메뉴 건너뛰기




Volumn 11, Issue 3, 2016, Pages

The BH3 mimetic obatoclax accumulates in lysosomes and causes their alkalinization

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; AUTOPHAGY PROTEIN 5; BECLIN 1; CARBOPLATIN; NAVITOCLAX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OBATOCLAX; BIOMIMETIC MATERIAL; CATHEPSIN; PROTEIN BCL 2; PYRROLE DERIVATIVE;

EID: 84961785821     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0150696     Document Type: Article
Times cited : (35)

References (44)
  • 1
    • 84908173579 scopus 로고    scopus 로고
    • Ovarian cancer
    • 24767708 Epub 2014/04/29
    • Jayson GC, Kohn EC, Kitchener HC, Ledermann JA. Ovarian cancer. Lancet. 2014;384(9951):1376-88. Epub 2014/04/29. doi: 10.1016/S0140-6736 (13) 62146-7 PMID: 24767708.
    • (2014) Lancet. , vol.384 , Issue.9951 , pp. 1376-1388
    • Jayson, G.C.1    Kohn, E.C.2    Kitchener, H.C.3    Ledermann, J.A.4
  • 2
    • 84864918124 scopus 로고    scopus 로고
    • Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine
    • 22898329 Epub 2012/08/18, PubMed Central PMCID: PMC3477050
    • Stamelos VA, Redman CW, Richardson A. Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. J Mol Signal. 2012;7(1):12. Epub 2012/08/18. doi: 10.1186/1750-2187-7-12 PMID: 22898329; PubMed Central PMCID: PMC3477050.
    • (2012) J Mol Signal. , vol.7 , Issue.1 , pp. 12
    • Stamelos, V.A.1    Redman, C.W.2    Richardson, A.3
  • 3
    • 37249003222 scopus 로고    scopus 로고
    • The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin
    • 18056200 Epub 2007/12/07
    • Witham J, Valenti MR, De-Haven-Brandon AK, Vidot S, Eccles SA, Kaye SB, et al. The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin. Clin Cancer Res. 2007;13(23):7191-8. Epub 2007/12/07. doi: 10.1158/1078-0432. CCR-07-0362 PMID: 18056200.
    • (2007) Clin Cancer Res. , vol.13 , Issue.23 , pp. 7191-7198
    • Witham, J.1    Valenti, M.R.2    De-Haven-Brandon, A.K.3    Vidot, S.4    Eccles, S.A.5    Kaye, S.B.6
  • 4
    • 84872837242 scopus 로고    scopus 로고
    • Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells
    • 23168176 Epub 2012/11/22
    • Stamelos VA, Robinson E, Redman CW, Richardson A. Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells. Gynecol Oncol. 2013;128(2):377-82. Epub 2012/11/22. doi: 10.1016/j.ygyno. 2012.11.019 PMID: 23168176.
    • (2013) Gynecol Oncol. , vol.128 , Issue.2 , pp. 377-382
    • Stamelos, V.A.1    Robinson, E.2    Redman, C.W.3    Richardson, A.4
  • 5
    • 37649023004 scopus 로고    scopus 로고
    • Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    • 18040043 Epub 2007/11/28, PubMed Central PMCID: PMC2148320
    • Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci USA. 2007;104(49):19512-7. Epub 2007/11/28. doi: 10.1073/pnas.0709443104 PMID: 18040043; PubMed Central PMCID: PMC2148320.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , Issue.49 , pp. 19512-19517
    • Nguyen, M.1    Marcellus, R.C.2    Roulston, A.3    Watson, M.4    Serfass, L.5    Murthy Madiraju, S.R.6
  • 6
    • 84876260453 scopus 로고    scopus 로고
    • An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies
    • 23515850 Epub 2013/03/22, PubMed Central PMCID: PMC3601645
    • Goard CA, Schimmer AD. An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies. Core Evid. 2013;8:15-26. Epub 2013/03/22. doi: 10.2147/CE. S42568 PMID: 23515850; PubMed Central PMCID: PMC3601645.
    • (2013) Core Evid. , vol.8 , pp. 15-26
    • Goard, C.A.1    Schimmer, A.D.2
  • 7
    • 84961812721 scopus 로고    scopus 로고
    • www.clinicaltrials.gov
    • www.clinicaltrials.gov. Available from: www.clinicaltrials.gov.
