Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis

Journal of Hepatology

Volumn 64, Issue 5, 2016, Pages 1058-1067

  McPhail, Mark J W ^a,b   Shawcross, Debbie L ^a   Lewis, Matthew R ^c   Coltart, Iona ^a   Want, Elizabeth J ^c   Antoniades, Charalambos G ^a,b   Veselkov, Kiril ^c   Triantafyllou, Evangelos ^b   Patel, Vishal ^b   Pop, Oltin ^b   Gomez Romero, Maria ^c   Kyriakides, Michael ^c   Zia, Rabiya ^c   Abeles, Robin D ^b   Crossey, Mary M E ^a   Jassem, Wayel ^b   O'Grady, John ^b   Heaton, Nigel ^b   Auzinger, Georg ^b   Bernal, William ^b   Quaglia, Alberto ^b   Coen, Muireann ^c   Nicholson, Jeremy K ^c   Wendon, Julia A ^b   Holmes, Elaine ^c   Taylor Robinson, Simon D ^a   more..

^a ST MARY S HOSPITAL   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Acute on chronic liver failure.; Metabolic profiling; Metabolomics; Metabonomics; Outcome prediction; Personalised medicine

Indexed keywords

LACTIC ACID; METHIONINE; PHENYLALANINE; TYROSINE; BIOLOGICAL MARKER; CYTOKINE;

ADULT; AGED; ARTICLE; CELL DEATH; CONTROLLED STUDY; DECOMPENSATED LIVER CIRRHOSIS; DOWN REGULATION; FEMALE; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LACTATE BLOOD LEVEL; LIVER CELL; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; SURVIVAL PREDICTION; TIME OF FLIGHT MASS SPECTROMETRY; TISSUE SECTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; BIOPSY; BLOOD; EPIDEMIOLOGY; FOLLOW UP; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CIRRHOSIS; METABOLISM; METABOLOMICS; MIDDLE AGED; MORTALITY; PATHOLOGY; PROCEDURES; RETROSPECTIVE STUDY; SURVIVAL RATE; TIME FACTOR; TRENDS; UNITED KINGDOM; YOUNG ADULT;

ADULT; AGED; BIOMARKERS; BIOPSY; CELL DEATH; CYTOKINES; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CIRRHOSIS; MALE; METABOLOMICS; MIDDLE AGED; RETROSPECTIVE STUDIES; SURVIVAL RATE; TIME FACTORS; UNITED KINGDOM; YOUNG ADULT;

EID: 84959450501     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2016.01.003     Document Type: Article

References (59)

