Obesity and cardiovascular disease

Circulation Research

Volumn 118, Issue 11, 2016, Pages 1752-1770

  Ortega, Francisco B ^a,b   Lavie, Carl J ^c   Blair, Steven N ^d  

^a UNIVERSITY OF GRANADA   (Spain)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

cardiovascular diseases; metabolically healthy obesity; morbidity; mortality; obesity

Indexed keywords

CARDIORESPIRATORY FITNESS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; DISEASE DURATION; DISEASE SEVERITY; HIGH RISK PATIENT; HUMAN; INCIDENCE; MIDDLE EAST; NORTH AFRICA; OBESITY; PACIFIC ISLANDS; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; WESTERN EUROPE; CARDIOVASCULAR DISEASES; GENETICS; METABOLISM;

CARDIOVASCULAR DISEASES; HUMANS; OBESITY; PHENOTYPE;

EID: 84962300385     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.306883     Document Type: Review

References (161)

1. Maclennan W, On the treatment of obesity and myxoedema by a new preparation of thyroid ("thyroglandin"). Br Med J 1898 2 79 80
2. Oliver T, Post-mortem in a case of extreme obesity. J Anat Physiol 1880 14 345 347
3. Perry AW, Nature and treatment of obesity. Cal State J Med 1903 1 356 359
4. Ng M, Fleming T, Robinson M, Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014 384 766 781. doi: 10.1016/S0140-6736(14)60460-8
5. Flegal KM, Kit BK, Orpana H, Graubard BI, Association of all-cause mortality with overweight and obesity using standard body mass index categories: A systematic review and meta-Analysis. JAMA 2013 309 71 82. doi: 10.1001/jama.2012.113905
6. Ekelund U, Franks PW, Wareham NJ, Aman J, Oxygen uptakes adjusted for body composition in normal-weight and obese adolescents. Obes Res 2004 12 513 520. doi: 10.1038/oby.2004.58
7. Salvadori A, Fanari P, Mazza P, Agosti R, Longhini E, Work capacity and cardiopulmonary adaptation of the obese subject during exercise testing. Chest 1992 101 674 679
8. Salvadori A, Fanari P, Tovaglieri I, Giacomotti E, Nibbio F, Belardi F, Longhini E, Ventilation and its control during incremental exercise in obesity. Respiration 2008 75 26 33. doi: 10.1159/000097245
9. Lavie CJ, McAuley PA, Church TS, Milani RV, Blair SN, Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox. J Am Coll Cardiol 2014 63 1345 1354. doi: 10.1016/j.jacc.2014.01.022
10. Lavie CJ, Alpert MA, Arena R, Mehra MR, Milani RV, Ventura HO, Impact of obesity and the obesity paradox on prevalence and prognosis in heart failure. JACC Heart Fail 2013 1 93 102. doi: 10.1016/j.jchf.2013.01.006
11. Alpert MA, Omran J, Mehra A, Ardhanari S, Impact of obesity and weight loss on cardiac performance and morphology in adults. Prog Cardiovasc Dis 2014 56 391 400. doi: 10.1016/j.pcad.2013.09.003
12. Brion MA, Ness AR, Davey Smith G, Leary SD, Association between body composition and blood pressure in a contemporary cohort of 9-year-old children. J Hum Hypertens 2007 21 283 290. doi: 10.1038/sj.jhh.1002152
13. Gracia-Marco L, Moreno LA, Ruiz JR, Body composition indices and single and clustered cardiovascular disease risk factors in adolescents: Providing clinical-based cut-points. Prog. Cardiovasc. Dis 2015;58:555-564. doi: 10.1016/j.pcad.2015.11.002
14. Grijalva-Eternod CS, Lawlor DA, Wells JC, Testing a capacity-load model for hypertension: disentangling early and late growth effects on childhood blood pressure in a prospective birth cohort. PLoS One 2013 8 e56078. doi: 10.1371/journal.pone.0056078
15. Lawlor DA, Benfield L, Logue J, Tilling K, Howe LD, Fraser A, Cherry L, Watt P, Ness AR, Davey Smith G, Sattar N, Association between general and central adiposity in childhood, and change in these, with cardiovascular risk factors in adolescence: prospective cohort study. BMJ 2010 341 c6224
16. Bigaard J, Frederiksen K, Tjønneland A, Thomsen BL, Overvad K, Heitmann BL, Sørensen TI, Body fat and fat-free mass and all-cause mortality. Obes Res 2004 12 1042 1049. doi: 10.1038/oby.2004.131
17. Moreno M, Puig J, Moreno-Navarrete JM, Xifra G, Ortega F, Ricart W, Fernández-Real JM, Lean mass, and not fat mass, is an independent determinant of carotid intima media thickness in obese subjects. Atherosclerosis 2015 243 493 498. doi: 10.1016/j.atherosclerosis.2015.09.012
