Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

Cell Death and Differentiation

Volumn 20, Issue 9, 2013, Pages 1161-1173

  Basit, F ^a   Cristofanon, S ^a   Fulda, S ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

autophagy; necroptosis; Obatoclax (GX15 070); rhabdomyosarcoma; RIP1

Indexed keywords

AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; BIM PROTEIN; BINDING PROTEIN; CASPASE 8; CELL DNA; CELL PROTEIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; OBATOCLAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN NOXA; RECEPTOR INTERACTING PROTEIN 1; RECEPTOR INTERACTING PROTEIN 3; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER INHIBITION; CELL MEMBRANE; CELL ORGANELLE; CELL SURVIVAL; CELL VIABILITY; CHORIOALLANTOIS; COLONY FORMATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; GENE SILENCING; IMMUNOPRECIPITATION; IN VIVO STUDY; NECROPTOSIS; NECROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RHABDOMYOSARCOMA; RNA INTERFERENCE; SARCOMA CELL;

AUTOPHAGY; CELL DEATH; CELL LINE; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GTPASE-ACTIVATING PROTEINS; HEK293 CELLS; HUMANS; IMIDAZOLES; INDOLES; MICROTUBULE-ASSOCIATED PROTEINS; NECROSIS; PHAGOSOMES; PYRROLES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84882281344     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.45     Document Type: Article

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