Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors

Neurobiology of Disease

Volumn 91, Issue , 2016, Pages 326-335

  Pitts, Elizabeth G ^a   Taylor, Jane R ^b   Gourley, Shannon L ^a,c  

^a EMORY UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Addiction; Goal directed; Instrumental; Operant; Orbitofrontal; Prelimbic; Review

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; COCAINE;

BRAIN NERVE CELL; CELL STRUCTURE; DECISION MAKING; DRUG SEEKING BEHAVIOR; FEEDING BEHAVIOR; HABIT; HUMAN; LOCOMOTION; NERVE CELL NETWORK; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; REINFORCEMENT; REVIEW; REWARD; SENSITIZATION; ANIMAL; DRUG EFFECTS; METABOLISM; NERVE CELL PLASTICITY; PHYSIOLOGY;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; COCAINE; DECISION MAKING; HUMANS; NEURONAL PLASTICITY; PREFRONTAL CORTEX; REWARD;

EID: 84963755447     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2016.02.021     Document Type: Review

References (141)

1. Ahmari S.E., Spellman T., Douglass N.L., Kheirbek M.A., Simpson H.B., Deisseroth K., Gordon J.A., Hen R. Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science 2013, 340(6137):1234-1239. 10.1126/science.1234733.
2. Altar C.A., Cai N., Bliven T., Juhasz M., Conner J.M., Acheson A.L., Lindsay R.M., Wiegand S.J. Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature 1997, 389(6653):856-860. 10.1038/39885.
3. Atwal J.K., Massie B., Miller F.D., Kaplan D.R. The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Neuron 2000, 27(2):265-277.
4. Autry A.E., Monteggia L.M. Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol. Rev. 2012, 64(2):238-258. 10.1124/pr.111.005108.
5. Balleine B.W., O'Doherty J.P. Human and rodent homologies in action control: corticostriatal determinants of goal-directed and habitual action. Neuropsychopharmacology 2010, 35(1):48-69. 10.1038/npp.2009.131.
6. Banner H., Bhat V., Etchamendy N., Joober R., Bohbot V.D. The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task. Eur. J. Neurol. 2011, 33(5):968-977. 10.1111/j. 1460-9568.2010.07550.x.
7. Barker J.M., Taylor J.R., De Vries T.J., Peters J. Brain-derived neurotrophic factor and addiction: pathological versus therapeutic effects on drug seeking. Brain Res. 2014, 10.1016/j.brainres.2014.10.058.
8. Berglind W.J., See R.E., Fuchs R.A., Ghee S.M., Whitfield T.W., Miller S.W., McGinty J.F. A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats. Eur. J. Neurol. 2007, 26(3):757-766. 10.1111/j.1460-9568.2007.05692.x.
9. Berglind W.J., Whitfield T.W., LaLumiere R.T., Kalivas P.W., McGinty J.F. A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens. J. Neurosci. 2009, 29(12):3715-3719. 10.1523/jneurosci.5457-08.2009.
10. Binder D.K., Scharfman H.E. Brain-derived neurotrophic factor. Growth Factors 2004, 22(3):123-131.
11. Bradfield L.A., Dezfouli A., van Holstein M., Chieng B., Balleine B.W. Medial orbitofrontal cortex mediates outcome retrieval in partially observable task situations. Neuron 2015, 88(6):1268-1280. 10.1016/j.neuron.2015.10.044.
12. Butkovich L.M., DePoy L.M., Allen A.G., Shapiro L.P., Swanson A.M., Gourley S.L. Adolescent-onset GABA alpha1 silencing regulates reward-related decision making. Eur J Neurosci. 2015, 10.1111/ejn.12995.
13. Cheng C.Y., Hong C.J., Yu Y.W., Chen T.J., Wu H.C., Tsai S.J. Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. Brain Res. Mol. Brain Res. 2005, 140(1-2):86-90. 10.1016/j.molbrainres.2005.07.008.
14. Choi D.C., Gourley S.L., Ressler K.J. Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning. Transl Psychiatry 2012, 2. 10.1038/tp.2012.128.
15. Corbit L.H., Chieng B.C., Balleine B.W. Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine. Neuropsychopharmacology 2014, 39(8):1893-1901. 10.1038/npp.2014.37.
