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Volumn 14, Issue 6, 2013, Pages 619-632

The transcriptional landscape of αβ T cell differentiation

(55)  Mingueneau, Michael a   Kreslavsky, Taras a,b   Gray, Daniel c,d   Heng, Tracy a,e   Cruse, Richard a   Ericson, Jeffrey a   Bendall, Sean f   Spitzer, Matthew H f   Nolan, Garry P f   Kobayashi, Koichi b,g   Von Boehmer, Harald b   Mathis, Diane a   Benoist, Christophe a   Best, Adam J h   Knell, Jamie h   Goldrath, Ananda h   Koller, Daphne i   Shay, Tal j   Regev, Aviv j   Cohen, Nadia k   more..


Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTOME;

EID: 84878258655     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2590     Document Type: Article
Times cited : (232)

References (93)
  • 1
    • 79959642720 scopus 로고    scopus 로고
    • The golden anniversary of the thymus
    • Miller, J.F. The golden anniversary of the thymus. Nat. Rev. Immunol. 11, 489-495 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 489-495
    • Miller, J.F.1
  • 2
    • 0024502409 scopus 로고
    • The thymus selects the useful, neglects the useless and destroys the harmful
    • von Boehmer, H., Teh, H.S. & Kisielow, P. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol. Today 10, 57-61 (1989).
    • (1989) Immunol. Today , vol.10 , pp. 57-61
    • Von Boehmer, H.1    Teh, H.S.2    Kisielow, P.3
  • 4
    • 0032968707 scopus 로고    scopus 로고
    • Regulation of T cell fate by Notch
    • Robey, E. Regulation of T cell fate by Notch. Annu. Rev. Immunol. 17, 283-295 (1999).
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 283-295
    • Robey, E.1
  • 5
    • 25844526684 scopus 로고    scopus 로고
    • Central tolerance: Learning self-control in the thymus
    • Hogquist, K.A., Baldwin, T.A. & Jameson, S.C. Central tolerance: learning self-control in the thymus. Nat. Rev. Immunol. 5, 772-782 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 772-782
    • Hogquist, K.A.1    Baldwin, T.A.2    Jameson, S.C.3
  • 7
    • 52949145604 scopus 로고    scopus 로고
    • Lineage fate and intense debate: Myths, models and mechanisms of CD4-versus CD8-lineage choice
    • Singer, A., Adoro, S. & Park, J.H. Lineage fate and intense debate: myths, models and mechanisms of CD4-versus CD8-lineage choice. Nat. Rev. Immunol. 8, 788-801 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 788-801
    • Singer, A.1    Adoro, S.2    Park, J.H.3
  • 8
    • 82555188020 scopus 로고    scopus 로고
    • On becoming a T cell, a convergence of factors kick it up a Notch along the way
    • Thompson, P.K. & Zuniga-Pfucker, J.C. On becoming a T cell, a convergence of factors kick it up a Notch along the way. Semin. Immunol. 23, 350-359 (2011).
    • (2011) Semin. Immunol. , vol.23 , pp. 350-359
    • Thompson, P.K.1    Zuniga-Pfucker, J.C.2
  • 9
    • 79959549536 scopus 로고    scopus 로고
    • T cell lineage commitment: Identity and renunciation
    • Rothenberg, E.V. T cell lineage commitment: identity and renunciation. J. Immunol. 186, 6649-6655 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 6649-6655
    • Rothenberg, E.V.1
  • 10
    • 0027153201 scopus 로고
    • A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8-triple-negative adult mouse thymocytes defned by CD44 and CD25 expression
    • Godfrey, D.I., Kennedy, J., Suda, T. & Zlotnik, A. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8-triple-negative adult mouse thymocytes defned by CD44 and CD25 expression. J. Immunol. 150, 4244-4252 (1993).
    • (1993) J. Immunol. , vol.150 , pp. 4244-4252
    • Godfrey, D.I.1    Kennedy, J.2    Suda, T.3    Zlotnik, A.4
  • 11
    • 34250212481 scopus 로고    scopus 로고
    • Commitment and developmental potential of extrathymic and intrathymic T cell precursors: Plenty to choose from
    • Bhandoola, A., von, B.H., Petrie, H.T. & Zuniga-Pfucker, J.C. Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 26, 678-689 (2007).
