Characterization of diabetic neuropathy in the Zucker diabetic Sprague-Dawley rat: A new animal model for type 2 diabetes

Journal of Diabetes Research

Volumn 2014, Issue , 2014, Pages

  Davidson, Eric P ^a   Coppey, Lawrence J ^a   Holmes, Amey ^b   Lupachyk, Sergey ^a   Dake, Brian L ^a   Oltman, Christine L ^b   Peterson, Richard G ^c   Yorek, Mark A ^a,b,d  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c PreClinOmics   (United States)

^d Veterans Administration   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ACETYLCHOLINE; CALCITONIN GENE RELATED PEPTIDE; CHOLESTEROL; FATTY ACID; INSULIN; TRIACYLGLYCEROL; 3-NITROTYROSINE; GLUCOSE BLOOD LEVEL; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETIC NEUROPATHY; FATTY ACID BLOOD LEVEL; FATTY LIVER; HINDLIMB; HYPERGLYCEMIA; INSULIN RESISTANCE; MALE; MOTOR NERVE CONDUCTION; NERVE FIBER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; RAT STRAIN; SCIATIC NERVE; SENSORY NERVE CONDUCTION; SERUM; SKIN NERVE; SPRAGUE DAWLEY RAT; TRIACYLGLYCEROL BLOOD LEVEL; ZUCKER DIABETIC FATTY RAT; AGE; ANALOGS AND DERIVATIVES; ANIMAL; ARTERIOLE; BLOOD; COMPLICATION; DIABETIC ANGIOPATHIES; DIABETIC NEUROPATHIES; DISEASE MODEL; GLUCOSE BLOOD LEVEL; LANGERHANS CELL; METABOLISM; NERVE CONDUCTION; NOCICEPTION; PATHOLOGY; PATHOPHYSIOLOGY; TIME; VASODILATATION; ZUCKER RAT;

AGE FACTORS; ANIMALS; ARTERIOLES; BLOOD GLUCOSE; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DIABETIC NEUROPATHIES; DISEASE MODELS, ANIMAL; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; LANGERHANS CELLS; MALE; NEURAL CONDUCTION; NOCICEPTION; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; SCIATIC NERVE; TIME FACTORS; TRIGLYCERIDES; TYROSINE; VASODILATION;

EID: 84908332619     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2014/714273     Document Type: Article

References (35)

