2008) Brain Res. , vol.1227 , pp. 248-254
    • Tanaka, Y.1    Marumo, T.2    Omura, T.3    Yoshida, S.4
  • 32
    • 0027169842 scopus 로고
    • Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation
    • Parkkinen J, Raulo E, Merenmies J, Nolo R, Kajander EO, Baumann M, Rauvala H. Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation. J Biol Chem. 1993;268:19726-19738.
    • (1993) J. Biol. Chem. , vol.268 , pp. 19726-19738
    • Parkkinen, J.1    Raulo, E.2    Merenmies, J.3    Nolo, R.4    Kajander, E.O.5    Baumann, M.6    Rauvala, H.7
  • 33
    • 34547105307 scopus 로고    scopus 로고
    • Activation of poly (ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus
    • Ditsworth D, Zong WX, Thompson CB. Activation of poly (ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus. J Biol Chem. 2007;282:17845-17854.
    • (2007) J. Biol. Chem. , vol.282 , pp. 17845-17854
    • Ditsworth, D.1    Zong, W.X.2    Thompson, C.B.3
  • 34
    • 61649086413 scopus 로고    scopus 로고
    • Regulation of HMGB1 release by autophagy
    • Thorburn J, Frankel AE, Thorburn A. Regulation of HMGB1 release by autophagy. Autophagy. 2009;5:247-249.
    • (2009) Autophagy , vol.5 , pp. 247-249
    • Thorburn, J.1    Frankel, A.E.2    Thorburn, A.3
  • 35
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature. 2002;418:191-195.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 36
    • 34248229237 scopus 로고    scopus 로고
    • The relationship between apoptosis and high mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic polycytidylic acid
    • Jiang W, Bell CW, Pisetsky DS. The relationship between apoptosis and high mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic polycytidylic acid. J Immunol. 2007;178:6495-6503.
    • (2007) J. Immunol. , vol.178 , pp. 6495-6503
    • Jiang, W.1    Bell, C.W.2    Pisetsky, D.S.3
  • 37
    • 0028851635 scopus 로고
    • The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
    • Hori O, Brett J, Slattery T, Cao R, Zhang J, Chen JX, Nagashima M, Nitecki D, Morser J, Stern D, Schmidt AM. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem. 1995;270:25752-25761.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25752-25761
    • Hori, O.1    Brett, J.2    Slattery, T.3    Cao, R.4    Zhang, J.5    Chen, J.X.6    Nagashima, M.7    Nitecki, D.8    Morser, J.9    Stern, D.10    Schmidt, A.M.11
  • 44
    • 40049104961 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts expression on T cells contributes to antigen specific cellular expansion in vivo
    • Moser B, Desai DD, Downie MP, Chen Y, Yan SF, Herold K, Schmidt AM, Clynes R. Receptor for advanced glycation endproducts expression on T cells contributes to antigen specific cellular expansion in vivo. J Immunol. 2007;179:8051-8058.
    • (2007) J. Immunol. , vol.179 , pp. 8051-8058
    • Moser, B.1    Desai, D.D.2    Downie, M.P.3    Chen, Y.4    Yan, S.F.5    Herold, K.6    Schmidt, A.M.7    Clynes, R.8
  • 53
    • 45149098188 scopus 로고    scopus 로고
    • S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products
    • Boyd JH, Kan B, Roberts H, Wang Y, Walley KR. S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res. 2008;102:1239-1246.
    • (2008) Circ. Res. , vol.102 , pp. 1239-1246
    • Boyd, J.H.1    Kan, B.2    Roberts, H.3    Wang, Y.4    Walley, K.R.5
  • 54
    • 57749122052 scopus 로고    scopus 로고
    • Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42
    • Hudson BI, Kalea AZ, Del Mar. Arriero M, Harja E, Boulanger E, D'Agati V, Schmidt AM. Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42. J Biol Chem. 2008;253:34457-34468.
    • (2008) J. Biol. Chem. , vol.253 , pp. 34457-34468
    • Hudson, B.I.1    Kalea, A.Z.2    Del Mar Arriero, M.3    Harja, E.4    Boulanger, E.5    D'Agati, V.6    Schmidt, A.M.7
  • 56
    • 0142039004 scopus 로고    scopus 로고
    • The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site
    • Ishihara K, Tsutsumi K, Kawane S, Nakajima M, Kasaoka T. The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site. FEBS Lett. 2003;550:107-113.