16. Corominas-Roso M., Roncero C., Eiroa-Orosa F.J., Gonzalvo B., Grau-Lopez L., Ribases M., Casas M. Brain-derived neurotrophic factor serum levels in cocaine-dependent patients during early abstinence. Eur. Neuropsychopharmacol. 2013, 23(9):1078-1084. 10.1016/j.euroneuro.2012.08.016.
17. Corominas-Roso M., Roncero C., Eiroa-Orosa F.J., Ribases M., Barral C., Daigre C., Casas M. Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms. Neuropsychobiology 2013, 68(3):146-155. 10.1159/000353259.
18. Corominas-Roso M., Roncero C., Daigre C., Grau-Lopez L., Ros-Cucurull E., Rodríguez-Cintas L., Casas M. Changes in brain-derived neurotrophic factor (BDNF) during abstinence could be associated with relapse in cocaine-dependent patients. Psychiatry Res. 2015, 225(3):309-314. 10.1016/j.psychres.2014.12.019.
19. DePoy L.M., Gourley S.L. Synaptic cytoskeletal plasticity in the prefrontal cortex following psychostimulant exposure. Traffic 2015, 10.1111/tra.12295.
20. DePoy L.M., Noble B., Allen A.G., Gourley S.L. Developmentally divergent effects of rho-kinase inhibition on cocaine- and BDNF-induced behavioral plasticity. Behav. Brain Res. 2013, 243:171-175. 10.1016/j.bbr.2013.01.004.
21. DePoy L.M., Perszyk R.E., Zimmermann K.S., Koleske A.J., Gourley S.L. Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors. Front. Pharmacol. 2014, 5:228. 10.3389/fphar.2014.00228.
22. DePoy L.M., Allen A.G., Gourley S.L. Adolescent cocaine self-administration induces habit behavior in adulthood: Sex differences and structural consequences 2016, (in review).
23. Dias-Ferreira E., Sousa J.C., Melo I., Morgado P., Mesquita A.R., Cerqueira J.J., Costa R.M., Sousa N. Chronic stress causes frontostriatal reorganization and affects decision-making. Science 2009, 325(5940):621-625. 10.1126/science.1171203.
24. Dong Y., Nestler E.J. The neural rejuvenation hypothesis of cocaine addiction. Trends Pharmacol. Sci. 2014, 35(8):374-383. 10.1016/j.tips.2014.05.005.
25. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., Zaitsev E., Gold B., Goldman D., Dean M., Lu B., Weinberger D.R. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112(2):257-269.
26. Everitt B.J. Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories - indications for novel treatments of addiction. Eur. J. Neurol. 2014, 40(1):2163-2182. 10.1111/ejn.12644.
27. Everitt B.J., Robbins T.W. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 2005, 8(11):1481-1489. 10.1038/nn1579.
28. Ferrario C.R., Gorny G., Crombag H.S., Li Y., Kolb B., Robinson T.E. Neural and behavioral plasticity associated with the transition from controlled to escalated cocaine use. Biol. Psychiatry 2005, 58(9):751-759. 10.1016/j.biopsych.2005.04.046.
29. Fuchs R.A., Evans K.A., Parker M.P., See R.E. Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats. J. Neurosci. 2004, 24(29):6600-6610. 10.1523/jneurosci.1924-04.2004.
30. Fumagalli F., Di Pasquale L., Caffino L., Racagni G., Riva M.A. Repeated exposure to cocaine differently modulates BDNF mRNA and protein levels in rat striatum and prefrontal cortex. Eur. J. Neurol. 2007, 26(10):2756-2763. 10.1111/j.1460-9568.2007.05918.x.
31. Fumagalli F., Caffino L., Racagni G., Riva M.A. Repeated stress prevents cocaine-induced activation of BDNF signaling in rat prefrontal cortex. Eur. Neuropsychopharmacol. 2009, 19(6):402-408. 10.1016/j.euroneuro.2009.01.003.
32. Fumagalli F., Moro F., Caffino L., Orru A., Cassina C., Giannotti G., Di Celmente A., Racagni G., Riva M.A., Cervo L. Region-specific effects on BDNF expression after contingent or non-contingent cocaine i.v. self-administration in rats. Int. J. Neuropsychopharmacol. 2013, 16(4):913-918. 10.1017/s146114571200096x.