  • 8
    • 44849133234 scopus 로고    scopus 로고
    • Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax)
    • 18451169 Epub 2008/05/03, PubMed Central PMCID: PMC4096127
    • Konopleva M, Watt J, Contractor R, Tsao T, Harris D, Estrov Z, et al. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax). Cancer Res. 2008;68(9):3413-20. Epub 2008/05/03. doi: 10.1158/0008-5472. CAN-07-1919 PMID: 18451169; PubMed Central PMCID: PMC4096127.
    • (2008) Cancer Res. , vol.68 , Issue.9 , pp. 3413-3420
    • Konopleva, M.1    Watt, J.2    Contractor, R.3    Tsao, T.4    Harris, D.5    Estrov, Z.6
  • 9
    • 77950231711 scopus 로고    scopus 로고
    • A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells
    • 20160031 Epub 2010/02/18, PubMed Central PMCID: PMC2831099
    • Smoot RL, Blechacz BR, Werneburg NW, Bronk SF, Sinicrope FA, Sirica AE, et al. A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells. Cancer Res. 2010;70(5):1960-9. Epub 2010/02/18. doi: 10.1158/0008-5472CAN-09-3535 PMID: 20160031; PubMed Central PMCID: PMC2831099.
    • (2010) Cancer Res. , vol.70 , Issue.5 , pp. 1960-1969
    • Smoot, R.L.1    Blechacz, B.R.2    Werneburg, N.W.3    Bronk, S.F.4    Sinicrope, F.A.5    Sirica, A.E.6
  • 10
    • 79959774131 scopus 로고    scopus 로고
    • Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK
    • 21368880 Epub 2010/01/01, PubMed Central PMCID: PMC3032298
    • McCoy F, Hurwitz J, McTavish N, Paul I, Barnes C, O'Hagan B, et al. Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK. Cell Death Dis. 2010;1:e108. Epub 2010/01/01. doi: 10.1038/cddis.2010.86 PMID: 21368880; PubMed Central PMCID: PMC3032298.
    • (2010) Cell Death Dis. , vol.1 , pp. e108
    • McCoy, F.1    Hurwitz, J.2    McTavish, N.3    Paul, I.4    Barnes, C.5    O'Hagan, B.6
  • 11
    • 84906994522 scopus 로고    scopus 로고
    • Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells
    • 25192188 Epub 2014/09/06, PubMed Central PMCID: PMC4156353
    • Koehler BC, Scherr AL, Lorenz S, Elssner C, Kautz N, Welte S, et al. Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells. PLoS One. 2014;9(9):e106571. Epub 2014/09/06. doi: 10.1371/journal.pone.0106571 PMID: 25192188; PubMed Central PMCID: PMC4156353.
    • (2014) PLoS One. , vol.9 , Issue.9 , pp. e106571
    • Koehler, B.C.1    Scherr, A.L.2    Lorenz, S.3    Elssner, C.4    Kautz, N.5    Welte, S.6
  • 12
    • 84904438962 scopus 로고    scopus 로고
    • Obatoclax induces G1/G0-phase arrest via p38/p21 (waf1/Cip1) signaling pathway in human esophageal cancer cells
    • 24788582 Epub 2014/05/03
    • Zhong D, Gu C, Shi L, Xun T, Li X, Liu S, et al. Obatoclax induces G1/G0-phase arrest via p38/p21 (waf1/Cip1) signaling pathway in human esophageal cancer cells. J Cell Biochem. 2014;115(9):1624-35. Epub 2014/05/03. doi: 10.1002/jcb.24829 PMID: 24788582.
    • (2014) J Cell Biochem. , vol.115 , Issue.9 , pp. 1624-1635
    • Zhong, D.1    Gu, C.2    Shi, L.3    Xun, T.4    Li, X.5    Liu, S.6
  • 13
    • 84878254063 scopus 로고    scopus 로고
    • Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia
    • 23393050 Epub 2013/02/09, PubMed Central PMCID: PMC3617634
    • Urtishak KA, Edwards AY, Wang LS, Hudome A, Robinson BW, Barrett JS, et al. Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia. Blood. 2013;121(14):2689-703. Epub 2013/02/09. doi: 10.1182/blood-2012-04-425033 PMID: 23393050; PubMed Central PMCID: PMC3617634.
