The hepatic sinusoid in aging and cirrhosis: Effects on hepatic substrate disposition and drug clearance

Clinical Pharmacokinetics

Volumn 44, Issue 2, 2005, Pages 187-200

  Le Couteur, David G ^a,e   Fraser, Robin ^b   Hilmer, Sarah ^a   Rivory, Laurent P ^c   McLean, Allan J ^d  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c University of Sydney   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e Department of Microbiology and Infectious Diseases   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; COLLAGEN;

AGING; BASEMENT MEMBRANE; CAPILLARY; DIFFUSION; DRUG CLEARANCE; DRUG DISPOSITION; DRUG MECHANISM; ENDOTHELIUM; HYPOXIA; LIVER CELL; LIVER CIRRHOSIS; LIVER DYSFUNCTION; LIVER SINUSOID; MACROMOLECULE; METABOLISM; OXYGEN TRANSPORT; PRIORITY JOURNAL; REVIEW;

AGING; ANIMALS; HEPATIC VEINS; HUMANS; LIVER; LIVER CIRRHOSIS; METABOLIC CLEARANCE RATE; PHARMACEUTICAL PREPARATIONS; SUBSTRATE SPECIFICITY;

EID: 13244297157     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200544020-00004     Document Type: Review

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