1. Clark J. B., Palmer C. J., Shaw W. N., The diabetic Zucker fatty rat. Proceedings of the Society for Experimental Biology and Medicine 1983 173 1 68 75 10.3181/00379727-173-41611 2-s2.0-0020534907
2. Peterson R. G., Shaw W. N., Neel M. A., Little L. A., Eichberg J., Zucker diabetic fatty rat as a model for non-insulin-dependent diabetes mellitus. ILAR News 1990 32 16 19
3. Peterson R. G., Neel M. A., Little L. A., Kincaid J. C., Eichberg J., Shafrir E., Neuropathic complications in the Zucker diabetic fatty rat (ZDF/ Drt-fa). Frontiers in Diabetes Research. Lessons From Animal Diabetes III 1990 London, UK Smith-Gordon 456 458
4. Shafrir E., Animal models of non-insulin-dependent diabetes. Diabetes/Metabolism Reviews 1992 8 3 179 208 10.1002/dmr.5610080302 2-s2.0-0027059040
5. Coppey L. J., Gellett J. S., Davidson E. P., Dunlap J. A., Yorek M. A., Changes in endoneurial blood flow, motor nerve conduction velocity and vascular relaxation of epineurial arterioles of the sciatic nerve in ZDF-obese diabetic rats. Diabetes/Metabolism Research and Reviews 2002 18 1 49 56 10.1002/dmrr.257 2-s2.0-0036194243
6. Oltman C. L., Coppey L. J., Gellett J. S., Davidson E. P., Lund D. D., Yorek M. A., Progression of vascular and neural dysfunction in sciatic nerves of Zucker diabetic fatty and Zucker rats. The American Journal of Physiology-Endocrinology and Metabolism 2005 289 1 E113 E122 10.1152/ajpendo.00594.2004 2-s2.0-21044459538
7. Oltman C. L., Davidson E. P., Coppey L. J., Kleinschmidt T. L., Lund D. D., Adebara E. T., Yorek M. A., Vascular and neural dysfunction in Zucker diabetic fatty rats: a difficult condition to reverse. Diabetes, Obesity and Metabolism 2008 10 1 64 74 10.1111/j.1463-1326.2007.00814.x 2-s2.0-37349043715
8. Coppey L. J., Gellett J. S., Yorek M. A., Mediation of vascular relaxation in epineurial arterioles of the sciatic nerve: effect of diabetes in type 1 and type 2 diabetic rat models. Endothelium: Journal of Endothelial Cell Research 2003 10 2 89 94 10.1080/10623320303366 2-s2.0-0042065403
9. Reinwald S., Peterson R. G., Allen M. R., Burr D. B., Skeletal changes associated with the onset of type 2 diabetes in the ZDF and ZDSD rodent models. American Journal of Physiology: Endocrinology and Metabolism 2009 296 4 E765 E774 10.1152/ajpendo.90937.2008 2-s2.0-65649135477
10. Davis J. E., Cain J., Banz W. J., Peterson R. G., Age-related differences in response to high-fat feeding on adipose tissue and metabolic profile in ZDSD rats. ISRN Obesity 2013 2013 8 584547 10.1155/2013/584547
11. Bełtowski J., Leptin and the regulation of endothelial function in physiological and pathological conditions. Clinical and Experimental Pharmacology and Physiology 2012 39 2 168 178 10.1111/j.1440-1681.2011.05623.x 2-s2.0-84856468453
12. Kaur J., A comprehensive review on metabolic syndrome. Cardiology Research and Practice 2014 2014 21 943162 10.1155/2014/943162
13. Ricci R., Bevilacqua F., The potential role of leptin and adiponectin in obesity: a comparative review. Veterinary Journal 2012 191 3 292 298 10.1016/j.tvjl.2011.04.009 2-s2.0-84857233109
14. Duvnjak L., Duvnjak M., The metabolic syndrome-an ongoing story. Journal of Physiology and Pharmacology 2009 60 19 24 2-s2.0-77955899564
15. Gade W., Schmit J., Collins M., Gade J., Beyond obesity: the diagnosis and pathophysiology of metabolic syndrome. Clinical Laboratory Science 2010 23 1 51 65 2-s2.0-77951226251
16. Davidson E. P., Coppey L. J., Calcutt N. A., Oltman C. L., Yorek M. A., Diet-induced obesity in Sprague-Dawley rats causes microvascular and neural dysfunction. Diabetes/Metabolism Research and Reviews 2010 26 4 306 318 10.1002/dmrr.1088 2-s2.0-77952782622
17. Davidson E. P., Coppey L. J., Holmes A., Dake B., Yorek M. A., Effect of treatment of high fat fed/low dose streptozotocin-diabetic rats with Ilepatril on vascular and neural complications. European Journal of Pharmacology 2011 668 3 497 506 10.1016/j.ejphar.2011.07.016 2-s2.0-80053573338
18. Davidson E. P., Coppey L. J., Holmes A., Yorek M. A., Changes in corneal innervation and sensitivity and acetylcholine-mediated vascular relaxation of the posterior ciliary artery in a type 2 diabetic rat. Investigative Ophthalmology and Visual Science 2012 53 3 1182 1187 10.1167/iovs.11-8806 2-s2.0-84860609962
