메뉴 건너뛰기




Volumn 191, Issue 4, 2013, Pages 1765-1774

Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GUANOSINE TRIPHOSPHATASE; IRGM1 PROTEIN; ISOPROTEIN; UNCLASSIFIED DRUG;

EID: 84881452463     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300641     Document Type: Article
Times cited : (33)

References (45)
  • 2
    • 84860258296 scopus 로고    scopus 로고
    • Interferon-inducible effector mechanisms in cellautonomous immunity
    • MacMicking, J. D. 2012. Interferon-inducible effector mechanisms in cellautonomous immunity. Nat. Rev. Immunol. 12: 367-382.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 367-382
    • MacMicking, J.D.1
  • 3
    • 79951552359 scopus 로고    scopus 로고
    • The immunity-related GTPases in mammals: A fast-evolving cell-autonomous resistance system against intracellular pathogens
    • Hunn, J. P., C. G. Feng, A. Sher, and J. C. Howard. 2011. The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens. Mamm. Genome 22: 43-54.
    • (2011) Mamm. Genome , vol.22 , pp. 43-54
    • Hunn, J.P.1    Feng, C.G.2    Sher, A.3    Howard, J.C.4
  • 4
    • 1142298755 scopus 로고    scopus 로고
    • P47 GTPases: Regulators of immunity to intracellular pathogens
    • Taylor, G. A., C. G. Feng, and A. Sher. 2004. p47 GTPases: regulators of immunity to intracellular pathogens. Nat. Rev. Immunol. 4: 100-109.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 100-109
    • Taylor, G.A.1    Feng, C.G.2    Sher, A.3
  • 8
    • 65449163019 scopus 로고    scopus 로고
    • Virulent Toxoplasma gondii evade immunity-related GTPasemediated parasite vacuole disruption within primed macrophages
    • Zhao, Y., D. J. Ferguson, D. C. Wilson, J. C. Howard, L. D. Sibley, and G. S. Yap. 2009. Virulent Toxoplasma gondii evade immunity-related GTPasemediated parasite vacuole disruption within primed macrophages. J. Immunol. 182: 3775-3781.
    • (2009) J. Immunol. , vol.182 , pp. 3775-3781
    • Zhao, Y.1    Ferguson, D.J.2    Wilson, D.C.3    Howard, J.C.4    Sibley, L.D.5    Yap, G.S.6
  • 11
    • 33748444233 scopus 로고    scopus 로고
    • Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages
    • Ling, Y. M., M. H. Shaw, C. Ayala, I. Coppens, G. A. Taylor, D. J. Ferguson, and G. S. Yap. 2006. Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J. Exp. Med. 203: 2063-2071.
    • (2006) J. Exp. Med. , vol.203 , pp. 2063-2071
    • Ling, Y.M.1    Shaw, M.H.2    Ayala, C.3    Coppens, I.4    Taylor, G.A.5    Ferguson, D.J.6    Yap, G.S.7
  • 12
    • 61449117883 scopus 로고    scopus 로고
    • Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunityrelated GTPases (IRG proteins) triggers necrotic cell death
    • Zhao, Y. O., A. Khaminets, J. P. Hunn, and J. C. Howard. 2009. Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunityrelated GTPases (IRG proteins) triggers necrotic cell death. PLoS Pathog. 5: e1000288.
    • (2009) PLoS Pathog. , vol.5
    • Zhao, Y.O.1    Khaminets, A.2    Hunn, J.P.3    Howard, J.C.4
  • 14
    • 0035898464 scopus 로고    scopus 로고
    • Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection
    • Collazo, C. M., G. S. Yap, G. D. Sempowski, K. C. Lusby, L. Tessarollo, G. F. Vande Woude, A. Sher, and G. A. Taylor. 2001. Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J. Exp. Med. 194: 181-188.
