Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis

Journal of Biological Chemistry

Volumn 287, Issue 52, 2012, Pages 43798-43809

  Skeldal, Sune ^a,b   Sykes, Alex M ^a   Glerup, Simon ^b   Matusica, Dusan ^a   Palstra, Nickless ^a   Autio, Henri ^c   Boskovic, Zoran ^a   Madsen, Peder ^b   Castrén, Eero ^c   Nykjaer, Anders ^b   Coulson, Elizabeth J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC RECEPTORS; CO-IMMUNOPRECIPITATION EXPERIMENTS; COMPLEX FORMATIONS; CONTACT POINTS; EXTRACELLULAR; EXTRACELLULAR DOMAINS; INTERACTION SITE; INTRACELLULAR DOMAIN; INTRAMEMBRANE PROTEOLYSIS; NEURONAL GROWTH; NEUROTROPHINS; P75 NEUROTROPHIN RECEPTOR; REGULATORY FUNCTIONS; SURFACE PLASMONS;

AMINO ACIDS; ENZYME ACTIVITY; ENZYME INHIBITION;

CELL DEATH;

NEUROTROPHIN RECEPTOR P75; SORTILIN;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STIMULATION; COMPLEX FORMATION; CONTROLLED STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; HEK293 CELLS; HUMANS; NERVE TISSUE PROTEINS; PEPTIDE MAPPING; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RATS; RECEPTORS, NERVE GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SURFACE PLASMON RESONANCE;

EID: 84871592894     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.374710     Document Type: Article

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