A weight loss diet intervention has a similar beneficial effect on both metabolically abnormal obese and metabolically healthy but obese premenopausal women

Annals of Nutrition and Metabolism

Volumn 62, Issue 3, 2013, Pages 223-230

  Ruiz, Jonatan R ^a,c   Ortega, Francisco B ^a,c   Labayen, Idoia ^b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

Cardiometabolic risk factors; Diet intervention; Liver mitochondrial function; Obesity; Women

Indexed keywords

ADIPOCYTOKINE; ALANINE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; INSULIN; LEPTIN; LIPID; LIVER ENZYME; TRIACYLGLYCEROL; C REACTIVE PROTEIN; CHOLESTEROL; THYROTROPIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BODY COMPOSITION; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET RESTRICTION; DIET THERAPY; FAT MASS; HUMAN; INSULIN RESISTANCE; LIFESTYLE; LIPID BLOOD LEVEL; MALE; OBESITY; PREMENOPAUSE; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT OUTCOME; WAIST CIRCUMFERENCE; WEIGHT REDUCTION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; BODY FAT; CARDIOMETABOLIC RISK; CLINICAL EFFECTIVENESS; CONTROLLED CLINICAL TRIAL; ENERGY METABOLISM; ENERGY RESTRICTED DIET; FATTY LIVER INDEX; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GENERAL PATHOLOGICAL PARAMETERS; INFLAMMATION; INTERVENTION STUDY; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; METABOLIC DISORDER; METABOLICALLY ABNORMAL OBESE; METABOLICALLY HEALTHY BUT OBESE; PROTEIN BLOOD LEVEL; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOSITY; ADULT; BODY MASS INDEX; C-REACTIVE PROTEIN; DIET, REDUCING; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LIFE STYLE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; PREMENOPAUSE; RISK FACTORS; WAIST CIRCUMFERENCE; WEIGHT LOSS; YOUNG ADULT;

EID: 84878016966     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000345026     Document Type: Article

References (41)