18. Ortega FB, Sui X, Lavie CJ, Blair SN, Body Mass Index, the Most Widely Used But Also Widely Criticized Index: Would a Criterion Standard Measure of Total Body Fat Be a Better Predictor of Cardiovascular Disease Mortality? Mayo Clin Proc 2016 91 443 455. doi: 10.1016/j.mayocp.2016.01.008
19. Wells JC, Commentary: The paradox of body mass index in obesity assessment: not a good index of adiposity, but not a bad index of cardio-metabolic risk. Int J Epidemiol 2014 43 672 674. doi: 10.1093/ije/dyu060
20. Forouzanfar MH, Alexander L, Anderson HR, Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: A systematic analysis for the global burden of disease study 2013. Lancet 2015 386 10010 2287 2323. doi: 10.1016/S0140-6736(15)00128-2
21. Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm EB, Danaei G, Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: A pooled analysis of 97 prospective cohorts with 1.8 million participants. Lancet 2014 383 970 983
22. Nakajima T, Fujioka S, Tokunaga K, Hirobe K, Matsuzawa Y, Tarui S, Noninvasive study of left ventricular performance in obese patients: influence of duration of obesity. Circulation 1985 71 481 486
23. Abdullah A, Wolfe R, Stoelwinder JU, de Courten M, Stevenson C, Walls HL, Peeters A, The number of years lived with obesity and the risk of all-cause and cause-specific mortality. Int J Epidemiol 2011 40 985 996. doi: 10.1093/ije/dyr018
24. Reis JP, Loria CM, Lewis CE, Powell-Wiley TM, Wei GS, Carr JJ, Terry JG, Liu K, Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age. JAMA 2013 310 280 288. doi: 10.1001/jama.2013.7833
25. Reis JP, Allen N, Gunderson EP, Lee JM, Lewis CE, Loria CM, Powell-Wiley TM, Rana JS, Sidney S, Wei G, Yano Y, Liu K, Excess body mass index- and waist circumference-years and incident cardiovascular disease: the CARDIA study. Obesity (Silver Spring) 2015 23 879 885. doi: 10.1002/oby.21023
26. The NS, Richardson AS, Gordon-Larsen P, Timing and duration of obesity in relation to diabetes: findings from an ethnically diverse, nationally representative sample. Diabetes Care 2013 36 865 872. doi: 10.2337/dc12-0536
27. Dowd JB, Zajacova A, Long-Term obesity and cardiovascular, inflammatory, and metabolic risk in U.S. adults. Am J Prev Med 2014 46 578 584. doi: 10.1016/j.amepre.2014.01.016
28. Tanamas SK, Wong E, Backholer K, Abdullah A, Wolfe R, Barendregt J, Peeters A, Duration of obesity and incident hypertension in adults from the Framingham Heart Study. J Hypertens 2015 33 542 545. discussion 545. doi: 10.1097/HJH.0000000000000441
29. Blair SN, Davey Smith G, Lee IM, Fox K, Hillsdon M, McKeown RE, Haskell WL, Marmot M, A tribute to Professor Jeremiah Morris: the man who invented the field of physical activity epidemiology. Ann Epidemiol 2010 20 651 660. doi: 10.1016/j.annepidem.2010.06.001
30. MORRIS JN, HEADY JA, RAFFLE PA, ROBERTS CG, PARKS JW, Coronary heart-disease and physical activity of work. Lancet 1953 265 1053 1057; contd
31. Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh CC, Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med 1986 314 605 613. doi: 10.1056/NEJM198603063141003
32. Paffenbarger RS Jr, Wing AL, Hyde RT, Physical activity as an index of heart attack risk in college alumni. Am J Epidemiol 1978 108 161 175
33. Paffenbarger RS Jr, Kampert JB, Lee IM, Hyde RT, Leung RW, Wing AL, Changes in physical activity and other lifeway patterns influencing longevity. Med Sci Sports Exerc 1994 26 857 865
34. Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT, Lancet Physical Activity Series Working Group Effect of physical inactivity on major non-communicable diseases worldwide: An analysis of burden of disease and life expectancy. Lancet 2012 380 219 229. doi: 10.1016/S0140-6736(12)61031-9
35. st century: evidence, improved methods and solutions using the '7 investments that work' as a framework. Br J Sports Med 2014 48 169 170. doi: 10.1136/bjsports-2013-093372
36. Myers J, McAuley P, Lavie CJ, Despres JP, Arena R, Kokkinos P, Physical activity and cardiorespiratory fitness as major markers of cardiovascular risk: their independent and interwoven importance to health status. Prog Cardiovasc Dis 2015 57 306 314. doi: 10.1016/j.pcad.2014.09.011
