The oxidative stress hypothesis in Alzheimer's disease

Psychiatria Danubina

Volumn 25, Issue 4, 2013, Pages 401-409

  Padurariu, Manuela ^a   Ciobica, Alin ^b,c   Lefter, Radu ^b   Serban, Ionela Lacramioara ^a   Stefanescu, Cristinel ^a   Chirita, Roxana ^a  

^a GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b ALEXANDRU IOAN CUZA UNIVERSITY OF IASI   (Romania)

^c ACADEMY OF ROMANIAN SCIENTISTS   (Romania)

Author keywords

Alzheimer; Antioxidant; Dementia; Oxidative stress

Indexed keywords

ANTIOXIDANT; BIOLOGICAL MARKER;

ALZHEIMER DISEASE; AMYLOID PLAQUE; DRUG RESEARCH; DRUG TREATMENT FAILURE; GENE MUTATION; HUMAN; HYPOTHESIS; MEDICAL DECISION MAKING; NEUROTOXICITY; OXIDATIVE STRESS; REVIEW;

ALZHEIMER DISEASE; ANTIOXIDANTS; BIOLOGICAL MARKERS; HUMANS; OXIDATIVE STRESS;

EID: 84884683578     PISSN: 03535053     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (58)

1. Aksenov MY, Tucker HM, Nair P, Aksenova MV, Butterfield DA, Estus S, Markesbery WR: The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease. J Mol Neurosci 1998; 11:151-64.
2. Atamna H, Cheung I, Ames BN: A method for detecting abasic sites in living cells: Age-dependent changes in base excision repair. Proc Natl Acad Sci USA 2000; 97:686-691.
3. Baldeiras I, Santana MT, Garrucho R, Pascoal A, Rodrigues D, Duro CR Oliveira: Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease. J Alzheimers Dis 2008; 15:117-128.
4. Beal MF: Oxidative damage as an early marker of Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 2005; 26:585-6.
5. Behl C: Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease. Cell Tissue Res 1997; 290:471-80.
6. Bild W, Ciobica A, Padurariu M, Bild V: The interdependence of the reactive species of oxygen, nitrogen, and carbon. J Physiol Biochem 2012; 69:147-54.
7. Birks J, Grimley Evans J: There is no convincing evidence that Ginkgo biloba is efficacious for dementia and cognitive impairment. Cochrane Summaries 2009.
8. Boothby LA, Doering PL: Vitamin C and vitamin E for Alzheimer's disease. Ann Pharmacother 2005; 39:2073-80.
9. Bourdel-Marchasson I, Delmas-Beauvieux MC, Peuchant E, Richard-Harston S, Decamps A, Reignier B, Emeriau JP, Rainfray M: Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients. Age Ageing 2001; 30:235-41.
10. Butterfield DA: Amyloid b-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. Free Radical Research 2002; 36:1307-1313.
11. Cardoso BR, Ong TP, Jacob-Filho W, Jaluul O, Freitas MI, Cozzolino SM: Nutritional status of selenium in Alzheimer's disease patients. Br J Nutr 2010; 103:803-6.
12. Chance B, Sies H, Boveris A: Hydroperoxid e metabolism in mammalian organs. Physiol Rev 1979; 59:527-605.
13. Ciobicã A, Hritcu L, Artenie V, Pãdurariu M: The effects of some cholinergic drugs on cognitive processes and oxidative stress in rat. Rev Med Chir Soc Med Nat Iasi 2009; 113:832-7.
14. Ciobica A, Hritcu L, Padurariu M, Dobrin R, Bild V: Effects of serotonin depletion on behavior and neuronal oxidative stress status in rat: relevance for anxiety and affective disorders. Adv Med Sci 2010; 55:289-296.
15. Ciobica A, Padurariu M, Dobrin I, Stefanescu C, Dobrin R: Oxidative stress in schizophrenia - focusing on the main markers. Psychiatr Danub 2011; 23:237-45.
