Insulin resistance induces posttranslational hepatic sortilin 1 degradation in mice

Journal of Biological Chemistry

Volumn 290, Issue 18, 2015, Pages 11526-11536

  Li, Jibiao ^a   Matye, David J ^a   Li, Tiangang ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

HEPATOCYTES; INSULIN RESISTANCE; NEW MECHANISMS; TYPE-2 DIABETES; UNDERLYING CAUSE;

INSULIN;

ABC TRANSPORTER G5; ACYL COENZYME A DESATURASE 1; APOLIPOPROTEIN B100; CD36 ANTIGEN; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN RECEPTOR; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PROTEIN KINASE B; SORTILIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; ENZYME INHIBITOR; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID HOMEOSTASIS; LIPOPROTEIN METABOLISM; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; UBIQUITINATION; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; CHEMISTRY; DRUG EFFECTS; HUMAN; LIVER; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION;

MUS;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID SEQUENCE; ANIMALS; APOLIPOPROTEIN B-100; CELL LINE; ENZYME INHIBITORS; HUMANS; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84929484708     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.641225     Document Type: Article

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