37. Lavie CJ, Arena R, Swift DL, Johannsen NM, Sui X, Lee DC, Earnest CP, Church TS, O'Keefe JH, Milani RV, Blair SN, Exercise and the cardiovascular system: clinical science and cardiovascular outcomes. Circ Res 2015 117 207 219. doi: 10.1161/CIRCRESAHA.117.305205
38. Blair SN, Kohl HW III, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW, Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 1989 262 2395 2401
39. Blair SN, Kampert JB, Kohl HW III, Barlow CE, Macera CA, Paffenbarger RS Jr, Gibbons LW, Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA 1996 276 205 210
40. Blair SN, Kohl HW III, Barlow CE, Paffenbarger RS Jr, Gibbons LW, Macera CA, Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. JAMA 1995 273 1093 1098
41. Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H, Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: A meta-Analysis. JAMA 2009 301 2024 2035. doi: 10.1001/jama.2009.681
42. Barry VW, Baruth M, Beets MW, Durstine JL, Liu J, Blair SN, Fitness vs. fatness on all-cause mortality: A meta-Analysis. Prog Cardiovasc Dis 2014 56 382 390. doi: 10.1016/j.pcad.2013.09.002
43. LaMonte MJ, Blair SN, Physical activity, cardiorespiratory fitness, and adiposity: contributions to disease risk. Curr Opin Clin Nutr Metab Care 2006 9 540 546. doi: 10.1097/01.mco.0000241662.92642.08
44. Wei M, Kampert JB, Barlow CE, Nichaman MZ, Gibbons LW, Paffenbarger RS Jr, Blair SN, Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA 1999 282 1547 1553
45. Lee CD, Blair SN, Jackson AS, Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. Am J Clin Nutr 1999 69 373 380
46. Lyerly GW, Sui X, Lavie CJ, Church TS, Hand GA, Blair SN, The association between cardiorespiratory fitness and risk of all-cause mortality among women with impaired fasting glucose or undiagnosed diabetes mellitus. Mayo Clin Proc 2009 84 780 786. doi: 10.1016/S0025-6196(11)60487-4
47. Farrell SW, Fitzgerald SJ, McAuley PA, Barlow CE, Cardiorespiratory fitness, adiposity, and all-cause mortality in women. Med Sci Sports Exerc 2010 42 2006 2012. doi: 10.1249/MSS.0b013e3181df12bf.
48. Sui X, LaMonte MJ, Blair SN, Cardiorespiratory fitness as a predictor of nonfatal cardiovascular events in asymptomatic women and men. Am J Epidemiol 2007 165 1413 1423. doi: 10.1093/aje/kwm031
49. Lyerly GW, Sui X, Lavie CJ, Church TS, Hand GA, Blair SN, The association between cardiorespiratory fitness and risk of all-cause mortality among women with impaired fasting glucose or undiagnosed diabetes mellitus. Mayo Clin Proc 2009 84 780 786. doi: 10.1016/S0025-6196(11)60487-4
50. Church TS, LaMonte MJ, Barlow CE, Blair SN, Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. Arch Intern Med 2005 165 2114 2120. doi: 10.1001/archinte.165.18.2114
51. McAuley PA, Sui X, Church TS, Hardin JW, Myers JN, Blair SN, The joint effects of cardiorespiratory fitness and adiposity on mortality risk in men with hypertension. Am J Hypertens 2009 22 1062 1069. doi: 10.1038/ajh.2009.122
52. Kim S, Kim JY, Lee DC, Lee HS, Lee JW, Jeon JY, Combined impact of cardiorespiratory fitness and visceral adiposity on metabolic syndrome in overweight and obese adults in Korea. PLoS One 2014 9 e85742. doi: 10.1371/journal.pone.0085742
53. Lavie CJ, Archer E, Shook RP, Blair SN, Metabolically healthy obesity, fitness, and prognosis. Ochsner J 2015;15:121-123
54. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr, International Diabetes Federation Task Force on Epidemiology and Prevention; Hational Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009 120 1640 1645. doi: 10.1161/CIRCULATIONAHA.109.192644
55. Stevens J, Cai J, Evenson KR, Thomas R, Fitness and fatness as predictors of mortality from all causes and from cardiovascular disease in men and women in the lipid research clinics study. Am J Epidemiol 2002 156 832 841
56. Stevens J, Evenson KR, Thomas O, Cai J, Thomas R, Associations of fitness and fatness with mortality in Russian and American men in the lipids research clinics study. Int J Obes Relat Metab Disord 2004 28 1463 1470. doi: 10.1038/sj.ijo.0802770
