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Volumn 99, Issue 5, 2014, Pages

Disruption of GIP/GIPR axis in human adipose tissue is linked to obesity and insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; G PROTEIN COUPLED RECEPTOR KINASE 2; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; GLUCOSE; HORMONE RECEPTOR; INCRETIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84899956174     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-3350     Document Type: Article
Times cited : (82)

References (39)
  • 1
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab. 2006; 3:153-165.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 2
    • 84855257784 scopus 로고    scopus 로고
    • Evolving treatment strategies for the management of type 2 diabetes
    • Cefalu WT. Evolving treatment strategies for the management of type 2 diabetes. Am J Med Sci. 2012;343:21-26.
    • (2012) Am J Med Sci , vol.343 , pp. 21-26
    • Cefalu, W.T.1
  • 3
    • 0036373430 scopus 로고    scopus 로고
    • Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients
    • Vilsbø ll T, Krarup T , Madsbad S, Holst JJ. Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients. Diabetologia. 2002;45:1111-1119.
    • (2002) Diabetologia , vol.45 , pp. 1111-1119
    • Vilsbø Ll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 4
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes EK, Willer CJ , Berndt SI, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42:937-948.
    • (2010) Nat Genet , vol.42 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3
  • 5
    • 0036068322 scopus 로고    scopus 로고
    • Inhibition of gastric inhibitory polypeptide signaling prevents obesity
    • Miyawaki K,YamadaY, Ban N, et al. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med. 2002;8:738-742.
    • (2002) Nat Med , vol.8 , pp. 738-742
    • Kyamaday, M.1    Ban, N.2
  • 6
    • 37149047560 scopus 로고    scopus 로고
    • GIP receptor antagonism rev erses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet
    • McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA, Flatt PR. GIP receptor antagonism rev erses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. Am J Physiol Endocrinol Metab. 2007; 293:E1746-E1755.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • McClean, P.L.1    Irwin, N.2    Cassidy, R.S.3    Holst, J.J.4    Gault, V.A.5    Flatt, P.R.6
  • 7
    • 49649125933 scopus 로고    scopus 로고
    • Targeted ablation of glucose-dependent insulinotropic polypeptideproducing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet
    • Althage MC, Ford EL , Wang S, Tso P, Polonsky KS, Wice BM. Targeted ablation of glucose-dependent insulinotropic polypeptideproducing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet. J Biol Chem. 2008;283:18365-18376.
    • (2008) J Biol Chem , vol.283 , pp. 18365-18376
    • Althage, M.C.1    Ford, E.L.2    Wang, S.3    Tso, P.4    Polonsky, K.S.5    Wice, B.M.6
  • 8
    • 52649128760 scopus 로고    scopus 로고
    • Vaccination against GIP for the treatment of obesity
    • Fulurija A, Lutz TA, Sladko K, et al. Vaccination against GIP for the treatment of obesity. PloS One. 2008;3:e3163.
    • (2008) PloS One , vol.3
    • Fulurija, A.1    Lutz, T.A.2    Sladko, K.3
  • 9
    • 84863615352 scopus 로고    scopus 로고
    • GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis
    • Kim SJ, Nian C, Karunakaran S, Clee SM, Isales CM, McIntosh CH. GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis. PloS One. 2012; 7: e40156.
    • (2012) PloS One , vol.7
    • Kim, S.J.1    Nian, C.2    Karunakaran, S.3    Clee, S.M.4    Isales, C.M.5    McIntosh, C.H.6
  • 10
    • 0033520869 scopus 로고    scopus 로고
    • GIP biology and fat metabolism
    • Yip RG, Wolfe MM. GIP biology and fat metabolism. Life Sci. 2000;66:91-103.
    • (2000) Life Sci , vol.66 , pp. 91-103
    • Yip, R.G.1    Wolfe, M.M.2
  • 11
    • 78149350158 scopus 로고    scopus 로고
    • GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene
    • Kim SJ, Nian C, McIntosh CH. GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene. J Lipid Res. 2010;51:3145-3157.