33. Gabbott P.L., Warner T.A., Busby S.J. Amygdala input monosynaptically innervates parvalbumin immunoreactive local circuit neurons in rat medial prefrontal cortex. Neuroscience 2006, 139(3):1039-1048. 10.1016/j.neuroscience.2006.01.026.
34. Gabriele A., Setlow B., Packard M.G. Cocaine self-administration alters the relative effectiveness of multiple memory systems during extinction. Learn. Mem. 2009, 16(5):296-299. 10.1101/lm.1253409.
35. Ghitza U.E., Zhai H., Wu P., Airavaara M., Shaham Y., Lu L. Role of BDNF and GDNF in drug reward and relapse: a review. Neurosci. Biobehav. Rev. 2010, 35(2):157-171. 10.1016/j.neubiorev.2009.11.009.
36. Giannotti G., Caffino L., Calabrese F., Racagni G., Riva M.A., Fumagalli F. Prolonged abstinence from developmental cocaine exposure dysregulates BDNF and its signaling network in the medial prefrontal cortex of adult rats. Int. J. Neuropsychopharmacol. 2014, 17(4):625-634. 10.1017/s1461145713001454.
37. Gipson C.D., Kupchik Y.M., Shen H., Reissner K.J., Thomas C.A., Kalivas P.W. Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation. Neuron 2013, 77(5):867-872. 10.1016/j.neuron.2013.01.005.
38. Gourley S.L., Howell J.L., Rios M., DiLeone R.J., Taylor J.R. Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. Learn. Mem. 2009, 16(12):756-760. 10.1101/lm.1547909.
39. Gourley S.L., Koleske A.J., Taylor J.R. Loss of dendrite stabilization by the abl-related gene (arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(39):16859-16864. 10.1073/pnas.0902286106.
40. Gourley S.L., Lee A.S., Howell J.L., Pittenger C., Taylor J.R. Dissociable regulation of instrumental action within mouse prefrontal cortex. Eur. J. Neurol. 2010, 32(10):1726-1734. 10.1111/j.1460-9568.2010.07438.x.
41. Gourley S.L., Swanson A.M., Jacobs A.M., Howell J.L., Mo M., Dileone R.J., Koleske A.J., Taylor J.R. Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Proc. Natl. Acad. Sci. U. S. A. 2012, 109(50):20714-20719. 10.1073/pnas.1208342109.
42. Gourley S.L., Olevska A., Warren M.S., Taylor J.R., Koleske A.J. Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity. J. Neurosci. 2012, 32(7):2314-2323. 10.1523/jneurosci.2730-11.2012.
43. Gourley S.L., Olevska A., Zimmermann K.S., Ressler K.J., Dileone R.J., Taylor J.R. The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum. Eur. J. Neurol. 2013, 38(3):2382-2388. 10.1111/ejn.12239.
44. Gourley S.L., Swanson A.M., Koleske A.J. Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience. J. Neurosci. 2013, 33(7):3107-3112. 10.1523/jneurosci.2138-12.2013.
45. Graybeal C., Feyder M., Schulman E., Saksida L.M., Bussey T.J., Brigman J.L., Holmes A. Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF. Nat. Neurosci. 2011, 14(12):1507-1509. 10.1038/nn.2954.
46. Gremel C.M., Costa R.M. Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions. Nat. Commun. 2013, 4:2264. 10.1038/ncomms3264.
47. Grimm J.W., Lu L., Hayashi T., Hope B.T., Su T.P., Shaham Y. Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J. Neurosci. 2003, 23(3):742-747.
48. Gross C., Raj N., Molinaro G., Allen A.G., Whyte A.J., Gibson J.R., Bassell G.J. Selective role of the catalytic PI3K subunit p110beta in impaired higher order cognition in fragile X syndrome. Cell Rep 2015, 11(5):681-688. 10.1016/j.celrep.2015.03.065.
49. Hearing M.C., Miller S.W., See R.E., McGinty J.F. Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats. Psychopharmacology 2008, 198(1):77-91. 10.1007/s00213-008-1090-2.
50. Heidbreder C.A., Groenewegen H.J. The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics. Neurosci. Biobehav. Rev. 2003, 27(6):555-579.
51. Heldt S.A., Zimmermann K., Parker K., Gaval M., Weinshenker D., Ressler K.J. BDNF deletion or TrkB impairment in amygdala inhibits both appetitive and aversive learning. J. Neurosci. 2014, 34(7):2444-2450. 10.1523/jneurosci.4085-12.2014.
