Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4336-4347

  Okaecwe, Thokozile ^a   Swanepoel, Abraham J ^a   Petzer, Anél ^a   Bergh, Jacobus J ^a   Petzer, Jacobus P ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

8 (Phenylsulfanyl)methyl caffeine; Caffeine; Competitive; Molecular docking; Monoamine oxidase; Phenoxymethylcaffeine; Reversible inhibition; Selectivity

Indexed keywords

8 (3 BROMOBENZYLOXY)CAFFEINE DERIVATIVE; 8 (3 BROMOPHENOXYMETHYL)CAFFEINE; 8 (3 CHLOROPHENOXYMETHYL)CAFFEINE; 8 (3 FLUOROPHENOXYMETHYL)CAFFEINE; 8 (3 METHOXYPHENOXYMETHYL)CAFFEINE; 8 (3 METHYLPHENOXYMETHYL)CAFFEINE; 8 (4 BROMOPHENOXYMETHYL)CAFFEINE; 8 (4 CHLOROPHENOXYMETHYL)CAFFEINE; 8 (4 FLUOROPHENOXYMETHYL)CAFFEINE; 8 (BENZYLSULFANYL)CAFFEINE DERIVATIVE; 8 [(PHENYLSULFANYL)METHYL]CAFFEINE; 8 [(PHENYLSULFANYL)METHYL]CAFFEINE DERIVATIVE; 8 [3 (TRIFLUOROMETHYL)PHENOXYMETHYL]CAFFEINE; 8 [[(3 BROMOPHENYL)SUFANYL]METHYL]CAFFEINE; 8 [[(3 CHLOROPHENYL)SUFANYL]METHYL]CAFFEINE; 8 [[(3 ETHOXYPHENYL)SUFANYL]METHYL]CAFFEINE; 8 [[(3 FLUOROPHENYL)SUFANYL]METHYL]CAFFEINE; 8 [[(3 METHOXYPHENYL)SUFANYL]METHYL]CAFFEINE; 8 [[(3 METHYLPHENYL)SUFANYL]METHYL]CAFFEINE; 8 [[(4 BROMOPHENYL)SUFANYL]METHYL]CAFFEINE; 8 [[(4 CHLOROPHENYL)SUFANYL]METHYL]CAFFEINE; 8 BENZYLOXYCAFFEINE DERIVATIVE; 8 PHENOXYMETHYLCAFFEINE; 8 PHENOXYMETHYLCAFFEINE DERIVATIVE; 8 SULFANYLCAFFEINE DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; MONOAMINE OXIDASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; PARKINSON DISEASE; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CAFFEINE; CATALYTIC DOMAIN; COMPUTER SIMULATION; HUMANS; KINETICS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863225554     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.048     Document Type: Article

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