메뉴 건너뛰기




Volumn 93, Issue , 2016, Pages 73-83

Computational modeling of cardiac fibroblasts and fibrosis

Author keywords

Cardiac fibroblast; Computational modeling; Fibrosis; Systems biology

Indexed keywords

CARDIOVASCULAR PARAMETERS; CELL FUNCTION; CELL INTERACTION; CELL MIGRATION; EXTRACELLULAR MATRIX; HEART CONDUCTION; HEART ELECTROPHYSIOLOGY; HEART FIBROBLAST; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE ARRHYTHMIA; HUMAN; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SIMULATION; TISSUE REMODELLING; ANIMAL; ARRHYTHMIAS, CARDIAC; BIOLOGICAL MODEL; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; COMPUTER SIMULATION; FIBROBLAST; FIBROSIS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE;

EID: 84962588253     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.11.020     Document Type: Review
Times cited : (47)

References (110)
  • 1
    • 0024319420 scopus 로고
    • Cardiac interstitium in health and disease: the fibrillar collagen network
    • Weber K.T. Cardiac interstitium in health and disease: the fibrillar collagen network. J. Am. Coll. Cardiol. 1989, 13:1637-1652. 10.1016/0735-1097(89)90360-4.
    • (1989) J. Am. Coll. Cardiol. , vol.13 , pp. 1637-1652
    • Weber, K.T.1
  • 2
    • 73349122017 scopus 로고    scopus 로고
    • Cardiac fibroblast: the renaissance cell
    • Souders C.A., Bowers S.L.K., Baudino T.A. Cardiac fibroblast: the renaissance cell. Circ. Res. 2009, 105:1164-1176. 10.1161/CIRCRESAHA.109.209809.
    • (2009) Circ. Res. , vol.105 , pp. 1164-1176
    • Souders, C.A.1    Bowers, S.L.K.2    Baudino, T.A.3
  • 3
    • 33645743440 scopus 로고    scopus 로고
    • Electrotonic modulation of cardiac impulse conduction by myofibroblasts
    • Miragoli M., Gaudesius G., Rohr S. Electrotonic modulation of cardiac impulse conduction by myofibroblasts. Circ. Res. 2006, 98:801-810. 10.1161/01.RES.0000214537.44195.a3.
    • (2006) Circ. Res. , vol.98 , pp. 801-810
    • Miragoli, M.1    Gaudesius, G.2    Rohr, S.3
  • 4
    • 84945460374 scopus 로고    scopus 로고
    • Cardiac fibroblasts as sentinel cells in cardiac tissue: receptors, signaling pathways and cellular functions
    • Díaz-Araya G., Vivar R., Humeres C., Boza P., Bolivar S., Muñoz C. Cardiac fibroblasts as sentinel cells in cardiac tissue: receptors, signaling pathways and cellular functions. Pharmacol. Res. 2015, 10.1016/j.phrs.2015.07.001.
    • (2015) Pharmacol. Res.
    • Díaz-Araya, G.1    Vivar, R.2    Humeres, C.3    Boza, P.4    Bolivar, S.5    Muñoz, C.6
  • 5
    • 22244481555 scopus 로고    scopus 로고
    • K+ currents activated by depolarization in cardiac fibroblasts
    • Shibukawa Y., Chilton E.L., Maccannell K.A., Clark R.B., Giles W.R. K+ currents activated by depolarization in cardiac fibroblasts. Biophys. J. 2005, 88:3924-3935. 10.1529/biophysj.104.054429.
    • (2005) Biophys. J. , vol.88 , pp. 3924-3935
    • Shibukawa, Y.1    Chilton, E.L.2    Maccannell, K.A.3    Clark, R.B.4    Giles, W.R.5
  • 6
    • 84874285627 scopus 로고    scopus 로고
    • Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation
    • Ma Y., Halade G.V., Zhang J., Ramirez T.A., Levin D., Voorhees A., et al. Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation. Circ. Res. 2013, 112:675-688. 10.1161/CIRCRESAHA.111.300502.
    • (2013) Circ. Res. , vol.112 , pp. 675-688
    • Ma, Y.1    Halade, G.V.2    Zhang, J.3    Ramirez, T.A.4    Levin, D.5    Voorhees, A.6
  • 7
    • 0034074371 scopus 로고    scopus 로고
    • Infarct scar: a dynamic tissue
    • Sun Y., Weber K.T. Infarct scar: a dynamic tissue. Cardiovasc. Res. 2000, 46:250-256. 10.1016/S0008-6363(00)00032-8.
    • (2000) Cardiovasc. Res. , vol.46 , pp. 250-256
    • Sun, Y.1    Weber, K.T.2
  • 8
    • 0028173386 scopus 로고
    • The alpha-smooth muscle actin-positive cells in healing human myocardial scars
    • Willems I.E., Havenith M.G., De Mey J.G., Daemen M.J. The alpha-smooth muscle actin-positive cells in healing human myocardial scars. Am. J. Pathol. 1994, 145:868-875.
    • (1994) Am. J. Pathol. , vol.145 , pp. 868-875
    • Willems, I.E.1    Havenith, M.G.2    De Mey, J.G.3    Daemen, M.J.4
  • 9
    • 32644448320 scopus 로고    scopus 로고
    • The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy
    • Asbun J., Villarreal F.J. The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy. J. Am. Coll. Cardiol. 2006, 47:693-700. 10.1016/j.jacc.2005.09.050.
    • (2006) J. Am. Coll. Cardiol. , vol.47 , pp. 693-700
    • Asbun, J.1    Villarreal, F.J.2
  • 10
    • 77952545257 scopus 로고    scopus 로고
    • A three-dimensional multi-agent-based model for the evolution of Chagas' disease
    • Galvão V., Miranda J.G.V. A three-dimensional multi-agent-based model for the evolution of Chagas' disease. Biosystems 2010, 100:225-230. 10.1016/j.biosystems.2010.03.007.
    • (2010) Biosystems , vol.100 , pp. 225-230
    • Galvão, V.1    Miranda, J.G.V.2
  • 11
    • 80055118797 scopus 로고    scopus 로고
    • Virus-induced dilated cardiomyopathy is characterized by increased levels of fibrotic extracellular matrix proteins and reduced amounts of energy-producing enzymes
    • Nishtala K., Phong T.Q., Steil L., Sauter M., Salazar M.G., Kandolf R., et al. Virus-induced dilated cardiomyopathy is characterized by increased levels of fibrotic extracellular matrix proteins and reduced amounts of energy-producing enzymes. Proteomics 2011, 11:4310-4320. 10.1002/pmic.201100229.
