Alterations of L-type calcium current and cardiac function in CaMKII δ knockout mice

Circulation Research

Volumn 107, Issue 3, 2010, Pages 398-407

  Xu, Lin ^a   Lai, Dongwu ^a   Cheng, Jun ^a   Lim, Hyun Joung ^a   Keskanokwong, Thitima ^a   Backs, Johannes ^b   Olson, Eric N ^b   Wang, Yanggan ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Calcium channel; CaMKII; Excitation contraction coupling; Myocytes

Indexed keywords

BARIUM ION; BETA 2 ADRENERGIC RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHANNEL L TYPE; CALCIUM ION; ISOPRENALINE; VOLTAGE GATED CALCIUM CHANNEL; 8 BROMO CYCLIC AMP; CALCIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BETA ADRENERGIC STIMULATION; CALCIUM CURRENT; COMPETITIVE INHIBITION; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ELECTRIC POTENTIAL; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART STRESS; HEART WORK; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SARCOMERE LENGTH; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; SUBSTITUTION REACTION; WESTERN BLOTTING; ANIMAL; BODY WEIGHT; DRUG EFFECT; GENETICS; HEART; HEART CONTRACTION; HISTOLOGY; KINETICS; MOUSE MUTANT; MUSCLE CELL; ORGAN SIZE; PHYSIOLOGY;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; HEART; ISOPROTERENOL; KINETICS; MICE; MICE, KNOCKOUT; MUSCLE CELLS; MYOCARDIAL CONTRACTION; ORGAN SIZE; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 77956640976     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.222562     Document Type: Article

References (42)