52. Hinton E.A., Wheeler M.G., Gourley S.L. Early-life cocaine interferes with BDNF-mediated behavioral plasticity. Learn. Mem. 2014, 21(5):253-257. 10.1101/lm.033290.113.
53. Hoover W.B., Vertes R.P. Projections of the medial orbital and ventral orbital cortex in the rat. J. Comp. Neurol. 2011, 519(18):3766-3801. 10.1002/cne.22733.
54. Horger B.A., Iyasere C.A., Berhow M.T., Messer C.J., Nestler E.J., Taylor J.R. Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor. J. Neurosci. 1999, 19(10):4110-4122.
55. Huang E.J., Reichardt L.F. Trk receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 2003, 72:609-642. 10.1146/annurev.biochem.72.121801.161629.
56. Hyman S.E., Malenka R.C., Nestler E.J. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu. Rev. Neurosci. 2006, 29:565-598. 10.1146/annurev.neuro.29.051605.113009.
57. Jang S.W., Liu X., Yepes M., Shepherd K.R., Miller G.W., Liu Y., Wilson W.D., Xiao G., Blanchi B., Sun Y.E., Ye K. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(6):2687-2692. 10.1073/pnas.0913572107.
58. Jay T.M., Witter M.P. Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin. J. Comp. Neurol. 1991, 313(4):574-586. 10.1002/cne.903130404.
59. Jentsch J.D., Taylor J.R. Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology 1999, 146(4):373-390.
60. Kabir Z.D., Katzman A.C., Kosofsky B.E. Molecular mechanisms mediating a deficit in recall of fear extinction in adult mice exposed to cocaine in utero. PLoS One 2013, 8(12). 10.1371/journal.pone.0084165.
61. Kalivas P.W. The glutamate homeostasis hypothesis of addiction. Nat. Rev. Neurosci. 2009, 10(8):561-572. 10.1038/nrn2515.
62. Kolb B., Muhammad A. Harnessing the power of neuroplasticity for intervention. Front. Hum. Neurosci. 2014, 8:377. 10.3389/fnhum.2014.00377.
63. Le Foll B., Diaz J., Sokoloff P. A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning. Neuroreport 2005, 16(2):175-178.
64. LeBlanc K.H., Maidment N.T., Ostlund S.B. Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats. PLoS One 2013, 8(4). 10.1371/journal.pone.0061355.
65. Li X., Wolf M.E. Multiple faces of BDNF in cocaine addiction. Behav. Brain Res. 2015, 279:240-254. 10.1016/j.bbr.2014.11.018.
66. Li X., DeJoseph M.R., Urban J.H., Bahi A., Dreyer J.L., Meredith G.E., Ford K.A., Ferrario C.R., Loweth J.A., Wolf M.E. Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance. J. Neurosci. 2013, 33(3):1130-1142. 10.1523/jneurosci.3082-12.2013.
67. Liu Q.R., Lu L., Zhu X.G., Gong J.P., Shaham Y., Uhl G.R. Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res. 2006, 1067(1):1-12. 10.1016/j.brainres.2005.10.004.
68. Logrip M.L., Barak S., Warnault V., Ron D. Corticostriatal BDNF and alcohol addiction. Brain Res. 2015, 10.1016/j.brainres.2015.03.025.
69. Lu Y., Christian K., Lu B. BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?. Neurobiol. Learn. Mem. 2008, 89(3):312-323. 10.1016/j.nlm.2007.08.018.
70. Lu H., Cheng P.L., Lim B.K., Khoshnevisrad N., Poo M.M. Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition. Neuron 2010, 67(5):821-833. 10.1016/j.neuron.2010.08.012.
71. Lu B., Nagappan G., Lu Y. BDNF and synaptic plasticity, cognitive function, and dysfunction. Handb. Exp. Pharmacol. 2014, 220:223-250. 10.1007/978-3-642-45106-5_9.
72. Lucantonio F., Stalnaker T.A., Shaham Y., Niv Y., Schoenbaum G. The impact of orbitofrontal dysfunction on cocaine addiction. Nat. Neurosci. 2012, 15(3):358-366. 10.1038/nn.3014.
73. Macenski M.J., Meisch R.A. Ratio size and cocaine concentration effects on oral cocaine-reinforced behavior. J. Exp. Anal. Behav. 1998, 70(2):185-201. 10.1901/jeab.1998.70-185.
