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Volumn 6, Issue , 2016, Pages

GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathway

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GPR40 PROTEIN, MOUSE; GW9508; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIVER X RECEPTOR; METHYLAMINE; PROPIONIC ACID DERIVATIVE;

EID: 84964851283     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep25237     Document Type: Article
Times cited : (35)

References (40)
  • 1
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning, J. D. & Horton, J. D. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. 114, 147-152 (2004).
    • (2004) J. Clin. Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 2
    • 20444473800 scopus 로고    scopus 로고
    • Mechanisms of disease: Pathogenesis of nonalcoholic fatty liver disease
    • Sanyal, A. J. Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease. Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 46-53 (2005).
    • (2005) Nat. Clin. Pract. Gastroenterol. Hepatol , vol.2 , pp. 46-53
    • Sanyal, A.J.1
  • 3
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor lxr?
    • Peet, D. J. et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR? . Cell 93, 693-704 (1998).
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1
  • 4
    • 0034284918 scopus 로고    scopus 로고
    • Regulation of absorption and abc1-mediated efflux of cholesterol by rxr heterodimers
    • Repa, J. et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289, 1524-1529 (2000).
    • (2000) Science , vol.289 , pp. 1524-1529
    • Repa, J.1
  • 5
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • Repa, J. J. & Mangelsdorf, D. J. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu. Rev. Cell Dev. Biol. 16, 459-481 (2000).
    • (2000) Annu. Rev. Cell Dev. Biol , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 6
    • 0036851863 scopus 로고    scopus 로고
    • The liver x receptor gene team: Potential new players in atherosclerosis
    • Repa, J. J. & Mangelsdorf, D. J. The liver X receptor gene team: potential new players in atherosclerosis. Nat. Med. 8, 1243-1248 (2002).
    • (2002) Nat. Med , vol.8 , pp. 1243-1248
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 7
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element-binding protein-1c gene (srebp-1c) by oxysterol receptors lxr? and lxr?
    • Repa, J. J. et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR? and LXR? . Gene Dev. 14, 2819-2830 (2000).
    • (2000) Gene Dev , vol.14 , pp. 2819-2830
    • Repa, J.J.1
  • 8
    • 0036251153 scopus 로고    scopus 로고
    • Srebps: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton, J. D., Goldstein, J. L. & Brown, M. S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125-1131 (2002).
    • (2002) J. Clin. Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 9
    • 0034669171 scopus 로고    scopus 로고
    • Role of lxrs in control of lipogenesis
    • Schultz, J. R. et al. Role of LXRs in control of lipogenesis. Gene Dev. 14, 2831-2838 (2000).
    • (2000) Gene Dev , vol.14 , pp. 2831-2838
    • Schultz, J.R.1
  • 10
    • 13444263540 scopus 로고    scopus 로고
    • Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through gpr120
    • Hirasawa, A. et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat. Med. 11, 90-94 (2004).
    • (2004) Nat. Med , vol.11 , pp. 90-94
    • Hirasawa, A.1
  • 11
    • 0037434991 scopus 로고    scopus 로고
    • Free fatty acids regulate insulin secretion from pancreatic ? Cells through gpr40
    • Itoh, Y. et al. Free fatty acids regulate insulin secretion from pancreatic ? cells through GPR40. Nature 422, 173-176 (2003).
    • (2003) Nature , vol.422 , pp. 173-176
    • Itoh, Y.1
  • 12
    • 33845954973 scopus 로고    scopus 로고
    • Medium-chain fatty acids as ligands for orphan g protein-coupled receptor gpr84
    • Wang, J., Wu, X., Simonavicius, N., Tian, H. & Ling, L. Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. J. Biol. Chem. 281, 34457-34464 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 34457-34464
    • Wang, J.1    Wu, X.2    Simonavicius, N.3    Tian, H.4    Ling, L.5
  • 13
    • 0038363378 scopus 로고    scopus 로고
    • The orphan g protein-coupled receptors gpr41 and gpr43 are activated by propionate and other short chain carboxylic acids
    • Brown, A. J. et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem. 278, 11312-11319 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 11312-11319
    • Brown, A.J.1
  • 14
    • 0037838892 scopus 로고    scopus 로고
    • The orphan g protein-coupled receptor gpr40 is activated by medium and long chain fatty acids
    • Briscoe, C. P. et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J. Biol. Chem. 278, 11303-11311 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 11303-11311
    • Briscoe, C.P.1
  • 15