19. Quattrini C., Tavakoli M., Jeziorska M., Kallinikos P., Tesfaye S., Finnigan J., Marshall A., Boulton A. J. M., Efron N., Malik R. A., Surrogate markers of small fiber damage in human diabetic neuropathy. Diabetes 2007 56 8 2148 2154 10.2337/db07-0285 2-s2.0-34547589982
20. Tavakoli M., Quattrini C., Abbott C., Kallinikos P., Marshall A., Finnigan J., Morgan P., Efron N., Boulton A. J. M., Malik R. A., Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy. Diabetes Care 2010 33 8 1792 1797 10.2337/dc10-0253 2-s2.0-77957558519
21. Coppey L. J., Davidson E. P., Dunlap J. A., Lund D. D., Yorek M. A., Slowing of motor nerve conduction velocity in streptozotocin-induced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve. Experimental Diabesity Research 2000 1 2 131 143 2-s2.0-0034570447
22. Terata K., Coppey L. J., Davidson E. P., Dunlap J. A., Gutterman D. D., Yorek M. A., Acetylcholine-induced arteriolar dilation is reduced in streptozotocin-induced diabetic rats with motor nerve dysfunction. British Journal of Pharmacology 1999 128 3 837 843 10.1038/sj.bjp.0702856 2-s2.0-0032701320
23. Coppey L. J., Holmes A., Davidson E. P., Yorek M. A., Partial replacement with menhaden oil improves peripheral neuropathy in high-fat-fed low-dose streptozotocin type 2 diabetic rat. Journal of Nutrition and Metabolism 2012 2012 8 950517 10.1155/2012/950517 2-s2.0-84873824806
24. Lupachyk S., Watcho P., Shevalye H., Vareniuk I., Obrosov A., Obrosova I. G., Yorek M. A., Na+/H+exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats. American Journal of Physiology-Endocrinology and Metabolism 2013 305 3 E396 E404 10.1152/ajpendo.00186.2013 2-s2.0-84881004137
25. Beiswenger K. K., Calcutt N. A., Mizisin A. P., Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice. Neuroscience Letters 2008 442 3 267 272 10.1016/j.neulet.2008.06.079 2-s2.0-48749104018
26. Lauria G., Lombardi R., Borgna M., Penza P., Bianchi R., Savino C., Canta A., Nicolini G., Marmiroli P., Cavaletti G., Intraepidermal nerve fiber density in rat foot pad: neuropathologic- neurophysiologic correlation. Journal of the Peripheral Nervous System 2005 10 2 202 208 10.1111/j.1085-9489.2005.0010210.x 2-s2.0-22144461459
27. Strom A., Brüggemann J., Ziegler I., Jeruschke K., Weiss J., Al-Hasani H., Roden M., Ziegler D., Pronounced reduction of cutaneous langerhans cell density in recently diagnosed type 2 diabetes. Diabetes 2014 63 3 1148 1153 10.2337/db13-1444 2-s2.0-84894472484
28. Ziegler D., Papanas N., Zhivov A., Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes. Diabetes 2014 63 7 2454 2463 10.2337/db13-1819
29. Beiswenger K. K., Calcutt N. A., Mizisin A. P., Epidermal nerve fiber quantification in the assessment of diabetic neuropathy. Acta Histochemica 2008 110 5 351 362 10.1016/j.acthis.2007.12.004 2-s2.0-48249151602
30. Brussee V., Guo G., Dong Y., Cheng C., Martinez J. A., Smith D., Glazner G. W., Fernyhough P., Zochodne D. W., Distal degenerative sensory neuropathy in a long-term type 2 diabetes rat model. Diabetes 2008 57 6 1664 1673 10.2337/db07-1737 2-s2.0-48249101970
31. Davidson E. P., Coppey L. J., Kardon R. H., Yorek M. A., Differences and similarities in development of corneal nerve damage and peripheral neuropathy and in diet- induced obesity and type 2 diabetic rats. Investigative Ophthalmology and Visual Science 2014 55 3 1222 1230 10.1167/iovs.13-13794 2-s2.0-84897610965
32. Yorek M. A., Coppey L. J., Gellett J. S., Davidson E. P., Sensory nerve innervation of epineurial arterioles of the sciatic nerve containing calcitonin gene-related peptide: effect of streptozotocin-induced diabetes. Experimental Diabesity Research 2004 5 3 187 193 10.1080/15438600490486732 2-s2.0-6344270357
33. Davidson E. P., Coppey L. J., Kleinschmidt T. L., Oltman C. L., Yorek M. A., Vascular and neural dysfunctions in obese Zucker rats: effect of AVE7688. Experimental Diabetes Research 2009 2009 8 912327 2-s2.0-68849113240 10.1155/2009/912327
34. Oltman C. L., Richou L. L., Davidson E. P., Coppey L. J., Lund D. D., Yorek M. A., Progression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats. The American Journal of Physiology-Heart and Circulatory Physiology 2006 291 4 H1780 H1787 10.1152/ajpheart.01297.2005 2-s2.0-33749321286
35. Oltman C. L., Kleinschmidt T. L., Davidson E. P., Coppey L. J., Lund D. D., Yorek M. A., Treatment of cardiovascular dysfunction associated with the metabolic syndrome and type 2 diabetes. Vascular Pharmacology 2008 48 1 47 53 10.1016/j.vph.2007.11.005 2-s2.0-38349057333