Tacrine induces apoptosis through lysosome- and mitochondria-dependent pathway in HepG2 cells

Toxicology in Vitro

Volumn 28, Issue 4, 2014, Pages 667-674

  Gao, Chunpeng ^a,b   Ding, Yue ^a   Zhong, Laifu ^a   Jiang, Liping ^a   Geng, Chengyan ^a   Yao, Xiaofeng ^a   Cao, Jun ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN MUNICIPAL CENTRAL HOSPITAL   (China)

Author keywords

Apoptosis; Lysosomes; Mitochondria; Oxidative stress; Tacrine

Indexed keywords

ANTIOXIDANT; CA 074ME; CASPASE 3; CATHEPSIN B; CATHEPSIN B INHIBITOR; CYTOCHROME C; REACTIVE OXYGEN METABOLITE; TACRINE; UNCLASSIFIED DRUG; YCG 063; CA 074 METHYL ESTER; CHOLINESTERASE INHIBITOR; DIPEPTIDE; HYDRAZONE DERIVATIVE; NITROIMIDAZOLE DERIVATIVE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME RELEASE; LYSOSOME; LYSOSOME MEMBRANE; MEMBRANE PERMEABILITY; MITOCHONDRION; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; DRUG EFFECTS; HEPG2 CELL LINE; HUMAN; METABOLISM;

APOPTOSIS; CATHEPSIN B; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; CYTOCHROMES C; DIPEPTIDES; HEP G2 CELLS; HUMANS; HYDRAZONES; LYSOSOMES; MITOCHONDRIA; NITROIMIDAZOLES; REACTIVE OXYGEN SPECIES; TACRINE;

EID: 84896051609     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.02.001     Document Type: Article

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