    • (2007) Immunity , vol.26 , pp. 678-689
    • Bhandoola, A.1    Von, B.H.2    Petrie, H.T.3    Zuniga-Pfucker, J.C.4
  • 12
    • 25444442035 scopus 로고    scopus 로고
    • Regulated costimulation in the thymus is critical for T cell development: Dysregulated CD28 costimulation can bypass the pre-TCR checkpoint
    • Williams, J.A. et al. Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint. J. Immunol. 175, 4199-4207 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 4199-4207
    • Williams, J.A.1
  • 13
    • 33747605056 scopus 로고    scopus 로고
    • Visualization of the earliest steps of yô T cell development in the adult thymus
    • Prinz, I. et al. Visualization of the earliest steps of yô T cell development in the adult thymus. Nat. Immunol. 7, 995-1003 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 995-1003
    • Prinz, I.1
  • 14
    • 84869238623 scopus 로고    scopus 로고
    • β-Selection-induced proliferation is required for aβ T cell differentiation
    • Kreslavsky, T. et al. β-Selection-induced proliferation is required for aβ T cell differentiation. Immunity 37, 840-853 (2012).
    • (2012) Immunity , vol.37 , pp. 840-853
    • Kreslavsky, T.1
  • 15
    • 0018170714 scopus 로고
    • Cytotoxic T cells learn specifcity for self H-2 during diffentiation in the thymus
    • Zinkernagel, R.M., Callahan, G.N., Klein, J. & Dennert, G. Cytotoxic T cells learn specifcity for self H-2 during diffentiation in the thymus. Nature 271, 251-253 (1978).
    • (1978) Nature , vol.271 , pp. 251-253
    • Zinkernagel, R.M.1    Callahan, G.N.2    Klein, J.3    Dennert, G.4
  • 16
    • 0023733271 scopus 로고
    • Positive selection of CD4+ thymocytes controlled by MHC class II gene products
    • MacDonald, H.R. et al. Positive selection of CD4+ thymocytes controlled by MHC class II gene products. Nature 336, 471-473 (1988).
    • (1988) Nature , vol.336 , pp. 471-473
    • MacDonald, H.R.1
  • 17
    • 0023683669 scopus 로고
    • Positive selection of antigen-specifc T cells in thymus by restricting MHC molecules
    • Kisielow, P., Teh, H.S., Bluthmann, H. & von Boehmer, H. Positive selection of antigen-specifc T cells in thymus by restricting MHC molecules. Nature 335, 730-733 (1988).
    • (1988) Nature , vol.335 , pp. 730-733
    • Kisielow, P.1    Teh, H.S.2    Bluthmann, H.3    Von Boehmer, H.4
  • 18
    • 0037036140 scopus 로고    scopus 로고
    • Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy
    • Bousso, P., Bhakta, N.R., Lewis, R.S. & Robey, E. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science 296, 1876-1880 (2002).
    • (2002) Science , vol.296 , pp. 1876-1880
    • Bousso, P.1    Bhakta, N.R.2    Lewis, R.S.3    Robey, E.4
  • 20
    • 0023813094 scopus 로고
    • Thymic major histocompatibility complex antigens and the aβ T-cell receptor determine the CD4/CD8 phenotype of T cells
    • Teh, H.S. et al. Thymic major histocompatibility complex antigens and the aβ T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335, 229-233 (1988).
    • (1988) Nature , vol.335 , pp. 229-233
    • Teh, H.S.1
  • 21
    • 0035320679 scopus 로고    scopus 로고
    • Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
    • Jordan, M.S. et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301-306 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 301-306
    • Jordan, M.S.1
  • 22
    • 0036199258 scopus 로고    scopus 로고
    • + T cells are positively selected in the thymus by agonist self-peptides
    • + T cells are positively selected in the thymus by agonist self-peptides. Immunity 16, 355-364 (2002).
    • (2002) Immunity , vol.16 , pp. 355-364
    • Leishman, A.J.1
  • 23
    • 79960843999 scopus 로고    scopus 로고
    • Post-thymic maturation: Young T cells assert their individuality
    • Fink, P.J. & Hendricks, D.W. Post-thymic maturation: young T cells assert their individuality. Nat. Rev. Immunol. 11, 544-549 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 544-549
    • Fink, P.J.1    Hendricks, D.W.2
  • 24
    • 0037769101 scopus 로고    scopus 로고
    • Characterization of transcriptional regulation during negative selection in vivo
    • DeRyckere, D., Mann, D.L. & DeGregori, J. Characterization of transcriptional regulation during negative selection in vivo. J. Immunol. 171, 802-811 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 802-811
    • Deryckere, D.1    Mann, D.L.2    Degregori, J.3
  • 25
    • 0141840803 scopus 로고    scopus 로고
    • Gene expression analysis of thymocyte selection in vivo
    • Schmitz, I., Clayton, L.K. & Reinherz, E.L. Gene expression analysis of thymocyte selection in vivo. Int. Immunol. 15, 1237-1248 (2003).