74. Marchant N.J., Li X., Shaham Y. Recent developments in animal models of drug relapse. Curr. Opin. Neurobiol. 2013, 23(4):675-683. 10.1016/j.conb.2013.01.003.
75. Mátyás F., Lee J., Shin H.S., Acsady L. The fear circuit of the mouse forebrain: connections between the mediodorsal thalamus, frontal cortices and basolateral amygdala. Eur. J. Neurol. 2014, 39(11):1810-1823. 10.1111/ejn.12610.
76. McDonald A.J. Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat. Neuroscience 1991, 44(1):1-14.
77. McDonald A.J., Mascagni F., Guo L. Projections of the medial and lateral prefrontal cortices to the amygdala: a Phaseolus vulgaris leucoagglutinin study in the rat. Neuroscience 1996, 71(1):55-75.
78. McGinty J.F., Whitfield T.W., Berglind W.J. Brain-derived neurotrophic factor and cocaine addiction. Brain Res. 2010, 1314:183-193. 10.1016/j.brainres.2009.08.078.
79. Miles F.J., Everitt B.J., Dickinson A. Oral cocaine seeking by rats: action or habit?. Behav. Neurosci. 2003, 117(5):927-938. 10.1037/0735-7044.117.5.927.
80. Miller T.R., Hendrie D. Substance abuse dollars and cents: a cost-benefit analysis (DHHS publication no. (SMA) 07-4298) 2008, Center for Substance Abuse Prevention, Substance Abuse and Mental Health Services Administration, Rockville, MD.
81. Moorman D.E., James M.H., McGlinchey E.M., Aston-Jones G. Differential roles of medial prefrontal subregions in the regulation of drug seeking. Brain Res. 2014, 10.1016/j.brainres.2014.12.024.
82. Morecraft R.J., Geula C., Mesulam M.M. Cytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkey. J. Comp. Neurol. 1992, 323(3):341-358. 10.1002/cne.903230304.
83. Morrow J.D., Saunders B.T., Maren S., Robinson T.E. Sign-tracking to an appetitive cue predicts incubation of conditioned fear in rats. Behav. Brain Res. 2015, 276:59-66. 10.1016/j.bbr.2014.04.002.
84. Nelson A., Killcross S. Amphetamine exposure enhances habit formation. J. Neurosci. 2006, 26(14):3805-3812. 10.1523/jneurosci.4305-05.2006.
85. Nelson A.J., Killcross S. Accelerated habit formation following amphetamine exposure is reversed by D1, but enhanced by D2, receptor antagonists. Front. Neurosci. 2013, 7:76. 10.3389/fnins.2013.00076.
86. Nordquist R.E., Voorn P., de Mooij-van Malsen J.G., Joosten R.N., Pennartz C.M., Vanderschuren L.J. Augmented reinforcer value and accelerated habit formation after repeated amphetamine treatment. Eur. Neuropsychopharmacol. 2007, 17(8):532-540. 10.1016/j.euroneuro.2006.12.005.
87. Ongur D., Price J.L. The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cereb. Cortex 2000, 10(3):206-219.
88. Ostlund S.B., Balleine B.W. Orbitofrontal cortex mediates outcome encoding in Pavlovian but not instrumental conditioning. J. Neurosci. 2007, 27(18):4819-4825. 10.1523/jneurosci.5443-06.2007.
89. Otis J.M., Fitzgerald M.K., Mueller D. Infralimbic BDNF/TrkB enhancement of GluN2B currents facilitates extinction of a cocaine-conditioned place preference. J. Neurosci. 2014, 34(17):6057-6064. 10.1523/jneurosci.4980-13.2014.
90. Park H., Poo M.M. Neurotrophin regulation of neural circuit development and function. Nat. Rev. Neurosci. 2013, 14(1):7-23. 10.1038/nrn3379.
91. Peters J., Kalivas P.W., Quirk G.J. Extinction circuits for fear and addiction overlap in prefrontal cortex. Learn. Mem. 2009, 16(5):279-288. 10.1101/lm.1041309.
92. Peterson A.B., Abel J.M., Lynch W.J. Dose-dependent effects of wheel running on cocaine-seeking and prefrontal cortex bdnf exon IV expression in rats. Psychopharmacology 2014, 231(7):1305-1314. 10.1007/s00213-013-3321-4.