    • (2013) Blood , vol.121 , Issue.14 , pp. 2689-2703
    • Urtishak, K.A.1    Edwards, A.Y.2    Wang, L.S.3    Hudome, A.4    Robinson, B.W.5    Barrett, J.S.6
  • 14
    • 84864882707 scopus 로고    scopus 로고
    • Copy number aberrations of BCL2 and CDKN2A/B identified by array-CGH in thymic epithelial tumors
    • 22825469 Epub 2012/07/25, PubMed Central PMCID: PMC3406591
    • Petrini I, Meltzer PS, Zucali PA, Luo J, Lee C, Santoro A, et al. Copy number aberrations of BCL2 and CDKN2A/B identified by array-CGH in thymic epithelial tumors. Cell Death Dis. 2012;3:e351. Epub 2012/07/25. doi: 10.1038/cddis.2012.92 PMID: 22825469; PubMed Central PMCID: PMC3406591.
    • (2012) Cell Death Dis. , vol.3 , pp. e351
    • Petrini, I.1    Meltzer, P.S.2    Zucali, P.A.3    Luo, J.4    Lee, C.5    Santoro, A.6
  • 15
    • 82955222366 scopus 로고    scopus 로고
    • Synthetic prodiginine obatoclax (GX15-070) and related analogues: Anion binding, transmembrane transport, and cytotoxicity properties
    • 22069220 Epub 2011/11/10
    • Diazde Grenu B, Iglesias Hernandez P, Espona M, Quinonero D, Light ME, Torroba T, et al. Synthetic prodiginine obatoclax (GX15-070) and related analogues: anion binding, transmembrane transport, and cytotoxicity properties. Chemistry. 2011;17(50):14074-83. Epub 2011/11/10. doi: 10.1002/chem. 201101547 PMID: 22069220.
    • (2011) Chemistry , vol.17 , Issue.50 , pp. 14074-14083
    • Diazde Grenu, B.1    Iglesias Hernandez, P.2    Espona, M.3    Quinonero, D.4    Light, M.E.5    Torroba, T.6
  • 16
    • 80051745794 scopus 로고    scopus 로고
    • Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis
    • 21822052 Epub 2011/08/09, PubMed Central PMCID: PMC3233494
    • Martinez-Paniagua MA, Baritaki S, Huerta-Yepez S, Ortiz-Navarrete VF, Gonzalez-Bonilla C, Bonavida B, et al. Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis. Cell Cycle. 2011;10(16):2792-805. Epub 2011/08/09. PMID: 21822052; PubMed Central PMCID: PMC3233494.
    • (2011) Cell Cycle. , vol.10 , Issue.16 , pp. 2792-2805
    • Martinez-Paniagua, M.A.1    Baritaki, S.2    Huerta-Yepez, S.3    Ortiz-Navarrete, V.F.4    Gonzalez-Bonilla, C.5    Bonavida, B.6
  • 17
    • 84855802012 scopus 로고    scopus 로고
    • Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: Prodigiosin vs. Obatoclax
    • 22155350 Epub 2011/12/14
    • Espona-Fiedler M, Soto-Cerrato V, Hosseini A, Lizcano JM, Guallar V, Quesada R, et al. Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: prodigiosin vs. obatoclax. Biochem Pharmacol. 2012;83(4):489-96. Epub 2011/12/14. doi: 10.1016/j.bcp. 2011.11.027 PMID: 22155350.
    • (2012) Biochem Pharmacol. , vol.83 , Issue.4 , pp. 489-496
    • Espona-Fiedler, M.1    Soto-Cerrato, V.2    Hosseini, A.3    Lizcano, J.M.4    Guallar, V.5    Quesada, R.6
  • 18
    • 84927692511 scopus 로고    scopus 로고
    • Obatoclax induces Beclin 1- and ATG5-dependent apoptosis and autophagy in adenoid cystic carcinoma cells
    • 25482163 Epub 2014/12/09
    • Liang LZ, Ma B, Liang YJ, Liu HC, Zhang TH, Zheng GS, et al. Obatoclax induces Beclin 1- and ATG5-dependent apoptosis and autophagy in adenoid cystic carcinoma cells. Oral Dis. 2015;21(4):470-7. Epub 2014/12/09. doi: 10.1111/odi.12305 PMID: 25482163.