    • (2003) Int. Immunol. , vol.15 , pp. 1237-1248
    • Schmitz, I.1    Clayton, L.K.2    Reinherz, E.L.3
  • 26
    • 10344231974 scopus 로고    scopus 로고
    • Generalized resistance to thymic deletion in the NOD mouse; A polygenic trait characterized by defective induction of Bim
    • Liston, A. et al. Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity 21, 817-830 (2004).
    • (2004) Immunity , vol.21 , pp. 817-830
    • Liston, A.1
  • 27
    • 6344274985 scopus 로고    scopus 로고
    • The regulated expression of a diverse set of genes during thymocyte positive selection in vivo
    • Mick, V.E. et al. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo. J. Immunol. 173, 5434-5444 (2004).
    • (2004) J. Immunol. , vol.173 , pp. 5434-5444
    • Mick, V.E.1
  • 28
    • 15244338878 scopus 로고    scopus 로고
    • Defective central tolerance induction in NOD mice: Genomics and genetics
    • Zucchelli, S. et al. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity 22, 385-396 (2005).
    • (2005) Immunity , vol.22 , pp. 385-396
    • Zucchelli, S.1
  • 29
    • 34548724573 scopus 로고    scopus 로고
    • Transcriptional analysis of clonal deletion in vivo
    • Baldwin, T.A. & Hogquist, K.A. Transcriptional analysis of clonal deletion in vivo. J. Immunol. 179, 837-844 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 837-844
    • Baldwin, T.A.1    Hogquist, K.A.2
  • 30
    • 84860387854 scopus 로고    scopus 로고
    • Thymic negative selection is functional in NOD mice
    • Mingueneau, M. et al. Thymic negative selection is functional in NOD mice. J. Exp. Med. 209, 623-637 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 623-637
    • Mingueneau, M.1
  • 31
    • 84859157183 scopus 로고    scopus 로고
    • Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity
    • Zhang, J.A. et al. Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity. Cell 149, 467-482 (2012).
    • (2012) Cell , vol.149 , pp. 467-482
    • Zhang, J.A.1
  • 32
    • 77954329976 scopus 로고    scopus 로고
    • An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b
    • Li, L., Leid, M. & Rothenberg, E.V. An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b. Science 329, 89-93 (2010).
    • (2010) Science , vol.329 , pp. 89-93
    • Li, L.1    Leid, M.2    Rothenberg, E.V.3
  • 33
    • 84862776978 scopus 로고    scopus 로고
    • The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential
    • Luc, S. et al. The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. Nat. Immunol. 13, 412-419 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 412-419
    • Luc, S.1
  • 35
    • 84859890898 scopus 로고    scopus 로고
    • Intrathymic programming of effector fates in three molecularly distinct yô T cell subtypes
    • Narayan, K. et al. Intrathymic programming of effector fates in three molecularly distinct yô T cell subtypes. Nat. Immunol. 13, 511-518 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 511-518
    • Narayan, K.1
  • 36
    • 77954321988 scopus 로고    scopus 로고
    • An essential developmental checkpoint for production of the T cell lineage
    • Ikawa, T. et al. An essential developmental checkpoint for production of the T cell lineage. Science 329, 93-96 (2010).
    • (2010) Science , vol.329 , pp. 93-96
    • Ikawa, T.1
  • 37
    • 77954326626 scopus 로고    scopus 로고
    • Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion
    • Li, P. et al. Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion. Science 329, 85-89 (2010).
    • (2010) Science , vol.329 , pp. 85-89
    • Li, P.1
  • 38
    • 77958519679 scopus 로고    scopus 로고
    • Multilayered specifcation of the T-cell lineage fate
    • Rothenberg, E.V., Zhang, J. & Li, L. Multilayered specifcation of the T-cell lineage fate. Immunol. Rev. 238, 150-168 (2010).