    • (2011) Proteomics , vol.11 , pp. 4310-4320
    • Nishtala, K.1    Phong, T.Q.2    Steil, L.3    Sauter, M.4    Salazar, M.G.5    Kandolf, R.6
  • 12
    • 0035923477 scopus 로고    scopus 로고
    • Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves
    • Rabkin E., Aikawa M., Stone J.R., Fukumoto Y., Libby P., Schoen F.J. Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation 2001, 104:2525-2532. 10.1161/hc4601.099489.
    • (2001) Circulation , vol.104 , pp. 2525-2532
    • Rabkin, E.1    Aikawa, M.2    Stone, J.R.3    Fukumoto, Y.4    Libby, P.5    Schoen, F.J.6
  • 13
    • 84865863380 scopus 로고    scopus 로고
    • Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality
    • Wong T.C., Piehler K., Meier C.G., Testa S.M., Klock A.M., Aneizi A.A., et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation 2012, 126:1206-1216. 10.1161/CIRCULATIONAHA.111.089409.
    • (2012) Circulation , vol.126 , pp. 1206-1216
    • Wong, T.C.1    Piehler, K.2    Meier, C.G.3    Testa, S.M.4    Klock, A.M.5    Aneizi, A.A.6
  • 14
    • 73049104933 scopus 로고    scopus 로고
    • Influence of myocardial fibrosis on left ventricular diastolic function: noninvasive assessment by cardiac magnetic resonance and echo
    • Moreo A., Ambrosio G., De Chiara B., Pu M., Tran T., Mauri F., et al. Influence of myocardial fibrosis on left ventricular diastolic function: noninvasive assessment by cardiac magnetic resonance and echo. Circ. Cardiovasc. Imaging 2009, 2:437-443. 10.1161/CIRCIMAGING.108.838367.
    • (2009) Circ. Cardiovasc. Imaging , vol.2 , pp. 437-443
    • Moreo, A.1    Ambrosio, G.2    De Chiara, B.3    Pu, M.4    Tran, T.5    Mauri, F.6
  • 15
    • 84932155852 scopus 로고    scopus 로고
    • Atrial fibrosis and conduction slowing in the left atrial appendage of patients undergoing thoracoscopic surgical pulmonary vein isolation for atrial fibrillation
    • Krul S.P.J., Berger W.R., Smit N.W., van Amersfoorth S.C.M., Driessen A.H.G., van Boven W.J., et al. Atrial fibrosis and conduction slowing in the left atrial appendage of patients undergoing thoracoscopic surgical pulmonary vein isolation for atrial fibrillation. Circ. Arrhythm. Electrophysiol. 2015, 8:288-295. 10.1161/CIRCEP.114.001752.
    • (2015) Circ. Arrhythm. Electrophysiol. , vol.8 , pp. 288-295
    • Krul, S.P.J.1    Berger, W.R.2    Smit, N.W.3    van Amersfoorth, S.C.M.4    Driessen, A.H.G.5    van Boven, W.J.6
  • 16
    • 84894049643 scopus 로고    scopus 로고
    • Advances in modeling ventricular arrhythmias: from mechanisms to the clinic
    • Trayanova N.A., Boyle P.M. Advances in modeling ventricular arrhythmias: from mechanisms to the clinic. Wiley Interdiscip. Rev. Syst. Biol. Med. 2014, 6:209-224. 10.1002/wsbm.1256.
    • (2014) Wiley Interdiscip. Rev. Syst. Biol. Med. , vol.6 , pp. 209-224
    • Trayanova, N.A.1    Boyle, P.M.2
  • 17
    • 79251648963 scopus 로고    scopus 로고
    • Computational models reduce complexity and accelerate insight into cardiac signaling networks
    • Yang J.H., Saucerman J.J. Computational models reduce complexity and accelerate insight into cardiac signaling networks. Circ. Res. 2011, 108:85-97. 10.1161/CIRCRESAHA.110.223602.
    • (2011) Circ. Res. , vol.108 , pp. 85-97
    • Yang, J.H.1    Saucerman, J.J.2
  • 18
    • 65649095952 scopus 로고    scopus 로고
    • Myofibroblasts in diseased hearts: new players in cardiac arrhythmias?
    • Rohr S. Myofibroblasts in diseased hearts: new players in cardiac arrhythmias?. Heart Rhythm. 2009, 6:848-856. 10.1016/j.hrthm.2009.02.038.
    • (2009) Heart Rhythm. , vol.6 , pp. 848-856
    • Rohr, S.1
  • 19
    • 0031049517 scopus 로고    scopus 로고
    • Microfibrosis produces electrical load variations due to loss of side-to-side cell connections: a major mechanism of structural heart disease arrhythmias
    • Spach M.S., Boineau J.P. Microfibrosis produces electrical load variations due to loss of side-to-side cell connections: a major mechanism of structural heart disease arrhythmias. Pacing Clin. Electrophysiol. 1997, 20:397-413.
    • (1997) Pacing Clin. Electrophysiol. , vol.20 , pp. 397-413
    • Spach, M.S.1    Boineau, J.P.2
  • 20
    • 0042232510 scopus 로고    scopus 로고
    • Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin
    • Gaudesius G., Miragoli M., Thomas S.P., Rohr S. Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circ. Res. 2003, 93:421-428. 10.1161/01.RES.0000089258.40661.0C.
    • (2003) Circ. Res. , vol.93 , pp. 421-428
    • Gaudesius, G.1    Miragoli, M.2    Thomas, S.P.3    Rohr, S.4
  • 21
    • 21144440135 scopus 로고    scopus 로고
    • K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts
    • Chilton L., Ohya S., Freed D., George E., Drobic V., Shibukawa Y., et al. K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts. Am. J. Physiol. Heart Circ. Physiol. 2005, 288:H2931-H2939. 10.1152/ajpheart.01220.2004.
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.288 , pp. H2931-H2939
    • Chilton, L.1    Ohya, S.2    Freed, D.3    George, E.4    Drobic, V.5    Shibukawa, Y.6
  • 22
    • 0028533619 scopus 로고
    • Mechanosensitive fibroblasts in the sino-atrial node region of rat heart: interaction with cardiomyocytes and possible role
    • Kohl P., Kamkin A.G., Kiseleva I.S., Noble D. Mechanosensitive fibroblasts in the sino-atrial node region of rat heart: interaction with cardiomyocytes and possible role. Exp. Physiol. 1994, 79:943-956.
    • (1994) Exp. Physiol. , vol.79 , pp. 943-956
    • Kohl, P.1    Kamkin, A.G.2    Kiseleva, I.S.3    Noble, D.4
  • 23
    • 78651240683 scopus 로고    scopus 로고
    • Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study
    • Oren R.V., Clancy C.E. Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. PLoS Comput. Biol. 2010, 6. 10.1371/journal.pcbi.1001041.