1. J.G. Williams, S.E. Roberts, M.F. Ali, W.Y. Cheung, D.R. Cohen, G. Demery, and et al. Gastroenterology services in the UK. The burden of disease, and the organisation and delivery of services for gastrointestinal and liver disorders: a review of the evidence Gut 56 2007 1 113
2. R. Moreau, R. Jalan, P. Gines, M. Pavesi, P. Angeli, J. Cordoba, and et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis Gastroenterology 144 2013 1426 1437 1437, e1421-e1429
3. D.L. Shawcross, M.J. Austin, R.D. Abeles, M.J. McPhail, A.D. Yeoman, N.J. Taylor, and et al. The impact of organ dysfunction in cirrhosis: survival at a cost? J Hepatol 56 2012 1054 1062
4. E. Cholongitas, M. Senzolo, C. Triantos, D. Samonakis, D. Patch, and A.K. Burroughs MELD is not enough-enough of MELD? J Hepatol 42 2005 475 477 Author reply 478-479
5. E. Cholongitas, M. Senzolo, D. Patch, S. Shaw, C. Hui, and A.K. Burroughs Review article: scoring systems for assessing prognosis in critically ill adult cirrhotics Aliment Pharmacol Ther 24 2006 453 464
6. R. Jalan, F. Saliba, M. Pavesi, A. Amoros, R. Moreau, P. Gines, and et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure J Hepatol 61 2014 1038 1047
7. J.K. Nicholson, J.C. Lindon, and E. Holmes 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 29 1999 1181 1189
8. J. Trygg, E. Holmes, and T. Lundstedt Chemometrics in metabonomics J Proteome Res 6 2007 469 479
9. J.K. Nicholson, and E. Holmes Global systems biology and personalized healthcare solutions Discov Med 6 2006 63 70
10. T.A. Clayton, J.C. Lindon, O. Cloarec, H. Antti, C. Charuel, G. Hanton, and et al. Pharmaco-metabonomic phenotyping and personalized drug treatment Nature 440 2006 1073 1077
11. T.A. Clayton, D. Baker, J.C. Lindon, J.R. Everett, and J.K. Nicholson Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism Proc Natl Acad Sci USA 106 2009 14728 14733
12. A. Backshall, R. Sharma, S.J. Clarke, and H.C. Keun Pharmacometabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine Clin Cancer Res 17 2011 3019 3028
13. J.T. Bjerrum, O.H. Nielsen, F. Hao, H. Tang, J.K. Nicholson, Y. Wang, and et al. Metabonomics in ulcerative colitis: diagnostics, biomarker identification, and insight into the pathophysiology J Proteome Res 9 2010 954 962
14. H.R. Williams, I.J. Cox, D.G. Walker, B.V. North, V.M. Patel, S.E. Marshall, and et al. Characterization of inflammatory bowel disease with urinary metabolic profiling Am J Gastroenterol 104 2009 1435 1444
15. M.I. Shariff, N.G. Ladep, I.J. Cox, H.R. Williams, E. Okeke, A. Malu, and et al. Characterization of urinary biomarkers of hepatocellular carcinoma using magnetic resonance spectroscopy in a Nigerian population J Proteome Res 9 2010 1096 1103
16. N.G. Ladep, A.C. Dona, M.R. Lewis, M.M. Crossey, M. Lemoine, E. Okeke, and et al. Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans Hepatology 60 2014 1291 1301
17. 1H NMR spectroscopy for the prediction of therapeutic outcome in patients with fulminant hepatic failure NMR Biomed 19 2006 521 526
18. J.R. Bales, J.D. Bell, J.K. Nicholson, P.J. Sadler, J.A. Timbrell, R.D. Hughes, and et al. Metabolic profiling of body fluids by proton NMR: self-poisoning episodes with paracetamol (acetaminophen) Magn Reson Med 6 1988 300 306
19. B. Jimenez, C. Montoliu, D.A. MacIntyre, M.A. Serra, A. Wassel, M. Jover, and et al. Serum metabolic signature of minimal hepatic encephalopathy by (1)H-nuclear magnetic resonance J Proteome Res 9 2010 5180 5187
20. R. Amathieu, P. Nahon, M. Triba, N. Bouchemal, J.C. Trinchet, M. Beaugrand, and et al. Metabolomic approach by 1H NMR spectroscopy of serum for the assessment of chronic liver failure in patients with cirrhosis J Proteome Res 10 2011 3239 3245
