Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors

Journal of Biological Chemistry

Volumn 280, Issue 16, 2005, Pages 15761-15766

  Hubálek, Frantisek ^a,d   Binda, Claudia ^b   Khalil, Ashraf ^c   Li, Min ^a   Mattevi, Andrea ^b   Castagnoli, Neal ^c   Edmondson, Dale E ^a,e  

^a EMORY UNIVERSITY   (United States)

^b UNIVERSITY OF PAVIA   (Italy)

^c VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^d NOVO NORDISK A S   (Denmark)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CONFORMATIONS; CRYSTAL STRUCTURE; METABOLISM; MOLECULAR DYNAMICS; MUTAGENESIS; PHENOLS; PROTEINS;

MONOAMINE OXIDASE B; MUTANT PROTEIN; NEUROTRANSMITTER; TRANS-FARNESOL;

ENZYMES;

1,4 DIPHENYL 2 BUTENE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; FARNESOL; ISATIN; ISOLEUCINE; MONOAMINE OXIDASE B INHIBITOR; MUTANT PROTEIN; PHENYLALANINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE;

ANIMALS; ENZYME INHIBITORS; FARNESOL; HUMANS; ISOLEUCINE; MONOAMINE OXIDASE; PROTEIN STRUCTURE, TERTIARY;

BOVINAE; EQUUS CABALLUS; GYMNOMYZA SAMOENSIS; OVIS ARIES;

EID: 18144423424     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500949200     Document Type: Article

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