Homeostatic Properties and Phenotypic Maturation of Murine CD4+ Pre-Thymic Emigrants in the Thymus

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Dong, Jie ^a   Chen, Yu ^a   Xu, Xi ^a   Jin, Rong ^a   Teng, Fei ^a   Yan, Fan ^a   Tang, Hui ^a   Li, Pingping ^a   Sun, Xiuyuan ^a   Li, Yan ^a   Wu, Hounan ^a   Zhang, Yu ^a   Ge, Qing ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; INTERLEUKIN 7; PROTEIN BCL 2;

ADOPTIVE TRANSFER; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL SELECTION; CELL SURVIVAL; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; HOMEOSTASIS; IN VITRO STUDY; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THYMOCYTE; THYMUS; UPREGULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELL SURVIVAL; DENDRITIC CELLS; HOMEOSTASIS; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PHENOTYPE; SIGNAL TRANSDUCTION; THYMOCYTES; THYMUS GLAND; UP-REGULATION;

EID: 84873659907     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056378     Document Type: Article

References (47)

1. Yager EJ, Ahmed M, Lanzer K, Randall TD, Woodland DL, et al. (2008) Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med 205: 711-723.
2. Mackall CL, Hakim FT, Gress RE, (1997) Restoration of T-cell homeostasis after T-cell depletion. Semin Immunol 9: 339-346.
3. Ge Q, Hu H, Eisen HN, Chen J, (2002) Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments. Proc Natl Acad Sci U S A 99: 2989-2994.
4. Jin R, Wang W, Yao JY, Zhou YB, Qian XP, et al. (2008) Characterization of the in vivo dynamics of medullary CD4+CD8- thymocyte development. J Immunol 180: 2256-2263.
5. Li J, Li Y, Yao JY, Jin R, Zhu MZ, et al. (2007) Developmental pathway of CD4+CD8- medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice. Proc Natl Acad Sci U S A 104: 18175-18180.
6. Ramsdell F, Jenkins M, Dinh Q, Fowlkes BJ, (1991) The majority of CD4+8- thymocytes are functionally immature. J Immunol 147: 1779-1785.
7. Vicari A, Abehsira-Amar O, Papiernik M, Boyd RL, Tucek CL, (1994) MTS-32 monoclonal antibody defines CD4+8- thymocyte subsets that differ in their maturation level, lymphokine secretion, and selection patterns. J Immunol 152: 2207-2213.
8. Lucas B, Vasseur F, Penit C, (1994) Production, selection, and maturation of thymocytes with high surface density of TCR. J Immunol 153: 53-62.
9. Bendelac A, Schwartz RH, (1991) CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation. Nature 353: 68-71.
10. Dyall R, Nikolic-Zugic J, (1995) The majority of postselection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells. J Exp Med 181: 235-245.
11. Kishimoto H, Sprent J, (1997) Negative selection in the thymus includes semimature T cells. J Exp Med 185: 263-271.
12. McCaughtry TM, Wilken MS, Hogquist KA, (2007) Thymic emigration revisited. J Exp Med 204: 2513-2520.
13. Ge Q, Chen WF, (2000) Effect of murine thymic epithelial cell line (MTEC1) on the functional expression of CD4(+)CD8(-) thymocyte subgroups. Int Immunol 12: 1127-1133.
14. Ge Q, Chen WF, (1999) Phenotypic identification of the subgroups of murine T-cell receptor alphabeta+ CD4+ CD8- thymocytes and its implication in the late stage of thymocyte development. Immunology 97: 665-671.
15. Weinreich MA, Hogquist KA, (2008) Thymic emigration: when and how T cells leave home. J Immunol 181: 2265-2270.
16. Gabor MJ, Godfrey DI, Scollay R, (1997) Recent thymic emigrants are distinct from most medullary thymocytes. Eur J Immunol 27: 2010-2015.
17. Boursalian TE, Golob J, Soper DM, Cooper CJ, Fink PJ, (2004) Continued maturation of thymic emigrants in the periphery. Nat Immunol 5: 418-425.
18. Hale JS, Boursalian TE, Turk GL, Fink PJ, (2006) Thymic output in aged mice. Proc Natl Acad Sci U S A 103: 8447-8452.
19. Makaroff LE, Hendricks DW, Niec RE, Fink PJ, (2009) Postthymic maturation influences the CD8 T cell response to antigen. Proc Natl Acad Sci U S A 106: 4799-4804.
20. Haines CJ, Giffon TD, Lu LS, Lu X, Tessier-Lavigne M, et al. (2009) Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. J Exp Med 206: 275-285.