    • (2010) PLoS Comput. Biol. , vol.6
    • Oren, R.V.1    Clancy, C.E.2
  • 24
    • 33846508259 scopus 로고    scopus 로고
    • A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts
    • MacCannell K.A., Bazzazi H., Chilton L., Shibukawa Y., Clark R.B., Giles W.R. A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts. Biophys. J. 2007, 92:4121-4132. 10.1529/biophysj.106.101410.
    • (2007) Biophys. J. , vol.92 , pp. 4121-4132
    • MacCannell, K.A.1    Bazzazi, H.2    Chilton, L.3    Shibukawa, Y.4    Clark, R.B.5    Giles, W.R.6
  • 26
    • 41249088278 scopus 로고    scopus 로고
    • Modelling cardiac fibroblasts: interactions with myocytes and their impact on impulse propagation
    • Jacquemet V., Henriquez C.S. Modelling cardiac fibroblasts: interactions with myocytes and their impact on impulse propagation. Europace 2007, 9(Suppl 6). 10.1093/europace/eum207.
    • (2007) Europace , vol.9
    • Jacquemet, V.1    Henriquez, C.S.2
  • 28
    • 0033696650 scopus 로고    scopus 로고
    • Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling
    • Ramirez R.J., Nattel S., Courtemanche M. Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling. Am. J. Physiol. Heart Circ. Physiol. 2000, 279:H1767-H1785.
    • (2000) Am. J. Physiol. Heart Circ. Physiol. , vol.279 , pp. H1767-H1785
    • Ramirez, R.J.1    Nattel, S.2    Courtemanche, M.3
  • 29
    • 44949135059 scopus 로고    scopus 로고
    • Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model
    • Jacquemet V., Henriquez C.S. Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model. Am. J. Physiol. Heart Circ. Physiol. 2008, 294:H2040-H2052. 10.1152/ajpheart.01298.2007.
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.294 , pp. H2040-H2052
    • Jacquemet, V.1    Henriquez, C.S.2
  • 30
    • 37449006539 scopus 로고    scopus 로고
    • Electrophysiological modeling of fibroblasts and their interaction with myocytes
    • Sachse F.B., Moreno A.P., Abildskov J.A. Electrophysiological modeling of fibroblasts and their interaction with myocytes. Ann. Biomed. Eng. 2008, 36:41-56. 10.1007/s10439-007-9405-8.
    • (2008) Ann. Biomed. Eng. , vol.36 , pp. 41-56
    • Sachse, F.B.1    Moreno, A.P.2    Abildskov, J.A.3
  • 31
    • 68049093192 scopus 로고    scopus 로고
    • Cardiac alternans induced by fibroblast-myocyte coupling: mechanistic insights from computational models
    • Xie Y., Garfinkel A., Weiss J.N., Qu Z. Cardiac alternans induced by fibroblast-myocyte coupling: mechanistic insights from computational models. Am. J. Physiol. Heart Circ. Physiol. 2009, 297:H775-H784. 10.1152/ajpheart.00341.2009.
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.297 , pp. H775-H784
    • Xie, Y.1    Garfinkel, A.2    Weiss, J.N.3    Qu, Z.4
  • 32
    • 70350484963 scopus 로고    scopus 로고
    • Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: a computational study
    • Xie Y., Garfinkel A., Camelliti P., Kohl P., Weiss J.N., Qu Z. Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: a computational study. Heart Rhythm. 2009, 6:1641-1649. 10.1016/j.hrthm.2009.08.003.
    • (2009) Heart Rhythm. , vol.6 , pp. 1641-1649
    • Xie, Y.1    Garfinkel, A.2    Camelliti, P.3    Kohl, P.4    Weiss, J.N.5    Qu, Z.6
  • 33
    • 63949084355 scopus 로고    scopus 로고
    • A model of electrical conduction in cardiac tissue including fibroblasts
    • Sachse F.B., Moreno A.P., Seemann G., Abildskov J.A. A model of electrical conduction in cardiac tissue including fibroblasts. Ann. Biomed. Eng. 2009, 37:874-889. 10.1007/s10439-009-9667-4.
    • (2009) Ann. Biomed. Eng. , vol.37 , pp. 874-889
    • Sachse, F.B.1    Moreno, A.P.2    Seemann, G.3    Abildskov, J.A.4
  • 34
    • 58149157461 scopus 로고    scopus 로고
    • Electrotonic myofibroblast-to-myocyte coupling increases propensity to reentrant arrhythmias in two-dimensional cardiac monolayers
    • Zlochiver S., Muñoz V., Vikstrom K.L., Taffet S.M., Berenfeld O., Jalife J. Electrotonic myofibroblast-to-myocyte coupling increases propensity to reentrant arrhythmias in two-dimensional cardiac monolayers. Biophys. J. 2008, 95:4469-4480. 10.1529/biophysj.108.136473.
    • (2008) Biophys. J. , vol.95 , pp. 4469-4480
    • Zlochiver, S.1    Muñoz, V.2    Vikstrom, K.L.3    Taffet, S.M.4    Berenfeld, O.5    Jalife, J.6
  • 35
    • 0033545725 scopus 로고    scopus 로고
    • Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study
    • Viswanathan P.C., Shaw R.M., Rudy Y. Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation 1999, 99:2466-2474. 10.1161/01.CIR.99.18.2466.
    • (1999) Circulation , vol.99 , pp. 2466-2474
    • Viswanathan, P.C.1    Shaw, R.M.2    Rudy, Y.3
  • 36
    • 84860386102 scopus 로고    scopus 로고
    • Modulation of spiral-wave dynamics and spontaneous activity in a fibroblast/myocyte heterocellular tissue - a computational study
    • Greisas A., Zlochiver S. Modulation of spiral-wave dynamics and spontaneous activity in a fibroblast/myocyte heterocellular tissue - a computational study. IEEE Trans. Biomed. Eng. 2012, 59:1398-1407. 10.1109/TBME.2012.2188291.
    • (2012) IEEE Trans. Biomed. Eng. , vol.59 , pp. 1398-1407
    • Greisas, A.1    Zlochiver, S.2
  • 37
    • 84856030636 scopus 로고    scopus 로고
    • The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: implications for electrogram-based catheter ablation
    • Ashihara T., Haraguchi R., Nakazawa K., Namba T., Ikeda T., Nakazawa Y., et al. The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: implications for electrogram-based catheter ablation. Circ. Res. 2012, 110:275-284. 10.1161/CIRCRESAHA.111.255026.
    • (2012) Circ. Res. , vol.110 , pp. 275-284
    • Ashihara, T.1    Haraguchi, R.2    Nakazawa, K.3    Namba, T.4    Ikeda, T.5    Nakazawa, Y.6
  • 38
    • 80053110376 scopus 로고    scopus 로고
    • Susceptibility to arrhythmia in the infarcted heart depends on myofibroblast density
    • McDowell K.S., Arevalo H.J., Maleckar M.M., Trayanova N.A. Susceptibility to arrhythmia in the infarcted heart depends on myofibroblast density. Biophys. J. 2011, 101:1307-1315. 10.1016/j.bpj.2011.08.009.