16. Ciobica A, Olteanu Z, Padurariu M, Hritcu L: The effects of low-dose pergolide on memory and oxidative stress in a 6-OHDA induced rat model of Parkinson's disease. J Physiol Biochem 2012; 68:59-69.
17. Del Rio D, Stewar AJ, Pellegrini N: A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 2005; 15:316-328.
18. Dumont M, Kipiani K, Yu F, Wille E, Katz M, Calingasan NY, Gouras GK, Lin MT, Beal MF: Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis 2011; 27:211-23.
19. Evans PH: Free radicals in brain metabolism and pathology. Br Med Bull 1993; 49:577-87.
20. Ferreiro E, Baldeiras I, Ferreira IL, Costa RO, Rego AC, Pereira CF, Oliveira CR: Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. Int J Cell Biol 2012; 735206.
21. Forero DA, Casadesus G, Perry G, Arboleda H: Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. J Cell Mol Med 2006; 10:796-805.
22. Gackowski D, Rozalski R, Siomek A, Dziaman T, Nicpon K, Klimarczyk M, Araszkiewicz A, Olinski R: Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia. J Neurol Sci 2008; 15:57-62.
23. Gandhi S, Abramov AY: Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev 2012; 428010.
24. Gao S, Jin Y, Hall KS, Liang C, Unverzagt FW, Ji R, Murrell JR, Cao J, Shen J, Ma F, Matesan J, Ying B, Cheng Y, Bian J, Li P, Hendrie HC: Selenium level and cognitive function in rural elderly Chinese. Am J Epidemiol 2007: 165:955-65.
25. Gao S, Jin Y, Unverzagt FW, Liang C, Hall KS, Cao J, Ma F, Murrell JR, Cheng Y, Li P, Bian J, Hendrie HC: Selenium level and depressive symptoms in a rural elderly Chinese cohort. BMC Psychiatry 2012; 3:12-72.
26. Greilberger J, Koidl C, Greilberger M, Lamprecht M, Schroecksnadel K, Leblhuber F, Fuchs D, Oettl K: Malondialdehyde, carbonyl proteins and albumindisulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease. Free Radic Res 2008; 42:633-638.
27. Halliwell B: Oxidative stress and cancer: have we moved forward? Biochem J 2007: 401:1-11.
28. Halliwell B, Gutteridge JMC: Free radical in biology and medicine, 4th edition. Oxford University Press, New York, 2007.
29. Hensley K, Butterfield DA, Hall N: Reactive oxygen species as causal agents in the neurotoxicity of the Alzheimer's disease-associated amyloid beta peptide. Ann N Y Acad Sci 1996; 786:120-134.
30. Hughes R, Michael Brainin: LundbeckNil Erik Gilhus European Guidelines. Acute Stroke, Parkinson's Disease, Alzheimer's Disease, Sleep Disorders. Edited by Richard Hughes, Michael Brainin, LundbeckNil Erik Gilhus, 2007.
31. Karelson E, Bogdanovic N, Garlind A, Winblad B, Zilmer K, Kullisaar T, Vihalemm T, Kairane C, Zilmer M: The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense. Neurochem Res 2001; 26:353-361.
32. Luo Y, George S. Roth: The Roles of Dopamine Oxidative Stress and Dopamine Receptor Signaling in Aging and Age-Related Neurodegeneration. Annals of Neurology 2005; 379:733-739.
33. Massaad CA: Neuronal and vascular oxidative stress in Alzheimer's disease. Curr Neuropharmacol 2011; 9:662-73.
34. Melo JB, Agostinho P Oliveira CR: Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide. Neurosci Res 2003; 45:117-27.
35. Nakajima K, Kohsaka S: Microglia: activation and their significance in the central nervous system. J Biochem 2001; 130:169-75.
36. Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA: RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci 1999; 19:1959-1964.