57. Diaz VA, Player MS, Mainous AG 3rd, Carek PJ, Geesey ME, Competing impact of excess weight versus cardiorespiratory fitness on cardiovascular risk. Am J Cardiol 2006 98 1468 1471. doi: 10.1016/j.amjcard.2006.06.048
58. Lee DC, Sui X, Church TS, Lavie CJ, Jackson AS, Blair SN, Changes in fitness and fatness on the development of cardiovascular disease risk factors hypertension, metabolic syndrome, and hypercholesterolemia. J Am Coll Cardiol 2012 59 665 672. doi: 10.1016/j.jacc.2011.11.013
59. Lee DC, Sui X, Artero EG, Lee IM, Church TS, McAuley PA, Stanford FC, Kohl HW III, Blair SN, Long-Term effects of changes in cardiorespiratory fitness and body mass index on all-cause and cardiovascular disease mortality in men: the Aerobics Center Longitudinal Study. Circulation 2011 124 2483 2490. doi: 10.1161/CIRCULATIONAHA.111.038422
60. Héroux M, Janssen I, Lam M, Lee DC, Hebert JR, Sui X, Blair SN, Dietary patterns and the risk of mortality: impact of cardiorespiratory fitness. Int J Epidemiol 2010 39 197 209. doi: 10.1093/ije/dyp191
61. Lavie CJ, Schutter AD, Milani RV, De Schutter A, Milani RV, Healthy obese versus unhealthy lean: the obesity paradox. Nat Rev Endocrinol 2014 1 8
62. Wang CY, Haskell WL, Farrell SW, Lamonte MJ, Blair SN, Curtin LR, Hughes JP, Burt VL, Cardiorespiratory fitness levels among US adults 20-49 years of age: findings from the 1999-2004 National Health and Nutrition Examination Survey. Am J Epidemiol 2010 171 426 435. doi: 10.1093/aje/kwp412
63. Duncan GE, The "fit but fat" concept revisited: population-based estimates using NHANES. Int J Behav Nutr Phys Act 2010 7 47. doi: 10.1186/1479-5868-7-47
64. Karelis AD, Metabolically healthy but obese individuals. Lancet 2008 372 1281 1283. doi: 10.1016/S0140-6736(08)61531-7
65. Primeau V, Coderre L, Karelis AD, Brochu M, Lavoie ME, Messier V, Sladek R, Rabasa-Lhoret R, Characterizing the profile of obese patients who are metabolically healthy. Int J Obes (Lond) 2011 35 971 981. doi: 10.1038/ijo.2010.216
66. Brochu M, Tchernof A, Dionne IJ, Sites CK, Eltabbakh GH, Sims EA, Poehlman ET, What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J Clin Endocrinol Metab 2001 86 1020 1025. doi: 10.1210/jcem.86.3.7365
67. Sims EA, Are there persons who are obese, but metabolically healthy? Metabolism 2001 50 1499 1504. doi: 10.1053/meta.2001.27213
68. Karelis AD, To be obese-does it matter if you are metabolically healthy? Nat Rev Endocrinol 2011 7 699 700. doi: 10.1038/nrendo.2011.181
69. Karelis AD, Brochu M, Rabasa-Lhoret R, Can we identify metabolically healthy but obese individuals (MHO)? Diabetes Metab 2004 30 569 572
70. Karelis AD, Brochu M, Rabasa-Lhoret R, Garrel D, Poehlman ET, Clinical markers for the identification of metabolically healthy but obese individuals. Diabetes Obes Metab 2004 6 456 457. doi: 10.1111/j.1462-8902.2004.00377.x.
71. Karelis AD, Faraj M, Bastard JP, St-Pierre DH, Brochu M, Prud'homme D, Rabasa-Lhoret R, The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab 2005 90 4145 4150. doi: 10.1210/jc.2005-0482
72. Karelis AD, Rabasa-Lhoret R, Characterization of metabolically healthy but obese individuals: should we add vitamin D to the puzzle? Diabetes Metab 2014 40 319 321. doi: 10.1016/j.diabet.2014.03.001
73. Karelis AD, Rabasa-Lhoret R, Obesity: Can inflammatory status define metabolic health? Nat Rev Endocrinol 2013 9 694 695. doi: 10.1038/nrendo.2013.198
74. Karelis AD, St-Pierre DH, Conus F, Rabasa-Lhoret R, Poehlman ET, Metabolic and body composition factors in subgroups of obesity: what do we know? J Clin Endocrinol Metab 2004 89 2569 2575. doi: 10.1210/jc.2004-0165
75. Plourde G, Karelis AD, Current issues in the identification and treatment of metabolically healthy but obese individuals. Nutr Metab Cardiovasc Dis 2014 24 455 459. doi: 10.1016/j.numecd.2013.12.002
76. Robillard MÈ Bellefeuille P, Comtois AS, Aubertin-Leheudre M, Karelis AD, The metabolically healthy but obese postmenopausal woman presents a favourable heart rate variability profile. Scand Cardiovasc J 2011 45 316 320. doi: 10.3109/14017431.2011.591818
77. Cole TJ, Lobstein T, Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. Pediatr Obes 2012 7 284 294. doi: 10.1111/j.2047-6310.2012.00064.x.
