The BDNF valine 68 to methionine polymorphism increases compulsive alcohol drinking in mice that is reversed by tropomyosin receptor kinase B activation

Biological Psychiatry

Volumn 79, Issue 6, 2016, Pages 463-473

  Warnault, Vincent ^a   Darcq, Emmanuel ^a   Morisot, Nadege ^a   Phamluong, Khanhky ^a   Wilbrecht, Linda ^b   Massa, Stephen M ^a,c   Longo, Frank M ^d   Ron, Dorit ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Addiction; Alcohol; BDNF; Ethanol; Growth factor; Polymorphism

Indexed keywords

ALCOHOL; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; DRUGS USED IN THE TREATMENT OF ADDICTION; LM 22A 4; METHIONINE 68; METHIONINE DERIVATIVE; PROTEIN KINASE B INHIBITOR; QUININE; SACCHARIN; TROPOMYOSIN; TROPOMYOSIN RECEPTOR KINASE B; UNCLASSIFIED DRUG; VALINE; VALINE 68; BENZAMIDE DERIVATIVE; METHIONINE; N,N',N'-TRIS(2-HYDROXYETHYL)-1,3,5-BENZENETRICARBOXAMIDE; PROTEIN TYROSINE KINASE;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOLISM; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; COMPULSION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE SEVERITY; DRINKING BEHAVIOR; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENOTYPE; HOMOZYGOTE; HUMAN; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TASTE; TREATMENT RESPONSE; VENTROMEDIAL PREFRONTAL CORTEX; ANIMAL; DISEASE MODEL; GENETICS; METABOLISM; TRANSGENIC MOUSE;

ALCOHOL DRINKING; ALCOHOLISM; ALLELES; ANIMALS; BENZAMIDES; BRAIN-DERIVED NEUROTROPHIC FACTOR; COMPULSIVE BEHAVIOR; DISEASE MODELS, ANIMAL; METHIONINE; MICE; MICE, TRANSGENIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-TYROSINE KINASES; RECEPTOR, TRKB; VALINE;

EID: 84958920594     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.06.007     Document Type: Article

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