-
1
-
-
1842737707
-
Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals
-
Huang, Y.H., Li, D., Winoto, A., Robey, E.A. Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proc. Natl. Acad. Sci. USA 101, 4936-4941 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4936-4941
-
-
Huang, Y.H.1
Li, D.2
Winoto, A.3
Robey, E.A.4
-
2
-
-
6344274985
-
The regulated expression of a diverse set of genes during thymocyte positive selection in vivo
-
Mick, V.E., Starr, T.K., McCaughtry, T.M., McNeil, L.K., Hogquist, K.A. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo. J. Immunol. 173, 5434-5444 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 5434-5444
-
-
Mick, V.E.1
Starr, T.K.2
McCaughtry, T.M.3
McNeil, L.K.4
Hogquist, K.A.5
-
3
-
-
4344668118
-
CCR7 signals are essential for cortex-medulla migration of developing thymocytes
-
Ueno, T. et al. CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J. Exp. Med. 200, 493-505 (2004).
-
(2004)
J. Exp. Med.
, vol.200
, pp. 493-505
-
-
Ueno, T.1
-
4
-
-
38949185052
-
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development
-
Setoguchi, R. et al. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science 319, 822-825 (2008).
-
(2008)
Science
, vol.319
, pp. 822-825
-
-
Setoguchi, R.1
-
5
-
-
40249095991
-
CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus
-
He, X. et al. CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity 28, 346-358 (2008).
-
(2008)
Immunity
, vol.28
, pp. 346-358
-
-
He, X.1
-
6
-
-
0031054632
-
Negative selection in the thymus includes semimature T cells
-
Kishimoto, H., Sprent, J. Negative selection in the thymus includes semimature T cells. J. Exp. Med. 185, 263-271 (1997).
-
(1997)
J. Exp. Med.
, vol.185
, pp. 263-271
-
-
Kishimoto, H.1
Sprent, J.2
-
7
-
-
2342458871
-
Negative selection of semimature CD4+8HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
-
Villunger, A. et al. Negative selection of semimature CD4+8HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling. Proc. Natl. Acad. Sci. USA 101, 7052-7057 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7052-7057
-
-
Villunger, A.1
-
8
-
-
84878662471
-
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development
-
Cowan, J.E. et al. The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development. J. Exp. Med. 210, 675-681 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 675-681
-
-
Cowan, J.E.1
-
9
-
-
36749066715
-
Developmental pathway of CD4+CD8 medullary thymocytes during mouse ontogeny and its defect in Aire-/-mice
-
Li, J. et al. Developmental pathway of CD4+CD8 medullary thymocytes during mouse ontogeny and its defect in Aire-/-mice. Proc. Natl. Acad. Sci. USA 104, 18175-18180 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 18175-18180
-
-
Li, J.1
-
10
-
-
35748979722
-
Thymic emigration revisited
-
McCaughtry, T.M., Wilken, M.S., Hogquist, K.A. Thymic emigration revisited. J. Exp. Med. 204, 2513-2520 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2513-2520
-
-
McCaughtry, T.M.1
Wilken, M.S.2
Hogquist, K.A.3
-
11
-
-
84906088444
-
Differential requirement for CCR4 and CCR7 during the development of innate and adaptive T cells in the adult thymus
-
Cowan, J.E. et al. Differential requirement for CCR4 and CCR7 during the development of innate and adaptive T cells in the adult thymus. J. Immunol. 193, 1204-1212 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 1204-1212
-
-
Cowan, J.E.1
-
12
-
-
9144228777
-
Continued maturation of thymic emigrants in the periphery
-
Boursalian, T.E., Golob, J., Soper, D.M., Cooper, C.J., Fink, P.J. Continued maturation of thymic emigrants in the periphery. Nat. Immunol. 5, 418-425 (2004).
-
(2004)
Nat. Immunol.
, vol.5
, pp. 418-425
-
-
Boursalian, T.E.1
Golob, J.2
Soper, D.M.3
Cooper, C.J.4
Fink, P.J.5
-
13
-
-
84878258655
-
Immunological Genome Consortium. The transcriptional landscape of T cell differentiation
-
Mingueneau, M. et al. Immunological Genome Consortium. The transcriptional landscape of T cell differentiation. Nat. Immunol. 14, 619-632 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 619-632
-
-
Mingueneau, M.1
-
14
-
-
52949145604
-
Lineage fate and intense debate: Myths, models and mechanisms of CD4-versus CD8-lineage choice
-
Singer, A., Adoro, S., Park, J.H. Lineage fate and intense debate: myths, models and mechanisms of CD4-versus CD8-lineage choice. Nat. Rev. Immunol. 8, 788-801 (2008).
