Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis

Circulation Research

Volumn 116, Issue 5, 2015, Pages 789-796

  Patel, Kevin M ^a   Strong, Alanna ^a   Tohyama, Junichiro ^a   Jin, Xueting ^b   Morales, Carlos R ^c   Billheimer, Jeffery ^a   Millar, John ^a   Kruth, Howard ^b   Rader, Daniel J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Atherosclerosis; Foam cell; Low density lipoprotein cholesterol; Macrophage; Receptor mediated endocytosis

Indexed keywords

25 HYDROXYCHOLESTEROL; GREEN FLUORESCENT PROTEIN; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SORTILIN; APOLIPOPROTEIN B MRNA EDITING ENZYME; CYTIDINE DEAMINASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ACTIN POLYMERIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ROOT; ARTICLE; ATHEROSCLEROSIS; BODY WEIGHT; BONE MARROW; BONE MARROW DERIVED MACROPHAGE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EX VIVO STUDY; FOAM CELL; INFLAMMATION; INTERNALIZATION; LIPID TRANSPORT; LIVER CELL; LIVER WEIGHT; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN WEIGHT; ADVERSE EFFECTS; ANIMAL; AORTIC DISEASES; BLOOD; BONE MARROW CELL; DEFICIENCY; FEMALE; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PHYSIOLOGY; RADIATION CHIMERA; TRANSGENIC MOUSE; WESTERN DIET;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; AORTIC DISEASES; ATHEROSCLEROSIS; BONE MARROW CELLS; CHOLESTEROL, LDL; CYTIDINE DEAMINASE; DIET, WESTERN; FEMALE; FOAM CELLS; LIPOPROTEINS, LDL; MACROPHAGES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RADIATION CHIMERA; RECEPTORS, LDL;

EID: 84924542270     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.305811     Document Type: Article

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