    • (2010) J Lipid Res , vol.51 , pp. 3145-3157
    • Kim, S.J.1    Nian, C.2    McIntosh, C.H.3
  • 12
    • 36549010103 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation
    • Song DH, Getty-Kaushik L, Tseng E, Simon J, Corkey BE, Wolfe MM. Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation. Gastroenterolo gy. 2007;133:1796-1805.
    • (2007) Gastroenterolo Gy , vol.133 , pp. 1796-1805
    • Song, D.H.1    Getty-Kaushik, L.2    Tseng, E.3    Simon, J.4    Corkey, B.E.5    Wolfe, M.M.6
  • 13
    • 0007866067 scopus 로고    scopus 로고
    • Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice
    • Miyawaki K, Yamada Y, Yano H, et al. Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci U S A. 1999;96:14843-14847.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14843-14847
    • Miyawaki, K.1    Yamada, Y.2    Yano, H.3
  • 14
    • 0022327582 scopus 로고
    • GIP increases insulin receptor affinity and cellular sensitivity in adipocytes
    • Starich GH, Bar RS, Mazzaferri EL. GIP increases insulin receptor affinity and cellular sensitivity in adipocytes. Am J Physiol. 1985; 249:E603-E607.
    • (1985) Am J Physiol , vol.249
    • Starich, G.H.1    Bar, R.S.2    Mazzaferri, E.L.3
  • 15
    • 83355173938 scopus 로고    scopus 로고
    • Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110-isofo rm of phosphatidylinositol 3-kinase
    • MohammadS,RamosLS, Buck J, Levin LR, Rubino F,McGrawTE. Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110-isofo rm of phosphatidylinositol 3-kinase. J Biol Chem. 2011;286: 43062-43070.
    • (2011) J Biol Chem , vol.286 , pp. 43062-43070
    • Mohammad, S.1    Ramos, L.S.2    Buck, J.3    Levin, L.R.4    Rubino, F.5    McGraw, T.E.6
  • 16
    • 84861782461 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic peptide impairs insulin signaling via inducin g adipocyte inflammation in glucose-dependent insulinotropic peptide receptoroverexpressing adipocytes
    • Nie Y, Ma RC, Chan JC, Xu H, Xu G. Glucose-dependent insulinotropic peptide impairs insulin signaling via inducin g adipocyte inflammation in glucose-dependent insulinotropic peptide receptoroverexpressing adipocytes. FASEB J. 2012;26:2383-2393.
    • (2012) FASEB J , vol.26 , pp. 2383-2393
    • Nie, Y.1    Ma, R.C.2    Chan, J.C.3    Xu, H.4    Xu, G.5
  • 17
    • 84871871605 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes
    • Timper K, Grisouard J, Sauter NS, et al. Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes. Am J Physiol Endocrinol Metab. 2013;304:E1-E13.
    • (2013) Am J Physiol Endocrinol Metab , vol.304
    • Timper, K.1    Grisouard, J.2    Sauter, N.S.3
  • 18
    • 34250195756 scopus 로고    scopus 로고
    • GIP receptormRNAexpression in different fat tissue depots in postmenopausal non-diabetic women
    • Rudovich N, Kaiser S, Engeli S, et al. GIP receptormRNAexpression in different fat tissue depots in postmenopausal non-diabetic women. Regul Pept. 2007;142:138-145.
    • (2007) Regul Pept , vol.142 , pp. 138-145
    • Rudovich, N.1    Kaiser, S.2    Engeli, S.3
  • 19
    • 33749145610 scopus 로고    scopus 로고
    • Pro12Ala sequence variant of the PPARGgene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome
    • Cardona F Morcillo S Gonzalo-Marín M Garrido-Sanchez L Macias-Gonzalez M Tinahones FJ. Pro12Ala sequence variant of the PPARGgene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome Clin Chem. 2006 52 1920-1925.