1. Karelis AD: Metabolically healthy but obese individuals. Lancet 2008; 372: 1281-1283.
2. Primeau V, Coderre L, Karelis AD, Brochu M, Lavoie ME, Messier V, Sladek R, Rabasa-Lhoret R: Characterizing the profile of obese patients who are metabolically healthy. Int J Obes (Lond) 2011; 35: 971-981.
3. Meigs JB, Wilson PW, Fox CS, Vasan RS, Nathan DM, Sullivan LM, D'Agostino RB: Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 2006; 91: 2906-2912.
4. Calori G, Lattuada G, Piemonti L, Garancini MP, Ragogna F, Villa M, Mannino S, Crosignani P, Bosi E, Luzi L, Ruotolo G, Perseghin G: Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona Study. Diabetes Care 2011; 34: 210-215.
5. Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Meigs JB, Bonadonna RC, Muggeo M: Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study. Diabetes Care 2007; 30: 318-324.
6. McLaughlin T, Abbasi F, Lamendola C, Reaven G: Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals: effect of differences in insulin sensitivity. Arch Intern Med 2007; 167: 642-648.
7. St-Pierre AC, Cantin B, Mauriege P, Bergeron J, Dagenais GR, Despres JP, Lamarche B: Insulin resistance syndrome, body mass index and the risk of ischemic heart disease. CMAJ 2005; 172: 1301-1305.
8. Voulgari C, Tentolouris N, Dilaveris P, Tousoulis D, Katsilambros N, Stefanadis C: Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals. J Am Coll Cardiol 2011; 58: 1343-1350.
9. Karelis AD, Faraj M, Bastard JP, St-Pierre DH, Brochu M, Prud'homme D, Rabasa-Lhoret R: The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab 2005; 90: 4145-4150.
10. Sesti G, Succurro E, Arturi F, Andreozzi F, Laino I, Perticone M, Sciacqua A, Hribal ML, Perticone F: IGF-1 levels link estimated glomerular filtration rate to insulin resistance in obesity: a study in obese, but metabolically healthy, subjects and obese, insulin-resistant subjects. Nutr Metab Cardiovasc Dis 2011; 21: 933-940.
11. Robillard ME, Bellefeuille P, Comtois AS, Aubertin-Leheudre M, Karelis AD: The metabolically healthy but obese postmenopausal woman presents a favourable heart rate variability profile. Scand Cardiovasc J 2011; 45: 316-320.
12. Ärnlöv J, Ingelsson E, Sundström J, Lind L: Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation 2010; 121: 230-236.
13. Kuk JL, Ardern CI: Are metabolically normal but obese individuals at lower risk for all-cause mortality? Diabetes Care 2009; 32: 2297-2299.
14. Perseghin G: Is a nutritional therapeutic approach unsuitable for metabolically healthy but obese women? Diabetologia 2008; 51: 1567-1569.
15. Evangelou P, Tzotzas T, Christou G, Elisaf MS, Kiortsis DN: Does the presence of metabolic syndome influence weight loss in obese and overweight women? Metab Syndr Relat Disord 2010; 8: 173-178.
16. Kantartzis K, Machann J, Schick F, Rittig K, Machicao F, Fritsche A, Haring HU, Stefan N: Effects of a lifestyle intervention in metabolically benign and malign obesity. Diabetologia 2011; 54: 864-868.
17. Sesti G, Folli F, Perego L, Hribal ML, Pontiroli AE: Effects of weight loss in metabolically healthy obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet. PLoS One 2011; 6:e17737.
18. Karelis AD, Messier V, Brochu M, Rabasa-Lhoret R: Metabolically healthy but obese women: effect of an energy-restricted diet. Diabetologia 2008; 51: 1752-1754.
19. Agueda M, Lasa A, Simon E, Ares R, Larrarte E, Labayen I: Association of circulating visfatin concentrations with insulin resistance and low-grade inflammation after dietary energy restriction in Spanish obese non-diabetic women: role of body composition changes. Nutr Metab Cardiovasc Dis 2012; 22: 208-214.
20. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F: Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112: 2735-2752.
21. Janiszewski PM, Ross R: Effects of weight loss among metabolically healthy obese men and women. Diabetes Care 2010; 33: 1957-1959.
22. Wallace TM, Levy JC, Matthews DR: Use and abuse of HOMA modeling. Diabetes Care 2004; 27: 1487-1495.
23. Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A, Tiribelli C: The fatty liver index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol 2006; 6: 33.
24. Labayen I, Forga L, Martinez JA: Nutrient oxidation and metabolic rate as affected by meals containing different proportions of carbohydrate and fat, in healthy young women. Eur J Nutr 1999; 38: 158-166.
25. Grattagliano I, Lauterburg BH, Palasciano G, Portincasa P: 13C-breath tests for clinical investigation of liver mitochondrial function. Eur J Clin Invest 2010; 40: 843-850.
26. Karelis AD, Rabasa-Lhoret R: Inclusion of Creactive protein in the identification of metabolically healthy but obese (MHO) individuals. Diabetes Metab 2008; 34: 183-184.
27. Wildman RP, Muntner P, Reynolds K, Mc-Ginn AP, Rajpathak S, Wylie-Rosett J, Sowers MR: The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med 2008; 168: 1617-1624.
28. Ortega FB, Lee DC, Katzmarzyk PT, Ruiz JR, Sui X, Church TS, Blair SN: The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness. Eur Heart J 2012, E-pub ahead of print.
29. Marini MA, Succurro E, Frontoni S, Hribal ML, Andreozzi F, Lauro R, Perticone F, Sesti G: Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women. Diabetes Care 2007; 30: 2145-2147.
30. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults. Am J Clin Nutr 1998; 68: 899-917.
31. Management of obesity in adults: project for European primary care. Int J Obes Relat Metab Disord 2004; 28(suppl 1):S226-S231.
32. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH: The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009; 9: 88.
33. Stefan N, Kantartzis K, Haring HU: Causes and metabolic consequences of fatty liver. Endocr Rev 2008; 29: 939-960.
34. Hanley AJ, Williams K, Festa A, Wagenknecht LE, D'Agostino RB Jr, Haffner SM: Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study. Diabetes 2005; 54: 3140-3147.
35. Thamer C, Tschritter O, Haap M, Shirkavand F, Machann J, Fritsche A, Schick F, Haring H, Stumvoll M: Elevated serum GGT concentrations predict reduced insulin sensitivity and increased intrahepatic lipids. Horm Metab Res 2005; 37: 246-251.
36. Shin MJ, Hyun YJ, Kim OY, Kim JY, Jang Y, Lee JH: Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women. Int J Obes (Lond) 2006; 30: 1529-1534.
37. Messier V, Karelis AD, Robillard ME, Bellefeuille P, Brochu M, Lavoie JM, Rabasa-Lhoret R: Metabolically healthy but obese individuals: relationship with hepatic enzymes. Metabolism 2010; 59: 20-24.
38. Nanri A, Mizoue T, Takahashi Y, Noda M, Inoue M, Tsugane S: Weight change and allcause, cancer and cardiovascular disease mortality in Japanese men and women: the Japan Public Health Center-Based Prospective Study. Int J Obes (Lond) 2010; 34: 348-356.
39. Rzehak P, Meisinger C, Woelke G, Brasche S, Strube G, Heinrich J: Weight change, weight cycling and mortality in the ERFORT Male Cohort Study. Eur J Epidemiol 2007; 22: 665-673.
40. Perez Morales ME, Jimenez Cruz A, Bacardi Gascon M: The effect of weight loss on mortality: a systematic review from 2000 to 2009 (in Spanish). Nutr Hosp 2010; 25: 718-724.
41. Heymsfield SB, Harp JB, Reitman ML, Beetsch JW, Schoeller DA, Erondu N, Pietrobelli A: Why do obese patients not lose more weight when treated with low-calorie diets? A mechanistic perspective. Am J Clin Nutr 2007; 85: 346-354.