93. Pierce R.C., Vanderschuren L.J. Kicking the habit: the neural basis of ingrained behaviors in cocaine addiction. Neurosci. Biobehav. Rev. 2010, 35(2):212-219. 10.1016/j.neubiorev.2010.01.007.
94. Radley J.J., Anderson R.M., Cosme C.V., Glanz R.M., Miller M.C., Romig-Martin S.A., LaLumiere R.T. The contingency of Cocaine Administration accounts for structural and functional medial prefrontal deficits and increased adrenocortical activation. J. Neurosci. 2015, 35(34):11897-11910. 10.1523/jneurosci.4961-14.2015.
95. Rapanelli M., Lew S.E., Frick L.R., Zanutto B.S. Plasticity in the rat prefrontal cortex: linking gene expression and an operant learning with a computational theory. PLoS One 2010, 5(1). 10.1371/journal.pone.0008656.
96. Reichardt L.F. Neurotrophin-regulated signalling pathways. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 2006, 361(1473):1545-1564. 10.1098/rstb.2006.1894.
97. Ren Q., Zhang J.C., Fujita Y., Ma M., Wu J., Hashimoto K. Effects of TrkB agonist 7,8-dihydroxyflavone on sensory gating deficits in mice after administration of methamphetamine. Pharmacol. Biochem. Behav. 2013, 106:124-127. 10.1016/j.pbb.2013.03.016.
98. Ren Q., Zhang J.C., Ma M., Fujita Y., Wu J., Hashimoto K. 7,8-dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine. Psychopharmacology 2014, 231(1):159-166. 10.1007/s00213-013-3221-7.
99. Robbins T.W., Ersche K.D., Everitt B.J. Drug addiction and the memory systems of the brain. Ann. N. Y. Acad. Sci. 2008, 1141:1-21. 10.1196/annals.1441.020.
100. Rodriguez-Romaguera J., Do-Monte F.H., Tanimura Y., Quirk G.J., Haber S.N. Enhancement of fear extinction with deep brain stimulation: evidence for medial orbitofrontal involvement. Neuropsychopharmacology 2015, 40(7):1726-1733. 10.1038/npp.2015.20.
101. Rosen G.D., Williams A.G., Capra J.A., Connolly M.T., Cruz B., Lu L., et al. The Mouse Brain Library 2000, http://www.mbl.org.
102. Russo S.J., Mazei-Robison M.S., Ables J.L., Nestler E.J. Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 2009, 56(Suppl. 1):73-82. 10.1016/j.neuropharm.2008.06.059.
103. Sadri-Vakili G., Kumaresan V., Schmidt H.D., Famous K.R., Chawla P., Vassoler F.M., Overland R.P., Xia E., Bass C.E., Terwilliger E.F., Pierce R.C., Cha J.H. Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. J. Neurosci. 2010, 30(35):11735-11744. 10.1523/jneurosci.2328-10.2010.
104. Saunders B.T., Robinson T.E. A cocaine cue acts as an incentive stimulus in some but not others: implications for addiction. Biol. Psychiatry 2010, 67(8):730-736. 10.1016/j.biopsych.2009.11.015.
105. Saunders B.T., Robinson T.E. Individual variation in the motivational properties of cocaine. Neuropsychopharmacology 2011, 36(8):1668-1676. 10.1038/npp.2011.48.
106. Schilman E.A., Uylings H.B., Galis-de Graaf Y., Joel D., Groenewegen H.J. The orbital cortex in rats topographically projects to central parts of the caudate-putamen complex. Neurosci. Lett. 2008, 432(1):40-45. 10.1016/j.neulet.2007.12.024.
107. Schmidt H.D., McGinty J.F., West A.E., Sadri-Vakili G. Epigenetics and psychostimulant addiction. Cold Spring Harb. Perspect. Med. 2013, 3(3):a012047. 10.1101/cshperspect.a012047.
108. Schmitzer-Torbert N., Apostolidis S., Amoa R., O'Rear C., Kaster M., Stowers J., Ritz R. Post-training cocaine administration facilitates habit learning and requires the infralimbic cortex and dorsolateral striatum. Neurobiol. Learn. Mem. 2015, 118:105-112. 10.1016/j.nlm.2014.11.007.
109. Schoenbaum G., Setlow B. Cocaine makes actions insensitive to outcomes but not extinction: implications for altered orbitofrontal-amygdalar function. Cereb. Cortex 2005, 15(8):1162-1169. 10.1093/cercor/bhh216.