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 788-801
-
-
Singer, A.1
Adoro, S.2
Park, J.H.3
-
15
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
-
Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355-360 (2004).
-
(2004)
Nature
, vol.427
, pp. 355-360
-
-
Matloubian, M.1
-
16
-
-
0028464674
-
Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
-
Arbonés, M.L. et al. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1, 247-260 (1994).
-
(1994)
Immunity
, vol.1
, pp. 247-260
-
-
Arbonés, M.L.1
-
17
-
-
33746334804
-
Kruppel-like factor 2 regulates thymocyte and T-cell migration
-
Carlson, C.M. et al. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature 442, 299-302 (2006).
-
(2006)
Nature
, vol.442
, pp. 299-302
-
-
Carlson, C.M.1
-
18
-
-
78649675371
-
Maturation-dependent licensing of naive T cells for rapid TNF production
-
Priyadharshini, B., Welsh, R.M., Greiner, D.L., Gerstein, R.M., Brehm, M.A. Maturation-dependent licensing of naive T cells for rapid TNF production. PLoS One 5, e15038 (2010).
-
(2010)
PLoS One
, vol.5
, pp. e15038
-
-
Priyadharshini, B.1
Welsh, R.M.2
Greiner, D.L.3
Gerstein, R.M.4
Brehm, M.A.5
-
19
-
-
0037716821
-
A genomic view of lymphocyte development
-
Hoffmann, R., Melchers, F. A genomic view of lymphocyte development. Curr. Opin. Immunol. 15, 239-245 (2003).
-
(2003)
Curr. Opin. Immunol.
, vol.15
, pp. 239-245
-
-
Hoffmann, R.1
Melchers, F.2
-
20
-
-
0026044445
-
The majority of CD4+8 thymocytes are functionally immature
-
Ramsdell, F., Jenkins, M., Dinh, Q., Fowlkes, B.J. The majority of CD4+8 thymocytes are functionally immature. J. Immunol. 147, 1779-1785 (1991).
-
(1991)
J. Immunol.
, vol.147
, pp. 1779-1785
-
-
Ramsdell, F.1
Jenkins, M.2
Dinh, Q.3
Fowlkes, B.J.4
-
21
-
-
33645056436
-
Commitment issues: Linking positive selection signals and lineage diversification in the thymus
-
Aliahmad, P., Kaye, J. Commitment issues: linking positive selection signals and lineage diversification in the thymus. Immunol. Rev. 209, 253-273 (2006).
-
(2006)
Immunol. Rev.
, vol.209
, pp. 253-273
-
-
Aliahmad, P.1
Kaye, J.2
-
22
-
-
77954901331
-
Decision checkpoints in the thymus
-
Carpenter, A.C., Bosselut, R. Decision checkpoints in the thymus. Nat. Immunol. 11, 666-673 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 666-673
-
-
Carpenter, A.C.1
Bosselut, R.2
-
23
-
-
84938937838
-
T Cell Adolescence: Maturation events beyond positive selection
-
Hogquist, K.A., Xing, Y., Hsu, F.C., Shapiro, V.S. T Cell Adolescence: Maturation Events Beyond Positive Selection. J. Immunol. 195, 1351-1357 (2015).
-
(2015)
J. Immunol.
, vol.195
, pp. 1351-1357
-
-
Hogquist, K.A.1
Xing, Y.2
Hsu, F.C.3
Shapiro, V.S.4
-
24
-
-
33748999526
-
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
-
Sato, S. et al. TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int. Immunol. 18, 1405-1411 (2006).
-
(2006)
Int. Immunol.
, vol.18
, pp. 1405-1411
-
-
Sato, S.1
-
25
-
-
32244432265
-
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance
-
Kurobe, H. et al. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Immunity 24, 165-177 (2006).
-
(2006)
Immunity
, vol.24
, pp. 165-177
-
-
Kurobe, H.1
-
26
-
-
33746111852
-
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
-
Wan, Y.Y., Chi, H., Xie, M., Schneider, M.D., Flavell, R.A. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat. Immunol. 7, 851-858 (2006).
-
(2006)
Nat. Immunol.