    • (2001) J. Exp. Med. , vol.194 , pp. 181-188
    • Collazo, C.M.1    Yap, G.S.2    Sempowski, G.D.3    Lusby, K.C.4    Tessarollo, L.5    Vande Woude, G.F.6    Sher, A.7    Taylor, G.A.8
  • 15
    • 29144436298 scopus 로고    scopus 로고
    • Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. [Published erratum appears in 2006 J. Immunol. 176: 3840.]
    • Santiago, H. C., C. G. Feng, A. Bafica, E. Roffe, R. M. Arantes, A. Cheever, G. Taylor, L. Q. Vieira, J. Aliberti, R. T. Gazzinelli, and A. Sher. 2005. Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. [Published erratum appears in 2006 J. Immunol. 176: 3840.] J. Immunol. 175: 8165-8172.
    • (2005) J. Immunol. , vol.175 , pp. 8165-8172
    • Santiago, H.C.1    Feng, C.G.2    Bafica, A.3    Roffe, E.4    Arantes, R.M.5    Cheever, A.6    Taylor, G.7    Vieira, L.Q.8    Aliberti, J.9    Gazzinelli, R.T.10    Sher, A.11
  • 16
    • 0142240338 scopus 로고    scopus 로고
    • Immune control of tuberculosis by IFN-gamma-inducible LRG-47
    • MacMicking, J. D., G. A. Taylor, and J. D. McKinney. 2003. Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 302: 654-659.
    • (2003) Science , vol.302 , pp. 654-659
    • MacMicking, J.D.1    Taylor, G.A.2    McKinney, J.D.3
  • 17
    • 1142292747 scopus 로고    scopus 로고
    • Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia
    • Feng, C. G., C. M. Collazo-Custodio, M. Eckhaus, S. Hieny, Y. Belkaid, K. Elkins, D. Jankovic, G. A. Taylor, and A. Sher. 2004. Mice deficient in LRG- 47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. J. Immunol. 172: 1163-1168.
    • (2004) J. Immunol. , vol.172 , pp. 1163-1168
    • Feng, C.G.1    Collazo-Custodio, C.M.2    Eckhaus, M.3    Hieny, S.4    Belkaid, Y.5    Elkins, K.6    Jankovic, D.7    Taylor, G.A.8    Sher, A.9
  • 21
    • 79959228478 scopus 로고    scopus 로고
    • The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens
    • Liesenfeld, O., I. Parvanova, J. Zerrahn, S. J. Han, F. Heinrich, M. Muñoz, F. Kaiser, T. Aebischer, T. Buch, A. Waisman, et al 2011. The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens. PLoS ONE 6: e20568.
    • (2011) PLoS ONE , vol.6
    • Liesenfeld, O.1    Parvanova, I.2    Zerrahn, J.3    Han, S.J.4    Heinrich, F.5    Muñoz, M.6    Kaiser, F.7    Aebischer, T.8    Buch, T.9    Waisman, A.10
  • 24
    • 79959853767 scopus 로고    scopus 로고
    • Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections
    • Coers, J., D. C. Gondek, A. J. Olive, A. Rohlfing, G. A. Taylor, and M. N. Starnbach. 2011. Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. PLoS Pathog. 7: e1001346.
    • (2011) PLoS Pathog. , vol.7
    • Coers, J.1    Gondek, D.C.2    Olive, A.J.3    Rohlfing, A.4    Taylor, G.A.5    Starnbach, M.N.6
  • 25
    • 13444310671 scopus 로고    scopus 로고
    • Immune control of phagosomal bacteria by p47 GTPases
    • MacMicking, J. D. 2005. Immune control of phagosomal bacteria by p47 GTPases. Curr. Opin. Microbiol. 8: 74-82.
    • (2005) Curr. Opin. Microbiol. , vol.8 , pp. 74-82
    • MacMicking, J.D.1
  • 26
    • 61649097480 scopus 로고    scopus 로고
    • Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy
    • Feng, C. G., L. Zheng, M. J. Lenardo, and A. Sher. 2009. Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy. Autophagy 5: 232-234.