21. Priyadharshini B, Welsh RM, Greiner DL, Gerstein RM, Brehm MA, (2010) Maturation-dependent licensing of naive T cells for rapid TNF production. PLoS One 5: e15038.
22. Lee CK, Kim K, Welniak LA, Murphy WJ, Muegge K, et al. (2001) Thymic emigrants isolated by a new method possess unique phenotypic and functional properties. Blood 97: 1360-1369.
23. Clise-Dwyer K, Huston GE, Buck AL, Duso DK, Swain SL, (2007) Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice. J Immunol 178: 1321-1331.
24. Chang JF, Thomas CA 3rd, Kung JT (1991) Induction of high level IL-2 production in CD4+8- T helper lymphocytes requires post-thymic development. J Immunol 147: 851-859.
25. Opiela SJ, Koru-Sengul T, Adkins B, (2009) Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants. Blood 113: 5635-5643.
26. Houston EG Jr, Nechanitzky R, Fink PJ, (2008) Cutting edge: Contact with secondary lymphoid organs drives postthymic T cell maturation. J Immunol 181: 5213-5217.
27. Houston EG Jr, Boursalian TE, Fink PJ (2012) Homeostatic signals do not drive post-thymic T cell maturation. Cell Immunol.
28. Teng F, Zhou Y, Jin R, Chen Y, Pei X, et al. (2011) The molecular signature underlying the thymic migration and maturation of TCRalphabeta+ CD4+ CD8 thymocytes. PLoS One 6: e25567.
29. Fink PJ, Hendricks DW, (2011) Post-thymic maturation: young T cells assert their individuality. Nat Rev Immunol 11: 544-549.
30. Houston EG Jr, Higdon LE, Fink PJ, (2011) Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool. Proc Natl Acad Sci U S A 108: 5366-5371.
31. Zachariah MA, Cyster JG, (2010) Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction. Science 328: 1129-1135.
32. Hadeiba H, Lahl K, Edalati A, Oderup C, Habtezion A, et al. (2012) Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance. Immunity 36: 438-450.
33. Anderson MS, Su MA, (2011) Aire and T cell development. Curr Opin Immunol 23: 198-206.
34. Proietto AI, van Dommelen S, Wu L, (2009) The impact of circulating dendritic cells on the development and differentiation of thymocytes. Immunol Cell Biol 87: 39-45.
35. Wu L, Shortman K, (2005) Heterogeneity of thymic dendritic cells. Semin Immunol 17: 304-312.
36. Li J, Park J, Foss D, Goldschneider I, (2009) Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. J Exp Med 206: 607-622.
37. Yamano T, Watanabe S, Hasegawa H, Suzuki T, Abe R, et al. (2011) Ex vivo-expanded DCs induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin grafts. Blood 117: 2640-2648.
38. Baba T, Nakamoto Y, Mukaida N, (2009) Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner. J Immunol 183: 3053-3063.
39. Bousso P, Wahn V, Douagi I, Horneff G, Pannetier C, et al. (2000) Diversity, functionality, and stability of the T cell repertoire derived in vivo from a single human T cell precursor. Proc Natl Acad Sci U S A 97: 274-278.
40. Woodland DL, Kotzin BL, Palmer E, (1990) Functional consequences of a T cell receptor D beta 2 and J beta 2 gene segment deletion. J Immunol 144: 379-385.
41. Nanda NK, Apple R, Sercarz E, (1991) Limitations in plasticity of the T-cell receptor repertoire. Proc Natl Acad Sci U S A 88: 9503-9507.
42. Funauchi M, Farrant J, Moreno C, Webster AD, (1995) Defects in antigen-driven lymphocyte responses in common variable immunodeficiency (CVID) are due to a reduction in the number of antigen-specific CD4+ T cells. Clin Exp Immunol 101: 82-88.
43. Berzins SP, Godfrey DI, Miller JF, Boyd RL, (1999) A central role for thymic emigrants in peripheral T cell homeostasis. Proc Natl Acad Sci U S A 96: 9787-9791.
44. Swain S, Clise-Dwyer K, Haynes L, (2005) Homeostasis and the age-associated defect of CD4 T cells. Semin Immunol 17: 370-377.
45. Jones SC, Clise-Dwyer K, Huston G, Dibble J, Eaton S, et al. (2008) Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects. J Immunol 180: 4465-4475.
46. Schnell FJ, Kersh GJ, (2005) Control of recent thymic emigrant survival by positive selection signals and early growth response gene 1. J Immunol 175: 2270-2277.
47. Mori K, Itoi M, Tsukamoto N, Kubo H, Amagai T, (2007) The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma. Int Immunol 19: 745-753.