The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi

PLoS Pathogens

Volumn 12, Issue 4, 2016, Pages

  Ersching, Jonatan ^a,h   Vasconcelos, José R ^a   Ferreira, Camila P ^a   Caetano, Braulia C ^b   Machado, Alexandre V ^c   Bruna–Romero, Oscar ^d   Baron, Monique A ^e   Ferreira, Ludmila R P ^e,f   Cunha Neto, Edécio ^e   Rock, Kenneth L ^b   Gazzinelli, Ricardo T ^b,c,g   Rodrigues, Maurício M ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

^f UNIVERSITY OF SANTO AMARO   (Brazil)

^g FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^h WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GAMMA INTERFERON; INTERLEUKIN 12P70; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME; PROTOZOAL VACCINE;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; BONE MARROW DERIVED DENDRITIC CELL; CARDIOMYOPATHY; CD8+ T LYMPHOCYTE; CHAGAS DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC IMMUNIZATION; HUMAN; IMMUNE RESPONSE; MALE; MOUSE; NONHUMAN; PHENOTYPE; REAL TIME POLYMERASE CHAIN REACTION; TRYPANOSOMA CRUZI; ANIMAL; C57BL MOUSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOLOGY; KNOCKOUT MOUSE; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHAGAS DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTOZOAN VACCINES; REAL-TIME POLYMERASE CHAIN REACTION; TRYPANOSOMA CRUZI; YOUNG ADULT;

EID: 84964847399     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005593     Document Type: Article

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