    • (2009) Autophagy , vol.5 , pp. 232-234
    • Feng, C.G.1    Zheng, L.2    Lenardo, M.J.3    Sher, A.4
  • 27
    • 77957687715 scopus 로고    scopus 로고
    • The mouse resistance protein Irgm1 (LRG- 47): A regulator or an effector of pathogen defense?
    • Hunn, J. P., and J. C. Howard. 2010. The mouse resistance protein Irgm1 (LRG- 47): a regulator or an effector of pathogen defense? PLoS Pathog. 6: e1001008.
    • (2010) PLoS Pathog. , vol.6
    • Hunn, J.P.1    Howard, J.C.2
  • 28
    • 36749064729 scopus 로고    scopus 로고
    • Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases)
    • Taylor, G. A., C. G. Feng, and A. Sher. 2007. Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases). Microbes Infect. 9: 1644-1651.
    • (2007) Microbes Infect. , vol.9 , pp. 1644-1651
    • Taylor, G.A.1    Feng, C.G.2    Sher, A.3
  • 29
    • 37049020693 scopus 로고    scopus 로고
    • Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families
    • Shenoy, A. R., B. H. Kim, H. P. Choi, T. Matsuzawa, S. Tiwari, and J. D. MacMicking. 2007. Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families. Immunobiology 212: 771-784.
    • (2007) Immunobiology , vol.212 , pp. 771-784
    • Shenoy, A.R.1    Kim, B.H.2    Choi, H.P.3    Matsuzawa, T.4    Tiwari, S.5    MacMicking, J.D.6
  • 30
    • 67651174262 scopus 로고    scopus 로고
    • Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria
    • Tiwari, S., H. P. Choi, T. Matsuzawa, M. Pypaert, and J. D. MacMicking. 2009. Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Nat. Immunol. 10: 907-917.
    • (2009) Nat. Immunol. , vol.10 , pp. 907-917
    • Tiwari, S.1    Choi, H.P.2    Matsuzawa, T.3    Pypaert, M.4    MacMicking, J.D.5
  • 31
    • 4043065683 scopus 로고    scopus 로고
    • Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG- 47 and IIGP1 on cellular membranes: Retargeting to plasma membrane induced by phagocytosis
    • Martens, S., K. Sabel, R. Lange, R. Uthaiah, E. Wolf, and J. C. Howard. 2004. Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG- 47 and IIGP1 on cellular membranes: retargeting to plasma membrane induced by phagocytosis. J. Immunol. 173: 2594-2606.
    • (2004) J. Immunol. , vol.173 , pp. 2594-2606
    • Martens, S.1    Sabel, K.2    Lange, R.3    Uthaiah, R.4    Wolf, E.5    Howard, J.C.6
  • 32
    • 10944253145 scopus 로고    scopus 로고
    • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    • Gutierrez, M. G., S. S. Master, S. B. Singh, G. A. Taylor, M. I. Colombo, and V. Deretic. 2004. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119: 753-766.
    • (2004) Cell , vol.119 , pp. 753-766
    • Gutierrez, M.G.1    Master, S.S.2    Singh, S.B.3    Taylor, G.A.4    Colombo, M.I.5    Deretic, V.6
  • 33
    • 33748506089 scopus 로고    scopus 로고
    • Human IRGM induces autophagy to eliminate intracellular mycobacteria
    • Singh, S. B., A. S. Davis, G. A. Taylor, and V. Deretic. 2006. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313: 1438-1441.
    • (2006) Science , vol.313 , pp. 1438-1441
    • Singh, S.B.1    Davis, A.S.2    Taylor, G.A.3    Deretic, V.4
  • 34
    • 77952304848 scopus 로고    scopus 로고
    • Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells
    • Xu, H., Z. Y. Wu, F. Fang, L. Guo, D. Chen, J. X. Chen, D. Stern, G. A. Taylor, H. Jiang, and S. S. Yan. 2010. Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. FASEB J. 24: 1583-1592.