    • (2010) Immunol. Rev. , vol.238 , pp. 150-168
    • Rothenberg, E.V.1    Zhang, J.2    Li, L.3
  • 39
    • 7444239120 scopus 로고    scopus 로고
    • A network of control mediated by regulator of calcium/calmodulin- dependent signaling
    • Rakhilin, S.V. et al. A network of control mediated by regulator of calcium/calmodulin-dependent signaling. Science 306, 698-701 (2004).
    • (2004) Science , vol.306 , pp. 698-701
    • Rakhilin, S.V.1
  • 40
    • 0035057909 scopus 로고    scopus 로고
    • TARPP a novel protein that accompanies TCR gene rearrangement and thymocyte education
    • Kisielow, J., Nairn, A.C. & Karjalainen, K. TARPP, a novel protein that accompanies TCR gene rearrangement and thymocyte education. Eur. J. Immunol. 31, 1141-1149 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1141-1149
    • Kisielow, J.1    Nairn, A.C.2    Karjalainen, K.3
  • 41
    • 33750094147 scopus 로고    scopus 로고
    • Disruption of diacylglycerol metabolism impairs the induction of T cell anergy
    • Olenchock, B.A. et al. Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. Nat. Immunol. 7, 1174-1181 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 1174-1181
    • Olenchock, B.A.1
  • 42
    • 50149083445 scopus 로고    scopus 로고
    • Synergistic control of T cell development and tumor suppression by diacylglycerol kinase a and Ç
    • Guo, R. et al. Synergistic control of T cell development and tumor suppression by diacylglycerol kinase a and Ç. Proc. Natl. Acad. Sci. USA 105, 11909-11914 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 11909-11914
    • Guo, R.1
  • 43
    • 0033681301 scopus 로고    scopus 로고
    • Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
    • Deftos, M.L. et al. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity 13, 73-84 (2000).
    • (2000) Immunity , vol.13 , pp. 73-84
    • Deftos, M.L.1
  • 44
    • 0036467663 scopus 로고    scopus 로고
    • Direct induction of T lymphocyte-specifc gene expression by the mammalian Notch signaling pathway
    • Reizis, B. & Leder, P. Direct induction of T lymphocyte-specifc gene expression by the mammalian Notch signaling pathway. Genes Dev. 16, 295-300 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 295-300
    • Reizis, B.1    Leder, P.2
  • 45
    • 65549171117 scopus 로고    scopus 로고
    • CSL-MAML-dependent Notch1 signaling controls T lineage-specifc IL-7Ra gene expression in early human thymopoiesis and leukemia
    • González-Garcia, S. et al. CSL-MAML-dependent Notch1 signaling controls T lineage-specifc IL-7Ra gene expression in early human thymopoiesis and leukemia. J. Exp. Med. 206, 779-791 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 779-791
    • González-Garcia, S.1
  • 46
    • 67650588402 scopus 로고    scopus 로고
    • Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A
    • Yashiro-Ohtani, Y. et al. Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev. 23, 1665-1676 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 1665-1676
    • Yashiro-Ohtani, Y.1
  • 47
    • 30444454357 scopus 로고    scopus 로고
    • Developmental and molecular characterization of emerging β-and yô-selected pre-T cells in the adult mouse thymus
    • Taghon, T. et al. Developmental and molecular characterization of emerging β-and yô-selected pre-T cells in the adult mouse thymus. Immunity 24, 53-64 (2006).
    • (2006) Immunity , vol.24 , pp. 53-64
    • Taghon, T.1
  • 48
    • 84055178955 scopus 로고    scopus 로고
    • T-cell factor 1 is a gatekeeper for T-cell specifcation in response to Notch signaling
    • Germar, K. et al. T-cell factor 1 is a gatekeeper for T-cell specifcation in response to Notch signaling. Proc. Natl. Acad. Sci. USA 108, 20060-20065 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 20060-20065
    • Germar, K.1
  • 49
    • 79961140554 scopus 로고    scopus 로고
    • A critical role for TCF-1 in T-lineage specifcation and differentiation
    • Weber, B.N. et al. A critical role for TCF-1 in T-lineage specifcation and differentiation. Nature 476, 63-68 (2011).
