Computational modeling of epithelial-mesenchymal transformations

BioSystems

Volumn 100, Issue 1, 2010, Pages 23-30

  Neagu, Adrian ^a,b   Mironov, Vladimir ^c   Kosztin, Ioan ^a   Barz, Bogdan ^a   Neagu, Monica ^b   Moreno Rodriguez, Ricardo A ^c   Markwald, Roger R ^c   Forgacs, Gabor ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b VICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Cushion tissue; Differential adhesion hypothesis; Monte Carlo simulation; Self assembly

Indexed keywords

CELL ORGANELLE; COMPUTER SIMULATION; MONTE CARLO ANALYSIS; NUMERICAL MODEL;

ARTICLE; BASEMENT MEMBRANE; CELL ADHESION; CELL INTERACTION; CELL TRANSFORMATION; COMPUTER SIMULATION; CONTROLLED STUDY; ENDOCARDIAL CUSHION; EPITHELIAL MESENCHYME TRANSFORMATION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; HEART DEVELOPMENT; MATHEMATICAL MODEL; MESENCHYME CELL; MONTE CARLO METHOD; PHENOTYPE;

EID: 77249155488     PISSN: 03032647     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biosystems.2009.12.004     Document Type: Article

References (58)

1. Amar J.G. The Monte Carlo method in science and engineering. Computing in Science & Engineering 8 (2006) 9-19
2. Arciniegas E., Frid M.G., Douglas I.S., and Stenmark K.R. Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension. American Journal of Physiology: Lung Cellular and Molecular Physiology (2007) 293
3. Armstrong E.J., and Bischoff J. Heart valve development: endothelial cell signaling and differentiation. Circulation Research 95 (2004) 459-470
4. Beysens D.A., Forgacs G., and Glazier J.A. Cell sorting is analogous to phase ordering in fluids. Proceedings of the National Academy of Sciences USA 97 (2000) 9467-9471
5. Boyer A.S., Erickson C.P., and Runyan R.B. Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFbeta signal transduction mechanisms. Developmental Dynamics vol. 214 (1999), An Official Publication of the American Association of Anatomists pp. 81-91
6. Butcher J.T., McQuinn T.C., Sedmera D., Turner D., and Markwald R.R. Transitions in early embryonic atrioventricular valvular function correspond with changes in cushion biomechanics that are predictable by tissue composition. Circulation Research 100 (2007) 1503-1511
7. Camenisch T.D., Runyan R.B., and Markwald R. Molecular regulation of cushion morphogenesis. In: Harvery R., and Rosenthal N. (Eds). Heart Development and Regeneration. 2nd ed. (2008), Elsevier, London
8. Cickovski T.M., Chengbang H., Chaturvedi R., Glimm T., Hentschel H.G.E., Alber M.S., Glazier J.A., Newman S.A., and Izaguirre J.A. A framework for three-dimensional simulation of morphogenesis. IEEE/ACM Transactions on Computational Biology and Bioinformatics 2 (2005) 273-288
9. Eisenberg L.M., and Markwald R.R. Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circulation Research 77 (1995) 1-6
10. Eyiyurekli M., Manley P., Lelkes P.I., and Breen D.E. A computational model of chemotaxis-based cell aggregation. Biosystems 93 (2008) 226-239
11. Fitzharris T.P. Origin and migration of cushion tissue in the developing heart. Scanning Electron Microscopy 2 (1981) 255-260
12. Flenner E., Marga F., Neagu A., Kosztin I., and Forgacs G. Relating biophysical properties across scales. Current Topics in Developmental Biology 81 (2008) 461-483
13. Forgacs G., Foty R.A., Shafrir Y., and Steinberg M.S. Viscoelastic properties of living embryonic tissues: a quantitative study. Biophysical Journal 74 (1998) 2227-2234
14. Foty R.A., Forgacs G., Pfleger C.M., and Steinberg M.S. Liquid properties of embryonic-tissues-measurement of interfacial-tensions. Physical Review Letters 72 (1994) 2298-2301
15. Foty R.A., Pfleger C.M., Forgacs G., and Steinberg M.S. Surface tensions of embryonic tissues predict their mutual envelopment behavior. Development 122 (1996) 1611-1620
