Characterization of metabolically healthy but obese individuals: Should we add vitamin D to the puzzle?

Diabetes and Metabolism

Volumn 40, Issue 5, 2014, Pages 319-321

  Karelis, A D ^a,b   Rabasa Lhoret, R ^c,d  

^a UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^b CENTRE DE RECHERCHE   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Cardiovascular disease; Inflammation; Metabolic risk factors; Mortality; Type 2 diabetes

Indexed keywords

C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VITAMIN D; 25-HYDROXYVITAMIN D;

DIETARY INTAKE; EDITORIAL; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; METABOLIC SYNDROME X; METABOLICALLY HEALTHY OBESE; METABOLISM; MISCELLANEOUS NAMED GROUPS; OBESITY; PHENOTYPE; PHYSICAL ACTIVITY; RISK FACTOR; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; BLOOD; CARDIOVASCULAR DISEASE; ENZYMOLOGY; FEMALE; INFLAMMATION; LIVER; MALE;

CARDIOVASCULAR DISEASES; FEMALE; HUMANS; INFLAMMATION; LIVER; MALE; METABOLIC SYNDROME X; OBESITY; VITAMIN D;

EID: 84908504950     PISSN: 12623636     EISSN: 18781780     Source Type: Journal    
DOI: 10.1016/j.diabet.2014.03.001     Document Type: Editorial

References (16)

1. Karelis A.D. Metabolically healthy but obese individuals. Lancet 2008, 372:1281-1283.
2. Phillips C.M., Dillon C., Harrington J.M., McCarthy V.J., Kearney P.M., Fitzgerald A.P., et al. Defining metabolically healthy obesity: role of dietary and lifestyle factors. PLoS One 2013, 8:e76188.
3. Khan H., Kunutsor S., Franco O.H., Chowdhury R. Vitamin D, type 2 diabetes and other metabolic outcomes: a systematic review and meta-analysis of prospective studies. Proc Nutr Soc 2013, 72:89-97.
4. Cavalier E., Delanaye P., Souberbielle J.C., Radermecker R.P. Vitamin D and type 2 diabetes mellitus: where do we stand?. Diabetes Metab 2011, 37:265-272.
5. Esteghamati A., Aryana Z., Esteghamati A., Nakhjavani M. Differences in vitamin D concentration between metabolically healthy and unhealthy obese adults: associations with inflammatory and cardiometabolic markers in 4391 individuals. Diabetes Metab 2014.
6. Karelis A.D., Rabasa-Lhoret R. Inclusion of C-reactive protein in the identification of metabolically healthy but obese (MHO) individuals. Diabetes Metab 2008, 34:183-184.
7. Autier P., Boniol M., Pizot C., Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol 2014, 2:76-89.
8. Karelis A.D., Rabasa-Lhoret R. Obesity: can inflammatory status define metabolic health?. Nat Rev Endocrinol 2013, 9:694-695.
9. Morales E., Gascon M., Martinez D., Casas M., Ballester F., Rodriguez-Bernal C.L., et al. Associations between blood persistent organic pollutants and 25-hydroxyvitamin D3 in pregnancy. Environ Int 2013, 57-8:34-41.
10. Gauthier M.S., Rabasa-Lhoret R., Prud'homme D., Karelis A.D., Geng D., van Bavel B., et al. The metabolically healthy but obese phenotype is associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype. J Clin Endocrinol Metab 2014.
11. Plourde G., Karelis A.D. Current issues in the identification and treatment of metabolically healthy but obese individuals. Nutr Metab Cardiovasc Dis 2014.
12. Calori G., Lattuada G., Piemonti L., Garancini M.P., Ragogna F., Villa M., et al. Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona study. Diabetes Care 2011, 34:210-215.
13. Arnlov J., Ingelsson E., Sundstrom J., Lind L. Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation 2010, 121:230-236.
14. Kramer C.K., Zinman B., Retnakaran R. Are metabolically healthy overweight and obesity benign conditions?: a systematic review and meta-analysis. Ann Intern Med 2013, 159:758-769.
15. Padwal R.S., Pajewski N.M., Allison D.B., Sharma A.M. Using the Edmonton obesity staging system to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ 2011, 183:E1059-E1066.
16. Appleton S.L., Seaborn C.J., Visvanathan R., Hill C.L., Gill T.K., Taylor A.W., et al. Diabetes and cardiovascular disease outcomes in the metabolically healthy obese phenotype: a cohort study. Diabetes Care 2013, 36:2388-2394.