    • (2011) Nature , vol.476 , pp. 63-68
    • Weber, B.N.1
  • 50
    • 33746546368 scopus 로고    scopus 로고
    • C-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
    • Weng, A.P. et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 20, 2096-2109 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 2096-2109
    • Weng, A.P.1
  • 51
    • 3042734665 scopus 로고    scopus 로고
    • Selection of the T-cell repertoire: Receptor-controlled checkpoints in T-cell development
    • von Boehmer, H. Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development. Adv. Immunol. 84, 201-238 (2004).
    • (2004) Adv. Immunol. , vol.84 , pp. 201-238
    • Von Boehmer, H.1
  • 52
    • 84865160657 scopus 로고    scopus 로고
    • HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes
    • Wong, G.W. et al. HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. Blood 120, 1439-1448 (2012).
    • (2012) Blood , vol.120 , pp. 1439-1448
    • Wong, G.W.1
  • 53
    • 33750615714 scopus 로고    scopus 로고
    • C-Myc mediates pre-TCR-induced proliferation but not developmental progression
    • Dose, M. et al. c-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood 108, 2669-2677 (2006).
    • (2006) Blood , vol.108 , pp. 2669-2677
    • Dose, M.1
  • 54
    • 77953934816 scopus 로고    scopus 로고
    • Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
    • Choi, S.H., Wright, J.B., Gerber, S.A. & Cole, M.D. Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. Genes Dev. 24, 1236-1241 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 1236-1241
    • Choi, S.H.1    Wright, J.B.2    Gerber, S.A.3    Cole, M.D.4
  • 55
    • 23144464363 scopus 로고    scopus 로고
    • Transcriptional regulation and transformation by Myc proteins
    • Adhikary, S. & Eilers, M. Transcriptional regulation and transformation by Myc proteins. Nat. Rev. Mol. Cell Biol. 6, 635-645 (2005).
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 635-645
    • Adhikary, S.1    Eilers, M.2
  • 56
    • 0032192408 scopus 로고    scopus 로고
    • Repression by the Mad(Mxi1)-Sin3 complex
    • Schreiber-Agus, N. & DePinho, R.A. Repression by the Mad(Mxi1)-Sin3 complex. Bioessays 20, 808-818 (1998).
    • (1998) Bioessays , vol.20 , pp. 808-818
    • Schreiber-Agus, N.1    Depinho, R.A.2
  • 57
    • 2142654263 scopus 로고    scopus 로고
    • Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation
    • Ciofani, M. et al. Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J. Immunol. 172, 5230-5239 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5230-5239
    • Ciofani, M.1
  • 58
    • 33749327182 scopus 로고    scopus 로고
    • The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor
    • Maillard, I. et al. The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. J. Exp. Med. 203, 2239-2245 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2239-2245
    • Maillard, I.1
  • 59
    • 0037119951 scopus 로고    scopus 로고
    • Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1
    • Iritani, B.M. et al. Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1. EMBO J. 21, 4820-4830 (2002).
    • (2002) EMBO J. , vol.21 , pp. 4820-4830
    • Iritani, B.M.1
  • 60
    • 80051757801 scopus 로고    scopus 로고
    • Peculiarities of cell death mechanisms in neutrophils
    • Geering, B. & Simon, H.U. Peculiarities of cell death mechanisms in neutrophils. Cell Death Differ. 18, 1457-1469 (2011).
    • (2011) Cell Death Differ. , vol.18 , pp. 1457-1469
    • Geering, B.1    Simon, H.U.2
  • 61
    • 84867010006 scopus 로고    scopus 로고
    • C-Myc is a universal amplifer of expressed genes in lymphocytes and embryonic stem cells
    • Nie, Z. et al. c-Myc is a universal amplifer of expressed genes in lymphocytes and embryonic stem cells. Cell 151, 68-79 (2012).
    • (2012) Cell , vol.151 , pp. 68-79
    • Nie, Z.1
  • 62
    • 84868010349 scopus 로고    scopus 로고
    • Revisiting global gene expression analysis
    • Lovén, J. et al. Revisiting global gene expression analysis. Cell 151, 476-482 (2012).
    • (2012) Cell , vol.151 , pp. 476-482
    • Lovén, J.1
  • 63
    • 33947104955 scopus 로고    scopus 로고
    • Dynamic regulation of miRNA expression in ordered stages of cellular development
    • Neilson, J.R., Zheng, G.X., Burge, C.B. & Sharp, P.A. Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev. 21, 578-589 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 578-589
    • Neilson, J.R.1    Zheng, G.X.2    Burge, C.B.3    Sharp, P.A.4
  • 66
    • 37049034259 scopus 로고    scopus 로고
    • Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors
    • Jones, M.E. & Zhuang, Y. Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity 27, 860-870 (2007).
