Effects of aldose reductase inhibitor CT-112 on the corneal epithelial barrier of galactose-fed rats

Current Eye Research

Volumn 16, Issue 6, 1997, Pages 595-599

  Yokoi, Norihiko ^a   Niiya, Akiko ^a   Komuro, Aoi ^a   Yokogaki, Syuichi ^b   Naka, Hiroaki ^b   Awata, Takashi ^b   Honma, Yoichi ^a   Yamada, Jun ^a   Tei, Mamoru ^a   Kinoshita, Shigeru ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b SENJU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Aldose reductase inhibitor; Carboxyfluorescein; Corneal epithelial barrier function; Fluorescein; Galactosemic rat

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; CARBOXYFLUORESCEIN; FLUORESCEIN; GALACTOSE; HORSERADISH PEROXIDASE; RISARESTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL JUNCTION; CELL MEMBRANE; CORNEA; CORNEA CELL; CORNEA EPITHELIUM; DIETARY INTAKE; ELECTRON MICROSCOPY; FLUOROPHOTOMETRY; HISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SLIT LAMP; TOPICAL DRUG ADMINISTRATION;

ALDEHYDE REDUCTASE; ANIMALS; CORNEA; DIET; ENZYME INHIBITORS; EPITHELIUM; FLUOROPHOTOMETRY; GALACTOSE; MALE; MICROSCOPY, ELECTRON; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLES; THIAZOLIDINEDIONES;

EID: 0030920528     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.16.6.595.5076     Document Type: Article

References (24)

1. Perry, H. D., Foulks, G. N., Thoft, R. A. and Tolentino, F. I. (1978) Corneal complication after closed vitrectomy through the pars plana. Arch. Ophthalmol. 96, 1401-1403.
2. Schultz, R. O., Van Horn, D. L., Peters, M. A., Klewwin, K. M. and Schutten, W. H. (1981) Diabetic keratopathy. Trans. Am. Ophthalmol. Soc. 79, 180-199.
3. Schultz, R. O., Peters, M. A., Sobocinski, R., Nassif, K. and Schultz, K. J. (1983) Diabetic keratopathy as a manifestation of peripheral neuropathy. Am. J. Ophthalmol. 96, 368-371.
4. Ohashi, Y., Matsuda, M., Hosotani, H., Tano, Y., Ishimoto, I., Fukuda, M. and Manabe, R. (1988) Aldose reductase inhibitor (CT-112) eyedrops for diabetic corneal epitheliopathy. Am. J. Ophthalmol. 105, 233-238.
5. Foulks, G. N., Thoft, R. A., Perry, H. D. and Tolentino, F. I. (1979) Factors related to corneal epithelial complications after closed vitrectomy in diabetes. Arch. Ophthalmol. 97, 1076-1078.
6. Kinoshita, J. H. (1965) Cataracts in galactosemia. Invest. Ophthalmol. 4, 786-799.
7. Kinoshita, J. H. (1974) Mechanism initiating cataract formation. Invest. Ophthalmol. Vis. Sci. 13, 713-724.
8. Kador, P. F. (1988) The role of aldose reductase in the development of diabetic complications. Med. Res. Rev. 8, 325-352.
9. Akagi, Y., Kador, P. F. and Kinoshita, J. H. (1987) Immunohistochemical localization for aldose reductase in diabetic lenses. Invest. Ophthalmol. Vis. Sci. 28, 163-167.
10. Akagi, Y., Yajima, Y., Kador, P. F., Kuwabara, T. and Kinoshita, J. H. (1984) Localization of aldose reductase in the human eye. Diabetes, 33, 562-566.
11. Takahashi, Y., Akagi, Y., Akimune, M., Tamura, K. and Itoi, M. (1986) The role of aldose reductase in diabetic corneal epitheliopathy, second report: the corneal epithelium of galactosemic rats. Acta Soc. Ophthalmol. Jpn. 90, 336-340.
12. Fukushi, S., Merola, L. O., Tanaka, M., Datiles, M. B. and Kinoshita, J. H. (1980) Reepithelization of denuded corneas in diabetic rats. Exp. Eye Res. 31, 611-621.
13. Datiles, M. B., Kador, P. F., Fukui, H. N., Hu, T.-S. and Kinoshita, J. H. (1983) Corneal re-epithelialization in galactosemic rats. Invest. Ophthalmol. Vis. Sci. 24, 563-569.
14. Awata, T., Sogo, S., Yamagami, Y. and Yamamoto, Y. (1988) Effect of aldose reductase inhibitor, CT-112, on healing of the corneal epithelium in galactose-fed rats. J. Ocular Pharmacol. 4, 195-201.
15. Tsubota, K., Chiba, K. and Shimazaki, J. (1991) Corneal epithelium in diabetic patients. Cornea, 10, 156-160.
16. Tsubota, K. and Yamada, M. (1993) The effect of aldose reductase inhibitor on the corneal epithelium. Cornea, 12, 161-162.
17. Göbbels, M., Spitznas, M. and Oldendoerp, J. (1989) Impairment of corneal epithelial barrier function in diabetics. Graefe's Arch. Clin. Exp. Ophthalmol. 227, 142-144.
18. Awata, T., Sogo, S. and Yamamoto, Y. (1986) Effects of aldose reductase inhibitor, CT-112, on sugar alcohol accumulation in corneal epithelium of galactose-fed rats. Jpn. J. Ophthalmol. 30, 245-250.
19. Yokoi, N. and Kinoshita, S. (1995) Clinical evaluation of corneal epithelial barrier function with the slit-lamp fluorophotometer. Cornea, 14, 485-489.
20. Grimes, P. A., Stone, R. A., Laties, A. M. and Li, W. (1982) Carboxyfluorescein. A probe of blood-ocular barriers with lower membrane permeability than fluorescein. Arch. Ophthalmol. 100, 635-639.
21. Lopez Bernal, D. and Ubels, J. L. (1991) Quantitative evaluation of corneal epithelial barrier: effect of artificial tears and preservatives. Curr. Eye Res. 10, 645-656.
22. Steuhl, P. and Rohen, J. W. (1983) Absorption of horse-radish peroxidase by the conjunctival epithelium of monkeys and rabbits. Graefe's Arch. Clin. Exp. Ophthalmol. 220, 13-18.
23. Mori, K., Takahashi, Y., Tsuduki, S., Kador, P. F. and Akagi, Y. (1994) Significance of aldose reductase to experimental corneal epitheliopathy. Invest. Ophthalmol. Vis. Sci. 35 (Suppl.), 1946.
24. Kim, E. K., Geroski, D. H., Holley, G. P., Urken, S. I. and Edelhauser, H. F. (1992) Corneal endothelial cytoskeletal changes in F-actin with aging, diabetes, and after cytochalasin exposure. Am. J. Ophthalmol. 114, 329-335.