Synthetic prodiginine obatoclax (GX15-070) and related analogues: Anion binding, transmembrane transport, and cytotoxicity properties

Chemistry - A European Journal

Volumn 17, Issue 50, 2011, Pages 14074-14083

  Díaz De Greñu, Borja ^a   Hernández, Paulina Iglesias ^b   Espona, Margarita ^b   Quiñonero, David ^c   Light, Mark E ^d   Torroba, Tomás ^a   Pérez Tomás, Ricardo ^b   Quesada, Roberto ^a  

^a UNIVERSITY OF BURGOS   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

antitumor agents; cytotoxicity; ionophores; liposomes; supramolecular chemistry

Indexed keywords

ANION EXCHANGERS; ANION-BINDING; ANTI-TUMOR AGENTS; ANTICANCER DRUG; CANCER CELLS; DENSITY FUNCTIONAL THEORY CALCULATIONS; GAIN INSIGHT; IN-VITRO; IONOPHORES; LIVING CELL; LOW CONCENTRATIONS; LUNG CARCINOMA; MECHANISM OF ACTION; NITRATE TRANSPORT; PH GRADIENTS; PHOSPHOLIPID LIPOSOMES; TRANSMEMBRANE TRANSPORT;

BINDING ENERGY; CELL CULTURE; CELL DEATH; CHLORINE COMPOUNDS; CYTOTOXICITY; DENSITY FUNCTIONAL THEORY; LIPID BILAYERS; LIPOSOMES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC COMPOUNDS; PHOSPHOLIPIDS; SUPRAMOLECULAR CHEMISTRY; TRANSPORT PROPERTIES;

NEGATIVE IONS;

ANION; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; IONOPHORE; LIPOSOME; OBATOCLAX; PRODIGININE; PRODIGIOSIN; PROTEIN BCL 2; PYRROLE DERIVATIVE;

ANIMAL; APOPTOSIS; ARTICLE; CATTLE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; ION TRANSPORT; LUNG TUMOR; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL CULTURE; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANIONS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL TRANSPORT; CATTLE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; ION TRANSPORT; IONOPHORES; LIPOSOMES; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; PRODIGIOSIN; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES; TUMOR CELLS, CULTURED;

EID: 82955222366     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201101547     Document Type: Article

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