Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channels

FASEB Journal

Volumn 30, Issue 3, 2016, Pages 1247-1262

  Wei, Shipeng ^a   Roessler, Bryan C ^a   Icyuz, Mert ^b   Chauvet, Sylvain ^a   Tao, Binli ^a   Hartman, John L ^b   Kirk, Kevin L ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

ABC transporter; Allostery; Ion channel; Phosphorylation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MULTIDRUG RESISTANCE PROTEIN; ADENOSINE TRIPHOSPHATASE; CFTR PROTEIN, HUMAN; PROTEIN BINDING;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS COUPLING REACTION; CRYSTAL STRUCTURE; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; THERMODYNAMICS; AMINO ACID SEQUENCE; BINDING SITE; CELL LINE; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MUTATION; P-GLYCOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84963877591     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-278382     Document Type: Article

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