Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 7, 2012, Pages 2482-2488

  Hamer, Mark ^a   Stamatakis, Emmanuel ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGE DISTRIBUTION; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CAUSAL ATTRIBUTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; FEMALE; FOLLOW UP; HAZARD RATIO; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OBESITY; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; UNITED KINGDOM; WAIST CIRCUMFERENCE;

ADULT; AGED; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; ENGLAND; FEMALE; HEALTH; HUMANS; MALE; METABOLIC DISEASES; MIDDLE AGED; OBESITY; RESIDENCE CHARACTERISTICS; RISK FACTORS; SCOTLAND;

EID: 84863586953     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-3475     Document Type: Article

References (26)

1. Blüher M 2010 The distinction of metabolically 'healthy' from 'unhealthy'obese individuals. Curr Opin Lipidol 21:38-43
2. Kopelman PG 2000 Obesity as a medical problem. Nature 404:635-643 (Pubitemid 30205068)
3. Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J, Qizilbash N, Collins R, Peto R 2009 Body-mass index and causespecific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 373:1083-1096
4. Emerging Risk Factors Collaboration, Wormser D, Kaptoge S, Di Angelantonio E, Wood AM, Pennells L, Thompson A, Sarwar N, Kizer JR, Lawlor DA, Nordestgaard BG, Ridker P, Salomaa V, Stevens J, Woodward M, Sattar N, Collins R, Thompson SG, Whitlock G, Danesh J 2011 Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet 377:1085-1095
5. Katzmarzyk PT, Janssen I, Ross R, Church TS, Blair SN 2006 The importance of waist circumference in the definition of metabolic syndrome: prospective analyses of mortality in men. Diabetes Care 29:404-409 (Pubitemid 44106526)
6. Kip KE, Marroquin OC, Kelley DE, Johnson BD, Kelsey SF, Shaw LJ, Rogers WJ, Reis SE 2004 Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women: a report from the Women's Ischemia Syndrome Evaluation (WISE) study. Circulation 109:706-713 (Pubitemid 38222888)
7. Song Y, Manson JE, Meigs JB, Ridker PM, Buring JE, Liu S 2007 Comparison of usefulness of body mass index versus metabolic risk factors in predicting 10-year risk of cardiovascular events in women. Am J Cardiol 100:1654-1658 (Pubitemid 350130235)
8. Meigs JB, Wilson PW, Fox CS, Vasan RS, Nathan DM, Sullivan LM, D'Agostino RB 2006 Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 91:2906-2912 (Pubitemid 44271734)
9. St-Pierre AC, Cantin B, Mauriège P, Bergeron J, Dagenais GR, Després JP, Lamarche B 2005 Insulin resistance syndrome, body mass index and the risk of ischemic heart disease. CMAJ 172:1301-1305 (Pubitemid 40745071)
10. Calori G, Lattuada G, Piemonti L, Garancini MP, Ragogna F, Villa M, Mannino S, Crosignani P, Bosi E, Luzi L, Ruotolo G, Perseghin G 2011 Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona Study. Diabetes Care 34:210-215
11. Ogorodnikova AD, Kim M, McGinn AP, Muntner P, Khan U, Wildman RP 2012 Incident cardiovascular disease events in metabolically benign obese individuals. Obesity (Silver Spring) 20:651-629
12. Arnlöv J, Ingelsson E, Sundström J, Lind L 2010 Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation 121:230-236
13. Flint AJ, Hu FB, Glynn RJ, Caspard H, Manson JE, Willett WC, Rimm EB 2010 Excess weight and the risk of incident coronary heart disease among men and women. Obesity 18:377-383
14. Khan UI, Wang D, Thurston RC, Sowers M, Sutton-Tyrrell K, Matthews KA, Barinas-Mitchell E, Wildman RP 2011 Burden of subclinical cardiovascular disease in "metabolically benign" and "atrisk"overweight and obese women: the Study of Women's Health Across the Nation (SWAN). Atherosclerosis 217:179-186
15. The Scottish Government Statistics 2007 Scottish Health Survey Publications. http://www.scotland.gov.uk/Topics/Statistics/Browse/Health/ scottish-health survey/Publications (accessed November 2007)
16. Joint Health Surveys Unit 2007 Health Survey for England Physical Activity Validation Study: substantive report. Leeds, UK: Health and Social Care Information Centre
17. Wildman RP, Muntner P, Reynolds K, McGinn AP, Rajpathak S, Wylie-Rosett J, Sowers MR 2008 The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the U.S. population (NHANES 1999-2004). Arch Intern Med 168:1617-1624
18. Grundy SM, Cleeman JI, Merz CN, Brewer Jr HB, Clark LT, Hunninghake DB, Pasternak RC, Smith Jr SC, Stone NJ 2004 Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 110:227-239 (Pubitemid 38924592)
19. Koster A, Stenholm S, Alley DE, Kim LJ, Simonsick EM, Kanaya AM, Visser M, Houston DK, Nicklas BJ, Tylavsky FA, Satterfield S, Goodpaster BH, Ferrucci L, Harris TB 2010 Health ABC Study. Body fat distribution and inflammation among obese older adults with and without metabolic syndrome. Obesity (Silver Spring) 18:2354-2361
20. Shea JL, King MT, Yi Y, Gulliver W, Sun G 5 January 2011 Body fat percentage is associated with cardiometabolic dysregulation in BMI-defined normal weight subjects. Nutr Metab Cardiovasc Dis 10.1016/j.numecd.2010.11.009
21. Klöting N, Fasshauer M, Dietrich A, Kovacs P, Schön MR, Kern M, Stumvoll M, Blüher M 2010 Insulin sensitive obesity. Am J Physiol Endocrinol Metab 299:E506-E515
22. Kilpeläinen TO, Zillikens MC, Stanèákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M, Halldorsson BV, Tikkanen E, Mangino M, Hayward C, et al. 2011 Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet 43:753-760
23. Wildman RP, Kaplan R, Manson JE, Rajkovic A, Connelly SA, Mackey RH, Tinker LF, Curb JD, Eaton CB, Wassertheil-Smoller S 2011 Body size phenotypes and inflammation in the Women's Health Initiative Observational Study. Obesity 19:1482-1491
24. Conus F, Allison DB, Rabasa-Lhoret R, St-Onge M, St-Pierre DH, Tremblay-Lebeau A, Poehlman ET 2004 Metabolic and behavioral characteristics of metabolically obese but normal-weight women. J Clin Endocrinol Metab 89:5013-5020 (Pubitemid 39391442)
25. Hamer M 2007 The relative influences of fitness and fatness on inflammatory factors. Prev Med 44:3-11 (Pubitemid 46073084)
26. Lindström J, Ilanne-Parikka P, Peltonen M, Aunola S, Eriksson JG, Hemiö K, Hämäläinen H, Härkönen P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Mannelin M, Paturi M, Sundvall J, Valle TT, Uusitupa M, Tuomilehto J 2006 Finnish Diabetes Prevention Study Group. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet 368:1673-1679 (Pubitemid 46048554)