16. Foty R.A., and Steinberg M.S. The differential adhesion hypothesis: a direct evaluation. Developmental Biology 278 (2005) 255-263
17. Galle J., Loeffler M., and Drasdo D. Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell Populations in vitro. Biophysical Journal 88 (2005) 62-75
18. Galle J., Sittig D., Hanisch I., Wobus M., Wandel E., Loeffler M., and Aust G. Individual cell-based models of tumor-environment interactions-multiple effects of CD97 on tumor invasion. American Journal of Pathology 169 (2006) 1802-1811
19. Gerisch A., and Chaplain M.A. Mathematical modelling of cancer cell invasion of tissue: local and non-local models and the effect of adhesion. Journal of Theoretical Biology 250 (2008) 684-704
20. Glazier J.A., Balter A., and Popławksi N.J. Magnetization to morphogenesis: a history of the GGH model. In: Anderson A.R.A., Chaplain M.A.J., and Rejniak R.A. (Eds). Single-cell-based Models in Biology and Medicine (2007), Birkhauser, Basel, Boston, Berlin 79-106
21. Glazier J.A., and Graner F. Simulation of the differential adhesion driven rearrangement of biological cells. Physical Review E 47 (1993) 2128-2154
22. Graner F., and Glazier J.A. Simulation of biological cell sorting using a 2-dimensional extended Potts-model. Physical Review Letters 69 (1992) 2013-2016
23. Grant M.R., Mostov K.E., Tlsty T.D., and Hunt C.A. Simulating properties of in vitro epithelial cell morphogenesis. PLoS Computational Biology 2 (2006) e129
24. Hamburger V., and Hamilton H.L. A series of normal stages in the development of the chick embryo. Journal of Morphology 88 (1951) 49-92
25. Hay E.D. The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Developmental Dynamics 233 (2005) 706-720
26. Hegedus B., Marga F., Jakab K., Sharpe-Timms K.L., and Forgacs G. The interplay of cell-cell and cell-matrix interactions in the invasive properties of brain tumors. Biophysical Journal 91 (2006) 2708-2716
27. Huang S., and Ingber D.E. The structural and mechanical complexity of cell-growth control. Nature Cell Biology 1 (1999) E131-E138
28. Hutson M.S., Brodland G.W., Yang J., and Viens D. Cell sorting in three dimensions: topology, fluctuations, and fluidlike instabilities. Physical Review Letters 101 (2008) 148105-148104
29. Icardo J.M. Changes in endocardial cell morphology during development of the endocardial cushions. Anatomy and Embryology 179 (1989) 443-448
30. Jakab K., Damon B., Neagu A., Kachurin A., and Forgacs G. Three-dimensional tissue constructs built by bioprinting. Biorheology 43 (2006) 509-513
31. Jakab K., Neagu A., Mironov V., Markwald R.R., and Forgacs G. Engineering biological structures of prescribed shape using self-assembling multicellular systems. Proceedings of the National Academy of Sciences U.S.A. 101 (2004) 2864-2869
32. Kurnit D.M., Aldridge J.F., Matsuoka R., and Matthysse S. Increased adhesiveness of trisomy 21 cells and atrioventricular canal malformations in Down syndrome: a stochastic model. American Journal of Medical Genetics 20 (1985) 385-399
33. Lao B.J., and Kamei D.T. Investigation of cellular movement in the prostate epithelium using an agent-based model. Journal of Theoretical Biology 250 (2008) 642-654
34. Lee J.M., Dedhar S., Kalluri R., and Thompson E.W. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. Journal of Cell Biology 172 (2006) 973-981
35. Markwald R., Eisenberg C., Eisenberg L., Trusk T., and Sugi Y. Epithelial-mesenchymal transformations in early avian heart development. Acta Anatomica 156 (1996) 173-186
36. Markwald R.R., Mjaatvedt C.H., Krug E.L., and Sinning A.R. Inductive interactions in heart development-role of cardiac adherons in cushion tissue formation. Annals of the New York Academy of Sciences 588 (1990) 13-25