    • (2015) Oral Dis. , vol.21 , Issue.4 , pp. 470-477
    • Liang, L.Z.1    Ma, B.2    Liang, Y.J.3    Liu, H.C.4    Zhang, T.H.5    Zheng, G.S.6
  • 19
    • 84914703122 scopus 로고    scopus 로고
    • Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells
    • 25333301 Epub 2014/10/22
    • Wang G, Chen S, Edwards H, Cui X, Cui L, Ge Y. Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells. Oncol Rep. 2014;32(6):2789-94. Epub 2014/10/22. doi: 10.3892/or.2014.3525 PMID: 25333301.
    • (2014) Oncol Rep. , vol.32 , Issue.6 , pp. 2789-2794
    • Wang, G.1    Chen, S.2    Edwards, H.3    Cui, X.4    Cui, L.5    Ge, Y.6
  • 20
    • 84900503589 scopus 로고    scopus 로고
    • Combination of AZD2281 (Olaparib) and GX15-070 (Obatoclax) results in synergistic antitumor activities in preclinical models of pancreatic cancer
    • 24534203 Epub 2014/02/19
    • Chen S, Wang G, Niu X, Zhao J, Tan W, Wang H, et al. Combination of AZD2281 (Olaparib) and GX15-070 (Obatoclax) results in synergistic antitumor activities in preclinical models of pancreatic cancer. Cancer Lett. 2014;348(1-2):20-8. Epub 2014/02/19. doi: 10.1016/j.canlet.2014.02.010 PMID: 24534203.
    • (2014) Cancer Lett. , vol.348 , Issue.1-2 , pp. 20-28
    • Chen, S.1    Wang, G.2    Niu, X.3    Zhao, J.4    Tan, W.5    Wang, H.6
  • 21
    • 84891826874 scopus 로고    scopus 로고
    • Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells
    • 24216166 Epub 2013/11/13, PubMed Central PMCID: PMC3944051
    • Yazbeck VY, Li C, Grandis JR, Zang Y, Johnson DE. Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells. Oral Oncol. 2014;50(2):120-7. Epub 2013/11/13. doi: 10.1016/j.oraloncology.2013.10.013 PMID: 24216166; PubMed Central PMCID: PMC3944051.
    • (2014) Oral Oncol. , vol.50 , Issue.2 , pp. 120-127
    • Yazbeck, V.Y.1    Li, C.2    Grandis, J.R.3    Zang, Y.4    Johnson, D.E.5
  • 22
    • 84874317892 scopus 로고    scopus 로고
    • BH3-mimeticsand cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components
    • 23437261 Epub 2013/02/26, PubMed Central PMCID: PMC3578861
    • Andreu-Fernandez V, Genoves A, Messeguer A, Orzaez M, Sancho M, Perez-Paya E. BH3-mimeticsand cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components. PLoSOne. 2013;8(2):e56881. Epub 2013/02/26. doi: 10.1371/journal.pone.0056881 PMID: 23437261; PubMed Central PMCID: PMC3578861.
    • (2013) PLoSOne. , vol.8 , Issue.2 , pp. e56881
    • Andreu-Fernandez, V.1    Genoves, A.2    Messeguer, A.3    Orzaez, M.4    Sancho, M.5    Perez-Paya, E.6
  • 23
    • 79955745789 scopus 로고    scopus 로고
    • Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas
    • 21492126 Epub 2011/04/16, PubMed Central PMCID: PMC3092002
    • Brem EA, Thudium K, Khubchandani S, Tsai PC, Olejniczak SH, Bhat S, et al. Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas. Br J Haematol. 2011;153(5):599-611. Epub 2011/04/16. doi: 10.1111/j.1365-2141.2011.08669.x PMID: 21492126; PubMed Central PMCID: PMC3092002.
    • (2011) Br J Haematol. , vol.153 , Issue.5 , pp. 599-611
    • Brem, E.A.1    Thudium, K.2    Khubchandani, S.3    Tsai, P.C.4    Olejniczak, S.H.5    Bhat, S.6
  • 24
    • 79958276489 scopus 로고    scopus 로고
    • GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy
    • 21364679 Epub 2011/03/03, PubMed Central PMCID: PMC3032343
    • Heidari N, Hicks MA, Harada H. GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy. Cell Death Dis. 2010;1:e76. Epub 2011/03/03. doi: 10.1038/cddis.2010.53 PMID: 21364679; PubMed Central PMCID: PMC3032343.