110. Schwabe L. Stress and the engagement of multiple memory systems: integration of animal and human studies. Hippocampus 2013, 23(11):1035-1043. 10.1002/hipo.22175.
111. Schwabe L., Dickinson A., Wolf O.T. Stress, habits, and drug addiction: a psychoneuroendocrinological perspective. Exp. Clin. Psychopharmacol. 2011, 19(1):53-63. 10.1037/a0022212.
112. Sesack S.R., Deutch A.Y., Roth R.H., Bunney B.S. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J. Comp. Neurol. 1989, 290(2):213-242. 10.1002/cne.902900205.
113. Simchon-Tenenbaum Y., Weizman A., Rehavi M. The impact of chronic early administration Of psychostimulants on brain expression of BDNF and other neuroplasticity-relevant proteins. J. Mol. Neurosci. 2015, 10.1007/s12031-015-0611-9.
114. Stalnaker T.A., Cooch N.K., Schoenbaum G. What the orbitofrontal cortex does not do. Nat. Neurosci. 2015, 18(5):620-627. 10.1038/nn.3982.
115. Su H., Tao J., Zhang J., Xie Y., Sun Y., Li L., Xu K., Han B., Lu Y., Sun H., Wei Y., Wang Y., Zhang Y., Zou S., Wu W., Zhang J., Zhang X., He J. An association between BDNF Val66Met polymorphism and impulsivity in methamphetamine abusers. Neurosci. Lett. 2014, 582:16-20. 10.1016/j.neulet.2014.08.030.
116. Substance Abuse and Mental Health Services Administration Results From the 2013 National Survey on Drug Use and Health: Mental Health Findings 2014, Substance Abuse and Mental Health Services Administration, Rockville, MD.
117. Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality The DAWN Report: Highlights of the 2010 Drug Abuse Warning Network (DAWN) Findings on Drug-Related Emergency Department Visits 2012, Rockville, MD.
118. Sun H., Cocker P.J., Zeeb F.D., Winstanley C.A. Chronic atomoxetine treatment during adolescence decreases impulsive choice, but not impulsive action, in adult rats and alters markers of synaptic plasticity in the orbitofrontal cortex. Psychopharmacology 2012, 219(2):285-301. 10.1007/s00213-011-2419-9.
119. Sun W.L., Eisenstein S.A., Zelek-Molik A., McGinty J.F. A single brain-derived neurotrophic factor infusion into the dorsomedial prefrontal cortex attenuates cocaine self-administration-induced phosphorylation of synapsin in the nucleus accumbens during early withdrawal. Int. J. Neuropsychopharmacol. 2014, 18(1). 10.1093/ijnp/pyu049.
120. Swanson A.M., Allen A.G., Shapiro L.P., Gourley S.L. GABAAalpha1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Neuropsychopharmacology 2015, 40(4):1027-1036. 10.1038/npp.2014.292.
121. Tian M., Zeng Y., Hu Y., Yuan X., Liu S., Li J., Lu P., Sun Y., Gao L., Fu D., Li Y., Wang S., McClintock S.M. 7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome. Neuropharmacology 2015, 89:43-53. 10.1016/j.neuropharm.2014.09.006.
122. Torregrossa M.M., Quinn J.J., Taylor J.R. Impulsivity, compulsivity, and habit: the role of orbitofrontal cortex revisited. Biol. Psychiatry 2008, 63(3):253-255. 10.1016/j.biopsych.2007.11.014.
123. Torregrossa M.M., Corlett P.R., Taylor J.R. Aberrant learning and memory in addiction. Neurobiol. Learn. Mem. 2011, 96(4):609-623. 10.1016/j.nlm.2011.02.014.
124. Tzeng W.Y., Chuang J.Y., Lin L.C., Cherng C.G., Lin K.Y., Chen L.H., Su C.C., Yu L. Companions reverse stressor-induced decreases in neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in dentate gyrus. Psychoneuroendocrinology 2013, 38(3):425-437. 10.1016/j.psyneuen.2012.07.002.
125. Vassoler F.M., White S.L., Schmidt H.D., Sadri-Vakili G., Pierce R.C. Epigenetic inheritance of a cocaine-resistance phenotype. Nat. Neurosci. 2013, 16(1):42-47. 10.1038/nn.3280.