78. Jolliffe CJ, Janssen I, Development of age-specific adolescent metabolic syndrome criteria that are linked to the Adult Treatment Panel III and International Diabetes Federation criteria. J Am Coll Cardiol 2007 49 891 898. doi: 10.1016/j.jacc.2006.08.065
79. Velho S, Paccaud F, Waeber G, Vollenweider P, Marques-Vidal P, Metabolically healthy obesity: different prevalences using different criteria. Eur J Clin Nutr 2010 64 1043 1051. doi: 10.1038/ejcn.2010.114
80. Wildman RP, Muntner P, Reynolds K, McGinn AP, Rajpathak S, Wylie-Rosett J, Sowers MR, The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med 2008 168 1617 1624. doi: 10.1001/archinte.168.15.1617
81. van Vliet-Ostaptchouk JV, Nuotio ML, Slagter SN, The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: A collaborative analysis of ten large cohort studies. BMC Endocr Disord 2014 14 9. doi: 10.1186/1472-6823-14-9
82. Metspalu A, Estonian Genome Project-before the take-off and take-off. Bioinformatics 2002 18 SUPPL 2 S152
83. Inouye M, Kettunen J, Soininen P, Metabonomic, transcriptomic, and genomic variation of a population cohort. Mol Syst Biol 2010 6 441. doi: 10.1038/msb.2010.93
84. Aromaa A, Koskinen S, Baseline results of the health 2000 health examination survey: health and functional capacity in Finland. Publications of the national public health institute b12/2004. 2004 1 148
85. Wichmann HE, Gieger C, Illig T, MONICA/KORA Study Group KORA-gen-resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen 2005 67 SUPPL 1 S26 S30. doi: 10.1055/s-2005-858226
86. Pattaro C, Marroni F, Riegler A, The genetic study of three population microisolates in South Tyrol (MICROS): study design and epidemiological perspectives. BMC Med Genet 2007 8 29. doi: 10.1186/1471-2350-8-29
87. Stolk RP, Rosmalen JG, Postma DS, de Boer RA, Navis G, Slaets JP, Ormel J, Wolffenbuttel BH, Universal risk factors for multifactorial diseases: LifeLines: A three-generation population-based study. Eur J Epidemiol 2008 23 67 74. doi: 10.1007/s10654-007-9204-4
88. Pinto-Sietsma SJ, Janssen WM, Hillege HL, Navis G, De Zeeuw D, De Jong PE, Urinary albumin excretion is associated with renal functional abnormalities in a nondiabetic population. J Am Soc Nephrol 2000 11 1882 1888
89. Krokstad S, Langhammer A, Hveem K, Holmen TL, Midthjell K, Stene TR, Bratberg G, Heggland J, Holmen J, Cohort Profile: the HUNT Study, Norway. Int J Epidemiol 2013 42 968 977. doi: 10.1093/ije/dys095
90. Power C, Elliott J, Cohort profile: 1958 British birth cohort (National Child Development Study). Int J Epidemiol 2006 35 34 41. doi: 10.1093/ije/dyi183
91. Eurostat Population structure and ageing. http://ec.europa.eu/eurostat/statistics-explained/index.php/Population
92. Beltrán-Sánchez H, Harhay MO, Harhay MM, McElligott S, Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010. J Am Coll Cardiol 2013 62 697 703. doi: 10.1016/j.jacc.2013.05.064
93. Pradhan AD, Sex differences in the metabolic syndrome: implications for cardiovascular health in women. Clin Chem 2014 60 44 52. doi: 10.1373/clinchem.2013.202549
94. Roberson L, Shaharyar S, Aneni E, Freitas W, Blaha M, Agatston A, Blumenthal R, Santos RD, Feiz H, Nasir K, Sposito A, The prevalence of the metabolically healthy obese phenotype in an aging population and its association with subclinical cardiovascular disease: The Brazilian study on healthy aging. Diabetol Metab Syndr 2014 6 121. doi: 10.1186/1758-5996-6-121
95. Cook S, Auinger P, Li C, Ford ES, Metabolic syndrome rates in United States adolescents, from the National Health and Nutrition Examination Survey, 1999-2002. J Pediatr 2008 152 165 170. doi: 10.1016/j.jpeds.2007.06.004
96. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH, Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med 2003 157 821 827. doi: 10.1001/archpedi.157.8.821
97. Miller JM, Kaylor MB, Johannsson M, Bay C, Churilla JR, Prevalence of metabolic syndrome and individual criterion in US adolescents: 2001-2010 National Health and Nutrition Examination Survey. Metab Syndr Relat Disord 2014 12 527 532. doi: 10.1089/met.2014.0055
98. Bokor S, Frelut ML, Vania A, Hadjiathanasiou CG, Anastasakou M, Malecka-Tendera E, Matusik P, Molnár D, Prevalence of metabolic syndrome in European obese children. Int J Pediatr Obes 2008 3 SUPPL 2 3 8. doi: 10.1080/17477160802404509
99. Ahrens W, Moreno LA, Mårild S, Molnár D, Siani A, De Henauw S, Böhmann J, Günther K, Hadjigeorgiou C, Iacoviello L, Lissner L, Veidebaum T, Pohlabeln H, Pigeot I, IDEFICS Consortium Metabolic syndrome in young children: definitions and results of the IDEFICS study. Int J Obes (Lond) 2014 38 SUPPL 2 S4 14. doi: 10.1038/ijo.2014.130
100. Blüher S, Schwarz P, Metabolically healthy obesity from childhood to adulthood-Does weight status alone matter? Metabolism 2014 63 1084 1092. doi: 10.1016/j.metabol.2014.06.009
101. Stefan N, Häring HU, Hu FB, Schulze MB, Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol 2013 1 152 162. doi: 10.1016/S2213-8587(13)70062-7
102. Stefan N, Kantartzis K, Machann J, Schick F, Thamer C, Rittig K, Balletshofer B, Machicao F, Fritsche A, Häring HU, Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 2008 168 1609 1616. doi: 10.1001/archinte.168.15.1609
103. Blüher M, The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. Curr Opin Lipidol 2010 21 38 43. doi: 10.1097/MOL.0b013e3283346ccc
104. Ortega FB, Cadenas-Sánchez C, Sui X, Blair SN, Lavie CJ, Role of fitness in the metabolically healthy but obese phenotype: A review and update. Prog Cardiovasc Dis 2015 58 76 86. doi: 10.1016/j.pcad.2015.05.001
105. Ortega FB, Lee DC, Katzmarzyk PT, Ruiz JR, Sui X, Church TS, Blair SN, The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness. Eur Heart J 2013 34 389 397. doi: 10.1093/eurheartj/ehs174
106. Grundy SM, Adipose tissue and metabolic syndrome: too much, too little or neither. Eur J Clin Invest 2015 45 1209 1217. doi: 10.1111/eci.12519
107. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, Schoelles K, Bariatric surgery: A systematic review and meta-Analysis. JAMA 2004 292 1724 1737. doi: 10.1001/jama.292.14.1724
108. Ricci C, Gaeta M, Rausa E, Macchitella Y, Bonavina L, Early impact of bariatric surgery on type II diabetes, hypertension, and hyperlipidemia: A systematic review, meta-Analysis and meta-regression on 6,587 patients. Obes Surg 2014 24 522 528. doi: 10.1007/s11695-013-1121-x.