    • (2003) FEBS Lett. , vol.550 , pp. 107-113
    • Ishihara, K.1    Tsutsumi, K.2    Kawane, S.3    Nakajima, M.4    Kasaoka, T.5
  • 59
    • 0031717894 scopus 로고    scopus 로고
    • Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts
    • Park L, Raman KG, Lee KJ, Lu Y, Ferran LJ Jr, Chow WS, Stern DM, Schmidt AM. Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts. Nat Med. 1998;4:1025-1031.
    • (1998) Nat. Med. , vol.4 , pp. 1025-1031
    • Park, L.1    Raman, K.G.2    Lee, K.J.3    Lu, Y.4    Ferran Jr., L.J.5    Chow, W.S.6    Stern, D.M.7    Schmidt, A.M.8
  • 65
    • 10644246127 scopus 로고    scopus 로고
    • Advanced glycation endproduct cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process
    • Bakris GL, Bank AJ, Kass DA, Neutel JM, Preston RA, Oparil S. Advanced glycation endproduct cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process. Am J Hypertens. 2004;1723S-1730S.
    • (2004) Am. J. Hypertens
    • Bakris, G.L.1    Bank, A.J.2    Kass, D.A.3    Neutel, J.M.4    Preston, R.A.5    Oparil, S.6
  • 66
    • 13444302216 scopus 로고    scopus 로고
    • S100B expression modulates left ventricular remodeling after myocardial infarction in mice
    • Tsoporis JN, Marks A, Haddad A, Dawood F, Liu PP, Parker TG. S100B expression modulates left ventricular remodeling after myocardial infarction in mice. Circulation. 2005;111:598-606.
    • (2005) Circulation , vol.111 , pp. 598-606
    • Tsoporis, J.N.1    Marks, A.2    Haddad, A.3    Dawood, F.4    Liu, P.P.5    Parker, T.G.6
  • 75
    • 0037180517 scopus 로고    scopus 로고
    • Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures
    • Tepper OM, Galiano RD, Capla JM, Kalka C, Gagne PJ, Jacobowitz GR, Levine JP, Gurtner GC. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation. 2002;106:2781-2786.
    • (2002) Circulation , vol.106 , pp. 2781-2786
    • Tepper, O.M.1    Galiano, R.D.2    Capla, J.M.3    Kalka, C.4    Gagne, P.J.5    Jacobowitz, G.R.6    Levine, J.P.7    Gurtner, G.C.8
  • 76
    • 71649112618 scopus 로고    scopus 로고
    • Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation endproducts
    • Liang C, Ren Y, Tan H, He Z, Jiang Q, Wu J, Zhen Y, Fan M, Wu Z. Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation endproducts. Br J Pharmacol. 2009;158:1865-1873.
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 1865-1873
    • Liang, C.1    Ren, Y.2    Tan, H.3    He, Z.4    Jiang, Q.5    Wu, J.6    Zhen, Y.7    Fan, M.8    Wu, Z.9
  • 77
    • 67650892020 scopus 로고    scopus 로고
    • C-reactive protein upregulates receptor for advanced glycation endproducts expression and alters antioxidant defenses in rat endothelial progenitor cells
    • Chen J, Huang L, Song M, Yu S, Gao P, Jing J. C-reactive protein upregulates receptor for advanced glycation endproducts expression and alters antioxidant defenses in rat endothelial progenitor cells. J Cardiovasc Pharmacol. 2009;53:359-367.
    • (2009) J. Cardiovasc. Pharmacol. , vol.53 , pp. 359-367
    • Chen, J.1    Huang, L.2    Song, M.3    Yu, S.4    Gao, P.5    Jing, J.6
  • 78
    • 61849161661 scopus 로고    scopus 로고
    • Advanced glycation endproducts impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2
    • Chen Q, Dong L, Wang L, Kang L, Xu B. Advanced glycation endproducts impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2. Biochem Biophys Res Commun. 2009;381:192-197.
    • (2009) Biochem. Biophys. Res. Commun. , vol.381 , pp. 192-197
    • Chen, Q.1    Dong, L.2    Wang, L.3    Kang, L.4    Xu, B.5
  • 80
    • 64549119691 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproduct (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury
    • Zeng S, Dun H, Ippagunta N, Rosario R, Zhang QY, Lefkowitch J, Yan SF, Schmidt AM, Emond JC. Receptor for advanced glycation endproduct (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury. J Hepatol. 2009;50:929-936.
    • (2009) J. Hepatol. , vol.50 , pp. 929-936
    • Zeng, S.1    Dun, H.2    Ippagunta, N.3    Rosario, R.4    Zhang, Q.Y.5    Lefkowitch, J.6    Yan, S.F.7    Schmidt, A.M.8    Emond, J.C.9
  • 84
    • 17144430517 scopus 로고    scopus 로고
    • Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury
    • Yonekura H, Yamamoto Y, Sakurai S, Watanabe T, Yamamoto H. Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury. J Pharmacol Sci. 2005;97:305-311.
