Mathematical model of renal interstitial fibrosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 39, 2014, Pages 14193-14198

  Hao, Wenrui ^a   Rovin, Brad H ^b   Friedman, Avner ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Math modeling; Renal fibrosis; Tubulointerstitial inflammation

Indexed keywords

BIOLOGICAL MARKER; CCL2 PROTEIN, HUMAN; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA;

BIOLOGICAL MODEL; CELL COUNT; DISEASE COURSE; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FIBROSIS; HUMAN; KIDNEY; KIDNEY TUBULE; LUPUS NEPHRITIS; MACROPHAGE; MATHEMATICAL PHENOMENA; METABOLISM; MYOFIBROBLAST; NEPHRITIS, INTERSTITIAL; PATHOLOGY; URINE;

BIOMARKERS; CELL COUNT; CHEMOKINE CCL2; DISEASE PROGRESSION; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; FIBROSIS; HUMANS; KIDNEY; KIDNEY TUBULES; LUPUS NEPHRITIS; MACROPHAGES; MATHEMATICAL CONCEPTS; MATRIX METALLOPROTEINASES; MODELS, BIOLOGICAL; MYOFIBROBLASTS; NEPHRITIS, INTERSTITIAL; PLATELET-DERIVED GROWTH FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84907572507     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1413970111     Document Type: Article

References (40)