21. K. Yu, G. Sheng, J. Sheng, Y. Chen, W. Xu, X. Liu, and et al. A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis B virus J Proteome Res 6 2007 2413 2419
22. L. Zhang, X. Jia, X. Peng, Q. Ou, Z. Zhang, C. Qiu, and et al. Development and validation of a liquid chromatography-mass spectrometry metabonomic platform in human plasma of liver failure caused by hepatitis B virus Acta Biochim Biophys Sin 42 2010 688 698
23. J.S. Lian, W. Liu, S.R. Hao, Y.Z. Guo, H.J. Huang, D.Y. Chen, and et al. A serum metabonomic study on the difference between alcohol- and HBV-induced liver cirrhosis by ultraperformance liquid chromatography coupled to mass spectrometry plus quadrupole time-of-flight mass spectrometry Chin Med J 124 2011 1367 1373
24. D. Beyoglu, and J.R. Idle The metabolomic window into hepatobiliary disease J Hepatol 59 2013 842 858
25. L.A. Possamai, M.J. McPhail, A. Quaglia, V. Zingarelli, R.D. Abeles, R. Tidswell, and et al. Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure - Crit Care Med 41 2013 2543 2550
26. D.G. Craig, P. Lee, E.A. Pryde, G.S. Masterton, P.C. Hayes, and K.J. Simpson Circulating apoptotic and necrotic cell death markers in patients with acute liver injury Liver Int 31 2011 1127 1136
27. D. Adebayo, V. Morabito, F. Andreola, G. Pieri, T.V. Luong, A. Dhillon, and et al. Mechanism of cell death in acute-on-chronic liver failure: a clinico-pathologic-biomarker study Liver Int 35 12 2015 2564 2574 10.1111/liv.12850
28. P.A. Berry, and J.A. Wendon The management of severe alcoholic liver disease and variceal bleeding in the intensive care unit Curr Opin Crit Care 12 2006 171 177
29. Shawcross. DaWJ Acute-on-chronic liver failure in cirrhosis: defining and managing organ dysfunction J.L. Vincent, Yearbook of intensive care and emergency medicine 2009 2009 Springer-Verlag, Berlin, Heidelberg New York 658 671
30. R.N. Pugh, I.M. Murray-Lyon, J.L. Dawson, M.C. Pietroni, and R. Williams Transection of the oesophagus for bleeding oesophageal varices Br J Surg 60 1973 646 649
31. P.S. Kamath, and W.R. Kim Advanced Liver Disease Study G. The model for end-stage liver disease (MELD) Hepatology 45 2007 797 805
32. K. Barber, S. Madden, J. Allen, D. Collett, J. Neuberger, and A. Gimson Elective liver transplant list mortality: development of a United Kingdom end-stage liver disease score Transplantation 92 2011 469 476
33. R. Jalan, M. Pavesi, F. Saliba, A. Amoros, J. Fernandez, P. Holland-Fischer, and et al. The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure J Hepatol 62 2015 831 840
34. O. Beckonert, H.C. Keun, T.M. Ebbels, J. Bundy, E. Holmes, J.C. Lindon, and et al. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts Nat Protoc 2 2007 2692 2703
35. C.A. Smith, E.J. Want, G. O'Maille, R. Abagyan, and G. Siuzdak XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification Anal Chem 78 2006 779 787
36. J. Cummings, M. Ranson, F. Butt, D. Moore, and C. Dive Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stability in cancer patient plasma Cancer Chemother Pharmacol 60 2007 921 924
37. M.R. Yun, F. Okajima, and D.S. Im The action mode of lysophosphatidylcholine in human monocytes J Pharmacol Sci 94 2004 45 50
38. N. Kume, M.I. Cybulsky, and M.A. Gimbrone Jr. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells J Clin Invest 90 1992 1138 1144
39. O. Murch, M. Collin, B. Sepodes, S.J. Foster, H. Mota-Filipe, and C. Thiemermann Lysophosphatidylcholine reduces the organ injury and dysfunction in rodent models of gram-negative and gram-positive shock Br J Pharmacol 148 2006 769 777
40. S. Li, H. Liu, Y. Jin, S. Lin, Z. Cai, and Y. Jiang Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice J Chromatogr B Analyt Technol Biomed Life Sci 879 2011 2369 2375