126. Viola T.W., Tractenberg S.G., Levandowski M.L., Pezzi J.C., Bauer M.E., Teixeira A.L., Grassi-Oliveira R. Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress. J. Psychiatry Neurosci. 2014, 39(3):206-214. 10.1503/jpn.130027.
127. von Diemen L., Kapczinski F., Sordi A.O., de Magalhães Narvaez J.C., Guimarães L.S.P., Kessler F.H.P., Pechansky F. Increase in brain-derived neurotrophic factor expression in early crack cocaine withdrawal. Int. J. Neuropsychopharmacol. 2014, 17(1):33-40. 10.1111/j.1369-1600.2012.00444.x.
128. Warnault V., Darcq E., Morisot N., Phamluong K., Wilbrecht L., Massa S.M., Ron D. The BDNF valine 68 to methionine polymorphism increases compulsive alcohol drinking in mice that Is reversed by tropomyosin receptor kinase B Activation. Biol. Psychiatry 2015, 10.1016/j.biopsych.2015.06.007.
129. Warren M.S., Bradley W.D., Gourley S.L., Lin Y.C., Simpson M.A., Reichardt L.F., Koleske A.J. Integrin beta1 signals through arg to regulate postnatal dendritic arborization, synapse density, and behavior. J. Neurosci. 2012, 32(8):2824-2834. 10.1523/jneurosci.3942-11.2012.
130. Whitfield T.W., Shi X., Sun W.L., McGinty J.F. The suppressive effect of an intra-prefrontal cortical infusion of BDNF on cocaine-seeking is trk receptor and extracellular signal-regulated protein kinase mitogen-activated protein kinase dependent. J. Neurosci. 2011, 31(3):834-842. 10.1523/jneurosci.4986-10.2011.
131. Yager L.M., Robinson T.E. A classically conditioned cocaine cue acquires greater control over motivated behavior in rats prone to attribute incentive salience to a food cue. Psychopharmacology 2013, 226(2):217-228. 10.1007/s00213-012-2890-y.
132. Yamada K., Nabeshima T. Brain-derived neurotrophic factor/TrkB signaling in memory processes. J. Pharmacol. Sci. 2003, 91(4):267-270.
133. Yan Q.S., Feng M.J., Yan S.E. RNA interference-mediated inhibition of brain-derived neurotrophic factor expression increases cocaine's cytotoxicity in cultured cells. Neurosci. Lett. 2007, 414(2):165-169. 10.1016/j.neulet.2006.12.016.
134. Yin H.H., Ostlund S.B., Balleine B.W. Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks. Eur. J. Neurol. 2008, 28(8):1437-1448. 10.1111/j.1460-9568.2008.06422.x.
135. Zapata A., Minney V.L., Shippenberg T.S. Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats. J. Neurosci. 2010, 30(46):15457-15463. 10.1523/jneurosci.4072-10.2010.
136. Zeng Y., Lv F., Li L., Yu H., Dong M., Fu Q. 7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. J. Neurochem. 2012, 122(4):800-811. 10.1111/j.1471-4159.2012.07830.x.
137. Zhang J.C., Wu J., Fujita Y., Yao W., Ren Q., Yang C., Li S.X., Shirayama Y., Hashimoto K. Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation. Int. J. Neuropsychopharmacol. 2014, 18(4). 10.1093/ijnp/pyu077.
138. Zhang Z., Liu X., Schroeder J.P., Chan C.B., Song M., Yu S.P., Weinshenker D., Ye K. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2014, 39(3):638-650. 10.1038/npp.2013.243.
139. Zhang Y., Zhu X., Huang C., Zhang X. Molecular changes in the medial prefrontal cortex and nucleus accumbens are associated with blocking the behavioral sensitization to cocaine. Sci. Report. 2015, 5. 10.1038/srep16172.
140. Zimmermann K.S., Yamin J., Rainnie D.G., Ressler K.J., Gourley S.L. Connections of the mouse orbitofrontal cortex and regulation of goal-directed action selection by BDNF-TrkB. Biol. Psychiatry 2015, (ahead of print).
141. Zingg B., Hintiryan H., Gou L., Song M.Y., Bay M., Bienkowski M.S., Dong H.W. Neural networks of the mouse neocortex. Cell 2014, 156(5):1096-1111. 10.1016/j.cell.2014.02.023.