    • (2006) Clin Chem , vol.52 , pp. 1920-1925
    • Cardona, F.1    Morcillo, S.2    Gonzalo-Marín, M.3    Garrido-Sanchez, L.4    Macias-Gonzalez, M.5    Tinahones, F.J.6
  • 20
    • 0035129323 scopus 로고    scopus 로고
    • Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation
    • Wabitsch M, Brenner RE, Melzner I, et al. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes Relat Metab Disord. 2001;25:8-15.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 8-15
    • WabitsMcIntosh, C.H.1    Brenner, R.E.2    Melzner, I.3
  • 21
    • 77954480730 scopus 로고    scopus 로고
    • Tumornecrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: Up-regulation in severe obesity is mediated by inflammation but not hypoxia
    • Vendrell J,Maymó-MasipE, Tinahones F, et al.Tumornecrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: up-regulation in severe obesity is mediated by inflammation but not hypoxia. J Clin En docrinol Metab. 2010;95: 2983-2992.
    • (2010) J Clin en Docrinol Metab , vol.95 , pp. 2983-2992
    • Jmaymó-Masipe, V.1    Tinahones, F.2
  • 22
    • 78650667231 scopus 로고    scopus 로고
    • Stromal stem cells from adipose tissue and bone marrow of age-matched female donors display distinct immunophenotypic pro files
    • Pachón-Pe na G, Yu G, Tucker A, et al. Stromal stem cells from adipose tissue and bone marrow of age-matched female donors display distinct immunophenotypic pro files. J Cell Physiol. 2011;226: 843-851.
    • (2011) J Cell Physiol , vol.226 , pp. 843-851
    • Pachón-Pe Na, G.1    Yu, G.2    Tucker, A.3
  • 23
    • 69949099328 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-induces insulin resista nce in human visceral but not subcutaneous adipocytes: Reversal by liver X receptor agonists
    • Ferná ndez-Veledo S, Vila-Bedmar R, Nieto-Vazquez I, Lorenzo M. c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-induces insulin resista nce in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists. J Clin Endocrinol Metab. 2009;94:3583-3593.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3583-3593
    • Fernández-Veledo, S.1    Vila-Bedmar, R.2    Nieto-Vazquez, I.3    Lorenzo, M.4
  • 24
    • 0034463864 scopus 로고    scopus 로고
    • Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling
    • Tseng CC, Zhang XY. Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling. Endocrinology. 2000;141:947-952.
    • (2000) Endocrinology , vol.141 , pp. 947-952
    • Tseng, C.C.1    Zhang, X.Y.2
  • 25
    • 79959199413 scopus 로고    scopus 로고
    • G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance
    • Mayor F Jr., Lucas E, Jurado-Pueyo M, et al. G Protein-coupled receptor kinase 2 (GRK2): a novel modulator of insulin resistance. Arch Physiol Biochem. 2011;117:125-130.
    • (2011) Arch Physiol Biochem , vol.117 , pp. 125-130
    • Mayor Jr., F.1    Lucas, E.2    Jurado-Pueyo, M.3
  • 26
    • 77957600228 scopus 로고    scopus 로고
    • Gproteincoupled receptor kinase 2 plays a relevant role in insulin resistance and obesity
    • Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, et al.Gproteincoupled receptor kinase 2 plays a relevant role in insulin resistance and obesity. Diabetes. 2010;59:2407-2417.
    • (2010) Diabetes , vol.59 , pp. 2407-2417
    • Garcia-Guerra, L.1    Nieto-Vazquez, I.2    Vila-Bedmar, R.3
  • 27
    • 84872290190 scopus 로고    scopus 로고
    • Hypoxia and adipose tissue function and dysfunction in obesity
    • Trayhurn P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev. 2013;93:1-21.
    • (2013) Physiol Rev , vol.93 , pp. 1-21
    • Trayhurn, P.1
  • 28
    • 80052096595 scopus 로고    scopus 로고
    • Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome
    • Lamers D, Famulla S, Wronkowitz N, et al. Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes. 2011;60:1917-1925.
    • (2011) Diabetes , vol.60 , pp. 1917-1925
    • Lamers, D.1    Famulla, S.2    Wronkowitz, N.3
  • 29
    • 76049099665 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective
    • Virtue S, Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective. Biochim Biophys Acta. 2010;1801:338-349.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 338-349
    • Virtue, S.1    Vidal-Puig, A.2
  • 30
    • 84878250644 scopus 로고    scopus 로고
    • Link between GIP and osteopontin in adipose tissue and insulin resistance
    • Ahlqvist E, Osmark P, Kuulasmaa T, et al. Link between GIP and osteopontin in adipose tissue and insulin resistance. Diabetes. 2013; 62:2088-2094.