    • (2011) Biophys. J. , vol.101 , pp. 1307-1315
    • McDowell, K.S.1    Arevalo, H.J.2    Maleckar, M.M.3    Trayanova, N.A.4
  • 39
    • 84899113897 scopus 로고    scopus 로고
    • Fibroblast-myocyte electrotonic coupling: does it occur in native cardiac tissue?
    • Kohl P., Gourdie R.G. Fibroblast-myocyte electrotonic coupling: does it occur in native cardiac tissue?. J. Mol. Cell. Cardiol. 2014, 70:37-46. 10.1016/j.yjmcc.2013.12.024.
    • (2014) J. Mol. Cell. Cardiol. , vol.70 , pp. 37-46
    • Kohl, P.1    Gourdie, R.G.2
  • 40
    • 0019194592 scopus 로고
    • An analysis of the mechanical disadvantage of myocardial infarction in the canine left ventricle
    • Bogen D.K., Rabinowitz S.A., Needleman A., McMahon T.A., Abelmann W.H. An analysis of the mechanical disadvantage of myocardial infarction in the canine left ventricle. Circ. Res. 1980, 47:728-741.
    • (1980) Circ. Res. , vol.47 , pp. 728-741
    • Bogen, D.K.1    Rabinowitz, S.A.2    Needleman, A.3    McMahon, T.A.4    Abelmann, W.H.5
  • 42
    • 84937635499 scopus 로고    scopus 로고
    • Changes in global and regional mechanics due to atrial fibrillation: insights from a coupled finite-element and circulation model
    • Moyer C.B., Norton P.T., Ferguson J.D., Holmes J.W. Changes in global and regional mechanics due to atrial fibrillation: insights from a coupled finite-element and circulation model. Ann. Biomed. Eng. 2015, 43:1600-1613. 10.1007/s10439-015-1256-0.
    • (2015) Ann. Biomed. Eng. , vol.43 , pp. 1600-1613
    • Moyer, C.B.1    Norton, P.T.2    Ferguson, J.D.3    Holmes, J.W.4
  • 43
    • 33845709504 scopus 로고    scopus 로고
    • Theoretical impact of the injection of material into the myocardium: a finite element model simulation
    • Wall S.T., Walker J.C., Healy K.E., Ratcliffe M.B., Guccione J.M. Theoretical impact of the injection of material into the myocardium: a finite element model simulation. Circulation 2006, 114:2627-2635. 10.1161/CIRCULATIONAHA.106.657270.
    • (2006) Circulation , vol.114 , pp. 2627-2635
    • Wall, S.T.1    Walker, J.C.2    Healy, K.E.3    Ratcliffe, M.B.4    Guccione, J.M.5
  • 44
    • 79951701992 scopus 로고    scopus 로고
    • Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction
    • Wenk J.F., Sun K., Zhang Z., Soleimani M., Ge L., Saloner D., et al. Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction. J. Biomech. Eng. 2011, 133:044501. 10.1115/1.4003438.
    • (2011) J. Biomech. Eng. , vol.133 , pp. 044501
    • Wenk, J.F.1    Sun, K.2    Zhang, Z.3    Soleimani, M.4    Ge, L.5    Saloner, D.6
  • 45
    • 0035800880 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure?
    • Creemers E.E.J.M., Cleutjens J.P.M., Smits J.F.M., Daemen M.J.A.P. Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure?. Circ. Res. 2001, 89:201-210. 10.1161/hh1501.094396.
    • (2001) Circ. Res. , vol.89 , pp. 201-210
    • Creemers, E.E.J.M.1    Cleutjens, J.P.M.2    Smits, J.F.M.3    Daemen, M.J.A.P.4
  • 46
    • 84855891599 scopus 로고    scopus 로고
    • Temporal and spatial expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases following myocardial infarction
    • Lindsey M.L., Zamilpa R. Temporal and spatial expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases following myocardial infarction. Cardiovasc. Ther. 2012, 30:31-41. 10.1111/j.1755-5922.2010.00207.x.
    • (2012) Cardiovasc. Ther. , vol.30 , pp. 31-41
    • Lindsey, M.L.1    Zamilpa, R.2
  • 47
    • 31344477231 scopus 로고    scopus 로고
    • Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window
    • Vanhoutte D., Schellings M., Pinto Y., Heymans S. Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window. Cardiovasc. Res. 2006, 69:604-613. 10.1016/j.cardiores.2005.10.002.
    • (2006) Cardiovasc. Res. , vol.69 , pp. 604-613
    • Vanhoutte, D.1    Schellings, M.2    Pinto, Y.3    Heymans, S.4
  • 48
    • 84914165870 scopus 로고    scopus 로고
    • Long range force transmission in fibrous matrices enabled by tension-driven alignment of fibers
    • (Submitted)
    • Wang H., Nair A., Chen C.S., Wells R.G., Shenoy V.B. Long range force transmission in fibrous matrices enabled by tension-driven alignment of fibers. Biophys. J. 2014, 107:2592-2603. (Submitted). 10.1016/j.bpj.2014.09.044.
    • (2014) Biophys. J. , vol.107 , pp. 2592-2603
    • Wang, H.1    Nair, A.2    Chen, C.S.3    Wells, R.G.4    Shenoy, V.B.5
  • 49
    • 0019459687 scopus 로고
    • Fibroblast traction as a mechanism for collagen morphogenesis
    • Harris A.K., Stopak D., Wild P. Fibroblast traction as a mechanism for collagen morphogenesis. Nature 1981, 290:249-251.
    • (1981) Nature , vol.290 , pp. 249-251
    • Harris, A.K.1    Stopak, D.2    Wild, P.3
  • 50
    • 0022470549 scopus 로고
    • Extracellular compartments in tendon morphogenesis: collagen fibril, bundle, and macroaggregate formation
    • Birk D.E., Trelstad R.L. Extracellular compartments in tendon morphogenesis: collagen fibril, bundle, and macroaggregate formation. J. Cell Biol. 1986, 103:231-240.
    • (1986) J. Cell Biol. , vol.103 , pp. 231-240
    • Birk, D.E.1    Trelstad, R.L.2
  • 51
    • 0018762445 scopus 로고
    • Tendon collagen fibrillogenesis: intracellular subassemblies and cell surface changes associated with fibril growth
    • Trelstad R.L., Hayashi K. Tendon collagen fibrillogenesis: intracellular subassemblies and cell surface changes associated with fibril growth. Dev. Biol. 1979, 71:228-242.