1. Tobimatsu T, Fujisawa H. Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs. J Biol Chem. 1989;264:17907-17912.
2. Baltas LG, Karczewski P, Krause EG. The cardiac sarcoplasmic reticulum phospholamban kinase is a distinct delta-CaM kinase isozyme. FEBS Lett. 1995;373:71-75.
3. Singer HA, Benscoter HA, Schworer CM. Novel Ca2+/calmodulindependent protein kinase II gamma-subunit variants expressed in vascular smooth muscle, brain, and cardiomyocytes. J Biol Chem. 1997;272:9393-9400.
4. Hoch B, Haase H, Schulze W, Hagemann D, Morano I, Krause EG, Karczewski P. Differentiation-dependent expression of cardiac delta-CaMKII isoforms. J Cell Biochem. 1998;68:259-268.
5. Anderson ME. Calmodulin kinase and L-type calcium channels; a recipe for arrhythmias? Trends Cardiovasc Med. 2004;14:152-161.
6. Wang Y, Tandan S, Cheng J, Yang C, Nguyen L, Sugianto J, Johnstone JL, Sun Y, Hill JA. Ca2 +/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure. J Biol Chem. 2008;283:25524-25532.
7. Perez-Reyes E, Schneider T. Molecular biology of calcium channels. Kidney Int. 1995;48:1111-1124.
8. De Waard M, Gurnett CA, Campbell KP. Structural and functional diversity of voltage-activated calcium channels. Ion Channels. 1996;4:41-87.
9. Van Coppenolle F, Ahidouch A, Guilbault P, Ouadid H. Regulation of endogenous Ca2+ channels by cyclic AMP and cyclic GMP-dependent protein kinases in Pleurodeles oocytes. Mol Cell Biochem. 1997;168:155-161.
10. Alden KJ, Goldspink PH, Ruch SW, Buttrick PM, Garcia J. Enhancement of L-type Ca (2 +) current from neonatal mouse ventricular myocytes by constitutively active PKC-betaII. Am J Physiol Cell Physiol. 2002;282: C768-C774.
11. Tandan S, Wang Y, Wang TT, Jiang N, Hall DD, Hell JW, Luo X, Rothermel BA, Hill JA. Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel. Circ Res. 2009;105:51-60.
12. Dzhura I, Wu Y, Colbran RJ, Corbin JD, Balser JR, Anderson ME. Cytoskeletal disrupting agents prevent calmodulin kinase, IQ domain and voltage-dependent facilitation of L-type Ca2+ channels. J Physiol. 2002;545:399-406.
13. Wang W, Zhu W, Wang S, Yang D, Crow MT, Xiao RP, Cheng H. Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circ Res. 2004;95:798-806.
14. Verrier RL, Antzelevitch C. Autonomic aspects of arrhythmogenesis: the enduring and the new. Curr Opin Cardiol. 2004;19:2-11.
15. Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci USA. 2009;106:2342-2347.
16. Yuan W, Bers DM. Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase. Am J Physiol. 1994;267: H982-H993.
17. Anderson ME, Braun AP, Schulman H, Premack BA. Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca (2 +)-induced enhancement of the L-type Ca2 + current in rabbit ventricular myocytes. Circ Res. 1994;75:854-861.
18. Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, Cao Z, Lu N, Takafumi A, Goto H, Daly MJ, Xavier RJ. Ca2+/calmodulindependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation. Mol Cell Biol. 2006;26:5497-5508.
19. Shi XZ, Pazdrak K, Saada N, Dai B, Palade P, Sarna SK. Negative transcriptional regulation of human colonic smooth muscle Cav1.2 channels by p50 and p65 subunits of nuclear factor-kappaB. Gastroenterology. 2005;129:1518-1532.
20. Guo J, Duff HJ. Calmodulin kinase II accelerates L-type Ca2+ current recovery from inactivation and compensates for the direct inhibitory effect of [Ca2 +]i in rat ventricular myocytes. J Physiol. 2006;574:509-518.
21. Vinogradova TM, Zhou YY, Bogdanov KY, Yang D, Kuschel M, Cheng H, Xiao RP. Sinoatrial node pacemaker activity requires Ca (2 +)/calmodulindependent protein kinase II activation. Circ Res. 2000;87:760-767.
22. Tsien RW, Bean BP, Hess P, Lansman JB, Nilius B, Nowycky MC. Mechanisms of calcium channel modulation by B-adrenergic agents and dihydropyridine Ca agonists. J Mol Cell Cardiol. 1986;18:691-710.
23. Tiaho F, Nargeot J, Richard S. Voltage-dependent regulation of L-type cardiac Ca channels by isoproterenol. Pflugers Arch. 1991;419:596-602.
24. Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE Jr, Thiel W, Guatimosim S, Song LS, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, Anderson ME. Calmodulin kinase II inhibition protects against structural heart disease. Nat Med. 2005;11:409-417.
25. Maltsev VA, Ji GJ, Wobus AM, Fleischmann BK, Hescheler J. Establishment of beta-adrenergic modulation of L-type Ca2 + current in the early stages of cardiomyocyte development. Circ Res. 1999;84:136-145.
26. Cerbai E, Guerra L, Varani K, Barbieri M, Borea PA, Mugelli A. Betaadrenoceptor subtypes in young and old rat ventricular myocytes: a combined patch-clamp and binding study. Br J Pharmacol. 1995;116:1835-1842.
27. Xiao RP, Ji X, Lakatta EG. Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol. 1995;47:322-329.
28. Zhou YY, Cheng H, Song LS, Wang D, Lakatta EG, Xiao RP. Spontaneous beta (2)-adrenergic signaling fails to modulate L-type Ca (2 +) current in mouse ventricular myocytes. Mol Pharmacol. 1999;56:485-493.
29. Kiely J, Hadcock JR, Bahouth SW, Malbon CC. Glucocorticoids downregulate beta 1-adrenergic-receptor expression by suppressing transcription of the receptor gene. Biochem J. 1994;302(Pt 2):397-403.
30. McNab TC, Tseng YT, Stabila JP, McGonnigal BG, Padbury JF. Liganded and unliganded steroid receptor modulation of beta 1 adrenergic receptor gene transcription. Pediatr Res. 2001;50:575-580.
31. Bristow MR, Minobe WA, Raynolds MV, Port JD, Rasmussen R, Ray PE, Feldman AM. Reduced beta 1 receptor messenger RNA abundance in the failing human heart. J Clin Invest. 1993;92:2737-2745.
32. Bers DM, Guo T. Calcium signaling in cardiac ventricular myocytes. Ann N y Acad Sci. 2005;1047:86-98.
33. Bers DM. Cardiac excitation-contraction coupling. Nature. 2002;415:198-205.
34. Roth DM, Swaney JS, Dalton ND, Gilpin EA, Ross J Jr. Impact of anesthesia on cardiac function during echocardiography in mice. Am J Physiol Heart Circ Physiol. 2002;282: H2134-H2140.
35. Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Heller BJ. Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest. 2009;119:1230-1240.
36. Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci USA. 2009;106:5972-5977.
37. Ross J Jr, Miura T, Kambayashi M, Eising GP, Ryu KH. Adrenergic control of the force-frequency relation. Circulation. 1995;92:2327-2332.
38. Picht E, DeSantiago J, Huke S, Kaetzel MA, Dedman JR, Bers DM. CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation. J Mol Cell Cardiol. 2007;42:196-205.
39. Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D. NF-kappa B functions in synaptic signaling and behavior. Nat Neurosci. 2003;6:1072-1078.
40. Li L, Satoh H, Ginsburg KS, Bers DM. The effect of Ca (2 +)-calmodulin-dependent protein kinase II on cardiac excitation-contraction coupling in ferret ventricular myocytes. J Physiol. 1997;501(Pt 1):17-31.
41. Xiao RP. Cell logic for dual coupling of a single class of receptors to G (s) and G (i) proteins. Circ Res. 2000;87:635-637.
42. Maier LS, Bers DM. Role of Ca2 +/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res. 2007;73:631-640.