    • 57349141546 scopus 로고    scopus 로고
    • Linoleic acid stimulates gluconeogenesis via ca2+/plc, cpla2, and PPAR pathways through gpr40 in primary cultured chicken hepatocytes
    • Suh, H. N., Huong, H. T., Song, C. H., Lee, J. H. & Han, H. J. Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes. Am. J. Physiol-cell. Ph 295, C1518-C1527 (2008).
    • (2008) Am. J. Physiol-cell. Ph , vol.295 , pp. C1518-C1527
    • Suh, H.N.1    Huong, H.T.2    Song, C.H.3    Lee, J.H.4    Han, H.J.5
  • 16
    • 84877272337 scopus 로고    scopus 로고
    • Multiple mechanisms of gw-9508, a selective g protein-coupled receptor 40 agonist, in the regulation of glucose homeostasis and insulin sensitivity
    • Ou, H.-Y. et al. Multiple mechanisms of GW-9508, a selective G protein-coupled receptor 40 agonist, in the regulation of glucose homeostasis and insulin sensitivity. Am. J. Physiol-endoc. M 304, E668-E676 (2013).
    • (2013) Am. J. Physiol-endoc. M , vol.304 , pp. E668-E676
    • Ou, H.-Y.1
  • 17
    • 84907990513 scopus 로고    scopus 로고
    • Activation of free fatty acid receptor 1 improves hepatic steatosis through a p38-dependent pathway
    • Ou, H.-Y. et al. Activation of free fatty acid receptor 1 improves hepatic steatosis through a p38-dependent pathway. J. Mol. Endocrinol. 53, 165-174 (2014).
    • (2014) J. Mol. Endocrinol , vol.53 , pp. 165-174
    • Ou, H.-Y.1
  • 18
    • 79959785171 scopus 로고    scopus 로고
    • N3 fatty acids ameliorate hepatic steatosis and dysfunction after lxr agonist ingestion in mice
    • Jung, U. J., Millman, P. N., Tall, A. R. & Deckelbaum, R. J. n? 3 Fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice. Bba-mol. Cell Biol. L. 1811, 491-497 (2011).
    • (2011) Bba-Mol. Cell Biol. L , vol.1811 , pp. 491-497
    • Jung, U.J.1    Millman, P.N.2    Tall, A.R.3    Deckelbaum, R.J.4
  • 19
    • 84879582536 scopus 로고    scopus 로고
    • Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of nlrp3 inflammasome activation
    • Yan, Y. et al. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity 38, 1154-1163 (2013).
    • (2013) Immunity , vol.38 , pp. 1154-1163
    • Yan, Y.1
  • 20
    • 0344236142 scopus 로고    scopus 로고
    • Novel putative srebp and lxr target genes identified by microarray analysis in liver of cholesterol-fed mice
    • Maxwell, K. N., Soccio, R. E., Duncan, E. M., Sehayek, E. & Breslow, J. L. Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice. J. Lipid. Res. 44, 2109-2119 (2003).
    • (2003) J. Lipid. Res , vol.44 , pp. 2109-2119
    • Maxwell, K.N.1    Soccio, R.E.2    Duncan, E.M.3    Sehayek, E.4    Breslow, J.L.5
  • 21
    • 79953755370 scopus 로고    scopus 로고
    • Ampk phosphorylates and inhibits srebp activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li, Y. et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13, 376-388 (2011).
    • (2011) Cell Metab , vol.13 , pp. 376-388
    • Li, Y.1
  • 22
    • 23044432463 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase kinase-α is an alternative upstream kinase for amp-Activated protein kinase
    • Hawley, S. A. et al. Calmodulin-dependent protein kinase kinase-α is an alternative upstream kinase for AMP-Activated protein kinase. Cell Metab. 2, 9-19 (2005).
    • (2005) Cell Metab , vol.2 , pp. 9-19
    • Hawley, S.A.1
  • 23
    • 0034927336 scopus 로고    scopus 로고
    • Regulation of phosphoinositide-specific phospholipase c
    • Rhee, S. G. Regulation of phosphoinositide-specific phospholipase C. Annu. Rev. Biochem. 70, 281-312 (2001).
    • (2001) Annu. Rev. Biochem , vol.70 , pp. 281-312
    • Rhee, S.G.1
  • 25
    • 23944509003 scopus 로고    scopus 로고
    • Acetyl-coenzyme a carboxylase: Crucial metabolic enzyme and attractive target for drug discovery
    • Tong, L. Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery. Cell Mol. Life Sci. 62, 1784-1803 (2005).
    • (2005) Cell Mol. Life Sci , vol.62 , pp. 1784-1803
    • Tong, L.1
  • 26
    • 23844471263 scopus 로고    scopus 로고
    • The ca2+/calmodulin-dependent protein kinase kinases are amp-Activated protein kinase kinases
    • Hurley, R. L. et al. The Ca2+/calmodulin-dependent protein kinase kinases are AMP-Activated protein kinase kinases. J. Biol. Chem. 280, 29060-29066 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 29060-29066
    • Hurley, R.L.1
  • 27
    • 23044437445 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase kinase-α acts upstream of amp-Activated protein kinase in mammalian cells
    • Woods, A. et al. Ca2+/calmodulin-dependent protein kinase kinase-α acts upstream of AMP-Activated protein kinase in mammalian cells. Cell Metab. 2, 21-33 (2005).
    • (2005) Cell Metab , vol.2 , pp. 21-33
    • Woods, A.1
  • 28
    • 25144470087 scopus 로고    scopus 로고
    • Oleic acid interacts with gpr40 to induce ca2+ signaling in rat islet ?-cells: Mediation by plc and l-type ca2+ channel and link to insulin release
