Sortilin mediates vascular calcification via its recruitment into extracellular vesicles

Journal of Clinical Investigation

Volumn 126, Issue 4, 2016, Pages 1323-1336

  Goettsch, Claudia ^a   Hutcheson, Joshua D ^a   Aikawa, Masanori ^a,b   Iwata, Hiroshi ^a   Pham, Tan ^a   Nykjaer, Anders ^c   Kjolby, Mads ^c   Rogers, Maximillian ^a   Michel, Thomas ^d   Shibasaki, Manabu ^a   Hagita, Sumihiko ^a   Kramann, Rafael ^a,e   Rader, Daniel J ^f   Libby, Peter ^b   Singh, Sasha A ^a   Aikawa, Elena ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d Cardiovascular Medicine   (United States)

^e RWTH AACHEN UNIVERSITY   (Germany)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ALPHA SMOOTH MUSCLE ACTIN; CASEIN KINASE II; CAVEOLIN 1; CD68 ANTIGEN; MESSENGER RNA; RAB11 PROTEIN; SORTILIN; ALKALINE PHOSPHATASE 2, MOUSE; CALCIUM BINDING PROTEIN; CARRIER PROTEIN; CASEIN KINASE I; FAM20C PROTEIN, HUMAN; FAM20C PROTEIN, MOUSE; RAB PROTEIN; SCLEROPROTEIN; TNAP PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROMA; BLOOD VESSEL CALCIFICATION; BONE MINERALIZATION; CALCIFICATION; CARBOXY TERMINAL SEQUENCE; CAROTID ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CORTICAL BONE; ENZYME ACTIVITY; EXOSOME; FEMUR; HUMAN; IMMUNOFLUORESCENCE; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRABECULAR BONE; ANIMAL; ATHEROSCLEROTIC PLAQUE; BIOSYNTHESIS; CELL CULTURE; GENETICS; KNOCKOUT MOUSE; MEMBRANE MICROPARTICLE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN TRANSPORT; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ALKALINE PHOSPHATASE; ANIMALS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CASEIN KINASE I; CASEIN KINASE II; CELL-DERIVED MICROPARTICLES; CELLS, CULTURED; EXTRACELLULAR MATRIX PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PLAQUE, ATHEROSCLEROTIC; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; VASCULAR CALCIFICATION;

EID: 84964645073     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI80851     Document Type: Article

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