    • (2010) Cell Death Dis. , vol.1 , pp. e76
    • Heidari, N.1    Hicks, M.A.2    Harada, H.3
  • 25
    • 77951171023 scopus 로고    scopus 로고
    • Induction of autophagydependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
    • 20200450 000276258100039
    • Bonapace L, Bornhauser BC, Schmitz M, Cario G, Ziegler U, Niggli FK, et al. Induction of autophagydependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest. 2010;120(4):1310-23. doi: 10.1172/Jci39987. ISI:000276258100039. PMID: 20200450
    • (2010) J Clin Invest. , vol.120 , Issue.4 , pp. 1310-1323
    • Bonapace, L.1    Bornhauser, B.C.2    Schmitz, M.3    Cario, G.4    Ziegler, U.5    Niggli, F.K.6
  • 26
    • 84869757978 scopus 로고    scopus 로고
    • Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress
    • 22989520 Epub 2012/09/20, PubMed Central PMCID: PMC3502625
    • Cruickshanks N, Tang Y, Booth L, Hamed H, Grant S, Dent P. Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress. Mol Pharmacol. 2012;82(6):1217-29. Epub 2012/09/20. doi: 10.1124/mol.112.081539 PMID: 22989520; PubMed Central PMCID: PMC3502625.
    • (2012) Mol Pharmacol. , vol.82 , Issue.6 , pp. 1217-1229
    • Cruickshanks, N.1    Tang, Y.2    Booth, L.3    Hamed, H.4    Grant, S.5    Dent, P.6
  • 27
    • 84858788427 scopus 로고    scopus 로고
    • Obatoclax and lapatinib interact to induce toxic autophagy through NOXA
    • 22219388 Epub 2012/01/06, PubMed Central PMCID: PMC3310419
    • Tang Y, Hamed HA, Cruickshanks N, Fisher PB, Grant S, Dent P. Obatoclax and lapatinib interact to induce toxic autophagy through NOXA. Mol Pharmacol. 2012;81(4):527-40. Epub 2012/01/06. doi: 10. 1124/mol.111.076851 PMID: 22219388; PubMed Central PMCID: PMC3310419.
    • (2012) Mol Pharmacol. , vol.81 , Issue.4 , pp. 527-540
    • Tang, Y.1    Hamed, H.A.2    Cruickshanks, N.3    Fisher, P.B.4    Grant, S.5    Dent, P.6
  • 28
    • 73549101691 scopus 로고    scopus 로고
    • Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy
    • 19823038 Epub 2009/10/14, PubMed Central PMCID: PMC3887451
    • Martin AP, Mitchell C, Rahmani M, Nephew KP, Grant S, Dent P. Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy. Cancer Biol Ther. 2009;8(21):2084-96. Epub 2009/10/14. PMID: 19823038; PubMed Central PMCID: PMC3887451.
    • (2009) Cancer Biol Ther. , vol.8 , Issue.21 , pp. 2084-2096
    • Martin, A.P.1    Mitchell, C.2    Rahmani, M.3    Nephew, K.P.4    Grant, S.5    Dent, P.6
  • 29
    • 84882281344 scopus 로고    scopus 로고
    • Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
    • 23744296 Epub 2013/06/08, PubMed Central PMCID: PMC3741498
    • Basit F, Cristofanon S, Fulda S. Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes. Cell Death Differ. 2013;20(9):1161-73. Epub 2013/06/08. doi: 10.1038/cdd.2013.45 PMID: 23744296; PubMed Central PMCID: PMC3741498.
    • (2013) Cell Death Differ. , vol.20 , Issue.9 , pp. 1161-1173
    • Basit, F.1    Cristofanon, S.2    Fulda, S.3
  • 30
    • 84876492939 scopus 로고    scopus 로고
    • GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogenresistant breast cancer cells
    • 23395885 Epub 2013/02/12, PubMed Central PMCID: PMC3624027
    • Schwartz-Roberts JL, Shajahan AN, Cook KL, Warri A, Abu-Asab M, Clarke R. GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogenresistant breast cancer cells. Mol Cancer Ther. 2013;12(4):448-59. Epub 2013/02/12. doi: 10.1158/1535-7163. MCT-12-0617 PMID: 23395885; PubMed Central PMCID: PMC3624027.
