Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 18, 2013, Pages 5128-5130

  Fioravanti, Rossella ^a   Desideri, Nicoletta ^a   Biava, Mariangela ^a   Proietti Monaco, Luca ^a   Grammatica, Laura ^a   Yáñez, Matilde ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

hMAO inhibitors; Monoamine oxidases; Pyrazole derivatives

Indexed keywords

MONOAMINE OXIDASE INHIBITOR; PYRAZOLE DERIVATIVE; SELEGILINE;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG SYNTHESIS; IC 50; SUBSTITUTION REACTION;

HMAO INHIBITORS; MONOAMINE OXIDASES; PYRAZOLE DERIVATIVES;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882661924     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.07.035     Document Type: Article

References (27)

1. M. Yamada, and H. Yasuhara Neurotoxicology 25 2004 215
2. P. Riederer, and M.B.H. Youdim J. Neurochem. 46 1986 1359
3. H.H. Fernandez, and J.J. Chen Pharmacotherapy 27 2007 174S
4. J.P. Finberg, J. Wang, K. Bankiewich, J. Harvey-White, I.J. Kopin, and D.S. Goldstein J. Neural Transm. Suppl. 52 1998 279
5. D.A. Di Monte, L.E. DeLanney, I. Irwin, J.E. Royland, P. Chan, M.W. Jacowec, and J.W. Langston Brain Res. 738 1996 53
6. P.A. LeWitt, and D.C. Taylor Neurotherapeutics 5 2008 210
7. M. Gesi, A. Santinami, R. Ruffoli, G. Conti, and F. Fornai Pharmacol. Toxicol. 89 2001 217
8. F. Fornai, G. Battaglia, M. Gesi, F.S. Giorgi, F. Orzi, and F. Nicoletti Brain Res. 887 2000 110
9. S.A. Marchitti, R.A. Deitrich, and V. Vasiliou Pharmacol. Rev. 59 2007 125
10. B. Halliwell J. Neurochem. 59 1992 1609
11. I. Lamensdorf, G. Eisenhofer, J. Harvey-White, A. Nechustan, K. Kirk, and I.J. Kopin Brain Res. 868 2000 191
12. A.M. Isloor, B. Kalluraya, and P. Shetty Eur. J. Med. Chem. 44 2009 3784
13. A.M. Isloor, B. Kalluraya, and M. Rao J. Saudi Chem. Soc. 4 2000 265
14. B. Kalluraya, A.M. Isloor, P.V. Frank, R.L. Jagadesha, S. Shenoy, and J. Indian Heterocycl. Chem. 2001 159
15. D. Sunil, A.M. Isloor, and P. Shetty Der Pharm. Chem. 1 2009 19
16. S.S. Parmar, B.R. Pandey, C. Dwivedi, and R.D. Harbison J. Pharm. Sci. 63 1974 1152
17. F. Manna, F. Chimenti, A. Bolasco, D. Secci, B. Bizzarri, O. Befani, P. Turini, B. Mondovì, S. Alcaro, and A. Tafi Bioorg. Med. Chem. Lett. 12 2002 3629
18. N. Gökhan-Kelekçi, S. Yabanoglu, E. Küpeli, U. Salgin, Ö. Özgen, G. Uçar, E. Yesilada, E. Kend, A. Yesilada, and A.A. Bilgin Bioorg. Med. Chem. 15 2007 5775
19. E. Palaska, M. Aytemir, I.T. Uzbay, and D. Erol Eur. J. Med. Chem. 36 2001 539
20. F. Chimenti, R. Fioravanti, A. Bolasco, F. Manna, P. Chimenti, D. Secci, F. Rossi, P. Turini, F. Ortuso, S. Alcaro, and M.C. Cardia Eur. J. Med. Chem. 10 2008 2262
21. R. Fioravanti, A. Bolasco, F. Manna, F. Rossi, F. Orallo, M. Yáñez, A. Vitali, F. Ortuso, and S. Alcaro Bioorg. Med. Chem. Lett. 20 2010 6479
22. F. Chimenti, S. Carradori, D. Secci, A. Bolasco, B. Bizzarri, P. Chimenti, A. Granese, M. Yáñez, and F. Orallo Eur. J. Med. Chem. 45 2010 800
23. K. Şentürk, O.U. Tan, S.Y. Çiftçi, G. Uçar, and E. Palaska Arch. Pharm. Chem. Life Sci. 345 2012 695
24. A. Bolasco, S. Carradori, and R. Fioravanti Expert Opin. Ther. Pat. 20 2010 909
25. N. Desideri, A. Bolasco, R. Fioravanti, L. Proietti Monaco, F. Orallo, M. Yáñez, F. Ortuso, and S. Alcaro J. Med. Chem. 54 2011 2155
26. N. Desideri, R. Fioravanti, L. Proietti Monaco, M. Biava, M. Yáñez, F. Ortuso, and S. Alcaro Eur. J. Med. Chem. 59 2013 91
27. M. Yáñez, N. Fraiz, E. Cano, and F. Orallo Biochem. Biophys. Res. Commun. 344 2006 688