109. Katzmarzyk PT, Church TS, Janssen I, Ross R, Blair SN, Metabolic syndrome, obesity, and mortality: impact of cardiorespiratory fitness. Diabetes Care 2005 28 391 397
110. Kramer CK, Zinman B, Retnakaran R, Are metabolically healthy overweight and obesity benign conditions?: A systematic review and meta-Analysis. Ann Intern Med 2013 159 758 769. doi: 10.7326/0003-4819-159-11-201312030-00008
111. Roberson LL, Aneni EC, Maziak W, Agatston A, Feldman T, Rouseff M, Tran T, Blaha MJ, Santos RD, Sposito A, Al-Mallah MH, Blankstein R, Budoff MJ, Nasir K, Beyond BMI: The "Metabolically healthy obese" phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality-A systematic review. BMC Public Health 2014 14 14. doi: 10.1186/1471-2458-14-14
112. Bo S, Musso G, Gambino R, Villois P, Gentile L, Durazzo M, Cavallo-Perin P, Cassader M, Prognostic implications for insulin-sensitive and insulin-resistant normal-weight and obese individuals from a population-based cohort. Am J Clin Nutr 2012 96 962 969. doi: 10.3945/ajcn.112.040006
113. Hamer M, Stamatakis E, Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality. J Clin Endocrinol Metab 2012 97 2482 2488. doi: 10.1210/jc.2011-3475
114. Hosseinpanah F, Barzin M, Sheikholeslami F, Azizi F, Effect of different obesity phenotypes on cardiovascular events in Tehran Lipid and Glucose Study (TLGS). Am J Cardiol 2011 107 412 416. doi: 10.1016/j.amjcard.2010.09.034
115. Song Y, Manson JE, Meigs JB, Ridker PM, Buring JE, Liu S, Comparison of usefulness of body mass index versus metabolic risk factors in predicting 10-year risk of cardiovascular events in women. Am J Cardiol 2007 100 1654 1658. doi: 10.1016/j.amjcard.2007.06.073
116. Voulgari C, Tentolouris N, Dilaveris P, Tousoulis D, Katsilambros N, Stefanadis C, Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals. J Am Coll Cardiol 2011 58 1343 1350. doi: 10.1016/j.jacc.2011.04.047
117. Alam I, Ng TP, Larbi A, Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective. Mediators Inflamm 2012 2012 456456. doi: 10.1155/2012/456456
118. Soriguer F, Gutiérrez-Repiso C, Rubio-Martín E, García-Fuentes E, Almaraz MC, Colomo N, Esteva de Antonio I, de Adana MS, Chaves FJ, Morcillo S, Valdés S, Rojo-Martínez G, Metabolically healthy but obese, a matter of time? Findings from the prospective Pizarra study. J Clin Endocrinol Metab 2013 98 2318 2325. doi: 10.1210/jc.2012-4253
119. Soprano M, Rusciano MR, Ciccarelli M, Maione AS, Formisano P, Illario M, Metabolic Syndrome and Aging: Calcium Signaling as Common Regulator. Curr Diabetes Rev 2015 12 84 89
120. Lavie CJ, Milani RV, Ventura HO, Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol 2009 53 1925 1932. doi: 10.1016/j.jacc.2008.12.068
121. Lavie CJ, De Schutter A, Milani RV, Healthy obese versus unhealthy lean: the obesity paradox. Nat Rev Endocrinol 2015 11 55 62. doi: 10.1038/nrendo.2014.165
122. Degoulet P, Legrain M, Réach I, Aimé F, Devriés C, Rojas P, Jacobs C, Mortality risk factors in patients treated by chronic hemodialysis. Report of the Diaphane collaborative study. Nephron 1982 31 103 110
123. Ellis SG, Elliott J, Horrigan M, Raymond RE, Howell G, Low-normal or excessive body mass index: newly identified and powerful risk factors for death and other complications with percutaneous coronary intervention. Am J Cardiol 1996 78 642 646
124. Gruberg L, Weissman NJ, Waksman R, Fuchs S, Deible R, Pinnow EE, Ahmed LM, Kent KM, Pichard AD, Suddath WO, Satler LF, Lindsay J Jr, The impact of obesity on the short-Term and long-Term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol 2002 39 578 584
125. Gurm HS, Brennan DM, Booth J, Tcheng JE, Lincoff AM, Topol EJ, Impact of body mass index on outcome after percutaneous coronary intervention (the obesity paradox). Am J Cardiol 2002 90 42 45
126. Lavie CJ, Osman AF, Milani RV, Mehra MR, Body composition and prognosis in chronic systolic heart failure: the obesity paradox. Am J Cardiol 2003 91 891 894
127. Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG, Mookadam F, Lopez-Jimenez F, Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review of cohort studies. Lancet 2006 368 666 678. doi: 10.1016/S0140-6736(06)69251-9
128. Sharma A, Lavie CJ, Borer JS, Vallakati A, Goel S, Lopez-Jimenez F, Arbab-Zadeh A, Mukherjee D, Lazar JM, Meta-Analysis of the relation of body mass index to all-cause and cardiovascular mortality and hospitalization in patients with chronic heart failure. Am J Cardiol 2015 115 1428 1434. doi: 10.1016/j.amjcard.2015.02.024
129. Shah R, Gayat E, Januzzi JL Jr, GREAT (Global Research on Acute Conditions Team) Network Body mass index and mortality in acutely decompensated heart failure across the world: A global obesity paradox. J Am Coll Cardiol 2014 63 778 785. doi: 10.1016/j.jacc.2013.09.072
130. Angerås O, Albertsson P, Karason K, Råmunddal T, Matejka G, James S, Lagerqvist B, Rosengren A, Omerovic E, Evidence for obesity paradox in patients with acute coronary syndromes: A report from the Swedish Coronary Angiography and Angioplasty Registry. Eur Heart J 2013 34 345 353. doi: 10.1093/eurheartj/ehs217
131. Wang ZJ, Zhou YJ, Galper BZ, Gao F, Yeh RW, Mauri L, Association of body mass index with mortality and cardiovascular events for patients with coronary artery disease: A systematic review and meta-Analysis. Heart 2015 101 1631 1638. doi: 10.1136/heartjnl-2014-307119
132. Lavie CJ, De Schutter A, Milani RV, Body composition and the obesity paradox in coronary heart disease: can heavier really be healthier? Heart 2015 101 1610 1611. doi: 10.1136/heartjnl-2015-307966
133. McAuley PA, Artero EG, Sui X, Lee DC, Church TS, Lavie CJ, Myers JN, España-Romero V, Blair SN, The obesity paradox, cardiorespiratory fitness, and coronary heart disease. Mayo Clin Proc 2012 87 443 451. doi: 10.1016/j.mayocp.2012.01.013
134. Lavie CJ, Ventura HO, Milani RV, Arena R, Critical impact of fitness in the prevention and treatment of heart failure. Am Heart J 2015 169 194 196. doi: 10.1016/j.ahj.2014.11.006
135. Lavie CJ, Cahalin LP, Chase P, Myers J, Bensimhon D, Peberdy MA, Ashley E, West E, Forman DE, Guazzi M, Arena R, Impact of cardiorespiratory fitness on the obesity paradox in patients with heart failure. Mayo Clin Proc 2013 88 251 258. doi: 10.1016/j.mayocp.2012.11.020
136. Lavie CJ, Ventura HO, The obesity paradox in heart failure: is it all about fitness, fat, or sex? JACC Heart Fail 2015 3 927 930. doi: 10.1016/j.jchf.2015.07.009
137. Jahangir E, De Schutter A, Lavie CJ, Low weight and overweightness in older adults: risk and clinical management. Prog Cardiovasc Dis 2014 57 127 133. doi: 10.1016/j.pcad.2014.01.001
138. Lavie CJ, Obesity and prognosis-just one of many cardiovascular paradoxes? Prog Cardiovasc Dis 2014 56 367 368. doi: 10.1016/j.pcad.2013.10.017
139. World Health Organization Obesity: Preventing and managing the global epidemic. Report of a who consultation. World Health Organ. Tech. Rep. Ser 2000 894 1 253
140. Flegal KM, Kalantar-Zadeh K, Overweight, mortality and survival. Obesity (Silver Spring) 2013 21 1744 1745. doi: 10.1002/oby.20588
141. de Hollander EL, Bemelmans WJ, Boshuizen HC, WC elderly collaborators The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: A meta-Analysis of 29 cohorts involving more than 58 000 elderly persons. Int J Epidemiol 2012 41 805 817. doi: 10.1093/ije/dys008
142. Song X, Jousilahti P, Stehouwer CD, Söderberg S, Onat A, Laatikainen T, Yudkin JS, Dankner R, Morris R, Tuomilehto J, Qiao Q, DECODE Study Group Cardiovascular and all-cause mortality in relation to various anthropometric measures of obesity in Europeans. Nutr Metab Cardiovasc Dis 2015 25 295 304. doi: 10.1016/j.numecd.2014.09.004
143. Martínez-González MA, García-Arellano A, Toledo E, Obesity indexes and total mortality among elderly subjects at high cardiovascular risk: the PREDIMED study. PLoS One 2014 9 e103246. doi: 10.1371/journal.pone.0103246
144. Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y, Healthy percentage body fat ranges: An approach for developing guidelines based on body mass index. Am J Clin Nutr 2000 72 694 701
145. Vicente-Rodríguez G, Rey-López JP, Mesana MI, Poortvliet E, Ortega FB, Polito A, Nagy E, Widhalm K, Sjöström M, Moreno LA, HELENA Study Group Reliability and intermethod agreement for body fat assessment among two field and two laboratory methods in adolescents. Obesity (Silver Spring) 2012 20 221 228. doi: 10.1038/oby.2011.272
146. Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J, Qizilbash N, Collins R, Peto R, Body-mass index and cause-specific mortality in 900 000 adults: Collaborative analyses of 57 prospective studies. Lancet 2009 373 1083 1096
147. Huang Y, Wang S, Cai X, Mai W, Hu Y, Tang H, Xu D, Prehypertension and incidence of cardiovascular disease: A meta-Analysis. BMC Med 2013 11 177. doi: 10.1186/1741-7015-11-177
148. Aparicio VA, Carbonell-Baeza A, Senhaji M, Martín S, Camiletti-Moirón D, Aranda P, Usefulness of fitness testing to establish metabolic syndrome in perimenopausal Moroccan women. Eur J Cardiovasc Nurs 2014 13 524 531. doi: 10.1177/1474515113516395
149. Yu R, Yau F, Ho SC, Woo J, Associations of cardiorespiratory fitness, physical activity, and obesity with metabolic syndrome in Hong Kong Chinese midlife women. BMC Public Health 2013 13 614. doi: 10.1186/1471-2458-13-614
150. Dalzill C, Nigam A, Juneau M, Guilbeault V, Latour E, Mauriège P, Gayda M, Intensive lifestyle intervention improves cardiometabolic and exercise parameters in metabolically healthy obese and metabolically unhealthy obese individuals. Can J Cardiol 2014 30 434 440. doi: 10.1016/j.cjca.2013.11.033
151. Kuk JL, Ardern CI, Are metabolically normal but obese individuals at lower risk for all-cause mortality? Diabetes Care 2009 32 2297 2299. doi: 10.2337/dc09-0574
152. Chaput JP, Sharma AM, Metabolically healthy overweight and obesity. Ann Intern Med 2014 160 513. doi: 10.7326/L14-5007
153. Dalleck LC, Van Guilder GP, Richardson TB, Bredle DL, Janot JM, A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype. Diabetes Metab Syndr Obes 2014 7 369 380. doi: 10.2147/DMSO.S67441
154. Ruiz JR, Ortega FB, Labayen I, A weight loss diet intervention has a similar beneficial effect on both metabolically abnormal obese and metabolically healthy but obese premenopausal women. Ann Nutr Metab 2013 62 223 230. doi: 10.1159/000345026
155. Li S, Chen W, Srinivasan SR, Xu J, Berenson GS, Relation of childhood obesity/cardiometabolic phenotypes to adult cardiometabolic profile: the Bogalusa Heart Study. Am J Epidemiol 2012 176 SUPPL 7 S142 S149. doi: 10.1093/aje/kws236
156. Martínez-Larrad MT, Corbatón Anchuelo A, Del Prado N, Ibarra Rueda JM, Gabriel R, Serrano-Ríos M, Profile of individuals who are metabolically healthy obese using different definition criteria. A population-based analysis in the Spanish population. PLoS One 2014 9 e106641. doi: 10.1371/journal.pone.0106641
157. Bouchard DR, Langlois MF, Brochu M, Dionne IJ, Baillargeon JP, Metabolically healthy obese women and functional capacity. Metab Syndr Relat Disord 2011 9 225 229. doi: 10.1089/met.2010.0101
158. Lwow F, Dunajska K, Milewicz A, Jedrzejuk D, Kik K, Szmigiero L, Effect of moderate-intensity exercise on oxidative stress indices in metabolically healthy obese and metabolically unhealthy obese phenotypes in postmenopausal women: A pilot study. Menopause 2011 18 646 653. doi: 10.1097/gme.0b013e3182038ec1
159. Sénéchal M, Wicklow B, Wittmeier K, Hay J, MacIntosh AC, Eskicioglu P, Venugopal N, McGavock JM, Cardiorespiratory fitness and adiposity in metabolically healthy overweight and obese youth. Pediatrics 2013 132 e85 e92. doi: 10.1542/peds.2013-0296
160. Mangge H, Zelzer S, Puerstner P, Schnedl WJ, Reeves G, Postolache TT, Weghuber D, Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults. Obesity (Silver Spring) 2013 21 E71 E77. doi: 10.1002/oby.20061
161. Cohen J, A power primer. Psychol Bull 1992 112 155 159