Self and Non-self Discrimination of Intracellular Membranes by the Innate Immune System

PLoS Pathogens

Volumn 9, Issue 9, 2013, Pages

  Coers, Jörn ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DNA BINDING PROTEIN; GALECTIN; LIPOPOLYSACCHARIDE; PATTERN RECOGNITION RECEPTOR; UBIQUITIN PROTEIN LIGASE E3; GUANOSINE TRIPHOSPHATASE; GVINP1 PROTEIN, HUMAN; LIGAND; LRSAM1 PROTEIN, HUMAN; NUCLEAR PROTEIN; POLYSACCHARIDE; UBIQUITIN PROTEIN LIGASE;

ANTIGEN RECOGNITION; ARTICLE; AUTOPHAGY; HUMAN; IMMUNOSURVEILLANCE; INNATE IMMUNITY; LEGIONELLA PNEUMOPHILA; NONHUMAN; SALMONELLA TYPHIMURIUM; UBIQUITINATION; ANIMAL; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BIOLOGICAL MODEL; COMPARATIVE STUDY; ENZYMOLOGY; IMMUNOLOGY; INTRACELLULAR MEMBRANE; METABOLISM; PHAGOCYTOSIS; PROTEIN MOTIF;

AMINO ACID MOTIFS; ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; AUTOPHAGY; GALECTINS; GTP PHOSPHOHYDROLASES; HUMANS; IMMUNITY, INNATE; INTRACELLULAR MEMBRANES; LIGANDS; MODELS, IMMUNOLOGICAL; NUCLEAR PROTEINS; PHAGOCYTOSIS; POLYSACCHARIDES; RECEPTORS, PATTERN RECOGNITION; UBIQUITIN-PROTEIN LIGASES;

EID: 84884688909     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003538     Document Type: Article

References (31)

1. Akira S, Uematsu S, Takeuchi O, (2006) Pathogen recognition and innate immunity. Cell 124: 783-801.
2. Janeway CA Jr, (1989) Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 54 Pt 1: 1-13.
3. Medzhitov R, Janeway CA Jr, (2002) Decoding the patterns of self and nonself by the innate immune system. Science 296: 298-300.
4. Vance RE, Isberg RR, Portnoy DA, (2009) Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe 6: 10-21.
5. Santaolalla R, Fukata M, Abreu MT, (2011) Innate immunity in the small intestine. Curr Opin Gastroenterol 27: 125-131.
6. Rock KL, Lai JJ, Kono H, (2011) Innate and adaptive immune responses to cell death. Immunol Rev 243: 191-205.
7. Chen GY, Nunez G, (2010) Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 10: 826-837.
8. Cemma M, Brumell JH, (2012) Interactions of pathogenic bacteria with autophagy systems. Curr Biol 22: R540-545.
9. Kumar Y, Valdivia RH, (2009) Leading a sheltered life: intracellular pathogens and maintenance of vacuolar compartments. Cell Host Microbe 5: 593-601.
10. Deretic V, (2012) Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors. Curr Opin Immunol 24: 21-31.
11. Stuart LM, Ezekowitz RA, (2005) Phagocytosis: elegant complexity. Immunity 22: 539-550.
12. Sumpter R Jr, Levine B, (2010) Autophagy and innate immunity: triggering, targeting and tuning. Semin Cell Dev Biol 21: 699-711.
13. MacMicking JD, (2012) Interferon-inducible effector mechanisms in cell-autonomous immunity. Nat Rev Immunol 12: 367-382.
14. Komander D, Rape M, (2012) The ubiquitin code. Annu Rev Biochem 81: 203-229.
15. Perrin AJ, Jiang X, Birmingham CL, So NS, Brumell JH, (2004) Recognition of bacteria in the cytosol of mammalian cells by the ubiquitin system. Curr Biol 14: 806-811.
16. Huett A, Heath RJ, Begun J, Sassi SO, Baxt LA, et al. (2012) The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium. Cell Host Microbe 12: 778-790.
17. Ng AC, Eisenberg JM, Heath RJ, Huett A, Robinson CM, et al. (2011) Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity. Proc Natl Acad Sci U S A 108 Suppl 1: 4631-4638.
18. Thurston TL, Wandel MP, von Muhlinen N, Foeglein A, Randow F, (2012) Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature 482: 414-418.
19. Vasta GR, (2012) Galectins as pattern recognition receptors: structure, function, and evolution. Adv Exp Med Biol 946: 21-36.
20. Dupont N, Lacas-Gervais S, Bertout J, Paz I, Freche B, et al. (2009) Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 6: 137-149.
21. Paz I, Sachse M, Dupont N, Mounier J, Cederfur C, et al. (2010) Galectin-3, a marker for vacuole lysis by invasive pathogens. Cell Microbiol 12: 530-544.
22. Beuzon CR, Meresse S, Unsworth KE, Ruiz-Albert J, Garvis S, et al. (2000) Salmonella maintains the integrity of its intracellular vacuole through the action of SifA. EMBO J 19: 3235-3249.
23. Creasey EA, Isberg RR, (2012) The protein SdhA maintains the integrity of the Legionella-containing vacuole. Proc Natl Acad Sci U S A 109: 3481-3486.
24. Kumar Y, Valdivia RH, (2008) Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. Cell Host Microbe 4: 159-169.
25. Haldar AK, Saka HA, Piro AS, Dunn JD, Henry SC, et al. (2013) IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins. PLoS Pathog 9: e1003414 doi:10.1371/journal.ppat.1003414.
26. Howard JC, Hunn JP, Steinfeldt T, (2011) The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii. Curr Opin Microbiol 14: 414-421.
27. Coers J, Bernstein-Hanley I, Grotsky D, Parvanova I, Howard JC, et al. (2008) Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. J Immunol 180: 6237-6245.
28. Martens S, Parvanova I, Zerrahn J, Griffiths G, Schell G, et al. (2005) Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases. PLoS Pathog 1: e24 doi:10.1371/journal.ppat.0010024.
29. Al-Zeer MA, Al-Younes HM, Braun PR, Zerrahn J, Meyer TF, (2009) IFN-γ-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagy. PLoS ONE 4: e4588 doi:10.1371/journal.pone.0004588.
30. Ling YM, Shaw MH, Ayala C, Coppens I, Taylor GA, et al. (2006) Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med 203: 2063-2071.
31. Hunn JP, Koenen-Waisman S, Papic N, Schroeder N, Pawlowski N, et al. (2008) Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii. EMBO J 27: 2495-2509.