    • (2007) Immunity , vol.27 , pp. 860-870
    • Jones, M.E.1    Zhuang, Y.2
  • 67
    • 0033984819 scopus 로고    scopus 로고
    • Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3
    • Rivera, R.R. et al. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3. Immunity 12, 17-26 (2000).
    • (2000) Immunity , vol.12 , pp. 17-26
    • Rivera, R.R.1
  • 68
    • 0035260791 scopus 로고    scopus 로고
    • Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade
    • Bain, G. et al. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat. Immunol. 2, 165-171 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 165-171
    • Bain, G.1
  • 69
    • 77956372057 scopus 로고    scopus 로고
    • NLR family member NLRC5 is a transcriptional regulator of MHC class i genes
    • Meissner, T.B. et al. NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc. Natl. Acad. Sci. USA 107, 13794-13799 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 13794-13799
    • Meissner, T.B.1
  • 70
    • 0037983739 scopus 로고    scopus 로고
    • Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney
    • Huang, B., Wu, P., Popov, K.M. & Harris, R.A. Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Diabetes 52, 1371-1376 (2003).
    • (2003) Diabetes , vol.52 , pp. 1371-1376
    • Huang, B.1    Wu, P.2    Popov, K.M.3    Harris, R.A.4
  • 71
    • 36148960475 scopus 로고    scopus 로고
    • Molecular identifcation of mammalian phosphopentomutase and glucose-1, 6-bisphosphate synthase, two members of the α-D-phosphohexomutase family
    • Maliekal, P. et al. Molecular identifcation of mammalian phosphopentomutase and glucose-1, 6-bisphosphate synthase, two members of the α-D-phosphohexomutase family. J. Biol. Chem. 282, 31844-31851 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 31844-31851
    • Maliekal, P.1
  • 72
    • 0031048826 scopus 로고    scopus 로고
    • Quantitative impact of thymic clonal deletion on the T cell repertoire
    • van Meerwijk, J.P. et al. Quantitative impact of thymic clonal deletion on the T cell repertoire. J. Exp. Med. 185, 377-383 (1997).
    • (1997) J. Exp. Med. , vol.185 , pp. 377-383
    • Van Meerwijk, J.P.1
  • 73
    • 0028054017 scopus 로고
    • T-cell apoptosis detected in situ during positive and negative selection in the thymus
    • Surh, C.D. & Sprent, J. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372, 100-103 (1994).
    • (1994) Nature , vol.372 , pp. 100-103
    • Surh, C.D.1    Sprent, J.2
  • 74
    • 0035313076 scopus 로고    scopus 로고
    • A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection
    • Viret, C. et al. A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection. J. Immunol. 166, 4429-4437 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 4429-4437
    • Viret, C.1
  • 75
    • 58149154739 scopus 로고    scopus 로고
    • Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
    • McCaughtry, T.M., Baldwin, T.A., Wilken, M.S. & Hogquist, K.A. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J. Exp. Med. 205, 2575-2584 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2575-2584
    • McCaughtry, T.M.1    Baldwin, T.A.2    Wilken, M.S.3    Hogquist, K.A.4
  • 76
    • 0033565719 scopus 로고    scopus 로고
    • Negative selection of T cells occurs throughout thymic development
    • Baldwin, K.K., Trenchak, B.P., Altman, J.D. & Davis, M.M. Negative selection of T cells occurs throughout thymic development. J. Immunol. 163, 689-698 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 689-698
    • Baldwin, K.K.1    Trenchak, B.P.2    Altman, J.D.3    Davis, M.M.4
  • 77
    • 33846240496 scopus 로고    scopus 로고
    • Identifcation of a T lineage-committed progenitor in adult blood
    • Krueger, A. & von Boehmer, H. Identifcation of a T lineage-committed progenitor in adult blood. Immunity 26, 105-116 (2007).
    • (2007) Immunity , vol.26 , pp. 105-116
    • Krueger, A.1    Von Boehmer, H.2
  • 78
    • 34147128008 scopus 로고    scopus 로고
    • Impairment of organ-specifc T cell negative selection by diabetes susceptibility genes: Genomic analysis by mRNA profling
    • Liston, A. et al. Impairment of organ-specifc T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profling. Genome Biol. 8, R12 (2007).
