Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells

Oral Oncology

Volumn 50, Issue 2, 2014, Pages 120-127

  Yazbeck, Victor Y ^a   Li, Changyou ^a   Grandis, Jennifer R ^a,b   Zang, Yan ^a   Johnson, Daniel E ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Autophagy; BCL 2; Head and neck cancer; Obatoclax

Indexed keywords

CHLOROQUINE; LIPOCORTIN 5; OBATOCLAX; PROPIDIUM IODIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CARCINOMA CELL; CELL CYCLE G1 PHASE; CELL GROWTH; CELL VIABILITY; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA CONTENT; DRUG POTENCY; DRUG STRUCTURE; GROWTH INHIBITION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MTT ASSAY; PRIORITY JOURNAL; PROTEIN DEGRADATION;

APOPTOSIS; AUTOPHAGY; BCL-2; HEAD AND NECK CANCER; OBATOCLAX;

APOPTOSIS; AUTOPHAGY; CARCINOMA, SQUAMOUS CELL; CELL SURVIVAL; HEAD AND NECK NEOPLASMS; HUMANS; INHIBITORY CONCENTRATION 50; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES;

EID: 84891826874     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2013.10.013     Document Type: Article

References (30)

1. A. Jemal, T. Murray, E. Ward, A. Samuels, R.C. Tiwari, and A. Ghafoor et al. Cancer statistics CA Cancer J Clin 55 1 2005 10 30
2. A.A. Forastiere, B. Metch, D.E. Schuller, J.F. Ensley, L.F. Hutchins, and P. Triozzi et al. Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group Study J Clin Oncol 10 8 1992 1245 1251
3. M.K. Gibson, Y. Li, B. Murphy, M.H. Hussain, R.C. DeConti, and J. Ensley et al. Randomized phase III evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395): an intergroup trial of the Eastern Cooperative Oncology Group J Clin Oncol 23 15 2005 3562 3567
4. C. Jacobs, G. Lyman, E. Velez-Garcia, K.S. Sridhar, W. Knight, and H. Hochster et al. A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck J Clin Oncol 10 2 1992 257 263
5. J.B. Vermorken, J. Trigo, R. Hitt, P. Koralewski, E. Diaz-Rubio, and F. Rolland et al. Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy J Clin Oncol: official J Am Soc Clin Oncol 25 16 2007 2171 2177
6. D.K. Trask, G.T. Wolf, C.R. Bradford, S.G. Fisher, K. Devaney, and M. Johnson et al. Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ preservation Laryngoscope 112 4 2002 638 644
7. A.C. Nichols, D.M. Finkelstein, W.C. Faquin, W.H. Westra, E.A. Mroz, and P. Kneuertz et al. Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer Clin Cancer Res: an official J Am Assoc Cancer Res 16 7 2010 2138 2146
8. R. Li, Y. Zang, C. Li, N.S. Patel, J.R. Grandis, and D.E. Johnson ABT-737 synergizes with chemotherapy to kill head and neck squamous cell carcinoma cells via a Noxa-mediated pathway Mol Pharmacol 75 5 2009 1231 1239
9. M.A. Hotz, J. Bosq, P. Zbaeren, J. Reed, G. Schwab, and S. Krajewski et al. Spontaneous apoptosis and the expression of p53 and Bcl-2 family proteins in locally advanced head and neck cancer Arch Otolaryngology - Head & neck surg 125 4 1999 417 422
10. D. Zhai, C. Jin, A.C. Satterthwait, and J.C. Reed Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins Cell Death Differ 13 8 2006 1419 1421
11. M. Konopleva, J. Watt, R. Contractor, T. Tsao, D. Harris, and Z. Estrov et al. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax) Cancer Res 68 9 2008 3413 3420
12. P. Perez-Galan, G. Roue, N. Villamor, E. Campo, and D. Colomer The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak Blood 109 10 2007 4441 4449
13. S. Trudel, Z.H. Li, J. Rauw, R.E. Tiedemann, X.Y. Wen, and A.K. Stewart Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma Blood 109 12 2007 5430 5438
14. J. Li, J. Viallet, and E.B. Haura A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells Cancer Chemother Pharmacol 61 3 2008 525 534
15. A.A. Chiappori, M.T. Schreeder, M.M. Moezi, J.J. Stephenson, J. Blakely, and R. Salgia et al. A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer Br J Cancer 106 5 2012 839 845
16. T. Oltersdorf, S.W. Elmore, A.R. Shoemaker, R.C. Armstrong, D.J. Augeri, and B.A. Belli et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature 435 7042 2005 677 681
17. C. Li, and D.E. Johnson Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation Cancer Lett 314 1 2012 102 107
18. Y. Zang, S.M. Thomas, E.T. Chan, C.J. Kirk, M.L. Freilino, and H.M. DeLancey et al. Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy Clin Cancer Res 18 20 2012 5639 5649
19. K.A. Urtishak, A.Y. Edwards, L.S. Wang, A. Hudome, B.W. Robinson, and J.S. Barrett et al. Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia Blood 121 14 2013 Apr 4 2689 2703
20. M.A. Martinez-Paniagua, S. Baritaki, S. Huerta-Yepez, V.F. Ortiz-Navarrete, C. Gonzalez-Bonilla, and B. Bonavida et al. Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis Cell Cycle 10 16 2011 2792 2805
21. K.L. Cook, A.N. Shajahan, and R. Clarke Autophagy and endocrine resistance in breast cancer Expert Rev Anticancer Ther 11 8 2011 1283 1294
22. D.J. Klionsky, H. Abeliovich, P. Agostinis, D.K. Agrawal, G. Aliev, and D.S. Askew et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy 4 2 2008 151 175
23. J. Pan, C. Cheng, S. Verstovsek, Q. Chen, Y. Jin, and Q. Cao The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells Cancer Lett 293 2 2010 167 174
24. Y. Tang, H.A. Hamed, N. Cruickshanks, P.B. Fisher, S. Grant, and P. Dent Obatoclax and lapatinib interact to induce toxic autophagy through NOXA Mol Pharmacol 81 4 2012 527 540
25. T.C. Chou, and P. Talalay Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Adv Enzyme Regul 22 1984 27 55
26. M. Nguyen, R.C. Marcellus, A. Roulston, M. Watson, L. Serfass, and S.R. Murthy Madiraju et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis Proc Natl Acad Sci USA 104 49 2007 19512 19517
27. E.A. Brem, K. Thudium, S. Khubchandani, P.C. Tsai, S.H. Olejniczak, and S. Bhat et al. Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas Br J Haematol 153 5 2011 599 611
28. C. Li, and D.E. Johnson Liberation of functional p53 by proteasome inhibition in human papilloma virus-positive head and neck squamous cell carcinoma cells promotes apoptosis and cell cycle arrest Cell Cycle 12 6 2013 923 934
29. S. Pattingre, A. Tassa, X. Qu, R. Garuti, X.H. Liang, and N. Mizushima et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy Cell 122 6 2005 927 939
30. M.M. Hippert, P.S. O'Toole, and A. Thorburn Autophagy in cancer: good, bad, or both? Cancer Res 66 19 2006 9349 9351