, vol.7
, pp. 851-858
-
-
Wan, Y.Y.1
Chi, H.2
Xie, M.3
Schneider, M.D.4
Flavell, R.A.5
-
27
-
-
0030298294
-
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-B activation prevents cell death
-
Liu, Z.G., Hsu, H., Goeddel, D.V., Karin, M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-B activation prevents cell death. Cell 87, 565-576 (1996).
-
(1996)
Cell
, vol.87
, pp. 565-576
-
-
Liu, Z.G.1
Hsu, H.2
Goeddel, D.V.3
Karin, M.4
-
28
-
-
34248570795
-
Ubiquitin-mediated activation of TAK1 and IKK
-
Adhikari, A., Xu, M., Chen, Z.J. Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 26, 3214-3226 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 3214-3226
-
-
Adhikari, A.1
Xu, M.2
Chen, Z.J.3
-
29
-
-
53349117702
-
Differential role of the transcription factor NF-B in selection and survival of CD4+ and CD8+ thymocytes
-
Jimi, E., Strickland, I., Voll, R.E., Long, M., Ghosh, S. Differential role of the transcription factor NF-B in selection and survival of CD4+ and CD8+ thymocytes. Immunity 29, 523-537 (2008).
-
(2008)
Immunity
, vol.29
, pp. 523-537
-
-
Jimi, E.1
Strickland, I.2
Voll, R.E.3
Long, M.4
Ghosh, S.5
-
30
-
-
84875414459
-
IRF7-dependent IFN-production in response to RANKL promotes medullary thymic epithelial cell development
-
Otero, D.C., Baker, D.P., David, M. IRF7-dependent IFN-production in response to RANKL promotes medullary thymic epithelial cell development. J. Immunol. 190, 3289-3298 (2013).
-
(2013)
J. Immunol.
, vol.190
, pp. 3289-3298
-
-
Otero, D.C.1
Baker, D.P.2
David, M.3
-
31
-
-
70349260311
-
Novel reporter mouse reveals constitutive and inflammatory expression of IFN-in vivo
-
Lienenklaus, S. et al. Novel reporter mouse reveals constitutive and inflammatory expression of IFN-in vivo. J. Immunol. 183, 3229-3236 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 3229-3236
-
-
Lienenklaus, S.1
-
32
-
-
77951753459
-
Functional crosstalk between type i and II interferon through the regulated expression of STAT1
-
Gough, D.J. et al. Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol. 8, e1000361 (2010).
-
(2010)
PLoS Biol.
, vol.8
, pp. e1000361
-
-
Gough, D.J.1
-
33
-
-
0034812001
-
Constitutive IFN-/signal for efficient IFN-/gene induction by virus
-
Hata, N. et al. Constitutive IFN-/signal for efficient IFN-/gene induction by virus. Biochem. Biophys. Res. Commun. 285, 518-525 (2001).
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.285
, pp. 518-525
-
-
Hata, N.1
-
34
-
-
84857415635
-
Constitutive type i interferon modulates homeostatic balance through tonic signaling
-
Gough, D.J., Messina, N.L., Clarke, C.J., Johnstone, R.W., Levy, D.E. Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity 36, 166-174 (2012).
-
(2012)
Immunity
, vol.36
, pp. 166-174
-
-
Gough, D.J.1
Messina, N.L.2
Clarke, C.J.3
Johnstone, R.W.4
Levy, D.E.5
-
35
-
-
84873659907
-
Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus
-
Dong, J. et al. Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus. PLoS One 8, e56378 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e56378
-
-
Dong, J.1
-
36
-
-
84864311450
-
Commensal bacteria calibrate the activation threshold of innate antiviral immunity
-
Abt, M.C. et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity 37, 158-170 (2012).
-
(2012)
Immunity
, vol.37
, pp. 158-170
-
-
Abt, M.C.1
-
37
-
-
84879600942
-
Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β
-
Kawashima, T. et al. Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β. Immunity 38, 1187-1197 (2013).
-
(2013)
Immunity
, vol.38
, pp. 1187-1197
-
-
Kawashima, T.1
-
38
-
-
84864322646
-
Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota
-
Ganal, S.C. et al. Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota. Immunity 37, 171-186 (2012).
-
(2012)
Immunity
, vol.37
, pp. 171-186
-
-
Ganal, S.C.1
-
39
-
-
84933680056
-
DNA-damage-induced type i interferon promotes senescence and inhibits stem cell function
-
Yu, Q. et al. DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function. Cell Rep. 11, 785-797 (2015).
