New coumarin derivatives: Design, synthesis and use as inhibitors of hMAO

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 14, 2014, Pages 3732-3738

  He, Xu ^a   Chen, Yan Yan ^a   Shi, Jing Bo ^a   Tang, Wen Jiang ^a   Pan, Zhi Xiang ^a   Dong, Zhi Qiang ^a   Song, Bao An ^b   Li, Jun ^a   Liu, Xin Hua ^a,b,c  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b GUIZHOU UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Coumarin; Design; hMAO B; Inhibitors; Synthesis

Indexed keywords

4 BROMOPHENYL 2 OXO 2H CHROMENE 3 CARBOTHIOATE; 4 BROMOPHENYL 6 NITRO 2 OXO 2H CHROMENE 3 CARBOTHIOATE; 4 BROMOPHENYL 6,7 DIBROMO 2 OXO 2H CHROMENE 3 CARBOTHIOATE; 6,8 DIBROMO N ISOPROPYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; 6,8 DIBROMO N SEC BUTYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; 6,8 DIBROMO N,N DIHEXYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; BUTY 2 OXO 2H CHROMENE 3 CARBOTHIOATE; BUTYL 6 NITRO 2 OXO 2H CHROMENE 3 CARBOTHIOATE; BUTYL 6,7 DIBROMO 2 OXO 2H CHROMENE 3 CARBOTHIOATE; COUMARIN DERIVATIVE; FURAN 2 YLMETHYL 2 OXO 2H CHROMENE 3 CARBOTHIOATE; FURAN 2 YLMETHYL 6 NITRO 2 OXO 2H CHROMENE 3 CARBOTHIOATE; IPRONIAZID; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; N ISOPROPYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N ISOPROPYL 6 NITRO 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N SEC BUTYL 6 NITRO 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N TERT BUTYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N TERT BUTYL 6 NITRO 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N,N DIHEXYL 6 NITRO 2 OXO 2H CHROMENE 3 CARBOXAMIDE; PYRIMIDIN 2 YL 2 OXO 2H CHROMENE 3 CARBOTHIOATE; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); COUMARIN; MONOAMINE OXIDASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; IC 50; LIGAND BINDING; MOLECULAR DOCKING; SCORING SYSTEM; SIMULATION; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; HUMAN; METABOLISM; SYNTHESIS;

COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902532838     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.05.002     Document Type: Article

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