IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation

Nature Communications

Volumn 6, Issue , 2015, Pages

  Xia, Pengyan ^a   Wang, Shuo ^a   Xiong, Zhen ^a,b   Ye, Buqing ^a   Huang, Li Yu ^c,d   Han, Ze Guang ^c,d   Fan, Zusen ^a,b  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c Shanghai Jiao Tong University   (China)

^d CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BINDING PROTEIN; INSULIN; INSULIN RECEPTOR TYROSINE KINASE SUBSTRATE; INTERFERON REGULATORY FACTOR 3; POLY(C) BINDING PROTEIN; PROTEIN TYROSINE KINASE; PROTEIN UBC9; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; DDX58 PROTEIN, MOUSE; DEAD BOX PROTEIN; IPS-1 PROTEIN, MOUSE; IRTKS PROTEIN, MOUSE; PCBP2 PROTEIN, MOUSE; RETINOIC ACID INDUCIBLE PROTEIN I; RNA BINDING PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN-CONJUGATING ENZYME UBC9;

CYTOPLASM; ENZYME ACTIVITY; IMMUNITY; INFECTIVITY; MITOCHONDRIAL DNA; PROTEIN; RNA;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; DOWN REGULATION; FEMALE; GENE INACTIVATION; INNATE IMMUNITY; INSULIN DEFICIENCY; INSULIN RESISTANCE; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; PLASMID; PROTEIN DEGRADATION; PROTEIN INTERACTION; RNA DEGRADATION; RNA VIRUS INFECTION; SIGNAL TRANSDUCTION; SUMOYLATION; VIRUS IMMUNITY; ANIMAL; CRISPR CAS SYSTEM; FIBROBLAST; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOLOGY; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOVIRUS INFECTION; VESICULOVIRUS;

RNA VIRUSES;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CRISPR-CAS SYSTEMS; DEAD BOX PROTEIN 58; DEAD-BOX RNA HELICASES; DOWN-REGULATION; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNITY, INNATE; IMMUNOPRECIPITATION; MACROPHAGES; MICE; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHABDOVIRIDAE INFECTIONS; RNA-BINDING PROTEINS; SUMOYLATION; UBIQUITIN-CONJUGATING ENZYMES; VESICULOVIRUS;

EID: 84941142802     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9132     Document Type: Article

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