-
(2015)
Cell Rep.
, vol.11
, pp. 785-797
-
-
Yu, Q.1
-
40
-
-
84922986861
-
DNA damage primes the type i interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity
-
Härtlova, A. et al. DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity. Immunity 42, 332-343 (2015).
-
(2015)
Immunity
, vol.42
, pp. 332-343
-
-
Härtlova, A.1
-
41
-
-
84928484992
-
IFN-/receptor signaling promotes regulatory T cell development and function under stress conditions
-
Metidji, A. et al. IFN-/receptor signaling promotes regulatory T cell development and function under stress conditions. J. Immunol. 194, 4265-4276 (2015).
-
(2015)
J. Immunol.
, vol.194
, pp. 4265-4276
-
-
Metidji, A.1
-
42
-
-
80053602333
-
The regulation of TNF signalling: What a tangled web we weave
-
Silke, J. The regulation of TNF signalling: what a tangled web we weave. Curr. Opin. Immunol. 23, 620-626 (2011).
-
(2011)
Curr. Opin. Immunol.
, vol.23
, pp. 620-626
-
-
Silke, J.1
-
43
-
-
23744456144
-
An essential role for c-FLIP in the efficient development of mature T lymphocytes
-
Zhang, N., He, Y.W. An essential role for c-FLIP in the efficient development of mature T lymphocytes. J. Exp. Med. 202, 395-404 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 395-404
-
-
Zhang, N.1
He, Y.W.2
-
44
-
-
33846235157
-
Bcl10/Malt1 signaling is essential for TCR-induced NF-B activation in thymocytes but dispensable for positive or negative selection
-
Jost, P.J. et al. Bcl10/Malt1 signaling is essential for TCR-induced NF-B activation in thymocytes but dispensable for positive or negative selection. J. Immunol. 178, 953-960 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 953-960
-
-
Jost, P.J.1
-
45
-
-
65549146581
-
CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells
-
Molinero, L.L. et al. CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells. J. Immunol. 182, 6736-6743 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 6736-6743
-
-
Molinero, L.L.1
-
46
-
-
65549114796
-
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery
-
Barnes, M.J. et al. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol. 7, e51 (2009).
-
(2009)
PLoS Biol.
, vol.7
, pp. e51
-
-
Barnes, M.J.1
-
47
-
-
84901280877
-
Overlapping and asymmetric functions of TCR signaling during thymic selection of CD4 and CD8 lineages
-
Sinclair, C., Seddon, B. Overlapping and asymmetric functions of TCR signaling during thymic selection of CD4 and CD8 lineages. J. Immunol. 192, 5151-5159 (2014).
-
(2014)
J. Immunol.
, vol.192
, pp. 5151-5159
-
-
Sinclair, C.1
Seddon, B.2
-
48
-
-
84926960339
-
Development of thymic Foxp3+ regulatory T cells: TGF-matters
-
Chen, W., Konkel, J.E. Development of thymic Foxp3+ regulatory T cells: TGF-matters. Eur. J. Immunol. 45, 958-965 (2015).
-
(2015)
Eur. J. Immunol.
, vol.45
, pp. 958-965
-
-
Chen, W.1
Konkel, J.E.2
-
49
-
-
34249678653
-
TGF signalling in control of T-cell-mediated self-reactivity
-
Rubtsov, Y.P., Rudensky, A.Y. TGF signalling in control of T-cell-mediated self-reactivity. Nat. Rev. Immunol. 7, 443-453 (2007).
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 443-453
-
-
Rubtsov, Y.P.1
Rudensky, A.Y.2
-
50
-
-
84899475568
-
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells
-
Mahmud, S.A. et al. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat. Immunol. 15, 473-481 (2014).
-
(2014)
Nat. Immunol.
, vol.15
, pp. 473-481
-
-
Mahmud, S.A.1
-
51
-
-
68249134207
-
KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors
-
Weinreich, M.A. et al. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity 31, 122-130 (2009).
-
(2009)
Immunity
, vol.31
, pp. 122-130
-
-
Weinreich, M.A.1
-
52
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545-15550 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
-
53
-
-
0038054341
-
PGC-1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha, V.K. et al. PGC-1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34, 267-273 (2003).
-
(2003)
Nat. Genet.
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
|