    • (2010) FASEB J. , vol.24 , pp. 1583-1592
    • Xu, H.1    Wu, Z.Y.2    Fang, F.3    Guo, L.4    Chen, D.5    Chen, J.X.6    Stern, D.7    Taylor, G.A.8    Jiang, H.9    Yan, S.S.10
  • 35
    • 37549048915 scopus 로고    scopus 로고
    • The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation
    • Feng, C. G., D. C. Weksberg, G. A. Taylor, A. Sher, and M. A. Goodell. 2008. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell 2: 83-89.
    • (2008) Cell Stem Cell , vol.2 , pp. 83-89
    • Feng, C.G.1    Weksberg, D.C.2    Taylor, G.A.3    Sher, A.4    Goodell, M.A.5
  • 37
    • 77649258180 scopus 로고    scopus 로고
    • Localisation and mislocalisation of the interferon-inducible immunityrelated GTPase, Irgm1 (LRG-47) in mouse cells
    • Zhao, Y. O., S. Könen-Waisman, G. A. Taylor, S. Martens, and J. C. Howard. 2010. Localisation and mislocalisation of the interferon-inducible immunityrelated GTPase, Irgm1 (LRG-47) in mouse cells. PLoS ONE 5: e8648.
    • (2010) PLoS ONE , vol.5
    • Zhao, Y.O.1    Könen-Waisman, S.2    Taylor, G.A.3    Martens, S.4    Howard, J.C.5
  • 39
  • 41
    • 82655189171 scopus 로고    scopus 로고
    • Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption
    • Chang, C. P., M. C. Yang, and H. Y. Lei. 2011. Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption. PLoS ONE 6: e28323.
    • (2011) PLoS ONE , vol.6
    • Chang, C.P.1    Yang, M.C.2    Lei, H.Y.3
  • 42
    • 0030828008 scopus 로고    scopus 로고
    • PHdependent perforation of macrophage phagosomes by listeriolysin O from Listeria monocytogenes
    • Beauregard, K. E., K. D. Lee, R. J. Collier, and J. A. Swanson. 1997. pHdependent perforation of macrophage phagosomes by listeriolysin O from Listeria monocytogenes. J. Exp. Med. 186: 1159-1163.
    • (1997) J. Exp. Med. , vol.186 , pp. 1159-1163
    • Beauregard, K.E.1    Lee, K.D.2    Collier, R.J.3    Swanson, J.A.4
  • 43
    • 34548548443 scopus 로고    scopus 로고
    • Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation. [Published erratum appears in 2007 J. Cell Sci. 120: 3489.]
    • Deghmane, A. E., H. Soualhine, H. Bach, K. Sendide, S. Itoh, A. Tam, S. Noubir, A. Talal, R. Lo, S. Toyoshima, et al. 2007. Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation. [Published erratum appears in 2007 J. Cell Sci. 120: 3489.] J. Cell Sci. 120: 2796-2806.
    • (2007) J. Cell Sci. , vol.120 , pp. 2796-2806
    • Deghmane, A.E.1    Soualhine, H.2    Bach, H.3    Sendide, K.4    Itoh, S.5    Tam, A.6    Noubir, S.7    Talal, A.8    Lo, R.9    Toyoshima, S.10
  • 44
    • 40449137860 scopus 로고    scopus 로고
    • Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha
    • Saban, M. R., M. A. O'Donnell, R. E. Hurst, X. R. Wu, C. Simpson, I. Dozmorov, C. Davis, and R. Saban. 2008. Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha. BMC Immunol. 9: 4.
    • (2008) BMC Immunol. , vol.9 , pp. 4
    • Saban, M.R.1    O'Donnell, M.A.2    Hurst, R.E.3    Wu, X.R.4    Simpson, C.5    Dozmorov, I.6    Davis, C.7    Saban, R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.