    • (2005) J. Pharmacol. Sci. , vol.97 , pp. 305-311
    • Yonekura, H.1    Yamamoto, Y.2    Sakurai, S.3    Watanabe, T.4    Yamamoto, H.5
  • 86
    • 54049108485 scopus 로고    scopus 로고
    • A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
    • Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME. A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10). FASEB J. 2008;22:3716-3727.
    • (2008) FASEB J , vol.22 , pp. 3716-3727
    • Raucci, A.1    Cugusi, S.2    Antonelli, A.3    Barabino, S.M.4    Monti, L.5    Bierhaus, A.6    Reiss, K.7    Saftig, P.8    Bianchi, M.E.9
  • 88
    • 65649127808 scopus 로고    scopus 로고
    • Soluble forms of RAGE in human diseases: Clinical and therapeutical implications
    • Santilli F, Vazzana N, Bucciarelli LG, Daví G. Soluble forms of RAGE in human diseases: clinical and therapeutical implications. Curr Med Chem. 2009;16:940-952.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 940-952
    • Santilli, F.1    Vazzana, N.2    Bucciarelli, L.G.3    Daví, G.4
  • 89
    • 33745741894 scopus 로고    scopus 로고
    • Soluble receptor for advanced glycation end products: From disease marker to potential therapeutic target
    • Geroldi D, Falcone C, Emanuele E. Soluble receptor for advanced glycation end products: from disease marker to potential therapeutic target. Curr Med Chem. 2006;13:1971-1978.
    • (2006) Curr. Med. Chem. , vol.13 , pp. 1971-1978
    • Geroldi, D.1    Falcone, C.2    Emanuele, E.3
  • 90
    • 33745601096 scopus 로고    scopus 로고
    • High levels of soluble receptor for advanced glycation end products may be marker of extreme longevity in humans
    • Geroldi D, Falcone C, Minoretti P, Emanuele E, Arra M, D'Angelo A. High levels of soluble receptor for advanced glycation end products may be marker of extreme longevity in humans. J Am Geriatr Soc. 2006;54:1149-1150.
    • (2006) J. Am. Geriatr. Soc. , vol.54 , pp. 1149-1150
    • Geroldi, D.1    Falcone, C.2    Minoretti, P.3    Emanuele, E.4    Arra, M.5    D'Angelo, A.6
  • 92
    • 77949527584 scopus 로고    scopus 로고
    • Soluble RAGE-modulating drugs: State-of-the-art and future perspectives for targeting vascular inflammation
    • In press
    • Lanati N, Emanuele E, Brondin N, Geroldi D. Soluble RAGE-modulating drugs: state-of-the-art and future perspectives for targeting vascular inflammation. Curr Vasc Pharmacol. In press.
    • Curr. Vasc. Pharmacol.
    • Lanati, N.1    Emanuele, E.2    Brondin, N.3    Geroldi, D.4
  • 95
    • 0037342124 scopus 로고    scopus 로고
    • The functional-374T/A RAGE gene polymorphism is associated with proteinura and cardiovascular disease in type 1 diabetic patients
    • Pettersson-Fernholm K, Forsblom C, Hudson BI, Perola M, Grant PJ, Groop PH. The functional-374T/A RAGE gene polymorphism is associated with proteinura and cardiovascular disease in type 1 diabetic patients. Diabetes. 2003;52:891-894.
    • (2003) Diabetes , vol.52 , pp. 891-894
    • Pettersson-Fernholm, K.1    Forsblom, C.2    Hudson, B.I.3    Perola, M.4    Grant, P.J.5    Groop, P.H.6
  • 97
    • 66949157648 scopus 로고    scopus 로고
    • RAGE: A novel biological and genetic marker for vascular disease
    • Kalea AZ, Schmidt AM, Hudson BI. RAGE: a novel biological and genetic marker for vascular disease. Clin Sci. 2009;116:621-637.
    • (2009) Clin. Sci. , vol.116 , pp. 621-637
    • Kalea, A.Z.1    Schmidt, A.M.2    Hudson, B.I.3
  • 98
    • 65449151412 scopus 로고    scopus 로고
    • Therapies for hyperglycaemia-induced diabetic complications: From animal models to clinical trials
    • Calcutt NA, Cooper ME, Kern TS, Schmidt AM. Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials. Nat Rev Drug Discov. 2009;8:417-429.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 417-429
    • Calcutt, N.A.1    Cooper, M.E.2    Kern, T.S.3    Schmidt, A.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.