    • (2013) Diabetes , vol.62 , pp. 2088-2094
    • Ahlqvist, E.1    Osmark, P.2    Kuulasmaa, T.3
  • 31
    • 55149088860 scopus 로고    scopus 로고
    • Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with type 2 diabetes
    • Højb erg PV, Vilsbø ll T, Zander M, et al. Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with type 2 diabetes. D iabet Med. 2008;25:1268-1275.
    • (2008) D Iabet Med , vol.25 , pp. 1268-1275
    • Højb Erg, P.V.1    Vilsbø Ll, T.2    Zander, M.3
  • 32
    • 80054883942 scopus 로고    scopus 로고
    • Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
    • Vendrell J, El Bekay R, Peral B, et al. Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance. Endocrinology. 2011;152:4072-4079.
    • (2011) Endocrinology , Issue.152 , pp. 4072-4079
    • Vendrell, J.1    El Bekay, R.2    Peral, B.3
  • 34
    • 77954891541 scopus 로고    scopus 로고
    • GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a high-fat d iet
    • Parlevliet ET, de Leeuw van Weenen JE, Romijn JA, Pijl H. GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a high-fat d iet. Am J Physiol Endocrinol Metab. 2010;299:E318-E324.
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Parlevliet, E.T.1    De Leeuw Van Weenen, J.E.2    Romijn, J.A.3    Pijl, H.4
  • 35
    • 79955675087 scopus 로고    scopus 로고
    • Characteristic of GLP-1 effects on glucose metabolism in human skel etal muscle from obese patients
    • Villanueva-Pen acarrillo ML, Martín-Duce A, Ramos-Álvarez I, et al. Characteristic of GLP-1 effects on glucose metabolism in human skel etal muscle from obese patients. Regul Pept. 2011;168:39-44.
    • (2011) Regul Pept , vol.168 , pp. 39-44
    • Villanueva-Pen Acarrillo, M.L.1    Martín-Duce, A.2    Ramos-Álvarez, I.3
  • 36
    • 0024271044 scopus 로고
    • Effects of gastric inhibitory polypeptide on glucose and lipid metabolism of isola ted rat adipocytes
    • Hauner H, Glatting G, Kaminska D, Pfeiffer EF. Effects of gastric inhibitory polypeptide on glucose and lipid metabolism of isola ted rat adipocytes. Ann Nutr Metab. 1988;32:282-288.
    • (1988) Ann Nutr Metab , vol.32 , pp. 282-288
    • Hauner, H.1    Glatting, G.2    Kaminska, D.3    Pfeiffer, E.F.4
  • 37
    • 34247880256 scopus 로고    scopus 로고
    • Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a pro tein kinase B, LKB1, and AMP-activated protein kinase cascade
    • Kim SJ, Nian C, McIntosh CH. Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a pro tein kinase B, LKB1, and AMP-activated protein kinase cascade. J Biol Chem. 2007;282:8557-8567.
    • (2007) J Biol Chem , vol.282 , pp. 8557-8567
    • Kim, S.J.1    Nian, C.2    McIntosh, C.H.3
  • 38
    • 79953307026 scopus 로고    scopus 로고
    • Adipocyte expression of the glucosedependent insulinotropic polypepti de receptor involves gene regulation by PPAR-and histone acetylation
    • Kim SJ, Nian C, McIntosh CH. Adipocyte expression of the glucosedependent insulinotropic polypepti de receptor involves gene regulation by PPAR-and histone acetylation. J Lipid Res. 2011;52: 759-770.
    • (2011) J Lipid Res , vol.52 , pp. 759-770
    • Kim, S.J.1    Nian, C.2    McIntosh, C.H.3
  • 39
    • 84869171494 scopus 로고    scopus 로고
    • DNA methylation plasticity of human adipose-derived stem cells in lineage commitment
    • Berdasco M, Melguizo C, Prados J, et al. DNA methylation plasticity of human adipose-derived stem cells in lineage commitment. Am J Pathol. 2012;181:2079-2093.
    • (2012) Am J Pathol , vol.181 , pp. 2079-2093
    • Berdasco, M.1    Melguizo, C.2    Prados, J.3


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