Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

BMC Biology

Volumn 14, Issue 1, 2016, Pages

  Maric Biresev, Jelena ^a   Hunn, Julia P ^b   Krut, Oleg ^c   Helms, J Bernd ^b   Martens, Sascha ^d   Howard, Jonathan C ^a,e,f  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^d UNIVERSITY OF VIENNA   (Austria)

^e INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^f MAX PLANCK INSTITUTE FOR PLANT BREEDING RESEARCH   (Germany)

Author keywords

Autophagy; Immunity related GTPases; Irgm1; Irgm3; IRGs; Lysosomes; Pathogen recognition

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; IFI1 PROTEIN, MOUSE; IGTP PROTEIN, MOUSE; IIGP1 PROTEIN, MOUSE;

ANIMAL; AUTOPHAGY; C57BL MOUSE; CELL LINE; GENE DELETION; GENETICS; IMMUNOLOGY; INFECTION; INNATE IMMUNITY; LYSOSOME; METABOLISM; MOUSE;

ANIMALS; AUTOPHAGY; CELL LINE; GENE DELETION; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; IMMUNITY, INNATE; INFECTION; LYSOSOMES; MICE; MICE, INBRED C57BL;

EID: 84963830521     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/s12915-016-0255-4     Document Type: Article

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