Molecular basis of the functional differences between soluble human versus murine MD-2: Role of Val135 in transfer of lipopolysaccharide from CD14 to MD-2

Journal of Immunology

Volumn 196, Issue 5, 2016, Pages 2309-2318

  Vašl, Jožica ^a   Oblak, Alja ^a   Peternelj, Tina T ^a   Klett, Javier ^b   Martín Santamaría, Sonsoles ^b   Gioannini, Theresa L ^c,d   Weiss, Jerrold P ^c   Jerala, Roman ^a,e  

^a NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c UNIVERSITY OF IOWA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e Centre of Excellence   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BIOLOGICAL FACTOR; CD14 ANTIGEN; HUMAN MYELOID DIFFERENTIATION FACTOR 2; LIPOPOLYSACCHARIDE; MURINE MYELOID DIFFERENTIATION FACTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; VALINE; PROTEIN BINDING; PROTEIN MD 2;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CELL ACTIVATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR BIOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; GENE EXPRESSION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN CONFORMATION; PROTEIN DOMAIN; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD14; BINDING SITES; BIOLOGICAL TRANSPORT; CELL LINE; GENE EXPRESSION; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 4;

EID: 84962016594     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1502074     Document Type: Article

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