Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

Brain

Volumn 138, Issue 12, 2015, Pages 3581-3597

  Natrajan, Muktha S ^a,b   De La Fuente, Alerie G ^a   Crawford, Abbe H ^a   Linehan, Eimear ^c   Nuñez, Vanessa ^d   Johnson, Kory R ^b   Wu, Tianxia ^b   Fitzgerald, Denise C ^c   Ricote, Mercedes ^d   Bielekova, Bibiana ^b   Franklin, Robin J M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^d CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

ageing; monocyte derived macrophages; myelin debris; remyelination; retinoid X receptor

Indexed keywords

ALITRETINOIN; BEXAROTENE; RETINOID X RECEPTOR; BENZOIC ACID DERIVATIVE; BIPHENYL DERIVATIVE; DIAZEPINYLBENZOIC ACID; RETINOID X RECEPTOR ALPHA; TETRALIN DERIVATIVE; TRANSCRIPTOME;

ADULT; AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL COUNT; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATION; ELECTRON MICROSCOPY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; MICROGLIA; MIDDLE AGED; MONOCYTE; MOUSE; MULTIPLE SCLEROSIS; MYELIN DEBRIS PHAGOCYTOSIS; MYELIN SHEATH; NONHUMAN; OLIGODENDROGLIA; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REMYELINIZATION; STEM CELL; UPREGULATION; WESTERN BLOTTING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; MACROPHAGE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; YOUNG ADULT;

ADULT; AGING; ANIMALS; BENZOATES; BIPHENYL COMPOUNDS; FEMALE; HUMANS; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; MONOCYTES; MULTIPLE SCLEROSIS; MYELIN SHEATH; PHAGOCYTOSIS; RETINOID X RECEPTOR ALPHA; SIGNAL TRANSDUCTION; TETRAHYDRONAPHTHALENES; TRANSCRIPTOME; YOUNG ADULT;

EID: 84951172662     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv289     Document Type: Article

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