Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner

Free Radical Biology and Medicine

Volumn 95, Issue , 2016, Pages 133-154

  Nacarelli, Timothy ^a   Azar, Ashley ^a   Sell, Christian ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BETA GALACTOSIDASE; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE SUBUNIT I; LAMIN; LAMIN B1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NADH DEHYDROGENASE (UBIQUINONE) 1 BETA SUBCOMPLEX 8 OF COMPLEX I; NUCLEOSIDE ANALOG; PARKIN; PINK1 PROTEIN; PROTEIN; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; PROTEIN P70; PROTEIN S6; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RNA DIRECTED DNA POLYMERASE INHIBITOR; SHORT HAIRPIN RNA; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE) IRON SULFUR SUBUNIT OF COMPLEX II; TUBERIN; UBIQUINOL CYTOCHROME C REDUCTASE; UBIQUINOL CYTOCHROME C REDUCTASE CORE PROTEIN II; UNCLASSIFIED DRUG; UNINDEXED DRUG; HYDROGEN PEROXIDE; MDM2 PROTEIN, HUMAN; NUCLEOSIDE; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL AGING; CELL STRESS; CELLULAR SENESCENCE; CONTROLLED STUDY; DNA DAMAGE; HEART FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LUNG FIBROBLAST; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL STRESS; MITOCHONDRION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; STEADY STATE; CELL PROLIFERATION; DRUG EFFECTS; FIBROBLAST; GENETICS; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION;

CELL PROLIFERATION; CELLULAR SENESCENCE; FIBROBLASTS; HUMANS; HYDROGEN PEROXIDE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MITOCHONDRIA; NUCLEOSIDES; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MDM2; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84962001853     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2016.03.008     Document Type: Article

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