    • (2013) Mol Cancer Ther. , vol.12 , Issue.4 , pp. 448-459
    • Schwartz-Roberts, J.L.1    Shajahan, A.N.2    Cook, K.L.3    Warri, A.4    Abu-Asab, M.5    Clarke, R.6
  • 31
    • 84943199868 scopus 로고    scopus 로고
    • Cell death by autophagy: Emerging molecular mechanisms and implications for cancer therapy
    • 25619832 Epub 2015/01/27
    • Fulda S, Kogel D. Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy. Oncogene. 2015. Epub 2015/01/27. doi: 10.1038/onc.2014.458 PMID: 25619832.
    • (2015) Oncogene.
    • Fulda, S.1    Kogel, D.2
  • 32
    • 76549129820 scopus 로고    scopus 로고
    • Drug combination studies and their synergy quantification using the Chou-Talalay method
    • 20068163 Epub 2010/01/14
    • Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 2010;70(2):440-6. Epub 2010/01/14. doi: 10.1158/0008-5472. CAN-09-1947 PMID: 20068163.
    • (2010) Cancer Res. , vol.70 , Issue.2 , pp. 440-446
    • Chou, T.C.1
  • 33
    • 77949915910 scopus 로고    scopus 로고
    • Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells
    • 20100569 Epub 2010/01/27
    • Vidot S, Witham J, Agarwal R, Greenhough S, Bamrah HS, Tigyi GJ, et al. Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells. Cell Signal. 2010;22(6):926-35. Epub 2010/01/27. doi: 10.1016/j.cellsig.2010.01.017 PMID: 20100569.
    • (2010) Cell Signal. , vol.22 , Issue.6 , pp. 926-935
    • Vidot, S.1    Witham, J.2    Agarwal, R.3    Greenhough, S.4    Bamrah, H.S.5    Tigyi, G.J.6
  • 34
    • 0030694182 scopus 로고    scopus 로고
    • Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: A role for paxillin tyrosine phosphorylation
    • 9372922 Epub 1997/12/31, PubMed Central PMCID: PMC232547
    • Richardson A, Malik RK, Hildebrand JD, Parsons JT. Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation. Mol Cell Biol. 1997;17(12):6906-14. Epub 1997/12/31. PMID: 9372922; PubMed Central PMCID: PMC232547.
    • (1997) Mol Cell Biol. , vol.17 , Issue.12 , pp. 6906-6914
    • Richardson, A.1    Malik, R.K.2    Hildebrand, J.D.3    Parsons, J.T.4
  • 35
    • 34047228186 scopus 로고    scopus 로고
    • Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide
    • 17068963 Epub 2006/10/31
    • Ruttger A, Mollenhauer J, Loser R, Gutschow M, Wiederanders B. Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide. Biotechniques. 2006;41(4):469-73. Epub 2006/10/31. PMID: 17068963.
    • (2006) Biotechniques. , vol.41 , Issue.4 , pp. 469-473
    • Ruttger, A.1    Mollenhauer, J.2    Loser, R.3    Gutschow, M.4    Wiederanders, B.5
  • 36
    • 71749096160 scopus 로고    scopus 로고
    • Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies
    • 19836374 000272748300025
    • Solomon VR, Lee H. Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies. Eur J Pharmacol. 2009;625(1-3):220-33. doi: 10.1016/j.ejphar.2009.06.063. ISI:000272748300025. PMID: 19836374
    • (2009) Eur J Pharmacol. , vol.625 , Issue.1-3 , pp. 220-233
    • Solomon, V.R.1    Lee, H.2
  • 37
    • 79961238238 scopus 로고    scopus 로고
    • Antimalarial activity of natural and synthetic prodiginines
    • 21736388 Epub 2011/07/09, PubMed Central PMCID: PMC4494750
    • Papireddy K, Smilkstein M, Kelly JX, Shweta, Salem SM, Alhamadsheh M, et al. Antimalarial activity of natural and synthetic prodiginines. J MedChem. 2011;54(15):5296-306. Epub 2011/07/09. doi: 10. 1021/jm200543y PMID: 21736388; PubMed Central PMCID: PMC4494750.