1. Rovin BH, Birmingham DJ, Nadasdy T (2012) Renal involvement in systemic lupus erythematosus. Schrier's Diseases of the Kidney, eds Schrier R, Neilson E, Molitoris B, Coffman T, Falk R (Lippincott Williams & Wilkins, Philadelphia), 9th Ed, pp 1522-1556.
2. Dhingra S, Qureshi R, Abdellatif A, Gaber LW, Truong LD (2014) Tubulointerstitial nephritis in systemic lupus erythematosus: Innocent bystander or ominous presage. Histol Histopathol 29(5):553-565.
3. Hsieh C, et al. (2011) Predicting outcomes of lupus nephritis with tubulointerstitial inflammation and scarring. Arthritis Care Res (Hoboken) 63(6):865-874.
4. Chen YE, Korbet SM, Katz RS, Schwartz MM, Lewis EJ; Collaborative Study Group (2008) Value of a complete or partial remission in severe lupus nephritis. Clin J Am Soc Nephrol 3(1):46-53.
5. Müller GA, Markovic-Lipkovski J, Frank J, Rodemann HP (1992) The role of interstitial cells in the progression of renal diseases. J Am Soc Nephrol 2(10, Suppl):S198-S205.
6. Peruzzi L, et al. (1996) Tubulointerstitial responses in the progression of glomerular diseases: albuminuria modulates alpha v beta 5 integrin. Kidney Int 50(4):1310-1320.
7. Schwartz MM, Korbet SM, Rydell J, Borok R, Genchi R (1995) Primary focal segmental glomerular sclerosis in adults: prognostic value of histologic variants. Am J Kidney Dis 25(6):845-852.
8. Walsh M, et al. (2010) Histopathologic features aid in predicting risk for progression of IgA nephropathy. Clin J Am Soc Nephrol 5(3):425-430.
9. Hill GS, Delahousse M, Nochy D, Mandet C, Bariéty J (2001) Proteinuria and tubulointerstitial lesions in lupus nephritis. Kidney Int 60(5):1893-1903.
10. Pichler R, et al. (1995) The pathogenesis of tubulointerstitial disease associated with glomerulonephritis: The glomerular cytokine theory. Miner Electrolyte Metab 21(4-5):317-327.
11. Bianco C, Griffin FM, Jr, Silverstein SC (1975) Studies of the macrophage complement receptor. Alteration of receptor function upon macrophage activation. J Exp Med 141(6):1278-1290.
12. Dorrington KJ (1976) Properties of the Fc receptor on macrophages. Immunol Commun 5(4):263-280.
13. Farris AB, Colvin RB (2012) Renal interstitial fibrosis: Mechanisms and evaluation. Curr Opin Nephrol Hypertens 21(3):289-300.
14. Gomez-Guerrero C, et al. (2010) Interaction of immune complexes with Fc receptors in mesangial cells: A potential target for the treatment of IgA nephropathy. Nephrology (Carlton) 3(1):95-101.
15. Simonson MS, Ismail-Beigi F (2011) Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop. J Biol Chem 286(13):11003-11008.
16. Vernon MA, Mylonas KJ, Hughes J (2010) Macrophages and renal fibrosis. Semin Nephrol 30(3):302-317.
17. Wada T, Yokoyama H, Matsushima K, Kobayashi K (2003) Monocyte chemoattractant protein-1: Does it play a role in diabetic nephropathy? Nephrol Dial Transplant 18(3): 457-459.
18. Wada T, et al. (2004) Gene therapy via blockade of monocyte chemoattractant protein- 1 for renal fibrosis. J Am Soc Nephrol 15(4):940-948.
19. Nikolic-Paterson DJ, Atkins RC (2001) The role of macrophages in glomerulonephritis. Nephrol Dial Transplant 16(Suppl 5):3-7.
20. Zhao H, et al. (2013) Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases. World J Nephrol 2(3):84-89.
21. Floege J, et al. (1998) Endogenous fibroblast growth factor-2 mediates cytotoxicity in experimental mesangioproliferative glomerulonephritis. J Am Soc Nephrol 9(5): 792-801.
22. Floege J, et al. (1999) Localization of fibroblast growth factor-2 (basic FGF) and FGF receptor-1 in adult human kidney. Kidney Int 56(3):883-897.
23. Ray PE, et al. (1994) bFGF and its low affinity receptors in the pathogenesis of HIV-associated nephropathy in transgenic mice. Kidney Int 46(3):759-772.
24. Strutz F, et al. (2001) TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2). Kidney Int 59(2):579-592.
25. Nakatsuji S, Yamate J, Sakuma S (1998) Macrophages, myofibroblasts, and extracellular matrix accumulation in interstitial fibrosis of chronic progressive nephropathy in aged rats. Vet Pathol 35(5):352-360.
26. Strutz F, Zeisberg M (2006) Renal fibroblasts and myofibroblasts in chronic kidney disease. J Am Soc Nephrol 17(11):2992-2998.
27. Alvarado A, et al. (2014) The value of repeat kidney biopsy in quiescent Argentinian lupus nephritis patients. Lupus 23(8):840-847.
28. Goel P, Sneyd J, Friedman A (2006) Homogenization of the cell cytoplasm: The calcium bidomain equations. Multiscale Model Simul 5(4):1045-1062.
29. Kipari T, et al. (2006) Nitric oxide is an important mediator of renal tubular epithelial cell death in vitro and in murine experimental hydronephrosis. Am J Pathol 169(2): 388-399.
30. Dai C, Yang J, Liu Y (2003) Transforming growth factor-beta1 potentiates renal tubular epithelial cell death by a mechanism independent of Smad signaling. J Biol Chem 278(14):12537-12545.
31. Shankland SJ, et al. (1997) Mesangial cell proliferation mediated by PDGF and bFGF is determined by levels of the cyclin kinase inhibitor p27Kip1. Kidney Int 51(4): 1088-1099.
32. Fan JM, et al. (1999) Transforming growth factor-beta regulates tubular epithelialmyofibroblast transdifferentiation in vitro. Kidney Int 56(4):1455-1467.
33. Rastaldi MP, et al. (2002) Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int 62(1):137-146.
34. Midgley AC, et al. (2013) Transforming growth factor-1 (TGF-1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. J Biol Chem 288(21):14824-14838.
35. Leask A (2007) TGFbeta, cardiac fibroblasts, and the fibrotic response. Cardiovasc Res 74(2):207-212.
36. Leask A, Abraham DJ (2004) TGF-beta signaling and the fibrotic response. FASEB J 18(7):816-827.
37. Lijnen P, Petrov V (2002) Transforming growth factor-beta 1-induced collagen production in cultures of cardiac fibroblasts is the result of the appearance of myofibroblasts. Methods Find Exp Clin Pharmacol 24(6):333-344.
38. Rovin BH, et al. (2005) Urine chemokines as biomarkers of human systemic lupus erythematosus activity. J Am Soc Nephrol 16(2):467-473.
39. Boor P, Sebeková K, Ostendorf T, Floege J (2007) Treatment targets in renal fibrosis. Nephrol Dial Transplant 22(12):3391-3407.
40. Chuang PY, Menon MC, He JC (2013) Molecular targets for treatment of kidney fibrosis. J Mol Med (Berl) 91(5):549-559.