    • Fujiwara, K., Maekawa, F. & Yada, T. Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet ?-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release. Am. J. Physiol-endoc. M 289, E670-E677 (2005).
    • (2005) Am. J. Physiol-endoc. M , vol.289 , pp. E670-E677
    • Fujiwara, K.1    Maekawa, F.2    Yada, T.3
  • 29
    • 80955180014 scopus 로고    scopus 로고
    • Free fatty acid receptors ffar1 and gpr120 as novel therapeutic targets for metabolic disorders
    • Hara, T., Hirasawa, A., Ichimura, A., Kimura, I. & Tsujimoto, G. Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders. J. Pharm. Sci. 100, 3594-3601 (2011).
    • (2011) J. Pharm. Sci , vol.100 , pp. 3594-3601
    • Hara, T.1    Hirasawa, A.2    Ichimura, A.3    Kimura, I.4    Tsujimoto, G.5
  • 30
    • 36148996843 scopus 로고    scopus 로고
    • G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes
    • Winzell, M. S. & Ahrén, B. G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes. Pharmacol. Therapeut. 116, 437-448 (2007).
    • (2007) Pharmacol. Therapeut , vol.116 , pp. 437-448
    • Winzell, M.S.1    Ahrén, B.2
  • 31
    • 0035063045 scopus 로고    scopus 로고
    • Key regulatory oxysterols in liver: Analysis as ? 4-3-ketone derivatives by hplc and response to physiological perturbations
    • Zhang, Z. et al. Key regulatory oxysterols in liver: analysis as ? 4-3-ketone derivatives by HPLC and response to physiological perturbations. J. Lipid. Res. 42, 649-658 (2001).
    • (2001) J. Lipid. Res , vol.42 , pp. 649-658
    • Zhang, Z.1
  • 32
    • 49649110937 scopus 로고    scopus 로고
    • Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    • Wouters, K. et al. Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 48, 474-486 (2008).
    • (2008) Hepatology , vol.48 , pp. 474-486
    • Wouters, K.1
  • 33
    • 50549100488 scopus 로고    scopus 로고
    • Regulation of amp-Activated protein kinase activity by g-protein coupled receptors: Potential utility in treatment of diabetes and heart disease
    • Hutchinson, D. S., Summers, R. J. & Bengtsson, T. Regulation of AMP-Activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease. Pharmacol. Therapeut. 119, 291-310 (2008).
    • (2008) Pharmacol. Therapeut , vol.119 , pp. 291-310
    • Hutchinson, D.S.1    Summers, R.J.2    Bengtsson, T.3
  • 34
    • 84858782079 scopus 로고    scopus 로고
    • Ampk: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie, D. G., Ross, F. A. & Hawley, S. A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Bio 13, 251-262 (2012).
    • (2012) Nat. Rev. Mol. Cell Bio , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 35
    • 65549114432 scopus 로고    scopus 로고
    • Overexpression of gpr40 in pancreatic ?-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice
    • Nagasumi, K. et al. Overexpression of GPR40 in pancreatic ?-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes 58, 1067-1076 (2009).
    • (2009) Diabetes , vol.58 , pp. 1067-1076
    • Nagasumi, K.1
  • 36
    • 84859625938 scopus 로고    scopus 로고
    • Tak-875 versus placebo or glimepiride in type 2 diabetes mellitus: A phase 2, randomised, double-blind, placebocontrolled trial
    • Burant, C. F. et al. TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebocontrolled trial. Lancet 379, 1403-1411 (2012).
    • (2012) Lancet , vol.379 , pp. 1403-1411
    • Burant, C.F.1
  • 37
    • 20944433543 scopus 로고    scopus 로고
    • The ffa receptor gpr40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
    • Steneberg, P., Rubins, N., Bartoov-Shifman, R., Walker, M. D. & Edlund, H. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab. 1, 245-258 (2005).
    • (2005) Cell Metab , vol.1 , pp. 245-258
    • Steneberg, P.1    Rubins, N.2    Bartoov-Shifman, R.3    Walker, M.D.4    Edlund, H.5
  • 38
    • 58149100292 scopus 로고    scopus 로고
    • Lack of ffar1/gpr40 does not protect mice from high-fat diet-induced metabolic disease
    • Lan, H. et al. Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease. Diabetes 57, 2999-3006 (2008).
    • (2008) Diabetes , vol.57 , pp. 2999-3006
    • Lan, H.1
  • 39
    • 34447120058 scopus 로고    scopus 로고
    • Hepatic niemann-pick c1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe
    • Temel, R. E. et al. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J. Clin. Invest. 117, 1968-1978 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 1968-1978
    • Temel, R.E.1
  • 40
    • 58749098423 scopus 로고    scopus 로고
    • Cideb, an er-And lipid droplet-Associated protein, mediates vldl lipidation and maturation by interacting with apolipoprotein b
    • Ye, J. et al. Cideb, an ER-And lipid droplet-Associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab. 9, 177-190 (2009).
    • (2009) Cell Metab , vol.9 , pp. 177-190
    • Ye, J.1


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