    • (1979) Dev. Biol. , vol.71 , pp. 228-242
    • Trelstad, R.L.1    Hayashi, K.2
  • 52
    • 2542439729 scopus 로고    scopus 로고
    • Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon
    • Canty E.G., Lu Y., Meadows R.S., Shaw M.K., Holmes D.F., Kadler K.E. Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon. J. Cell Biol. 2004, 165:553-563. 10.1083/jcb.200312071.
    • (2004) J. Cell Biol. , vol.165 , pp. 553-563
    • Canty, E.G.1    Lu, Y.2    Meadows, R.S.3    Shaw, M.K.4    Holmes, D.F.5    Kadler, K.E.6
  • 53
    • 84947745483 scopus 로고    scopus 로고
    • Monocyte and macrophage contributions to cardiac remodeling
    • Nahrendorf M., Sam F.H.M. Monocyte and macrophage contributions to cardiac remodeling. J. Mol. Cell. Cardiol. 2016.
    • (2016) J. Mol. Cell. Cardiol.
    • Nahrendorf, M.1    Sam, F.H.M.2
  • 54
    • 84949683193 scopus 로고    scopus 로고
    • Modifying the mechanics of healing infarcts: better the enemy of good?
    • Richardson W.J., Clarke S.A.H.J. Modifying the mechanics of healing infarcts: better the enemy of good?. J. Mol. Cell. Cardiol. 2016.
    • (2016) J. Mol. Cell. Cardiol.
    • Richardson, W.J.1    Clarke, S.A.H.J.2
  • 55
    • 0042512203 scopus 로고    scopus 로고
    • Computational analyses of mechanically induced collagen fiber remodeling in the aortic heart valve
    • Driessen N.J., Boerboom R.A., Huyghe J.M., Bouten C.V., Baaijens F.P. Computational analyses of mechanically induced collagen fiber remodeling in the aortic heart valve. J. Biomech. Eng. 2003, 125:549-557.
    • (2003) J. Biomech. Eng. , vol.125 , pp. 549-557
    • Driessen, N.J.1    Boerboom, R.A.2    Huyghe, J.M.3    Bouten, C.V.4    Baaijens, F.P.5
  • 56
    • 18444398776 scopus 로고    scopus 로고
    • Improved prediction of the collagen fiber architecture in the aortic heart valve
    • Driessen N.J.B., Bouten C.V.C., Baaijens F.P.T. Improved prediction of the collagen fiber architecture in the aortic heart valve. J. Biomech. Eng. 2005, 127:329-336.
    • (2005) J. Biomech. Eng. , vol.127 , pp. 329-336
    • Driessen, N.J.B.1    Bouten, C.V.C.2    Baaijens, F.P.T.3
  • 58
    • 0033592238 scopus 로고    scopus 로고
    • Mathematical modelling of extracellular matrix dynamics using discrete cells: fiber orientation and tissue regeneration
    • Dallon J.C., Sherratt J.A., Maini P.K. Mathematical modelling of extracellular matrix dynamics using discrete cells: fiber orientation and tissue regeneration. J. Theor. Biol. 1999, 199:449-471. 10.1006/jtbi.1999.0971.
    • (1999) J. Theor. Biol. , vol.199 , pp. 449-471
    • Dallon, J.C.1    Sherratt, J.A.2    Maini, P.K.3
  • 59
    • 0034470281 scopus 로고    scopus 로고
    • Biological implications of a discrete mathematical model for collagen deposition and alignment in dermal wound repair
    • Dallon J., Sherratt J., Maini P., Ferguson M. Biological implications of a discrete mathematical model for collagen deposition and alignment in dermal wound repair. IMA J. Math. Appl. Med. Biol. 2000, 17:379-393.
    • (2000) IMA J. Math. Appl. Med. Biol. , vol.17 , pp. 379-393
    • Dallon, J.1    Sherratt, J.2    Maini, P.3    Ferguson, M.4
  • 60
    • 0034798578 scopus 로고    scopus 로고
    • Modeling the effects of transforming growth factor-beta on extracellular matrix alignment in dermal wound repair
    • Dallon JC, Sherratt JA, Maini PK. Modeling the effects of transforming growth factor-beta on extracellular matrix alignment in dermal wound repair. Wound Repair Regen. 9:278-86.
    • Wound Repair Regen , vol.9 , pp. 278-286
    • Dallon, J.C.1    Sherratt, J.A.2    Maini, P.K.3
  • 61
    • 33646509272 scopus 로고    scopus 로고
    • Fibroblast migration and collagen deposition during dermal wound healing: mathematical modelling and clinical implications
    • McDougall S., Dallon J., Sherratt J., Maini P. Fibroblast migration and collagen deposition during dermal wound healing: mathematical modelling and clinical implications. Philos. Trans. A Math Phys. Eng. Sci. 2006, 364:1385-1405. 10.1098/rsta.2006.1773.
    • (2006) Philos. Trans. A Math Phys. Eng. Sci. , vol.364 , pp. 1385-1405
    • McDougall, S.1    Dallon, J.2    Sherratt, J.3    Maini, P.4
  • 62
    • 84866357319 scopus 로고    scopus 로고
    • Mechanical regulation of fibroblast migration and collagen remodelling in healing myocardial infarcts
    • Rouillard A.D., Holmes J.W. Mechanical regulation of fibroblast migration and collagen remodelling in healing myocardial infarcts. J. Physiol. 2012, 590:4585-4602. 10.1113/jphysiol.2012.229484.
    • (2012) J. Physiol. , vol.590 , pp. 4585-4602
    • Rouillard, A.D.1    Holmes, J.W.2
  • 63
    • 84859652373 scopus 로고    scopus 로고
    • Regional mechanics determine collagen fiber structure in healing myocardial infarcts
    • Fomovsky G.M., Rouillard A.D., Holmes J.W. Regional mechanics determine collagen fiber structure in healing myocardial infarcts. J. Mol. Cell. Cardiol. 2012, 52:1083-1090. 10.1016/j.yjmcc.2012.02.012.
    • (2012) J. Mol. Cell. Cardiol. , vol.52 , pp. 1083-1090
    • Fomovsky, G.M.1    Rouillard, A.D.2    Holmes, J.W.3
  • 64
    • 73549098869 scopus 로고    scopus 로고
    • Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat
    • Fomovsky G.M., Holmes J.W. Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat. Am. J. Physiol. Heart Circ. Physiol. 2010, 298:H221-H228. 10.1152/ajpheart.00495.2009.
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.298 , pp. H221-H228
    • Fomovsky, G.M.1    Holmes, J.W.2
  • 65
    • 0031008379 scopus 로고    scopus 로고
    • Functional implications of myocardial scar structure
    • Holmes J.W., Nuñez J.A., Covell J.W. Functional implications of myocardial scar structure. Am. J. Phys. 1997, 272:H2123-H2130.
