Pharmacokinetic variations in cancer patients with liver dysfunction: applications and challenges of pharmacometabolomics

Cancer Chemotherapy and Pharmacology

Volumn 78, Issue 3, 2016, Pages 465-489

  Aboel Dahab, Ali ^a   El Hag, Dhia ^b   Moutamed, Gamal M ^c,d   Aboel Dahab, Sarah ^c   Abuknesha, Ramadan ^a   Smith, Norman W ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MEDICAL SCIENCES AND TECHNOLOGY   (Sudan)

^c The British University in Egypt   (Egypt)

^d MSA University   (Egypt)

Author keywords

Anticancer drugs; Metabolomics; Pharmacokinetic variations; Pharmacometabolomics; Toxicity

Indexed keywords

ABIRATERONE ACETATE; ANALGESIC AGENT; ANTINEOPLASTIC AGENT; CERITINIB; IMATINIB; MORPHINE; TAPENTADOL;

CANCER CHEMOTHERAPY; CANCER PATIENT; CLINICAL PHARMACOLOGY; DATA ANALYSIS; DRUG ABSORPTION; DRUG ADMINISTRATION; DRUG BILE LEVEL; DRUG DISTRIBUTION; DRUG METABOLISM; HUMAN; LIQUID CHROMATOGRAPHY; LIVER DYSFUNCTION; MALIGNANT NEOPLASTIC DISEASE; MASS SPECTROMETRY; METABOLOMICS; MULTIVARIATE ANALYSIS; PHARMACOMETABOLOMICS; PRIORITY JOURNAL; REVIEW; ANIMAL; COMPLICATION; LIVER DISEASE; NEOPLASMS; PERSONALIZED MEDICINE; PHARMACOGENETICS; PROCEDURES;

ANALGESICS; ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; LIVER DISEASES; METABOLOMICS; NEOPLASMS; PHARMACOGENETICS; PRECISION MEDICINE;

EID: 84964009502     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-016-3028-4     Document Type: Review

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