The Anti-cancer Drug Chlorambucil as a Substrate for the Human Polymorphic Enzyme Glutathione Transferase P1-1: Kinetic Properties and Crystallographic Characterisation of Allelic Variants

Journal of Molecular Biology

Volumn 380, Issue 1, 2008, Pages 131-144

  Parker, Lorien J ^a,b   Ciccone, Sarah ^c   Italiano, Louis C ^a,b   Primavera, Alessandra ^c   Oakley, Aaron J ^a   Morton, Craig J ^a   Hancock, Nancy C ^a   Bello, Mario Lo ^c   Parker, Michael W ^a,b  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

anti cancer drugs; detoxification; glutathione transferases; polymorphisms; X ray crystallography

Indexed keywords

CHLORAMBUCIL; ENZYME VARIANT; GLUTATHIONE; GLUTATHIONE TRANSFERASE P1;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CONJUGATION; CRYSTAL STRUCTURE; DRUG INACTIVATION; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME POLYMORPHISM; ENZYME STABILITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; STRESS; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY;

EID: 44649175626     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.04.066     Document Type: Article

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