    • (1997) Am. J. Phys. , vol.272 , pp. H2123-H2130
    • Holmes, J.W.1    Nuñez, J.A.2    Covell, J.W.3
  • 66
    • 84908661481 scopus 로고    scopus 로고
    • Coupled agent-based and finite-element models for predicting scar structure following myocardial infarction
    • Rouillard A.D., Holmes J.W. Coupled agent-based and finite-element models for predicting scar structure following myocardial infarction. Prog. Biophys. Mol. Biol. 2014, 10.1016/j.pbiomolbio.2014.06.010.
    • (2014) Prog. Biophys. Mol. Biol.
    • Rouillard, A.D.1    Holmes, J.W.2
  • 67
    • 84896746312 scopus 로고    scopus 로고
    • Agent-based modeling traction force mediated compaction of cell-populated collagen gels using physically realistic fibril mechanics
    • Reinhardt J.W., Gooch K.J. Agent-based modeling traction force mediated compaction of cell-populated collagen gels using physically realistic fibril mechanics. J. Biomech. Eng. 2014, 136:021024. 10.1115/1.4026179.
    • (2014) J. Biomech. Eng. , vol.136 , pp. 021024
    • Reinhardt, J.W.1    Gooch, K.J.2
  • 68
    • 84928828508 scopus 로고    scopus 로고
    • The emergence of extracellular matrix mechanics and cell traction forces as important regulators of cellular self-organization
    • Checa S., Rausch M.K., Petersen A., Kuhl E., Duda G.N. The emergence of extracellular matrix mechanics and cell traction forces as important regulators of cellular self-organization. Biomech. Model. Mechanobiol. 2014, 10.1007/s10237-014-0581-9.
    • (2014) Biomech. Model. Mechanobiol.
    • Checa, S.1    Rausch, M.K.2    Petersen, A.3    Kuhl, E.4    Duda, G.N.5
  • 69
    • 77249155488 scopus 로고    scopus 로고
    • Computational modeling of epithelial-mesenchymal transformations
    • Neagu A., Mironov V., Kosztin I., Barz B., Neagu M., Moreno-Rodriguez R.A., et al. Computational modeling of epithelial-mesenchymal transformations. Biosystems 2010, 100:23-30. 10.1016/j.biosystems.2009.12.004.
    • (2010) Biosystems , vol.100 , pp. 23-30
    • Neagu, A.1    Mironov, V.2    Kosztin, I.3    Barz, B.4    Neagu, M.5    Moreno-Rodriguez, R.A.6
  • 70
    • 79955550281 scopus 로고    scopus 로고
    • Combining experimental and mathematical modeling to reveal mechanisms of macrophage-dependent left ventricular remodeling
    • Jin Y.-F., Han H.-C., Berger J., Dai Q., Lindsey M.L. Combining experimental and mathematical modeling to reveal mechanisms of macrophage-dependent left ventricular remodeling. BMC Syst. Biol. 2011, 5:60. 10.1186/1752-0509-5-60.
    • (2011) BMC Syst. Biol. , vol.5 , pp. 60
    • Jin, Y.-F.1    Han, H.-C.2    Berger, J.3    Dai, Q.4    Lindsey, M.L.5
  • 71
    • 51749108892 scopus 로고    scopus 로고
    • Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation
    • Galvão V., Miranda J.G.V., Ribeiro-dos-Santos R. Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation. Bioinformatics 2008, 24:2051-2056. 10.1093/bioinformatics/btn362.
    • (2008) Bioinformatics , vol.24 , pp. 2051-2056
    • Galvão, V.1    Miranda, J.G.V.2    Ribeiro-dos-Santos, R.3
  • 74
    • 79954652304 scopus 로고    scopus 로고
    • An agent-based model of inflammation and fibrosis following particulate exposure in the lung
    • Brown B.N., Price I.M., Toapanta F.R., DeAlmeida D.R., Wiley C.A., Ross T.M., et al. An agent-based model of inflammation and fibrosis following particulate exposure in the lung. Math. Biosci. 2011, 231:186-196. 10.1016/j.mbs.2011.03.005.
    • (2011) Math. Biosci. , vol.231 , pp. 186-196
    • Brown, B.N.1    Price, I.M.2    Toapanta, F.R.3    DeAlmeida, D.R.4    Wiley, C.A.5    Ross, T.M.6
  • 75
    • 84890114728 scopus 로고
    • Mesoscopic modeling as a starting point for computational analyses of cystic fibrosis as a systemic disease
    • Voit E.O. Mesoscopic modeling as a starting point for computational analyses of cystic fibrosis as a systemic disease. Biochim. Biophys. Acta, Proteins Proteomics 1844, 2014:258-270. 10.1016/j.bbapap.2013.03.023.
    • (1844) Biochim. Biophys. Acta, Proteins Proteomics , vol.2014 , pp. 258-270
    • Voit, E.O.1
  • 77
    • 84907572507 scopus 로고    scopus 로고
    • Mathematical model of renal interstitial fibrosis
    • Hao W., Rovin B.H., Friedman A. Mathematical model of renal interstitial fibrosis. Proc. Natl. Acad. Sci. 2014, 111:14193-14198. 10.1073/pnas.1413970111.
    • (2014) Proc. Natl. Acad. Sci. , vol.111 , pp. 14193-14198
    • Hao, W.1    Rovin, B.H.2    Friedman, A.3
  • 78
    • 0036212767 scopus 로고    scopus 로고
    • Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
    • Schoeberl B., Eichler-Jonsson C., Gilles E.D., Müller G. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat. Biotechnol. 2002, 20:370-375. 10.1038/nbt0402-370.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 370-375
    • Schoeberl, B.1    Eichler-Jonsson, C.2    Gilles, E.D.3    Müller, G.4
  • 79
    • 38049136866 scopus 로고    scopus 로고
    • A biochemical model of matrix metalloproteinase 9 activation and inhibition
    • Vempati P., Karagiannis E.D., Popel A.S. A biochemical model of matrix metalloproteinase 9 activation and inhibition. J. Biol. Chem. 2007, 282:37585-37596. 10.1074/jbc.M611500200.
    • (2007) J. Biol. Chem. , vol.282 , pp. 37585-37596
    • Vempati, P.1    Karagiannis, E.D.2    Popel, A.S.3
  • 80
    • 84899081318 scopus 로고    scopus 로고
    • Fibroblasts in myocardial infarction: a role in inflammation and repair
    • Shinde A.V., Frangogiannis N.G. Fibroblasts in myocardial infarction: a role in inflammation and repair. J. Mol. Cell. Cardiol. 2014, 70:74-82. 10.1016/j.yjmcc.2013.11.015.
    • (2014) J. Mol. Cell. Cardiol. , vol.70 , pp. 74-82
    • Shinde, A.V.1    Frangogiannis, N.G.2
  • 81
    • 18744404266 scopus 로고    scopus 로고
    • Modeling of signal-response cascades using decision tree analysis
    • Hautaniemi S., Kharait S., Iwabu A., Wells A., Lauffenburger D.A. Modeling of signal-response cascades using decision tree analysis. Bioinformatics 2005, 21:2027-2035. 10.1093/bioinformatics/bti278.