41. L. Zhang, X. Jia, X. Peng, Q. Ou, Z. Zhang, C. Qiu, and et al. Development and validation of a liquid chromatography-mass spectrometry metabonomic platform in human plasma of liver failure caused by hepatitis B virus Acta Biochim Biophys Sin (Shanghai) 42 2010 688 698
42. R. Amathieu, P. Nahon, M. Triba, N. Bouchemal, J.C. Trinchet, M. Beaugrand, and et al. Metabolomic approach by 1H NMR spectroscopy of serum for the assessment of chronic liver failure in patients with cirrhosis J Proteome Res 10 2011 3239 3245
43. G.V. Papatheodoridis, E. Hadziyannis, E. Tsochatzis, A. Georgiou, G. Kafiri, D.G. Tiniakos, and et al. Serum apoptotic caspase activity in chronic hepatitis C and nonalcoholic Fatty liver disease J Clin Gastroenterol 44 2010 e87 e95
44. G.V. Papatheodoridis, E. Hadziyannis, E. Tsochatzis, N. Chrysanthos, A. Georgiou, G. Kafiri, and et al. Serum apoptotic caspase activity as a marker of severity in HBeAg-negative chronic hepatitis B virus infection Gut 57 2008 500 506
45. S.J. Zheng, S. Liu, M. Liu, M.A. McCrae, J.F. Li, Y.P. Han, and et al. Prognostic value of M30/M65 for outcome of hepatitis B virus-related acute-on-chronic liver failure World J Gastroenterol 20 2014 2403 2411
46. G. Kramer, H. Erdal, H.J. Mertens, M. Nap, J. Mauermann, G. Steiner, and et al. Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18 Cancer Res 64 2004 1751 1756
47. M.S. Han, S.Y. Park, K. Shinzawa, S. Kim, K.W. Chung, J.H. Lee, and et al. Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes J Lipid Res 49 2008 84 97
48. M. Takahashi, H. Okazaki, Y. Ogata, K. Takeuchi, U. Ikeda, and K. Shimada Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism Atherosclerosis 161 2002 387 394
49. J.J. Yan, J.S. Jung, J.E. Lee, J. Lee, S.O. Huh, H.S. Kim, and et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis Nat Med 10 2004 161 167
50. M.E. Bollard, N.R. Contel, T.M. Ebbels, L. Smith, O. Beckonert, G.H. Cantor, and et al. NMR-based metabolic profiling identifies biomarkers of liver regeneration following partial hepatectomy in the rat J Proteome Res 9 2010 59 69
51. H. Li, Q. Xia, B. Zeng, S.T. Li, H. Liu, Q. Li, and et al. Submassive hepatic necrosis distinguishes HBV-associated acute on chronic liver failure from cirrhotic patients with acute decompensation J Hepatol 63 2015 50 59
52. J. Cai, T. Han, C. Nie, X. Jia, Y. Liu, Z. Zhu, and et al. Biomarkers of oxidation stress, inflammation, necrosis and apoptosis are associated with hepatitis B-related acute-on-chronic liver failure Clin Res Hepatol Gastroenterol 40 1 2016 41 50 10.1016/j.clinre.2015.06.009
53. K. Fukuhara, A. Ohno, Y. Ando, T. Yamoto, and H. Okuda A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity Drug Metab Pharmacokinet 26 2011 399 406
54. M. Kyriakides, R.N. Hardwick, Z. Jin, M.J. Goedken, E. Holmes, N.J. Cherrington, and et al. Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat Toxicol Sci 142 2014 105 116
55. P. Tessari, M. Vettore, R. Millioni, L. Puricelli, and R. Orlando Effect of liver cirrhosis on phenylalanine and tyrosine metabolism Curr Opin Clin Nutr Metab Care 13 2010 81 86
56. D.L. Shawcross, Y. Sharifi, J.B. Canavan, A.D. Yeoman, R.D. Abeles, N.J. Taylor, and et al. Infection and systemic inflammation, not ammonia, are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis J Hepatol 54 2011 640 649
57. J.M. Kinross, E. Holmes, A.W. Darzi, and J.K. Nicholson Metabolic phenotyping for monitoring surgical patients Lancet 377 2011 1817 1819
58. R. Mirnezami, J.M. Kinross, P.A. Vorkas, R. Goldin, E. Holmes, J. Nicholson, and et al. Implementation of molecular phenotyping approaches in the personalized surgical patient journey Ann Surg 255 2012 881 889
59. W.S. Oetting, P.N. Robinson, M.S. Greenblatt, R.G. Cotton, T. Beck, J.C. Carey, and et al. Getting ready for the Human Phenome Project: the 2012 forum of the Human Variome Project Hum Mutat 34 2013 661 666