    • (2007) Genome Biol. , vol.8
    • Liston, A.1
  • 79
    • 84859162436 scopus 로고    scopus 로고
    • Receptors that interact with nectin and nectin-like proteins in the immunosurveillance and immunotherapy of cancer
    • Chan, C.J., Andrews, D.M. & Smyth, M.J. Receptors that interact with nectin and nectin-like proteins in the immunosurveillance and immunotherapy of cancer. Curr. Opin. Immunol. 24, 246-251 (2012).
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 246-251
    • Chan, C.J.1    Andrews, D.M.2    Smyth, M.J.3
  • 80
    • 70349247895 scopus 로고    scopus 로고
    • CD4-CD8 lineage differentiation: Thpok-ing into the nucleus
    • Wang, L. & Bosselut, R. CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. J. Immunol. 183, 2903-2910 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 2903-2910
    • Wang, L.1    Bosselut, R.2
  • 81
    • 0031573129 scopus 로고    scopus 로고
    • Expansion of mature thymocyte subsets before emigration to the periphery
    • Pénit, C. & Vasseur, F. Expansion of mature thymocyte subsets before emigration to the periphery. J. Immunol. 159, 4848-4856 (1997).
    • (1997) J. Immunol. , vol.159 , pp. 4848-4856
    • Pénit, C.1    Vasseur, F.2
  • 82
    • 84856341012 scopus 로고    scopus 로고
    • XCL1 and XCR1 in the immune system
    • Lei, Y. & Takahama, Y. XCL1 and XCR1 in the immune system. Microbes Infect. 14, 262-267 (2012).
    • (2012) Microbes Infect. , vol.14 , pp. 262-267
    • Lei, Y.1    Takahama, Y.2
  • 83
    • 0034611605 scopus 로고    scopus 로고
    • Reversible activation of c-Myc in thymocytes enhances positive selection and induces proliferation and apoptosis in vitro
    • Rudolph, B., Hueber, A.O. & Evan, G.I. Reversible activation of c-Myc in thymocytes enhances positive selection and induces proliferation and apoptosis in vitro. Oncogene 19, 1891-1900 (2000).
    • (2000) Oncogene , vol.19 , pp. 1891-1900
    • Rudolph, B.1    Hueber, A.O.2    Evan, G.I.3
  • 84
    • 84869168809 scopus 로고    scopus 로고
    • The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy
    • Yu, S. et al. The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity 37, 813-826 (2012).
    • (2012) Immunity , vol.37 , pp. 813-826
    • Yu, S.1
  • 85
    • 34548257820 scopus 로고    scopus 로고
    • Immediate-early and delayed primary response genes are distinct in function and genomic architecture
    • Tullai, J.W. et al. Immediate-early and delayed primary response genes are distinct in function and genomic architecture. J. Biol. Chem. 282, 23981-23995 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 23981-23995
    • Tullai, J.W.1
  • 86
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet, P. et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286, 1735-1738 (1999).
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1
  • 87
    • 79955750055 scopus 로고    scopus 로고
    • Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum
    • Bendall, S.C. et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 332, 687-696 (2011).
    • (2011) Science , vol.332 , pp. 687-696
    • Bendall, S.C.1
  • 88
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang, W., Sherman, B.T. & Lempicki, R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57 (2009).
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 89
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang, W., Sherman, B.T. & Lempicki, R.A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37, 1-13 (2009).
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1-13
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 91
    • 60849139395 scopus 로고    scopus 로고
    • GOrilla: A tool for discovery and visualization of enriched GO terms in ranked gene lists
    • Eden, E. et al. GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinformatics 10, 48 (2009).
    • (2009) BMC Bioinformatics , vol.10 , pp. 48
    • Eden, E.1
  • 92
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: Kyoto encyclopedia of genes and genomes
    • Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27-30 (2000).
    • (2000) Nucleic Acids Res. , vol.28 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 93
    • 84858983547 scopus 로고    scopus 로고
    • KEGG for integration and interpretation of large-scale molecular data sets
    • Kanehisa, M. et al. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 40, D109-D114 (2012).
    • (2012) Nucleic Acids Res. , vol.40
    • Kanehisa, M.1


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