    • (2005) Bioinformatics , vol.21 , pp. 2027-2035
    • Hautaniemi, S.1    Kharait, S.2    Iwabu, A.3    Wells, A.4    Lauffenburger, D.A.5
  • 82
    • 34548802103 scopus 로고    scopus 로고
    • Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility
    • Kharait S., Hautaniemi S., Wu S., Iwabu A., Lauffenburger D.A., Wells A. Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility. BMC Syst. Biol. 2007, 1:9. 10.1186/1752-0509-1-9.
    • (2007) BMC Syst. Biol. , vol.1 , pp. 9
    • Kharait, S.1    Hautaniemi, S.2    Wu, S.3    Iwabu, A.4    Lauffenburger, D.A.5    Wells, A.6
  • 83
    • 79951828117 scopus 로고    scopus 로고
    • Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading
    • Rangamani P., Fardin M.A., Xiong Y., Lipshtat A., Rossier O., Sheetz M.P., et al. Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading. Biophys. J. 2011, 100:845-857. 10.1016/j.bpj.2010.12.3732.
    • (2011) Biophys. J. , vol.100 , pp. 845-857
    • Rangamani, P.1    Fardin, M.A.2    Xiong, Y.3    Lipshtat, A.4    Rossier, O.5    Sheetz, M.P.6
  • 84
    • 84930243042 scopus 로고    scopus 로고
    • Network modeling approach to predict myofibroblast differentiation
    • Schroer A.K., Ryzhova L.M., Merryman W.D. Network modeling approach to predict myofibroblast differentiation. Cell. Mol. Bioeng. 2014, 7:446-459. 10.1007/s12195-014-0344-9.
    • (2014) Cell. Mol. Bioeng. , vol.7 , pp. 446-459
    • Schroer, A.K.1    Ryzhova, L.M.2    Merryman, W.D.3
  • 86
    • 84927725580 scopus 로고    scopus 로고
    • Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks
    • Desai P., Yang J., Tian B., Sun H., Kalita M., Ju H., et al. Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks. Cell. Signal. 2015, 27:1413-1425. 10.1016/j.cellsig.2015.03.024.
    • (2015) Cell. Signal. , vol.27 , pp. 1413-1425
    • Desai, P.1    Yang, J.2    Tian, B.3    Sun, H.4    Kalita, M.5    Ju, H.6
  • 87
    • 84899897293 scopus 로고    scopus 로고
    • Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair
    • Furtado M.B., Costa M.W., Pranoto E.A., Salimova E., Pinto A.R., Lam N.T., et al. Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair. Circ. Res. 2014, 114:1422-1434. 10.1161/CIRCRESAHA.114.302530.
    • (2014) Circ. Res. , vol.114 , pp. 1422-1434
    • Furtado, M.B.1    Costa, M.W.2    Pranoto, E.A.3    Salimova, E.4    Pinto, A.R.5    Lam, N.T.6
  • 88
    • 84894474780 scopus 로고    scopus 로고
    • Mechanical boundary conditions bias fibroblast invasion in a collagen-fibrin wound model
    • Rouillard A.D., Holmes J.W. Mechanical boundary conditions bias fibroblast invasion in a collagen-fibrin wound model. Biophys. J. 2014, 106:932-943. 10.1016/j.bpj.2013.12.002.
    • (2014) Biophys. J. , vol.106 , pp. 932-943
    • Rouillard, A.D.1    Holmes, J.W.2
  • 89
    • 80052051371 scopus 로고    scopus 로고
    • Graphical approach to model reduction for nonlinear biochemical networks
    • Holland D.O., Krainak N.C., Saucerman J.J. Graphical approach to model reduction for nonlinear biochemical networks. PLoS One 2011, 6. 10.1371/journal.pone.0023795.
    • (2011) PLoS One , vol.6
    • Holland, D.O.1    Krainak, N.C.2    Saucerman, J.J.3
  • 92
    • 84924718204 scopus 로고    scopus 로고
    • Systems approaches in integrative cardiac biology: illustrations from cardiac heterocellular signalling studies
    • Nim H.T., Boyd S.E., Rosenthal N.A. Systems approaches in integrative cardiac biology: illustrations from cardiac heterocellular signalling studies. Prog. Biophys. Mol. Biol. 2015, 117:69-77. 10.1016/j.pbiomolbio.2014.11.006.
    • (2015) Prog. Biophys. Mol. Biol. , vol.117 , pp. 69-77
    • Nim, H.T.1    Boyd, S.E.2    Rosenthal, N.A.3
  • 93
    • 84872513387 scopus 로고    scopus 로고
    • An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection
    • Jensen K.J., Garmaroudi F.S., Zhang J., Lin J., Boroomand S., Zhang M., et al. An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection. Cell Host Microbe 2013, 13:67-76. 10.1016/j.chom.2012.11.009.
    • (2013) Cell Host Microbe , vol.13 , pp. 67-76
    • Jensen, K.J.1    Garmaroudi, F.S.2    Zhang, J.3    Lin, J.4    Boroomand, S.5    Zhang, M.6
  • 94
    • 84925231771 scopus 로고    scopus 로고
    • Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients
    • Kupfer P., Huber R., Weber M., Vlaic S., Häupl T., Koczan D., et al. Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients. BMC Med. Genet. 2014, 7:40. 10.1186/1755-8794-7-40.
    • (2014) BMC Med. Genet. , vol.7 , pp. 40
    • Kupfer, P.1    Huber, R.2    Weber, M.3    Vlaic, S.4    Häupl, T.5    Koczan, D.6
  • 95
    • 84871796377 scopus 로고    scopus 로고
    • Myofibroblast-mediated mechanisms of pathological remodelling of the heart
    • Weber K.T., Sun Y., Bhattacharya S.K., Ahokas R.A., Gerling I.C. Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat. Rev. Cardiol. 2013, 10:15-26. 10.1038/nrcardio.2012.158.
    • (2013) Nat. Rev. Cardiol. , vol.10 , pp. 15-26
    • Weber, K.T.1    Sun, Y.2    Bhattacharya, S.K.3    Ahokas, R.A.4    Gerling, I.C.5
  • 96
    • 84880559564 scopus 로고    scopus 로고
    • Multiscale computational models of complex biological systems
    • Walpole J., Papin J.A., Peirce S.M. Multiscale computational models of complex biological systems. Annu. Rev. Biomed. Eng. 2013, 15:137-154. 10.1146/annurev-bioeng-071811-150104.
