Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation

FASEB Journal

Volumn 30, Issue 4, 2016, Pages 1464-1479

  Jung, Gwanghyun ^a,b   Fajardo, Giovanni ^a,b   Ribeiro, Alexandre J S ^c   Kooiker, Kristina Bezold ^a,b   Coronado, Michael ^a,b   Zhao, Mingming ^a,b   Hu, Dong Qing ^a,b   Reddy, Sushma ^a,b   Kodo, Kazuki ^a,b   Sriram, Krishna ^d   Insel, Paul A ^d   Wu, Joseph C ^a   Pruitt, Beth L ^c   Bernstein, Daniel ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c Stanford University   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiotoxicity testing; Cell signaling maturation; adrenergic receptor

Indexed keywords

BETA ADRENERGIC RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CAVEOLIN; CYCLIC AMP; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CALCIUM;

ARTICLE; CARDIAC MUSCLE CELL; CARDIOTOXICITY; CELL DEATH; CELL MATURATION; CONTROLLED STUDY; EVOLUTION; HEART FAILURE; HEART FUNCTION; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MECHANICAL STIMULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STIMULATION; TECHNOLOGY; BIOMECHANICS; CELL CULTURE; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CYTOLOGY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; HEK293 CELL LINE; IMMUNOBLOTTING; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR;

BIOMECHANICAL PHENOMENA; CALCIUM; CELL DIFFERENTIATION; CELLS, CULTURED; CYCLIC AMP; GENE EXPRESSION PROFILING; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; INDUCED PLURIPOTENT STEM CELLS; MICROSCOPY, CONFOCAL; MYOCYTES, CARDIAC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84963974245     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-280982     Document Type: Article

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