    • (2011) J MedChem. , vol.54 , Issue.15 , pp. 5296-5306
    • Papireddy, K.1    Smilkstein, M.2    Kelly, J.X.3    Shweta4    Salem, S.M.5    Alhamadsheh, M.6
  • 38
    • 44849107047 scopus 로고    scopus 로고
    • The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes
    • 18449189 Epub 2008/05/02
    • Graves AR, Curran PK, Smith CL, Mindell JA. The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes. Nature. 2008;453(7196):788-92. Epub 2008/05/02. doi: 10.1038/nature06907 PMID: 18449189.
    • (2008) Nature. , vol.453 , Issue.7196 , pp. 788-792
    • Graves, A.R.1    Curran, P.K.2    Smith, C.L.3    Mindell, J.A.4
  • 39
    • 84872288221 scopus 로고    scopus 로고
    • Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition
    • 23168408 Epub 2012/11/22, PubMed Central PMCID: PMC3543021
    • Von Schwarzenberg K, Wiedmann RM, Oak P, Schulz S, Zischka H, Wanner G, et al. Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition. J Biol Chem. 2013;288(2):1385-96. Epub 2012/11/22. doi: 10.1074/jbc. M112.412007 PMID: 23168408; PubMed Central PMCID: PMC3543021.
    • (2013) J Biol Chem. , vol.288 , Issue.2 , pp. 1385-1396
    • Von Schwarzenberg, K.1    Wiedmann, R.M.2    Oak, P.3    Schulz, S.4    Zischka, H.5    Wanner, G.6
  • 41
    • 84906043176 scopus 로고    scopus 로고
    • Targeting SQSTM1/p62 induces cargo loading failure and converts autophagyto apoptosis via NBK/Bik
    • 25002530 Epub 2014/07/09, PubMed Central PMCID: PMC4135623
    • Chen S, Zhou L, Zhang Y, Leng Y, Pei XY, Lin H, et al. Targeting SQSTM1/p62 induces cargo loading failure and converts autophagyto apoptosis via NBK/Bik. Mol Cell Biol. 2014;34(18):3435-49. Epub 2014/07/09. doi: 10.1128/MCB.01383-13 PMID: 25002530; PubMed Central PMCID: PMC4135623.
    • (2014) Mol Cell Biol. , vol.34 , Issue.18 , pp. 3435-3449
    • Chen, S.1    Zhou, L.2    Zhang, Y.3    Leng, Y.4    Pei, X.Y.5    Lin, H.6
  • 42
    • 84860331447 scopus 로고    scopus 로고
    • A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation
    • 22465052 Epub 2012/04/03
    • Chen KF, Su JC, Liu CY, Huang JW, Chen KC, Chen WL, et al. A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation. Cancer Lett. 2012;321(1):27-35. Epub 2012/04/03. doi: 10.1016/j.canlet.2012.03.023 PMID: 22465052.
    • (2012) Cancer Lett. , vol.321 , Issue.1 , pp. 27-35
    • Chen, K.F.1    Su, J.C.2    Liu, C.Y.3    Huang, J.W.4    Chen, K.C.5    Chen, W.L.6
  • 43
    • 84859939822 scopus 로고    scopus 로고
    • Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XLand MCL-1
    • 22357666 Epub 2012/02/24, PubMed Central PMCID: PMC3336802
    • Cruickshanks N, Hamed HA, Bareford MD, Poklepovic A, Fisher PB, Grant S, et al. Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XLand MCL-1. Mol Pharmacol. 2012;81(5):748-58. Epub 2012/02/24. doi: 10.1124/mol.112.077586 PMID: 22357666; PubMed Central PMCID: PMC3336802.
    • (2012) Mol Pharmacol. , vol.81 , Issue.5 , pp. 748-758
    • Cruickshanks, N.1    Hamed, H.A.2    Bareford, M.D.3    Poklepovic, A.4    Fisher, P.B.5    Grant, S.6
  • 44
    • 84876070821 scopus 로고    scopus 로고
    • BH3 profiling-measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions
    • 22230093 Epub 2012/01/11, PubMed Central PMCID: PMC3770266
    • Del Gaizo Moore V, Letai A. BH3 profiling-measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions. Cancer Lett. 2013;332(2):202-5. Epub 2012/01/11. doi: 10. 1016/j.canlet.2011.12.021 PMID: 22230093; PubMed Central PMCID: PMC3770266.
    • (2013) Cancer Lett. , vol.332 , Issue.2 , pp. 202-205
    • Del Gaizo Moore, V.1    Letai, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.