37. Shukla V, Mishra SK, Pant HC: Oxidative stress in neurodegeneration. Adv Pharmacol Sci 2011; 572634.
38. Uttara B, Singh AV, Zamboni P, Mahajan RT: Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 2009; 7:65-74.
39. Padurariu M, Ciobica A, Hritcu L, Stoica B, Bild W, Stefanescu C: Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett 2010; 469:6-10.
40. Padurariu M, Ciobica A, Dobrin I, Stefanescu C: Evaluation of antioxidant enzymes activities and lipid peroxidation in schizophrenic patients treated with typical and atypical antipsychotics. Neurosci Lett 2010; 479:317-20.
41. Pérez VI, Buffenstein R, Masamsetti V, Leonard S, Salmon AB, Mele J, Andziak B, Yang T, Edrey Y, Friguet B, Ward W, Richardson A, Chaudhuri A: Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci U S A 2009; 106:3059-64.
42. Porta EA: Pigments in aging: an overview. Ann N Y Acad Sci 2002; 959:57-65.
43. Ranjana K, Negi R, Pande D, Khanna S, Khanna HD: Markers of Oxidative Stress in Generalized Anxiety Psychiatric Disorder: Therapeutic Implications. Journal of Stress Physiology & Biochemistry 2012; 8:2.
44. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB: Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 2010, 49:1603-16.
45. Richter C, Gogvadze V, Laffranchi R, Schlapbach R, Schwezer M, Suter M, Walter P, Yaffee M: Oxidants in mitochondria: Fromphysiology to diseases. Biochim Biophy Acta 1995; 1271:67-74.
46. Rottkamp CA, Raina AK, Zhu X, Gaier E, Bush AI, Atwood CS, Chevion M, Perry G, Smith MA: Redox-active iron mediates amyloid-beta toxicity. Free Radic Biol Med 2004; 30:447-450.
47. Rowan MJ, Klyubin I, Wang Q, Anwyl R: Mechanisms of the inhibitory effects of amyloid beta-protein on synaptic plasticity. Exp Gerontol 2004, 39:1661-1667.
48. Sies H: Oxidative stress: oxidants and antioxidants. Exp Physiol 1997; 82:291-5.
49. Singh RP, Shashwat Sharad, Kapur S: Free Radicals and Oxidative Stress in Neurodegenerative Diseases Relevance of Dietary Antioxidants Journal. Indian Academy of Clinical Medicine JIACM 2004; 5:218-25.
50. Smith MA: Oxidative stress and iron imbalance in Alzheimer disease: how rust became the fuss! J Alzheimers Dis 2006; 9:305-8.
51. Stefanescu C, Ciobica A: The relevance of oxidative stress status in first episode and recurrent depression. J Affect Disord 2012; 143:34-8.
52. Webster R: Neurotransmitters, Drugs and Brain Function. John Wiley & Sons, 2003.
53. Winslow BT, Onysko MK, Stob CM, Hazlewood KA: Treatment of Alzheimer disease. Am Fam Physician 2011; 82:1403-12.
54. Xi Huang, Cuajungco MP, Atwood CS, et al.: Cu(II) potentiation of Alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem 2004; 274:37111-37116.
55. Yamada K, Tanaka T, Han D, Senzaki K, Kameyama T, Nabeshima T: Protective effects of idebenone and alphatocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci 1999; 11:83-90.
56. Yang X, Yang Y, Li G, Wang J, Yang ES: Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation. J Mol Neurosci 2008; 34:165-71.
57. Zheng L, Roberg K Jerhammar F Marcusson J Terman A: Oxidative stress induces intralysosomal accumulation of Alzheimer amyloid beta-protein in cultured neuroblastoma cells. Ann N Y Acad Sci 2006; 1067:248-51.
58. Zhu X, Perry G, Moreira PI: Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease. J Alzheimers Dis 2006; 9:147-53.