37. Metropolis N., Rosenbluth A.W., Rosenbluth M.N., Teller A.H., and et Telle E. Equation of state calculations by fast computing machines. Journal of Chemical Physics 21 (1953) 1087-1097
38. Mjaatvedt C.H., and Markwald R.R. Induction of an epithelial-mesenchymal transition by an in vivo adheron-like complex. Developmental Biology 136 (1989) 118-128
39. Mombach J.C.M., Glazier J.A., Raphael R.C., and Zajac M. Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations. Physical Review Letters 75 (1995) 2244-12244
40. Moreno-Rodriguez R.A., de la Cruz M.V., and Krug E.L. Temporal and spatial asymmetries in the initial distribution of mesenchyme cells in the atrioventricular canal cushions of the developing chick heart. The Anatomical Record 248 (1997) 84-92
41. Neagu A., Jakab K., Jamison R., and Forgacs G. Role of physical mechanisms in biological self-organization. Physical Review Letters 95 (2005) 178104
42. Neagu A., Kosztin I., Jakab K., Barz B., Neagu M., Jamison R., and Forgacs G. Computational modeling of tissue self-assembly. Modern Physics Letters B 20 (2006) 1217-1231
43. Newman T.J. Modeling multicellular systems using subcellular elements. Mathematical Biosciences and Engineering 2 (2005) 611-622
44. O'Riordan E., Mendelev N., Patschan S., Patschan D., Eskander J., Cohen-Gould L., Chander P., and Goligorsky M.S. Chronic NOS inhibition actuates endothelial-mesenchymal transformation. American Journal of Physiology, Heart and Circulatory Physiology 292 (2007) H285-294
45. Person A.D., Klewer S.E., and Runyan R.B. Cell biology of cardiac cushion development. International Review of Cytology 243 (2005) 287-335
46. Ramis-Conde I., Drasdo D., Anderson A.R.A., and Chaplain M.A.J. Modeling the influence of the E-cadherin-{beta}-catenin pathway in cancer cell invasion: a multiscale approach. Biophysical Journal 95 (2008) 155-165
47. Runyan R.B., Potts J.D., Sharma R.V., Loeber C.P., Chiang J.J., and Bhalla R.C. Signal transduction of a tissue interaction during embryonic heart development. Cell Regulation 1 (1990) 301-313
48. Schaller G., and Meyer-Hermann M. A modelling approach towards epidermal homoeostasis control. Journal of Theoretical Biology 247 (2007) 554-573
49. Schroeder J.A., Jackson L.F., Lee D.C., and Camenisch T.D. Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling. Journal of Molecular Medicine 81 (2003) 392-403
50. Shelton E.L., and Yutzey K.E. Tbx20 regulation of endocardial cushion cell proliferation and extracellular matrix gene expression. Developmental Biology 302 (2007) 376-388
51. Steinberg M.S. Reconstruction of tissues by dissociated cells. Some morphogenetic tissue movements and the sorting out of embryonic cells may have a common explanation. Science 141 (1963) 401-408
52. Steinberg M.S. Adhesion in development: an historical overview. Developmental Biology 180 (1996) 377-388
53. Steinberg M.S. Differential adhesion in morphogenesis: a modern view. Current Opinion in Genetics & Development 17 (2007) 281-286
54. Sugi Y., Ito N., Szebenyi G., Myers K., Fallon J.F., Mikawa T., and Markwald R.R. Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation. Developmental Biology 258 (2003) 252-263
55. Thiery J.P. Epithelial-mesenchymal transitions in development and pathologies. Current Opinion in Cell Biology 6 (2003) 740-746
56. Wessels A., and Sedmera D. Developmental anatomy of the heart: a tale of mice and man. Physiological Genomics 15 (2003) 165-176
57. Zeisberg E.M., Potenta S., Xie L., Zeisberg M., and Kalluri R. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Research 67 (2007) 10123-10128
58. Zeisberg E.M., Tarnavsk I.O., Zeisberg M., Dorfman A.L., McMullen J.R., Gustafsson E., Chandraker A., Yuan X., Pu W.T., Roberts A.B., Neilson E.G., Sayegh M.H., Izumo S., and Kalluri R. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nature Medicine 8 (2007) 952-961