    • (2013) Annu. Rev. Biomed. Eng. , vol.15 , pp. 137-154
    • Walpole, J.1    Papin, J.A.2    Peirce, S.M.3
  • 97
    • 84868376130 scopus 로고    scopus 로고
    • Multiscale models of cell signaling
    • Bajikar S.S., Janes K.A. Multiscale models of cell signaling. Ann. Biomed. Eng. 2012, 40:2319-2327. 10.1007/s10439-012-0560-1.
    • (2012) Ann. Biomed. Eng. , vol.40 , pp. 2319-2327
    • Bajikar, S.S.1    Janes, K.A.2
  • 98
    • 84897543206 scopus 로고    scopus 로고
    • Multiscale modeling of blood flow: from single cells to blood rheology
    • Fedosov D.A., Noguchi H., Gompper G. Multiscale modeling of blood flow: from single cells to blood rheology. Biomech. Model. Mechanobiol. 2014, 13:239-258. 10.1007/s10237-013-0497-9.
    • (2014) Biomech. Model. Mechanobiol. , vol.13 , pp. 239-258
    • Fedosov, D.A.1    Noguchi, H.2    Gompper, G.3
  • 99
    • 84962537235 scopus 로고    scopus 로고
    • Wound Healing: Multi-Scale Modeling
    • Springer Berlin Heidelberg, Berlin, Heidelberg, A. Gefen (Ed.)
    • Vermolen F., Gefen A. Wound Healing: Multi-Scale Modeling. Multiscale Comput. Model. Biomech. Biomed. Eng. 2013, 321-345. Springer Berlin Heidelberg, Berlin, Heidelberg. A. Gefen (Ed.).
    • (2013) Multiscale Comput. Model. Biomech. Biomed. Eng. , pp. 321-345
    • Vermolen, F.1    Gefen, A.2
  • 100
    • 85085219228 scopus 로고    scopus 로고
    • Multiscale Computational Modeling in Vascular Biology: From Molecular Mechanisms to Tissue-Level Structure and Function
    • Springer Berlin Heidelberg, Berlin, Heidelberg, A. Gefen (Ed.)
    • Hayenga H., Thorne B., Yen P., Papin J., Peirce S.M., Humphrey J.D. Multiscale Computational Modeling in Vascular Biology: From Molecular Mechanisms to Tissue-Level Structure and Function. Multiscale Comput. Model. Biomech. Biomed. Eng. 2013, 209-240. Springer Berlin Heidelberg, Berlin, Heidelberg. A. Gefen (Ed.).
    • (2013) Multiscale Comput. Model. Biomech. Biomed. Eng. , pp. 209-240
    • Hayenga, H.1    Thorne, B.2    Yen, P.3    Papin, J.4    Peirce, S.M.5    Humphrey, J.D.6
  • 101
    • 77956393865 scopus 로고    scopus 로고
    • On the multiscale modeling of heart valve biomechanics in health and disease
    • Weinberg E.J., Shahmirzadi D., Mofrad M.R.K. On the multiscale modeling of heart valve biomechanics in health and disease. Biomech. Model. Mechanobiol. 2010, 9:373-387. 10.1007/s10237-009-0181-2.
    • (2010) Biomech. Model. Mechanobiol. , vol.9 , pp. 373-387
    • Weinberg, E.J.1    Shahmirzadi, D.2    Mofrad, M.R.K.3
  • 102
    • 33947406414 scopus 로고    scopus 로고
    • Multiscale modeling: physiome project standards, tools, and databases
    • Hunter P.J., Li W.W., McCulloch A.D., Noble D. Multiscale modeling: physiome project standards, tools, and databases. Computer (Long Beach Calif) 2006, 39:48-54. 10.1109/MC.2006.392.
    • (2006) Computer (Long Beach Calif) , vol.39 , pp. 48-54
    • Hunter, P.J.1    Li, W.W.2    McCulloch, A.D.3    Noble, D.4
  • 103
    • 80054770583 scopus 로고    scopus 로고
    • Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype
    • Campbell S.G., McCulloch A.D. Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype. J. R. Soc. Interface 2011, 8:1550-1561. 10.1098/rsif.2011.0184.
    • (2011) J. R. Soc. Interface , vol.8 , pp. 1550-1561
    • Campbell, S.G.1    McCulloch, A.D.2
  • 104
    • 84949669458 scopus 로고    scopus 로고
    • Gaining myocytes or losing fibroblasts: challenges in cardiac fibroblast reprogramming for infarct repair
    • Czubryt M.P., Safi H.A.N.R. Gaining myocytes or losing fibroblasts: challenges in cardiac fibroblast reprogramming for infarct repair. J. Mol. Cell. Cardiol. 2016.
    • (2016) J. Mol. Cell. Cardiol.
    • Czubryt, M.P.1    Safi, H.A.N.R.2
  • 105
  • 106
    • 84901236111 scopus 로고    scopus 로고
    • Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation
    • Ryall K.A., Bezzerides V.J., Rosenzweig A., Saucerman J.J. Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation. J. Mol. Cell. Cardiol. 2014, 72:74-84. 10.1016/j.yjmcc.2014.02.013.
    • (2014) J. Mol. Cell. Cardiol. , vol.72 , pp. 74-84
    • Ryall, K.A.1    Bezzerides, V.J.2    Rosenzweig, A.3    Saucerman, J.J.4
  • 107
    • 84889065876 scopus 로고    scopus 로고
    • PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling
    • Yang J.H., Polanowska-Grabowska R.K., Smith J.S., Shields C.W., Saucerman J.J. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling. J. Mol. Cell. Cardiol. 2014, 66:83-93. 10.1016/j.yjmcc.2013.11.001.
    • (2014) J. Mol. Cell. Cardiol. , vol.66 , pp. 83-93
    • Yang, J.H.1    Polanowska-Grabowska, R.K.2    Smith, J.S.3    Shields, C.W.4    Saucerman, J.J.5
  • 108
    • 84893059304 scopus 로고    scopus 로고
    • Scaffold state switching amplifies, accelerates, and insulates protein kinase c signaling
    • Greenwald E.C., Redden J.M., Dodge-Kafka K.L., Saucerman J.J. Scaffold state switching amplifies, accelerates, and insulates protein kinase c signaling. J. Biol. Chem. 2014, 289:2353-2360. 10.1074/jbc.M113.497941.
    • (2014) J. Biol. Chem. , vol.289 , pp. 2353-2360
    • Greenwald, E.C.1    Redden, J.M.2    Dodge-Kafka, K.L.3    Saucerman, J.J.4
  • 109
    • 0037066036 scopus 로고    scopus 로고
    • Na+ channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism
    • Clancy C.E., Rudy Y. Na+ channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation 2002, 105:1208-1213. 10.1161/hc1002.105183.
    • (2002) Circulation , vol.105 , pp. 1208-1213
    • Clancy, C.E.1    Rudy, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.